Renoprotective Effect of Formononetin by Suppressing Smad3 Expression in Db/Db Mice

References

• Lovisa S, Zeisberg M, Kalluri R. Partial epithelial-to-mesenchymal transition and other new mechanisms of kidney fibrosis. Trends Endocrinol Metab. 2016;27(10):681–695. doi:10.1016/j.tem.2016.06.004
   PubMed Web of Science ®Google Scholar
• Marshall CB. Rethinking glomerular basement membrane thickening in diabetic nephropathy: adaptive or pathogenic? Am J Physiol Renal Physiol. 2016;311(5):F831–F843. doi:10.1152/ajprenal.00313.2016
   PubMedGoogle Scholar
• Liu YW, Hao YC, Chen YJ, et al. Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats. Phytother Res. 2018;32(8):1574–1582. doi:10.1002/ptr.6088
   PubMed Web of Science ®Google Scholar
• Sun J, Wang Y, Cui W, et al. Role of epigenetic histone modifications in diabetic kidney disease involving renal fibrosis. J Diabetes Res. 2017;2017:7242384. doi:10.1155/2017/7242384
   PubMedGoogle Scholar
• Wei Z, Cao J, Zhang X, Yin D, Xu D, Lu G. EPA attenuates epithelial-mesenchymal transition and fibrosis through the TGF-β1/Smad3/ILK pathway in renal tubular epithelial HK-2 cells by up-regulating miR-541. Int J Clin Exp Pathol. 2019;12(7):2516–2525.
   PubMed Web of Science ®Google Scholar
• Jin Z, Gu C, Tian F, Jia Z, Yang J. NDRG2 knockdown promotes fibrosis in renal tubular epithelial cells through TGF-β1/Smad3 pathway. Cell Tissue Res. 2017;369(3):603–610. doi:10.1007/s00441-017-2643-7
   PubMedGoogle Scholar
• Feng M, Tang PM, Huang XR, et al. TGF-β mediates renal fibrosis via the Smad3-Erbb4-IR long noncoding RNA axis. Mol Ther. 2018;26(1):148–161. doi:10.1016/j.ymthe.2017.09.024
   PubMed Web of Science ®Google Scholar
• Peng H, Li Y, Wang C, et al. ROCK1 induces endothelial-to-mesenchymal transition in glomeruli to aggravate albuminuria in diabetic nephropathy. Sci Rep. 2016;6(1):20304. doi:10.1038/srep20304
   PubMedGoogle Scholar
• Zhao L, Zhao J, Wang X, et al. Serum response factor induces endothelial-mesenchymal transition in glomerular endothelial cells to aggravate proteinuria in diabetic nephropathy. Physiol Genomics. 2016;48(10):711–718. doi:10.1152/physiolgenomics.00082.2016
   PubMed Web of Science ®Google Scholar
• Daehn IS. Glomerular endothelial cell stress and cross-talk with podocytes in early [corrected] diabetic kidney disease. Front Med (Lausanne). 2018;5:76. doi:10.3389/fmed.2018.00076
   PubMed Web of Science ®Google Scholar
• Smith BN, Bhowmick NA. Role of EMT in metastasis and therapy resistance. J Clin Med. 2016;5(2):17. doi:10.3390/jcm5020017
   PubMed Web of Science ®Google Scholar
• Yu CH, Suriguga GM, Liu WJ, et al. High glucose induced endothelial to mesenchymal transition in human umbilical vein endothelial cell. Exp Mol Pathol. 2017;102(3):377–383. doi:10.1016/j.yexmp.2017.03.007
   PubMedGoogle Scholar
• Song S, Qiu D, Luo F, et al. Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells. J Mol Endocrinol. 2018;61(3):101–113. doi:10.1530/JME-18-0069
   PubMed Web of Science ®Google Scholar
• Zhan J, Liu M, Pan L, He L, Guo Y. Oxidative stress and TGF-β1/smads signaling are involved in Rosa roxburghii fruit extract alleviating renal fibrosis. Evid Based Complement Alternat Med. 2019;2019:4946580. doi:10.1155/2019/4946580
   PubMedGoogle Scholar
• Wang T, Li Y, Chen J, Xie L, Xiao T. TGF-β1/Smad3 signaling promotes collagen synthesis in pulmonary artery smooth muscle by down-regulating miR-29b. Int J Clin Exp Pathol. 2018;11(12):5592–5601.
   PubMedGoogle Scholar
• Wu Y, Wang L, Wang X, Wang Y, Zhang Q, Liu W. Renalase contributes to protection against renal fibrosis via inhibiting oxidative stress in rats. Int Urol Nephrol. 2018;50(7):1347–1354. doi:10.1007/s11255-018-1820-2
   PubMed Web of Science ®Google Scholar
• Wu X, Guan Y, Yan J, et al. ShenKang injection suppresses kidney fibrosis and oxidative stress via transforming growth factor-β/Smad3 signalling pathway in vivo and in vitro. J Pharm Pharmacol. 2015;67(8):1054–1065. doi:10.1111/jphp.12412
   PubMedGoogle Scholar
• Montorfano I, Becerra A, Cerro R, et al. Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway. Lab Invest. 2014;94(10):1068–1082. doi:10.1038/labinvest.2014.100
   PubMedGoogle Scholar
• Qiu L, Ye H, Chen L, Hong Y, Zhong F, Zhang T. Red clover extract ameliorates dyslipidemia in streptozotocin-induced diabetic C57BL/6 mice by activating hepatic PPARα. Phytother Res. 2012;26(6):860–864. doi:10.1002/ptr.3641
   PubMedGoogle Scholar
• Lai PK, Chan JY, Cheng L, et al. Isolation of anti-inflammatory fractions and compounds from the root of astragalus membranaceus. Phytother Res. 2013;27(4):581–587. doi:10.1002/ptr.4759
   PubMed Web of Science ®Google Scholar
• Jia WC, Liu G, Zhang CD, Zhang SP. Formononetin attenuates hydrogen peroxide (H2O2)-induced apoptosis and NF-κB activation in RGC-5 cells. Eur Rev Med Pharmacol Sci. 2014;18(15):2191–2197.
   PubMedGoogle Scholar
• Oza MJ, Kulkarni YA. Formononetin treatment in type 2 diabetic rats reduces insulin resistance and hyperglycemia. Front Pharmacol. 2018;9:739. doi:10.3389/fphar.2018.00739
   PubMedGoogle Scholar
• Oza MJ, Kulkarni YA. Formononetin attenuates kidney damage in type 2 diabetic rats. Life Sci. 2019;219:109–121. doi:10.1016/j.lfs.2019.01.013
   PubMed Web of Science ®Google Scholar
• Do MH, Hur J, Choi J, Kim Y, Park HY, Ha SK. Spatholobus suberectus ameliorates diabetes-induced renal damage by suppressing advanced glycation end products in db/db mice. Int J Mol Sci. 2018;19(9):2774. doi:10.3390/ijms19092774
   PubMedGoogle Scholar
• Zhou Z, Zhou X, Dong Y, Li M, Xu Y. Formononetin ameliorates high glucose-induced endothelial dysfunction by inhibiting the JAK/STAT signaling pathway. Mol Med Rep. 2019;20(3):2893–2901. doi:10.3892/mmr.2019.10512
   PubMedGoogle Scholar
• Zar Kalai F, Han J, Ksouri R, Abdelly C, Isoda H. Oral administration of nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db/db mice model through the modulation of balance. Food Chem Toxicol. 2014;72:247–256. doi:10.1016/j.fct.2014.07.029
   PubMedGoogle Scholar
• Senturk B, Demircan BM, Ozkan AD, et al. Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice. Biomater Sci. 2017;5(7):1293–1303. doi:10.1039/C7BM00251C
   PubMedGoogle Scholar
• Pei F, Li BY, Zhang Z, et al. Beneficial effects of phlorizin on diabetic nephropathy in diabetic db/db mice. J Diabetes Complications. 2014;28(5):596–603. doi:10.1016/j.jdiacomp.2014.04.010
   PubMedGoogle Scholar
• Jia ZH, Liu ZH, Zheng JM, Zeng CH, Li LS. Combined therapy of rhein and benazepril on the treatment of diabetic nephropathy in db/db mice. Exp Clin Endocrinol Diabetes. 2007;115(9):571–576. doi:10.1055/s-2007-981469
   PubMed Web of Science ®Google Scholar
• Eisenreich A, Leppert U. Update on the protective renal effects of metformin in diabetic nephropathy. Curr Med Chem. 2017;24(31):3397–3412. doi:10.2174/0929867324666170404143102
   PubMedGoogle Scholar
• Ravindran S, Kuruvilla V, Wilbur K, Munusamy S. Nephroprotective effects of metformin in diabetic nephropathy. J Cell Physiol. 2017;232(4):731–742. doi:10.1002/jcp.25598
   PubMed Web of Science ®Google Scholar
• Wang J, Wang L, Zhou J, Qin A, Chen Z. The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice. Biomed Pharmacother. 2018;106:1250–1257. doi:10.1016/j.biopha.2018.07.063
   PubMed Web of Science ®Google Scholar
• Nie T, Zhao S, Mao L, et al. The natural compound, formononetin, extracted from astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity. Br J Pharmacol. 2018;175(9):1439–1450. doi:10.1111/bph.14139
   PubMed Web of Science ®Google Scholar
• Einbinder Y, Ohana M, Benchetrit S, et al. Glucagon-like peptide-1 and vitamin D: anti-inflammatory response in diabetic kidney disease in db/db mice and in cultured endothelial cells. Diabetes Metab Res Rev. 2016;32(8):805–815. doi:10.1002/dmrr.2801
   PubMed Web of Science ®Google Scholar
• Mima A. Renal protection by sodium-glucose cotransporter 2 inhibitors and its underlying mechanisms in diabetic kidney disease. J Diabetes Complications. 2018;32(7):720–725. doi:10.1016/j.jdiacomp.2018.04.011
   PubMed Web of Science ®Google Scholar
• Liu Y, Dai W, Ye S. The olive constituent oleuropein exerts nephritic protective effects on diabetic nephropathy in db/db mice. Arch Physiol Biochem. 2019;1–8. doi:10.1080/13813455.2019.1691603
   Google Scholar
• Yaribeygi H, Sathyapalan T, Atkin SL, Sahebkar A. Molecular mechanisms linking oxidative stress and diabetes mellitus. Oxid Med Cell Longev. 2020;2020:8609213. doi:10.1155/2020/8609213
   PubMed Web of Science ®Google Scholar
• Singh P, Prasad SM. Antioxidant enzyme responses to the oxidative stress due to chlorpyrifos, dimethoate and dieldrin stress in palak (Spinacia oleracea L.) and their toxicity alleviation by soil amendments in tropical croplands. Sci Total Environ. 2018;630:839–848. doi:10.1016/j.scitotenv.2018.02.203
   PubMed Web of Science ®Google Scholar
• Nikolic-Paterson DJ, Wang S, Lan HY. Macrophages promote renal fibrosis through direct and indirect mechanisms. Kidney Int Suppl. 2014;4(1):34–38. doi:10.1038/kisup.2014.7
   Web of Science ®Google Scholar
• Zhao JH. Mesangial cells and renal fibrosis. Adv Exp Med Biol. 2019;1165:165–194.
   PubMed Web of Science ®Google Scholar
• Huang S, Liu F, Niu Q, et al. GLIPR-2 overexpression in HK-2 cells promotes cell EMT and migration through ERK1/2 activation. PLoS One. 2013;8(3):e58574. doi:10.1371/journal.pone.0058574
   PubMedGoogle Scholar
• Bai X, He T, Liu J, et al. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Exp Dermatol. 2015;24(5):355–360. doi:10.1111/exd.12665
   PubMed Web of Science ®Google Scholar
• McGrath JC, Lilley E. Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP. Br J Pharmacol. 2015;172(13):3189–3193. doi:10.1111/bph.12955
   PubMed Web of Science ®Google Scholar