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Original Research

Circulating miRNA Signatures Associated with Insulin Resistance in Adolescents with Obesity

ORCID Icon, , ORCID Icon &
Pages 4929-4939 | Published online: 10 Dec 2020

References

  • Hales C, Carroll M, Fryar C, Ogden C. Prevalence of obesity among adults and youth: United States, 2015–2016. NCHS Data Brief. 2017.
  • Poirier P, Giles TD, Bray GA, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2006;113(6):898–918. doi:10.1161/CIRCULATIONAHA.106.171016
  • Weiss R, Dziura J, Burgert TS, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004;350(23):2362–2374. doi:10.1056/NEJMoa031049
  • Skinner AC, Skelton JA. Prevalence and trends in obesity and severe obesity among children in the United States, 1999-2012. JAMA Pediatrics. 2014;168(6):561–566. doi:10.1001/jamapediatrics.2014.21
  • de Luca C, Olefsky JM. Inflammation and insulin resistance. FEBS Lett. 2008;582(1):97–105. doi:10.1016/j.febslet.2007.11.057
  • Levy-Marchal C, Arslanian S, Cutfield W, et al. Insulin resistance in children: consensus, perspective, and future directions. J Clin Endocrinol Metab. 2010;95(12):5189–5198. doi:10.1210/jc.2010-1047
  • Ambros V. The functions of animal microRNAs. Nature. 2004;431(7006):350–355. doi:10.1038/nature02871
  • Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92–105. doi:10.1101/gr.082701.108
  • Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell. 2006;11(4):441–450. doi:10.1016/j.devcel.2006.09.009
  • Dumortier O, Hinault C, Van Obberghen E. MicroRNAs and metabolism crosstalk in energy homeostasis. Cell Metab. 2013;18(3):312–324. doi:10.1016/j.cmet.2013.06.004
  • Ji C, Guo X. The clinical potential of circulating microRNAs in obesity. Nat Rev Endocrinol. 2019;15(12):731–743. doi:10.1038/s41574-019-0260-0
  • Rottiers V, Naar AM. MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol. 2012;13(4):239–250. doi:10.1038/nrm3313
  • Landrier J-F, Derghal A, Mounien L. MicroRNAs in obesity and related metabolic disorders. Cells. 2019;8(8):8. doi:10.3390/cells8080859
  • Gallo A, Tandon M, Alevizos I, Illei GG, Afarinkia K. The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PLoS One. 2012;7(3):e30679. doi:10.1371/journal.pone.0030679
  • Vickers KC, Remaley AT. Lipid-based carriers of microRNAs and intercellular communication. Curr Opin Lipidol. 2012;23(2):91–97. doi:10.1097/MOL.0b013e328350a425
  • Prats-Puig A, Ortega FJ, Mercader JM, et al. Changes in circulating microRNAs are associated with childhood obesity. J Clin Endocrinol Metab. 2013;98(10):E1655–60. doi:10.1210/jc.2013-1496
  • Oses M, Margareto Sanchez J, Portillo MP, Aguilera CM, Labayen I. Circulating miRNAs as biomarkers of obesity and obesity-associated comorbidities in children and adolescents: a systematic review. Nutrients. 2019;11(12):12. doi:10.3390/nu11122890
  • Trajkovski M, Hausser J, Soutschek J, et al. MicroRNAs 103 and 107 regulate insulin sensitivity. Nature. 2011;474(7353):649–653. doi:10.1038/nature10112
  • Tas E, Bai S, Ou X, et al. Fibroblast growth factor-21 to adiponectin ratio: a potential biomarker to monitor liver fat in children with obesity. Front Endocrinol. 2020;11. doi:10.3389/fendo.2020.00654
  • Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics. 2005;115(4):e500–3. doi:10.1542/peds.2004-1921
  • Matsuhisa M, Yamasaki Y, Emoto M, et al. A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects. Diabetes Res Clin Pract. 2007;77(1):151–154. doi:10.1016/j.diabres.2006.10.005
  • Giannini C, Santoro N, Caprio S, et al. The triglyceride-to-HDL cholesterol ratio: association with insulin resistance in obese youths of different ethnic backgrounds. Diabetes Care. 2011;34(8):1869–1874. doi:10.2337/dc10-2234
  • Adams-Huet B, Devaraj S, Siegel D, Jialal I. Increased adipose tissue insulin resistance in metabolic syndrome: relationship to circulating adipokines. Metab Syndr Relat Disord. 2014;12(10):503–507. doi:10.1089/met.2014.0092
  • Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. 2000;23(1):57–63. doi:10.2337/diacare.23.1.57
  • Reinehr T. Changes in the atherogenic risk factor profile according to degree of weight loss. Arch Dis Child. 2004;89(5):419–422. doi:10.1136/adc.2003.028803
  • Valerio G, Licenziati MR, Iannuzzi A, et al. Insulin resistance and impaired glucose tolerance in obese children and adolescents from southern Italy. Nutr Metab Cardiovasc Dis. 2006;16(4):279–284. doi:10.1016/j.numecd.2005.12.007
  • Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3(7):RESEARCH0034. doi:10.1186/gb-2002-3-7-research0034
  • Miller RM, Chambers TL, Burns SP. Validating InBody®570 multi-frequency bioelectrical impedance analyzer versus DXA for body fat percentage analysis. JEPonline. 2016;19(5):8. doi:10.1249/01.mss.0000487979.68551.d7
  • Ortega FJ, Mercader JM, Catalan V, et al. Targeting the circulating microRNA signature of obesity. Clin Chem. 2013;59(5):781–792. doi:10.1373/clinchem.2012.195776
  • Iacomino G, Siani A. Role of microRNAs in obesity and obesity-related diseases. Genes Nutr. 2017;12:23. doi:10.1186/s12263-017-0577-z
  • Thompson MD, Cismowski MJ, Serpico M, Pusateri A, Brigstock DR. Elevation of circulating microRNA levels in obese children compared to healthy controls. Clin Obes. 2017;7(4):216–221. doi:10.1111/cob.12192
  • Iacomino G, Russo P, Marena P, et al. Circulating microRNAs are associated with early childhood obesity: results of the I.Family Study.. Genes Nutr. 2019;14(1):2. doi:10.1186/s12263-018-0622-6
  • Myers MG, Leibel RL, Seeley RJ, Schwartz MW. Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab. 2010;21(11):643–651. doi:10.1016/j.tem.2010.08.002
  • Nigro E, Scudiero O, Monaco ML, et al. New insight into adiponectin role in obesity and obesity-related diseases. Biomed Res Int. 2014;2014:658913. doi:10.1155/2014/658913
  • Masotti A, Baldassarre A, Fabrizi M, et al. Oral glucose tolerance test unravels circulating miRNAs associated with insulin resistance in obese preschoolers. Pediatr Obes. 2017;12(3):229–238. doi:10.1111/ijpo.12133
  • Chuang T-Y, Wu H-L, Chen -C-C, et al. MicroRNA-223 expression is upregulated in insulin resistant human adipose tissue. J Diabetes Res. 2015;2015:943659. doi:10.1155/2015/943659
  • Meerson A, Traurig M, Ossowski V, Fleming JM, Mullins M, Baier LJ. Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-α. Diabetologia. 2013;56(9):1971–1979. doi:10.1007/s00125-013-2950-9
  • Nunez Lopez YO, Garufi G, Pasarica M, Seyhan AA. Elevated and correlated expressions of miR-24, miR-30d, miR-146a, and SFRP-4 in human abdominal adipose tissue play a role in adiposity and insulin resistance. Int J Endocrinol. 2018;2018:7351902. doi:10.1155/2018/7351902
  • Matulewicz N, Stefanowicz M, Nikolajuk A, Karczewska-Kupczewska M. Markers of adipogenesis, but not inflammation, in adipose tissue are independently related to insulin sensitivity. J Clin Endocrinol Metab. 2017;102(8):3040–3049. doi:10.1210/jc.2017-00597
  • Li WD, Xia JR, Lian YS. Hepatic miR215 target Rictor and modulation of hepatic insulin signalling in rats. Mol Med Rep. 2019;19(5):3723–3731. doi:10.3892/mmr.2019.10031
  • Zhou T, Meng X, Che H, et al. Regulation of insulin resistance by multiple MiRNAs via targeting the GLUT4 signalling pathway. Cell Physiol Biochem. 2016;38(5):2063–2078. doi:10.1159/000445565
  • Nigi L, Grieco GE, Ventriglia G, et al. MicroRNAs as regulators of insulin signaling: research updates and potential therapeutic perspectives in type 2 diabetes. Int J Mol Sci. 2018;19(12):12. doi:10.3390/ijms19123705
  • Lustig Y, Barhod E, Ashwal-Fluss R, et al. RNA-binding protein PTB and microRNA-221 coregulate AdipoR1 translation and adiponectin signaling. Diabetes. 2014;63(2):433–445. doi:10.2337/db13-1032
  • Deiuliis JA. MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics. Int J Obes. 2016;40(1):88–101. doi:10.1038/ijo.2015.170
  • Ameling S, Kacprowski T, Chilukoti RK, et al. Associations of circulating plasma microRNAs with age, body mass index and sex in a population-based study. BMC Med Genomics. 2015;8(1):61. doi:10.1186/s12920-015-0136-7
  • Chou -W-W, Wang Y-T, Liao Y-C, Chuang S-C, Wang S-N, Juo S-HH. Decreased MicroRNA-221 is associated with high levels of TNF-a in human adipose tissue-derived mesenchymal stem cells from obese woman. Cell Physiol Biochem. 2013;32(1):127–137. doi:10.1159/000350131
  • Hijmans JG, Diehl KJ, Bammert TD, et al. Influence of overweight and obesity on circulating inflammation-related microRNA. Microrna. 2018;7(2):148–154. doi:10.2174/2211536607666180402120806
  • Gallo W, Esguerra JLS, Eliasson L, Melander O. miR-483-5p associates with obesity and insulin resistance and independently associates with new onset diabetes mellitus and cardiovascular disease. PLoS One. 2018;13(11):e0206974. doi:10.1371/journal.pone.0206974
  • Reza A, Choi YJ, Han SG, et al. Roles of microRNAs in mammalian reproduction: from the commitment of germ cells to peri-implantation embryos. Biol Rev Camb Philos Soc. 2019;94(2):415–438. doi:10.1111/brv.12459
  • Vilela BS, Vasques AC, Cassani RS, et al. The HOMA-Adiponectin (HOMA-AD) closely mirrors the HOMA-IR Index in the screening of insulin resistance in the Brazilian Metabolic Syndrome Study (BRAMS). PLoS One. 2016;11(8):e0158751. doi:10.1371/journal.pone.0158751
  • Ryden M, Andersson DP, Arner P. Usefulness of surrogate markers to determine insulin action in fat cells. Int J Obes. 2020.