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Original Research

Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet

ORCID Icon, ORCID Icon, , , &
Pages 3337-3348 | Published online: 25 Sep 2020

References

  • Mohamed GA, Ibrahim SR, Elkhayat ES, El Dine RS. Natural anti-obesity agents. Bulletin Faculty Pharm Cairo Univ. 2014;52(2):269–284. doi:10.1016/j.bfopcu.2014.05.001
  • Kim JH, Kim O-K, Yoon H-G, et al. Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats. Food Nutr Res. 2016;60(1):30428. doi:10.3402/fnr.v60.30428
  • Furukawa S, Fujita T, Shimabukuro M, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2017;114(12):1752–1761. doi:10.1172/JCI21625
  • Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis. Bmc Public Health. 2009;9(1). doi:10.1186/1471-2458-9-88
  • Word Health Organization. Obesity and Overweight; 2016. Available from https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accessed October 14, 2019
  • Rodríguez-Pérez C, Segura-Carretero A, Del Mar Contreras M. Phenolic compounds as natural and multifunctional anti-obesity agents: A review. Crit Rev Food Sci Nutr. 2019;59(8):1212–1229. doi:10.1080/10408398.2017.1399859
  • Mayer MA, Hocht C, Puyó A, Taira CA. Recent advances in obesity pharmacotherapy. Curr Clin Pharmacol. 2009;4(1):53–61. doi:10.2174/157488409787236128
  • Sheba AL, Ilakkia A. Anti-obesity effect of hibiscus Sabdariffa L.- A review. Int J Pharma Bio Sci. 2016;7(4). doi:10.22376/ijpbs.2016.7.4.b341-345
  • Sun -N-N, Wu T-Y, Chau C-F. Natural dietary and herbal products in anti-obesity treatment. Molecules. 2016;21(10):1351. doi:10.3390/molecules21101351
  • Cerdá B, Periago P, Espín JC, Tomás-Barberán FA. Identification of urolithin A as a metabolite produced by human colon microflora from ellagic acid and related compounds. J Agric Food Chem. 2005;53(14):5571–5576. doi:10.1021/jf050384i
  • González‐Sarrías A, Giménez‐Bastida JA, García‐Conesa MT, et al. Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice. Mol Nutr Food Res. 2010;54(3):311–322. doi:10.1002/mnfr.200900152
  • Savi M, Bocchi L, Mena P, et al. In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats. Cardiovasc Diabetol. 2017;16(1):80. doi:10.1186/s12933-017-0561-3
  • Espín JC, Larrosa M, García-Conesa MT, Tomás-Barberán F. Biological significance of urolithins, the gut microbial ellagic acid-derived metabolites: the evidence so far. Evid Based Complement Alternat Med. 2013;2013:1–15. doi:10.1155/2013/270418
  • García-Muñoz C, Hernández L, Pérez A, Vaillant F. Diversity of urinary excretion patterns of main ellagitannins’ colonic metabolites after ingestion of tropical highland blackberry (Rubus adenotrichus) juice. Food Res Int. 2014;55:161–169. doi:10.1016/j.foodres.2013.10.049
  • Cerdá B, Espín JC, Parra S, Martínez P, Tomás-Barberán FA. The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy–6H–dibenzopyran–6–one derivatives by the colonic microflora of healthy humans. Eur J Nutr. 2004;43(4):205–220. doi:10.1007/s00394-004-0461-7
  • Seeram NP, Aronson WJ, Zhang Y, et al. Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J of Agri Food Chem. 2007;55(19):7732–7737. doi:10.1021/jf071303g
  • Al-Muammar MN, Khan F. Obesity: the preventive role of the pomegranate (Punica granatum). Nutrition. 2012;28(6):595–604. doi:10.1016/j.nut.2011.11.013
  • Woods SC, Seeley RJ, Rushing PA, D’Alessio D, Tso P. A controlled high-fat diet induces an obese syndrome in rats. J Nutr. 2003;133(4):1081–1087. doi:10.1093/jn/133.4.1081
  • Yang C, Li LH, Yang LG, Lu H, Wang SK, Sun GJ. Anti-obesity and Hypolipidemic effects of garlic oil and onion oil in rats fed a high-fat diet. Nutr Metab. 2018;15.
  • Vanzo A, Vrhovsek U, Tramer F, Mattivi F, Passamonti S. Exceptionally fast uptake and metabolism of cyanidin 3-glucoside by rat kidneys and liver. J Nat Prod. 2011;74(5):1049–1054. doi:10.1021/np100948a
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72(1–2):248–254. doi:10.1016/0003-2697(76)90527-3
  • Aebi H. Catalase in Vitro. In: Methods in Enzymology. Vol. 105. Elsevier; 1984:121–126.
  • Li X. Improved pyrogallol autoxidation method: a reliable and cheap superoxide-scavenging assay suitable for all antioxidants. J Agric Food Chem. 2012;60(25):6418–6424. doi:10.1021/jf204970r
  • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351–358. doi:10.1016/0003-2697(79)90738-3
  • Folch J, Lees M, Stanley G. A simple method for total lipid extraction and purification. J Biol Chem. 1957;226(1):497–509.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. methods. 2001;25(4):402–408. doi:10.1006/meth.2001.1262
  • Shin J-W, Seol I-C, Son C-G. Interpretation of animal dose and human equivalent dose for drug development. J Korean Oriental Med. 2010;31(3):1–7.
  • Hwang NH, Woo SL. Frontiers in Biomedical Engineering: Proceedings of the World Congress for Chinese Biomedical Engineers. Springer Science & Business Media; 2003.
  • Tomás‐Barberán FA, González‐Sarrías A, García‐Villalba R, et al. Urolithins, the rescue of “old” metabolites to understand a “new” concept: metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status. Mol Nutr Food Res. 2017;61(1):1500901. doi:10.1002/mnfr.201500901
  • Echeverria F, Valenzuela R, Bustamante A, et al. Attenuation of High-Fat Diet-Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol- (HT-) Eicosapentaenoic Acid Supplementation Mainly Relies on HT. Oxid Med Cell Longev. 2018;2018:5109503. doi:10.1155/2018/5109503
  • Abarca-Gómez L, Abdeen ZA, Hamid ZA, et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128· 9 million children, adolescents, and adults. Lancet. 2017;390(10113):2627–2642.
  • Rodriguez-Ramiro I, Vauzour D, Minihane A. Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms. Proce Nutrition Soc. 2016;75(1):47–60. doi:10.1017/S0029665115004218
  • Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2(5):270–278. doi:10.4161/oxim.2.5.9498
  • Sayed S, Ahmed M, El-Shehawi A, et al. Ginger Water Reduces Body Weight Gain and Improves Energy Expenditure in Rats. Foods. 2020;9(1):1. doi:10.3390/foods9010038
  • Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science. 2011;332(6037):1519–1523. doi:10.1126/science.1204265
  • Blokhina O, Virolainen E, Fagerstedt KV. Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann Bot. 2003;91(2):179–194. doi:10.1093/aob/mcf118
  • Svegliati-Baroni G, Candelaresi C, Saccomanno S, et al. A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-α and n-3 polyunsaturated fatty acid treatment on liver injury. Am J Pathol. 2006;169(3):846–860. doi:10.2353/ajpath.2006.050953
  • Kang I, Kim Y, Tomás‐Barberán FA, Espín JC, Chung S. Urolithin A, C, and D, but not iso‐urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes. Mol Nutr Food Res. 2016;60(5):1129–1138. doi:10.1002/mnfr.201500796
  • Zhao W, Wang L, Haller V, Ritsch A, Novel A. Candidate for Prevention and Treatment of Atherosclerosis: urolithin B Decreases Lipid Plaque Deposition in apoE−/− Mice and Increases Early Stages of Reverse Cholesterol Transport in ox‐LDL Treated Macrophages Cells. Mol Nutr Food Res. 2019;63(10):1800887. doi:10.1002/mnfr.201800887
  • Lei F, Zhang X, Wang W, et al. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes. 2007;31(6):1023. doi:10.1038/sj.ijo.0803502
  • Drent ML, van der Veen EA. First clinical studies with orlistat: a short review. Obes Res. 1995;3(Suppl 4):623S–625S. doi:10.1002/j.1550-8528.1995.tb00236.x
  • Dib L, Bugge A, Collins S. LXRα fuels fatty acid-stimulated oxygen consumption in white adipocytes. J Lipid Res. 2014;55(2):247–257. doi:10.1194/jlr.M043422
  • Strable MS, Ntambi JM. Genetic control of de novo lipogenesis: role in diet-induced obesity. Crit Rev Biochem Mol Biol. 2010;45(3):199–214. doi:10.3109/10409231003667500
  • Knebel B, Haas J, Hartwig S, et al. Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass. PLoS One. 2012;7(2):e31812. doi:10.1371/journal.pone.0031812
  • Ferré P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes. 2004;53(suppl 1):S43–S50. doi:10.2337/diabetes.53.2007.S43
  • Yeh Y-T, Cho -Y-Y, Hsieh S-C, Chiang A-N. Chinese olive extract ameliorates hepatic lipid accumulation in vitro and in vivo by regulating lipid metabolism. Sci Rep. 2018;8(1):1057. doi:10.1038/s41598-018-19553-1
  • Hashimoto T, Cook WS, Qi C, Yeldandi AV, Reddy JK, Rao MS. Defect in peroxisome proliferator-activated receptor α-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem. 2000;275(37):28918–28928. doi:10.1074/jbc.M910350199
  • Hampton RY. ER stress response: getting the UPR hand on misfolded proteins. Current Biol. 2000;10(14):R518–R521. doi:10.1016/S0960-9822(00)00583-2
  • Rutkowski DT, Wu J, Back S-H, et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell. 2008;15(6):829–840. doi:10.1016/j.devcel.2008.10.015
  • Özcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 2004;306(5695):457–461. doi:10.1126/science.1103160