108
Views
4
CrossRef citations to date
0
Altmetric
Original Research

LncRNA LINC00673 is Downregulated in Diabetic Retinopathy and Regulates the Apoptosis of Retinal Pigment Epithelial Cells via Negatively Regulating p53

, &
Pages 4233-4240 | Published online: 13 Oct 2021

References

  • Karuranga S , Fernandes JDR , Huang Y , Malanda B ; International Diabetes Federation, editors. IDF Diabetes Atlas . 8th ed. Brussels, Belgium: International Diabetes Federation; 2017.
  • Toi PL , Anothaisintawee T , Chaikledkaew U , Briones JR , Reutrakul S , Thakkinstian A . Preventive role of diet interventions and dietary factors in type 2 diabetes mellitus: an umbrella review. Nutrients . 2020;12(9):2722. doi:10.3390/nu12092722
  • Brownlee M . The pathobiology of diabetic complications: a unifying mechanism. Diabetes . 2005;54(6):1615–1625. doi:10.2337/diabetes.54.6.1615 15919781
  • Fong DS , Aiello L , Gardner TW , et al. Retinopathy in diabetes. Diabetes Care . 2004;27(Suppl 1):S84–S87. doi:10.2337/diacare.27.2007.S84 14693935
  • Tracey ML , McHugh SM , Fitzgerald AP , Buckley CM , Canavan RJ , Kearney PM . Trends in blindness due to diabetic retinopathy among adults aged 18–69 years over a decade in Ireland. Diabetes Res Clin Pract . 2016;121:1–8. doi:10.1016/j.diabres.2016.08.016 27612011
  • Kung CP , Murphy ME . The role of the p53 tumor suppressor in metabolism and diabetes. J Endocrinol . 2016;231(2):R61–R75. doi:10.1530/JOE-16-0324 27613337
  • Kundu N , Domingues CC , Chou C , et al. Use of p53-silenced endothelial progenitor cells to treat ischemia in diabetic peripheral vascular disease. J Am Heart Assoc . 2017;6(4). doi:10.1161/JAHA.116.005146
  • Gu J , Wang S , Guo H , et al. Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis. Cell Death Dis . 2018;9(2):82. doi:10.1038/s41419-017-0093-5 29362483
  • Grossi E , Sánchez Y , Huarte M . Expanding the p53 regulatory network: lncRNAs take up the challenge. Biochim Biophys Acta . 2016;1859(1):200–208. doi:10.1016/j.bbagrm.2015.07.011 26196323
  • Wu Z , Wu P , Zuo X , et al. LncRNA-N1LR enhances neuroprotection against ischemic stroke probably by inhibiting p53 phosphorylation. Mol Neurobiol . 2017;54(10):7670–7685. doi:10.1007/s12035-016-0246-z 27844279
  • Leung A , Natarajan R . Long noncoding RNAs in diabetes and diabetic complications. Antioxid Redox Signal . 2018;29(11):1064–1073. doi:10.1089/ars.2017.7315 28934861
  • Meng XF , Zhao LY , Chu XF . LncRNA LINC00673 inhibits p53 expression by interacting with EZH2 and DNMT1 in papillary thyroid carcinoma. Eur Rev Med Pharmacol Sci . 2019;23(5):2075–2083.30915752
  • Huang M , Hou J , Wang Y , et al. Long noncoding RNA LINC00673 is activated by SP1 and exerts oncogenic properties by interacting with LSD1 and EZH2 in gastric cancer. Mol Ther . 2017;25(4):1014–1026. doi:10.1016/j.ymthe.2017.01.017 28214253
  • Simó R , Villarroel M , Corraliza L , Hernández C , Garcia-Ramírez M . The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier–implications for the pathogenesis of diabetic retinopathy. J Biomed Biotechnol . 2010;2010:190724. doi:10.1155/2010/190724 20182540
  • Xia T , Rizzolo LJ . Effects of diabetic retinopathy on the barrier functions of the retinal pigment epithelium. Vision Res . 2017;139:72–81. doi:10.1016/j.visres.2017.02.006 28347688
  • Li Y , Xu F , Xiao H , Han F . Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. J Cell Biochem . 2018;119(1):817–823.28657668
  • Zhou Q , Zhou L , Qian J , Yuan ZL , Chen ZJ . NKILA inhibition protects retinal pigment epithelium cells from hypoxia by facilitating NFκB activation. Biochem Biophys Res Commun . 2018;503(4):3134–3141. doi:10.1016/j.bbrc.2018.08.105 30144973
  • Gong L , Liu F , Xiong Z , et al. Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes. Proc Natl Acad Sci USA . 2018;115(17):E3987–E3995. doi:10.1073/pnas.1715237115 29622681