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Original Research

LncRNA MIR503HG Promotes High-Glucose-Induced Proximal Tubular Cell Apoptosis by Targeting miR-503-5p/Bcl-2 Pathway

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Pages 4507-4517 | Published online: 20 Nov 2020

References

  • Alicic RZ, Rooney MT, Tuttle KR. Diabetic kidney disease: challenges, progress, and possibilities. Clin J Am Soc Nephrol. 2017;12(12):2032–2045. doi:10.2215/CJN.11491116
  • Wang H, Zhang H, Chen X, et al. The decreased expression of electron transfer flavoprotein β is associated with tubular cell apoptosis in diabetic nephropathy. Int J Mol Med. 2016;37(5):1290–1298. doi:10.3892/ijmm.2016.2533
  • Magri CJ, Fava S. The role of tubular injury in diabetic nephropathy. Eur J Intern Med. 2009;20(6):551–555. doi:10.1016/j.ejim.2008.12.012
  • Liu B, Shyr Y, Cai J, Liu Q. Interplay between miRNAs and host genes and their role in cancer. Brief Funct Genomics. 2019;18(4):255–266. doi:10.1093/bfgp/elz002
  • Pachera E, Assassi S, Salazar GA, et al. Long noncoding RNA H19X is a key mediator of TGF-β–driven fibrosis. J Clin Invest. 2020;130(9):4888–4905. doi:10.1172/JCI135439
  • Dohi O, Yasui K, Gen Y, et al. Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma. Int J Oncol. 2013;42(2):411–418. doi:10.3892/ijo.2012.1724
  • Huang PS, Chung IH, Lin YH, Lin TK, Chen WJ, Lin KH. The long non-coding RNA MIR503HG enhances proliferation of human ALK-negative anaplastic large-cell lymphoma. Int J Mol Sci. 2018;19(5):1463. doi:10.3390/ijms19051463
  • Zhu X, Zhang C, Fan Q, et al. Inhibiting microRNA-503 and microRNA-181d with losartan ameliorates diabetic nephropathy in KKAy mice. Med Sci Monit. 2016;22:3902–3909. doi:10.12659/MSM.900938
  • Pescador N, Pérez-Barba M, Ibarra JM, et al. Serum circulating microRNA profiling for identification of potential type 2 diabetes and obesity biomarkers. PLoS One. 2013;8(10):e77251. doi:10.1371/journal.pone.0077251
  • Sheikhbahaei S, Manizheh D, Mohammad S, et al. Can MiR-503 be used as a marker in diabetic patients with ischemic stroke? BMC Endocr Disord. 2019;19(1):42. doi:10.1186/s12902-019-0371-6
  • Xu K, Bian D, Hao L, et al. microRNA-503 contribute to pancreatic beta cell dysfunction by targeting the mTOR pathway in gestational diabetes mellitus. EXCLI J. 2017;16:1177–1187.
  • Yan Z, Wang H, Liang J, Li Y, Li X. MicroRNA-503-5p improves carotid artery stenosis by inhibiting the proliferation of vascular smooth muscle cells. Exp Ther Med. 2020;20(5):85. doi:10.3892/etm.2020.9213
  • Chen K, Zhao XL, Li LB, et al. miR-503/Apelin-12 mediates high glucose-induced microvascular endothelial cells injury via JNK and p38MAPK signaling pathway. Regen Ther. 2020;14:111–118. doi:10.1016/j.reth.2019.12.002
  • Zha F, Bai L, Tang B, et al. MicroRNA-503 contributes to podocyte injury via targeting E2F3 in diabetic nephropathy. J Cell Biochem. 2019;120(8):12574–12581. doi:10.1002/jcb.28524
  • Qu R, Hu C, Tang Y, Yu Q, Shi G. Long non-coding RNA BLACAT1 induces tamoxifen resistance in human breast cancer by regulating miR-503/Bcl-2 axis. Cancer Manage Res. 2020;12:1771–1777. doi:10.2147/CMAR.S239981
  • Wagener FA, Dekker D, Berden JH, Scharstuhl A, van der Vlag J. The role of reactive oxygen species in apoptosis of the diabetic kidney. Apoptosis. 2009;14(12):1451–1458.
  • Tong Y, Chuan J, Bai L, et al. The protective effect of shikonin on renal tubular epithelial cell injury induced by high glucose. Biomed Pharmacother. 2018;98:701–708. doi:10.1016/j.biopha.2017.12.112
  • Ju Y, Su Y, Chen Q, et al. Protective effects of astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats. Biomed Pharmacother. 2019;109:84–92. doi:10.1016/j.biopha.2018.10.041
  • Cech TR, Steitz JA. The noncoding RNA revolution-trashing old rules to forge new ones. Cell. 2014;157(1):77–94. doi:10.1016/j.cell.2014.03.008
  • Adams BD, Parsons C, Walker L, Zhang WC, Slack FJ. Targeting noncoding RNAs in disease. J Clin Invest. 2017;127(3):761–771. doi:10.1172/JCI84424
  • Rodriguez A, Griffiths-Jones S, Ashurst JL, et al. Identification of mammalian microRNA host genes and transcription units. Genome Res. 2004;14(10A):1902–1910. doi:10.1101/gr.2722704
  • Yan C, Chen Y, Kong W, et al. PVT1-derived miR-1207-5p promotes breast cancer cell growth by targeting STAT6. Cancer Sci. 2017;108(5):868–876. doi:10.1111/cas.13212
  • Fiedler J, Breckwoldt K, Remmele CW, et al. Development of long noncoding RNA-based strategies to modulate tissue vascularization. J Am Coll Cardiol. 2015;66(18):2005–2015. doi:10.1016/j.jacc.2015.07.081
  • Miao Y, Wan Q, Liu X, Wang Y, Luo Y, Liu D. miR-503 is involved in the protective effect of phase II enzyme inducer (CPDT) in diabetic cardiomyopathy via Nrf2/ARE signaling pathway. Biomed Res Int. 2017;2017:9167450. doi:10.1155/2017/9167450
  • Caporali A, Meloni M, Vollenkle C, et al. Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation. 2011;123(3):282–291. doi:10.1161/CIRCULATIONAHA.110.952325
  • Caporali A, Meloni M, Nailor A, et al. p75(NTR)-dependent activation of NF-kappaB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia. Nat Commun. 2015;6:8024.
  • Hou LJ, Han JJ, Liu Y. Up-regulation of microRNA-503 by high glucose reduces the migration and proliferation but promotes the apoptosis of human umbilical vein endothelial cells by inhibiting the expression of insulin-like growth factor-1 receptor. Eur Rev Med Pharmacol Sci. 2018;22(11):3515–3523.
  • Tang NP, Hui TT, Ma J, Mei QB. Effects of miR-503-5p on apoptosis of human pulmonary microvascular endothelial cells in simulated microgravity. J Cell Biochem. 2019;120(1):727–737. doi:10.1002/jcb.27430
  • Wang H, Liang L, Dong Q, et al. Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1/NF-κB pathway in hepatocellular carcinoma. Theranostics. 2018;8(10):2814–2829. doi:10.7150/thno.23012