Sirt6-Mediated Endothelial-to-Mesenchymal Transition Contributes Toward Diabetic Cardiomyopathy via the Notch1 Signaling Pathway

References

• Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14(2):88–98. doi:10.1038/nrendo.2017.151
   PubMed Web of Science ®Google Scholar
• Dillmann WH. Diabetic cardiomyopathy. Circ Res. 2019;124(8):1160–1162. doi:10.1161/circresaha.118.314665
   PubMed Web of Science ®Google Scholar
• Riehle C, Bauersachs J. Of mice and men: models and mechanisms of diabetic cardiomyopathy. Basic Res Cardiol. 2018;114(1):2. doi:10.1007/s00395-018-0711-0
   PubMed Web of Science ®Google Scholar
• Jia G, Hill MA, Sowers JR. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ Res. 2018;122(4):624–638. doi:10.1161/circresaha.117.311586
   PubMed Web of Science ®Google Scholar
• Tong M, Saito T, Zhai P, et al. Mitophagy is essential for maintaining cardiac function during high fat diet-induced diabetic cardiomyopathy. Circ Res. 2019;124(9):1360–1371. doi:10.1161/circresaha.118.314607
   PubMed Web of Science ®Google Scholar
• Piera-Velazquez S, Jimenez SA. Endothelial to mesenchymal transition: role in physiology and in the pathogenesis of human diseases. Physiol Rev. 2019;99(2):1281–1324. doi:10.1152/physrev.00021.2018
   PubMed Web of Science ®Google Scholar
• Pérez L, Muñoz-Durango N, Riedel CA, et al. Endothelial-to-mesenchymal transition: cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions. Cytokine Growth Factor Rev. 2017;33:41–54. doi:10.1016/j.cytogfr.2016.09.002
   PubMed Web of Science ®Google Scholar
• Li Y, Lui KO, Zhou B. Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases. Nat Rev Cardiol. 2018;15(8):445–456. doi:10.1038/s41569-018-0023-y
   PubMedGoogle Scholar
• Segers VFM, Brutsaert DL, De Keulenaer GW. Cardiac remodeling: endothelial cells have more to say than just NO. Front Physiol. 2018;9:382. doi:10.3389/fphys.2018.00382
   PubMed Web of Science ®Google Scholar
• Talman V, Kivelä R. Cardiomyocyte-endothelial cell interactions in cardiac remodeling and regeneration. Front Cardiovasc Med. 2018;5:101. doi:10.3389/fcvm.2018.00101
   PubMed Web of Science ®Google Scholar
• Potente M, Mäkinen T. Vascular heterogeneity and specialization in development and disease. Nat Rev Mol Cell Biol. 2017;18(8):477–494. doi:10.1038/nrm.2017.36
   PubMed Web of Science ®Google Scholar
• Brutsaert DL. Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity. Physiol Rev. 2003;83(1):59–115. doi:10.1152/physrev.00017.2002
   PubMedGoogle Scholar
• Hu J, Wang S, Xiong Z, et al. Exosomal Mst1 transfer from cardiac microvascular endothelial cells to cardiomyocytes deteriorates diabetic cardiomyopathy. Biochim Biophys Acta Mol Basis Dis. 2018;1864(11):3639–3649. doi:10.1016/j.bbadis.2018.08.026
   PubMedGoogle Scholar
• Chang AR, Ferrer CM, Mostoslavsky R. SIRT6, a mammalian deacylase with multitasking abilities. Physiol Rev. 2020;100(1):145–169. doi:10.1152/physrev.00030.2018
   PubMed Web of Science ®Google Scholar
• Kuang J, Chen L, Tang Q, Zhang J, Li Y, He J. The role of Sirt6 in obesity and diabetes. Front Physiol. 2018;9:135. doi:10.3389/fphys.2018.00135
   PubMed Web of Science ®Google Scholar
• Wang T, Sun C, Hu L, et al. Sirt6 stabilizes atherosclerosis plaques by promoting macrophage autophagy and reducing contact with endothelial cells. Biochem Cell Biol. 2020;98(2):120–129. doi:10.1139/bcb-2019-0057
   PubMedGoogle Scholar
• Kuwabara Y, Horie T, Baba O, et al. MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway. Circ Res. 2015;116(2):279–288. doi:10.1161/circresaha.116.304707
   PubMed Web of Science ®Google Scholar
• Cheng Z, Zhang M, Hu J, et al. Mst1 knockout enhances cardiomyocyte autophagic flux to alleviate angiotensin II-induced cardiac injury independent of angiotensin II receptors. J Mol Cell Cardiol. 2018;125:117–128. doi:10.1016/j.yjmcc.2018.08.028
   PubMed Web of Science ®Google Scholar
• Xiong Z, Li Y, Zhao Z, et al. Mst1 knockdown alleviates cardiac lipotoxicity and inhibits the development of diabetic cardiomyopathy in db/ db mice. Biochim Biophys Acta Mol Basis Dis. 2020;1866(8):165806. doi:10.1016/j.bbadis.2020.165806
   PubMedGoogle Scholar
• Hulshoff MS, Xu X, Krenning G, Zeisberg EM. Epigenetic regulation of endothelial-to-mesenchymal transition in chronic heart disease. Arterioscler Thromb Vasc Biol. 2018;38(9):1986–1996. doi:10.1161/atvbaha.118.311276
   PubMedGoogle Scholar
• Eelen G, de Zeeuw P, Simons M, Carmeliet P. Endothelial cell metabolism in normal and diseased vasculature. Circ Res. 2015;116(7):1231–1244. doi:10.1161/circresaha.116.302855
   PubMed Web of Science ®Google Scholar
• Tian DY, Jin XR, Zeng X, Wang Y. Notch signaling in endothelial cells: is it the therapeutic target for vascular neointimal hyperplasia? Int J Mol Sci. 2017;18(8):1615. doi:10.3390/ijms18081615
   PubMedGoogle Scholar
• Paulus WJ, Tschöpe C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol. 2013;62(4):263–271. doi:10.1016/j.jacc.2013.02.092
   PubMed Web of Science ®Google Scholar
• Jiang F, Mohr F, Ullrich ND, Hecker M, Wagner AH. Endothelial cell modulation of cardiomyocyte gene expression. Exp Cell Res. 2019;383(2):111565. doi:10.1016/j.yexcr.2019.111565
   PubMedGoogle Scholar
• Wang B, Wu Y, Ge Z, Zhang X, Yan Y, Xie Y. NLRC5 deficiency ameliorates cardiac fibrosis in diabetic cardiomyopathy by regulating EndMT through Smad2/3 signaling pathway. Biochem Biophys Res Commun. 2020;528(3):545–553. doi:10.1016/j.bbrc.2020.05.151
   PubMedGoogle Scholar
• Qin W, Zhang L, Li Z, et al. SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition. Int J Cardiol. 2019;295:7–13. doi:10.1016/j.ijcard.2019.07.082
   PubMedGoogle Scholar
• Liu Y, Zou J, Li B, et al. RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells. Int J Mol Med. 2017;40(1):65–74. doi:10.3892/ijmm.2017.2998
   PubMedGoogle Scholar
• Lin QQ, Zhao J, Zheng CG, Chun J. Roles of notch signaling pathway and endothelial-mesenchymal transition in vascular endothelial dysfunction and atherosclerosis. Eur Rev Med Pharmacol Sci. 2018;22(19):6485–6491. doi:10.26355/eurrev_201810_16062
   PubMed Web of Science ®Google Scholar
• Liu M, Liang K, Zhen J, et al. Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling. Nat Commun. 2017;8(1):413. doi:10.1038/s41467-017-00498-4
   PubMed Web of Science ®Google Scholar
• Hu X, Zhu S, Liu R, et al. Sirt6 deficiency impairs corneal epithelial wound healing. Aging. 2018;10(8):1932–1946. doi:10.18632/aging.101513
   PubMedGoogle Scholar