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Review

The Therapeutic Role of Carotenoids in Diabetic Retinopathy: A Systematic Review

ORCID Icon, , , ORCID Icon, &
Pages 2347-2358 | Published online: 03 Jul 2020

References

  • Hammes HP. Diabetic retinopathy: hyperglycaemia, oxidative stress and beyond. Diabetologia. 2017;61:29–38.
  • Yau JW, Rogers SL, Kawasaki R, et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35(3):556–564. doi:10.2337/dc11-1909
  • Ting DS, Cheung GC, Wong TY. Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review. Clin Experiment Ophthalmol. 2016;44(4):260–277. doi:10.1111/ceo.12696
  • Olivares AM, Althoff K, Chen GF, et al. Animal models of diabetic retinopathy. Curr Diab Rep. 2017;17(10):93. doi:10.1007/s11892-017-0913-0
  • Whitmire W, Al-Gayyar MM, Abdelsaid M, Yousufzai BK, El-Remessy AB. Alteration of growth factors and neuronal death in diabetic retinopathy: what we have learned so far. Mol Vis. 2011;17:300–308.
  • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813–820. doi:10.1038/414813a
  • Chistiakov DA. Diabetic retinopathy: pathogenic mechanisms and current treatments. Diabetes Metab Syndr. 2011;5(3):165–172. doi:10.1016/j.dsx.2012.02.025
  • Khalaf FR, Fahmy HM, Ibrahim AK, et al. Does a diabetic retinopathy educational program raise awareness among elderly diabetic patients? Diabetes Metab Syndr Obes. 2019;12:1867–1875. doi:10.2147/DMSO.S208072
  • Mohamed Q, Gillies MC, Wong TY. Management of diabetic retinopathy: a systematic review. JAMA. 2007;298(8):902–916. doi:10.1001/jama.298.8.902
  • Duh EJ, Sun JK, Stitt AW. Diabetic retinopathy: current understanding, mechanisms, and treatment strategies. JCI Insight. 2017;2(14):e93751. doi:10.1172/jci.insight.93751
  • Jonas JB. Intravitreal triamcinolone acetonide for diabetic retinopathy. Dev Ophthalmol. 2007;39:96–110.
  • Coucha M, Elshaer SL, Eldahshan WS, Mysona BA, El-Remessy AB. Molecular mechanisms of diabetic retinopathy: potential therapeutic targets. Middle East Afr J Ophthalmol. 2015;22(2):135–144. doi:10.4103/0974-9233.154386
  • Simo R, Hernandez C. Advances in the medical treatment of diabetic retinopathy. Diabetes Care. 2009;32(8):1556–1562. doi:10.2337/dc09-0565
  • Khan ZA, Chakrabarti S. Cellular signaling and potential new treatment targets in diabetic retinopathy. Exp Diabetes Res. 2007;2007:31867. doi:10.1155/2007/31867
  • Xavier AA, Perez-Galvez A. Carotenoids as a source of antioxidants in the diet. Subcell Biochem. 2016;79:359–375.
  • Milani A, Basirnejad M, Shahbazi S, Bolhassani A. Carotenoids: biochemistry, pharmacology and treatment. Br J Pharmacol. 2017;174(11):1290–1324. doi:10.1111/bph.13625
  • Stahl W, Sies H. Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta. 2005;1740(2):101–107. doi:10.1016/j.bbadis.2004.12.006
  • Alvarez R, Vaz B, Gronemeyer H, de Lera AR. Functions, therapeutic applications, and synthesis of retinoids and carotenoids. Chem Rev. 2014;114(1):1–125. doi:10.1021/cr400126u
  • Bolhassani A. Cancer chemoprevention by natural carotenoids as an efficient strategy. Anticancer Agents Med Chem. 2015;15(8):1026–1031. doi:10.2174/1871520615666150302125707
  • Gammone MA, Pluchinotta FR, Bergante S, Tettamanti G, D’Orazio N. Prevention of cardiovascular diseases with carotenoids. Front Biosci. 2017;9:165–171. doi:10.2741/s480
  • Roohbakhsh A, Karimi G, Iranshahi M. Carotenoids in the treatment of diabetes mellitus and its complications: a mechanistic review. Biomed Pharmacother. 2017;91:31–42. doi:10.1016/j.biopha.2017.04.057
  • Sugiura M, Nakamura M, Ogawa K, Ikoma Y, Yano M. High serum carotenoids associated with lower risk for bone loss and osteoporosis in post-menopausal Japanese female subjects: prospective cohort study. PLoS One. 2012;7(12):e52643. doi:10.1371/journal.pone.0052643
  • Wise J. Diet rich in carotenoids is linked to reduced risk of advanced age related macular degeneration. BMJ. 2015;351:h5384. doi:10.1136/bmj.h5384
  • Moeller SM, Voland R, Tinker L, et al. Associations between age-related nuclear cataract and lutein and zeaxanthin in the diet and serum in the Carotenoids in the Age-Related Eye Disease Study, an ancillary study of the women’s health initiative. Arch Ophthalmol. 2008;126(3):354–364. doi:10.1001/archopht.126.3.354
  • Mohammadzadeh Honarvar N, Saedisomeolia A, Abdolahi M, et al. Molecular anti-inflammatory mechanisms of retinoids and carotenoids in Alzheimer’s disease: a review of current evidence. J Mol Neurosci. 2017;61(3):289–304. doi:10.1007/s12031-016-0857-x
  • Murillo AG, Fernandez ML. Potential of dietary non-provitamin A carotenoids in the prevention and treatment of diabetic microvascular complications. Adv Nutr. 2016;7(1):14–24. doi:10.3945/an.115.009803
  • Brazionis L, Rowley K, Itsiopoulos C, O’Dea K. Plasma carotenoids and diabetic retinopathy. Br J Nutr. 2008;101(2):270. doi:10.1017/S0007114508006545
  • She C, Shang F, Zhou K, Liu N. Serum carotenoids and risks of diabetes and diabetic retinopathy in a Chinese population sample. Curr Mol Med. 2017;17(4). doi:10.2174/1566524017666171106112131
  • Moher D, Shamseer L, Clarke Met al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1. doi:10.1186/2046-4053-4-1
  • Moschos MM, Dettoraki M, Tsatsos M, Kitsos G, Kalogeropoulos C. Effect of carotenoids dietary supplementation on macular function in diabetic patients. Eye Vision. 2017;4(1):23. doi:10.1186/s40662-017-0088-4
  • Sahli MW, Mares JA, Meyers KJ, et al. Dietary intake of lutein and diabetic retinopathy in the Atherosclerosis Risk in Communities Study (ARIC). Ophthalmic Epidemiol. 2016;23(2):99–108. doi:10.3109/09286586.2015.1129426
  • Zhang P-C, Wu C-R, Wang Z-L, et al. Effect of lutein supplementation on visual function in nonproliferative diabetic retinopathy. Asia Pac J Clin Nutr. 2013;26(3):406–411.
  • Tanaka S, Yoshimura Y, Kawasaki R, et al. Fruit intake and incident diabetic retinopathy with type 2 diabetes. Epidemiology. 2013;24(2):204–211. doi:10.1097/EDE.0b013e318281725e
  • Hu BJ, Hu YN, Lin S, Ma WJ, Li XR. Application of lutein and zeaxanthin in nonproliferative diabetic retinopathy. Int J Ophthalmol. 2011;4(3):303–306. doi:10.3980/j.issn.2222-3959.2011.03.19
  • McClinton KJ, Aliani M, Kuny S, Sauve Y, Suh M. Differential effect of a carotenoid-rich diet on retina function in non-diabetic and diabetic rats. Nutr Neurosci. 2019;1–11. doi:10.1080/1028415X.2018.1563664
  • Sharavana G, Baskaran V. Lutein downregulates retinal vascular endothelial growth factor possibly via hypoxia inducible factor 1 alpha and X-box binding protein 1 expression in streptozotocin induced diabetic rats. J Funct Foods. 2017;31:97–103. doi:10.1016/j.jff.2017.01.023
  • Yeh PT, Huang HW, Yang CM, Yang WS, Yang CH. Astaxanthin inhibits expression of retinal oxidative stress and inflammatory mediators in streptozotocin-induced diabetic rats. PLoS One. 2016;11(1):e0146438. doi:10.1371/journal.pone.0146438
  • Kowluru RA, Zhong Q, Santos JM, Thandampallayam M, Putt D, Gierhart DL. Beneficial effects of the nutritional supplements on the development of diabetic retinopathy. Nutr Metab. 2014;11(1):8. doi:10.1186/1743-7075-11-8
  • Yu HF, Wark L, Ji H, et al. Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice. Mol Nutr Food Res. 2013;57(7):1158–1169. doi:10.1002/mnfr.201200642
  • Tang L, Zhang Y, Jiang Y, et al. Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes. Exp Biol Med. 2011;236(9):1051–1063. doi:10.1258/ebm.2011.010400
  • Sasaki M, Ozawa Y, Kurihara T, et al. Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes. Diabetologia. 2010;53(5):971–979. doi:10.1007/s00125-009-1655-6
  • Kowluru RA, Koppolu P. Diabetes-induced activation of caspase-3 in retina: effect of antioxidant therapy. Free Radic Res. 2002;36(9):993–999. doi:10.1080/1071576021000006572
  • Kowluru RA, Koppolu P, Chakrabarti S, Chen S. Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants. Free Radic Res. 2003;37(11):1169–1180. doi:10.1080/10715760310001604189
  • Arnal E, Miranda M, Johnsen-Soriano S, et al. Beneficial effect of docosahexanoic acid and lutein on retinal structural, metabolic, and functional abnormalities in diabetic rats. Curr Eye Res. 2009;34(11):928–938. doi:10.3109/02713680903205238
  • Kowluru RA, Menon B, Gierhart DL. Beneficial effect of zeaxanthin on retinal metabolic abnormalities in diabetic rats. Invest Ophthalmol Vis Sci. 2008;49(4):1645–1651. doi:10.1167/iovs.07-0764
  • Kowluru RA, Engerman RL, Case GL, Kern TS. Retinal glutamate in diabetes and effect of antioxidants. Neurochem Int. 2001;38(5):385–390. doi:10.1016/S0197-0186(00)00112-1
  • Muriach M, Miranda M, Arnal E, Bosch-Morel F, Romero FJ. Effect of lutein in the retina of diabetic mice. Eur J Ophthalmol. 2007;17(3):477–478.
  • Dene BA, Maritim AC, Sanders RA, Watkins JB. Effects of antioxidant treatment on normal and diabetic rat retinal enzyme activities. J Ocul Pharmacol Th. 2005;21(1):28–35. doi:10.1089/jop.2005.21.28
  • Hwang JS, Han SG, Lee CH, Seo HG. Lutein suppresses hyperglycemia‐induced premature senescence of retinal pigment epithelial cells by upregulating SIRT1. J Food Biochem. 2018;42(3):e12495. doi:10.1111/jfbc.12495
  • Yang X, Huo F, Liu B, et al. Crocin inhibits oxidative stress and pro-inflammatory response of microglial cells associated with diabetic retinopathy through the activation of PI3K/Akt signaling pathway. J Mol Neurosci. 2017;61(4):581–589. doi:10.1007/s12031-017-0899-8
  • Baccouche B, Mbarek S, Dellaa A, et al. Protective effect of astaxanthin on primary retinal cells of the gerbil Psammomys obesus cultured in diabetic milieu. J Food Biochem. 2017;41(1):e1745. doi:10.1111/jfbc.12274
  • Umigai N, Tanaka J, Tsuruma K, Shimazawa M, Hara H. Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation. Curr Neurovasc Res. 2012;9(2):102–109. doi:10.2174/156720212800410830
  • Sun Z, Liu J, Zeng X, et al. Protective actions of microalgae against endogenous and exogenous advanced glycation endproducts (AGEs) in human retinal pigment epithelial cells. Food Funct. 2011;2(5):251–258. doi:10.1039/c1fo10021a
  • Lorenzi M. The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient. Exp Diabetes Res. 2007;2007(3):61038. doi:10.1155/2007/61038
  • Chen M, Curtis TM, Stitt AW. Advanced glycation end products and diabetic retinopathy. Curr Med Chem. 2013;20(26):3234–3240. doi:10.2174/09298673113209990025
  • Galvez MI. Protein kinase C inhibitors in the treatment of diabetic retinopathy. Review. Curr Pharm Biotechnol. 2011;12(3):386–391. doi:10.2174/138920111794480606
  • Semba RD, Huang H, Lutty GA, Van Eyk JE, Hart GW. The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy. Proteomics Clin Appl. 2014;8(3–4):218–231. doi:10.1002/prca.201300076
  • Kowluru RA, Mishra M. Oxidative stress, mitochondrial damage and diabetic retinopathy. Biochim Biophys Acta. 2015;1852(11):2474–2483. doi:10.1016/j.bbadis.2015.08.001
  • Behl T, Kaur I, Kotwani A. Implication of oxidative stress in progression of diabetic retinopathy. Surv Ophthalmol. 2016;61(2):187–196. doi:10.1016/j.survophthal.2015.06.001
  • Wu MY, Yiang GT, Lai TT, Li CJ. The oxidative stress and mitochondrial dysfunction during the pathogenesis of diabetic retinopathy. Oxid Med Cell Longev. 2018;2018:3420187. doi:10.1155/2018/3420187
  • Sahajpal NS, Goel RK, Chaubey A, Aurora R, Jain SK. Pathological perturbations in diabetic retinopathy: hyperglycemia, AGEs, oxidative stress and inflammatory pathways. Curr Protein Pept Sci. 2019;20(1):92–110. doi:10.2174/1389203719666180928123449
  • Neelam K, Goenadi CJ, Lun K, Yip CC, Au Eong KG. Putative protective role of lutein and zeaxanthin in diabetic retinopathy. Br J Ophthalmol. 2017;101(5):551–558. doi:10.1136/bjophthalmol-2016-309814
  • Muriach M, Bosch-Morell F, Alexander G, et al. Lutein effect on retina and hippocampus of diabetic mice. Free Radic Biol Med. 2006;41(6):979–984. doi:10.1016/j.freeradbiomed.2006.06.023
  • Hozawa A, Jacobs DR, Steffes MW, Gross MD, Steffen LM, Lee DH. Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) study. Clin Chem. 2007;53(3):447–455. doi:10.1373/clinchem.2006.074930
  • Simo R, Stitt AW, Gardner TW. Neurodegeneration in diabetic retinopathy: does it really matter? Diabetologia. 2018;61(9):1902–1912. doi:10.1007/s00125-018-4692-1
  • Barber AJ, Baccouche B. Neurodegeneration in diabetic retinopathy: potential for novel therapies. Vision Res. 2017;139:82–92. doi:10.1016/j.visres.2017.06.014