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Original Research

The Role of PPARδ Agosnist GW501516 in Rats with Gestational Diabetes Mellitus

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Pages 2307-2316 | Published online: 30 Jun 2020

References

  • Committee on Practice B-O. ACOG practice bulletin no. 190: gestational diabetes mellitus. Obstet Gynecol. 2018;131(2):e49–e64. doi:10.1097/AOG.0000000000002501
  • Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers MH. The pathophysiology of gestational diabetes mellitus. Int J Mol Sci. 2018;19(11):3342. doi:10.3390/ijms19113342
  • Mirza AZ, Althagafi II, Shamshad H. Role of PPAR receptor in different diseases and their ligands: physiological importance and clinical implications. Eur J Med Chem. 2019;166:502–513. doi:10.1016/j.ejmech.2019.01.067
  • Doktorova M, Zwarts I, Zutphen TV, et al. Intestinal PPARdelta protects against diet-induced obesity, insulin resistance and dyslipidemia. Sci Rep. 2017;7(1):846. doi:10.1038/s41598-017-00889-z
  • Fan W, Waizenegger W, Lin CS, et al. PPARdelta promotes running endurance by preserving glucose. Cell Metab. 2017;25(5):1186–1193 e1184. doi:10.1016/j.cmet.2017.04.006
  • Wilding JP. The importance of free fatty acids in the development of Type 2 diabetes. Diabet Med. 2007;24(9):934–945. doi:10.1111/j.1464-5491.2007.02186.x
  • Wan J, Jiang L, Lu Q, Ke L, Li X, Tong N. Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells. Biochem Biophys Res Commun. 2010;391(3):1567–1572. doi:10.1016/j.bbrc.2009.12.127
  • Yang Y, Ren J, Tong Y, Hu X, Lv Q, Tong N. Protective role of PPARdelta in lipoapoptosis of pancreatic beta cells. Lipids. 2016;51(11):1259–1268. doi:10.1007/s11745-016-4190-5
  • Huang Y, Chen X, Chen X, et al. Angiopoietin-like protein 8 in early pregnancy improves the prediction of gestational diabetes. Diabetologia. 2018;61(3):574–580. doi:10.1007/s00125-017-4505-y
  • Martinez-Perez B, Ejarque M, Gutierrez C, et al. Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth. Transl Res. 2016;178:1–12. doi:10.1016/j.trsl.2016.06.012
  • Yi P, Park JS, Melton DA. Retraction notice to: betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell. 2017;168(1–2):326. doi:10.1016/j.cell.2016.12.017
  • Matsuzaka T, Shimano H, Yahagi N, et al. Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice. Diabetes. 2004;53(3):560–569. doi:10.2337/diabetes.53.3.560
  • Im SS, Kang SY, Kim SY, et al. Glucose-stimulated upregulation of GLUT2 gene is mediated by sterol response element-binding protein-1c in the hepatocytes. Diabetes. 2005;54(6):1684–1691. doi:10.2337/diabetes.54.6.1684
  • Marks J, Carvou NJC, Debnam ES, Srai SK, Unwin RJ. Diabetes increases facilitative glucose uptake and GLUT2 expression at the rat proximal tubule brush border membrane. J Physiol. 2003;553(1):137–145. doi:10.1113/jphysiol.2003.046268
  • Rencurel F, Waeber G, Antoine B, et al. Requirement of glucose metabolism for regulation of glucose transporter type 2 (GLUT2) gene expression in liver. Biochem J. 1996;314(Pt 3):903–909. doi:10.1042/bj3140903
  • Kramer DK, Al-Khalili L, Perrini S, et al. Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes. 2005;54(4):1157–1163. doi:10.2337/diabetes.54.4.1157
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 2001;25(4):402–408. doi:10.1006/meth.2001.1262
  • Costa V, Foti D, Paonessa F, et al. The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor- (PPAR) and thiazolidinedione-PPAR agonists. Endocr Relat Cancer. 2008;15(1):325–335. doi:10.1677/ERC-07-0226
  • Capobianco E, Martinez N, Fornes D, et al. PPAR activation as a regulator of lipid metabolism, nitric oxide production and lipid peroxidation in the placenta from type 2 diabetic patients. Mol Cell Endocrinol. 2013;377(1–2):7–15. doi:10.1016/j.mce.2013.06.027
  • Catalano PM, Nizielski SE, Shao J, Preston L, Qiao L, Friedman JE. Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy. Am J Physiol Endocrinol Metab. 2002;282(3):E522–E533. doi:10.1152/ajpendo.00124.2001
  • He W, Barak Y, Hevener A, et al. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003;100(26):15712–15717. doi:10.1073/pnas.2536828100
  • Camacho A, Huang JK, Delint-Ramirez I, et al. Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis. Eur J Neurosci. 2013;38(5):2672–2683. doi:10.1111/ejn.12281
  • Olefsky JM. Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest. 2000;106(4):467–472. doi:10.1172/JCI10843
  • Rong Guo X, Li Wang X, Chen Y, et al. ANGPTL8/betatrophin alleviates insulin resistance via the Akt-GSK3beta or Akt-FoxO1 pathway in HepG2 cells. Exp Cell Res. 2016;345(2):158–167. doi:10.1016/j.yexcr.2015.09.012
  • Zhang R. Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem Biophys Res Commun. 2012;424(4):786–792. doi:10.1016/j.bbrc.2012.07.038
  • Li J, Xu S, Liu Y, et al. Activated PPARbeta/delta protects pancreatic beta cells in type 2 diabetic goto-kakizaki rats from lipoapoptosis via GPR40. Lipids. 2019;54(10):603–616. doi:10.1002/lipd.12182
  • Magliano DC, Penna-de-Carvalho A, Vazquez-Carrera M, Mandarim-de-Lacerda CA, Aguila MB. Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system. Endocrine. 2015;50(2):355–367. doi:10.1007/s12020-015-0590-1
  • Wang X, Sng MK, Foo S, et al. Early controlled release of peroxisome proliferator-activated receptor beta/delta agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment. J Control Release. 2015;197:138–147. doi:10.1016/j.jconrel.2014.11.001