miR-140-5p Aggravates Insulin Resistance via Directly Targeting GYS1 and PPP1CC in Insulin-Resistant HepG2 Cells

References

• Saeedi P , Petersohn I , Salpea P , et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9(th) edition. Diabetes Res Clin Pract . 2019;157:107843. doi:10.1016/j.diabres.2019.107843 31518657
   PubMed Web of Science ®Google Scholar
• Chatterjee S , Khunti K , Davies MJ . Type 2 diabetes. Lancet . 2017;389(10085):2239–2251. doi:10.1016/S0140-6736(17)30058-2 28190580
   PubMed Web of Science ®Google Scholar
• Kabekkodu SP , Shukla V , Varghese VK , Chakrabarty S , Satyamoorthy K . Clustered miRNAs and their role in biological functions and diseases. Biol Rev Camb Philos Soc . 2018;93(4):1955–1986.29797774
   PubMed Web of Science ®Google Scholar
• He L , Hannon GJ . MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet . 2004;5(7):522–531. doi:10.1038/nrg1379 15211354
   PubMed Web of Science ®Google Scholar
• Kim J , Yao F , Xiao Z , Sun Y , Ma L . MicroRNAs and metastasis: small RNAs play big roles. Cancer Metastasis Rev . 2018;37(1):5–15.29234933
   PubMed Web of Science ®Google Scholar
• Feng J , Xing W , Xie L . Regulatory Roles of MicroRNAs in Diabetes. Int J Mol Sci . 2016;17:10.
   Web of Science ®Google Scholar
• Guo C , Sun YQ , Li Q , Zhang JC . MiR-7, miR-9 and miR-375 contribute to effect of Exendin-4 on pancreatic β-cells in high-fat-diet-fed mice. Clin Invest Med . 2018;41(1):E16–e24. doi:10.25011/cim.v41i1.29459 29603687
   PubMed Web of Science ®Google Scholar
• Frost RJ , Olson EN . Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proc Natl Acad Sci U S A . 2011;108(52):21075–21080. doi:10.1073/pnas.1118922109 22160727
   PubMed Web of Science ®Google Scholar
• Nair S , Jayabalan N , Guanzon D , et al. Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity. Clin sci . 2018;132(22):2451–2467. doi:10.1042/CS20180487
   Web of Science ®Google Scholar
• Villard A , Marchand L , Thivolet C , Rome S . Diagnostic Value of Cell-free Circulating MicroRNAs for Obesity and Type 2 Diabetes: a Meta-analysis. J Mol Biomark Diagn . 2015;6(6):45.
   Google Scholar
• Xiong Z , Li B , Wang W , et al. MiR-140 targets RAP2A to enable the proliferation of insulin-treated ovarian granulosa cells. J Ovarian Res . 2020;13(1):13. doi:10.1186/s13048-020-0611-4 32024547
   PubMed Web of Science ®Google Scholar
• Al-Rawaf HA . Circulating microRNAs and adipokines as markers of metabolic syndrome in adolescents with obesity. Clin nutrition . 2019;38(5):2231–2238. doi:10.1016/j.clnu.2018.09.024
   Web of Science ®Google Scholar
• Zhu D , Lv W , Zhou X , et al. Long non-coding RNA TMPO-AS1 promotes tumor progression via sponging miR-140-5p in breast cancer. Exp Ther Med . 2021;21(1):17. doi:10.3892/etm.2020.9449 33235626
   PubMed Web of Science ®Google Scholar
• Wu S , Xu R , Zhu X , et al. The long noncoding RNA LINC01140/miR-140-5p/FGF9 axis modulates bladder cancer cell aggressiveness and macrophage M2 polarization. Aging . 2020;12(24):25845–25864. doi:10.18632/aging.202147 33234721
   PubMedGoogle Scholar
• Mei J , Liu G , Wang W , et al. OIP5-AS1 modulates epigenetic regulator HDAC7 to enhance non-small cell lung cancer metastasis via miR-140-5p. Oncol Lett . 2020;20(4):7. doi:10.3892/ol.2020.11868 32774481
   PubMed Web of Science ®Google Scholar
• Huang C , Li J , Zhang X , et al. The miR-140-5p/KLF9/KCNQ1 axis promotes the progression of renal cell carcinoma. FASEB j . 2020;34(8):10623–10639. doi:10.1096/fj.202000088RR 32596959
   PubMed Web of Science ®Google Scholar
• Barrea L , Caprio M , Tuccinardi D , et al. Could ketogenic diet “starve” cancer? Emerging evidence. Crit Rev Food Sci Nutr . 2020;1–22.
   Web of Science ®Google Scholar
• Gao P , Tchernyshyov I , Chang TC , et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature . 2009;458(7239):762–765. doi:10.1038/nature07823 19219026
   PubMed Web of Science ®Google Scholar
• Fernández-Tajes J , Gaulton KJ , van de Bunt M , et al. Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data. Genome Med . 2019;11(1):19. doi:10.1186/s13073-019-0628-8 30914061
   PubMed Web of Science ®Google Scholar
• Diedisheim M , Carcarino E , Vandiedonck C , Roussel R , Gautier JF , Venteclef N . Regulation of inflammation in diabetes: from genetics to epigenomics evidence. Mol Metab . 2020;41:101041. doi:10.1016/j.molmet.2020.101041 32603690
   PubMed Web of Science ®Google Scholar
• Zhu Y , Zhang H , Wei Y , et al. Pea-derived peptides, VLP, LLP, VA, and LL, improve insulin resistance in HepG2 cells via activating IRS-1/PI3K/AKT and blocking ROS-mediated p38MAPK signaling. J Food Biochem . 2020;44(11):e13454. doi:10.1111/jfbc.13454 32875583
   PubMed Web of Science ®Google Scholar
• Li J , Ding X , Jian T , et al. Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway. PeerJ . 2020;8:e10413. doi:10.7717/peerj.10413 33240683
   PubMed Web of Science ®Google Scholar
• Ma YM , Tao RY , Liu Q , et al. PTP1B inhibitor improves both insulin resistance and lipid abnormalities in vivo and in vitro. Mol Cell Biochem . 2011;357(1–2):65–72. doi:10.1007/s11010-011-0876-4 21603884
   PubMed Web of Science ®Google Scholar
• Zhang C , Qian D , Zhao H , Lv N , Yu P , Sun Z . MiR17 improves insulin sensitivity through inhibiting expression of ASK1 and anti-inflammation of macrophages. Biomed Pharmacother . 2018;100::448–454. doi:10.1016/j.biopha.2018.02.012
   Web of Science ®Google Scholar
• Lin M , Mao ZJ . lncRNA-mRNA competing endogenous RNA network in IR-hepG2 cells ameliorated by APBBR decreasing ROS levels: a systematic analysis. PeerJ . 2020;8:e8604. doi:10.7717/peerj.8604 32140303
   PubMed Web of Science ®Google Scholar
• Wang W , Ding XQ , Gu TT . Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377. Free Radic Biol Med . 2015;83::214–226. doi:10.1016/j.freeradbiomed.2015.02.029
   Web of Science ®Google Scholar
• Zhang X , Xu X , Ge G , et al. miR‑498 inhibits the growth and metastasis of liver cancer by targeting ZEB2. Oncol Rep . 2019;41(3):1638–1648. doi:10.3892/or.2018.6948 30592286
   PubMed Web of Science ®Google Scholar
• Tan PY , Wen LJ , Li HN , Chai SW . MiR-548c-3p inhibits the proliferation, migration and invasion of human breast cancer cell by targeting E2F3. Cytotechnology . 2020;72(5):751–761. doi:10.1007/s10616-020-00418-3 32902720
   PubMed Web of Science ®Google Scholar
• Zhu H , Leung SW . Identification of microRNA biomarkers in type 2 diabetes: a meta-analysis of controlled profiling studies. Diabetologia . 2015;58(5):900–911. doi:10.1007/s00125-015-3510-2 25677225
   PubMed Web of Science ®Google Scholar
• Yang D , Li R , Xia J , et al. Long Noncoding RNA PCAT18 Upregulates SPRR3 to Promote Colorectal Cancer Progression by Binding to miR-759. Cancer Manag Res . 2020;12::11445–11452. doi:10.2147/CMAR.S272652
   Web of Science ®Google Scholar
• Li H , Wang X . Expression of miR-140-5p and miR-370 in nephroblastoma and its effect on cell proliferation. J BUON . 2020;25(4):2105–2109.33099960
   PubMed Web of Science ®Google Scholar
• den Biggelaar LJ , Sep SJ , Eussen SJ , et al. Discriminatory ability of simple OGTT-based beta cell function indices for prediction of prediabetes and type 2 diabetes: the CODAM study. Diabetologia . 2017;60(3):432–441. doi:10.1007/s00125-016-4165-3 27933333
   PubMed Web of Science ®Google Scholar
• Yang WM , Jeong HJ , Park SW , Lee W . Obesity-induced miR-15b is linked causally to the development of insulin resistance through the repression of the insulin receptor in hepatocytes. Mol Nutr Food Res . 2015;59(11):2303–2314. doi:10.1002/mnfr.201500107 26179126
   PubMed Web of Science ®Google Scholar
• Yang WM , Jeong HJ , Park SY , Lee W . Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes. FEBS Lett . 2014;588(13):2170–2176. doi:10.1016/j.febslet.2014.05.011 24844433
   PubMed Web of Science ®Google Scholar
• Fernandez-Twinn DS , Alfaradhi MZ , Martin-Gronert MS , et al. Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms. Mol Metab . 2014;3(3):325–333. doi:10.1016/j.molmet.2014.01.007 24749062
   PubMed Web of Science ®Google Scholar
• Kitao N , Nakamura A , Miyoshi H , et al. The role of glucokinase and insulin receptor substrate-2 in the proliferation of pancreatic beta cells induced by short-term high-fat diet feeding in mice. Metabolism . 2018;85::48–58.
   Web of Science ®Google Scholar
• Guo Y , Li G , Li H , et al. MicroRNA-15a Inhibits Glucose Transporter 4 Translocation and Impairs Glucose Metabolism in L6 Skeletal Muscle Via Targeting of Vesicle-Associated Membrane Protein-Associated Protein A. Canadian j Diabetes . 2020;44(3):261–266.e262. doi:10.1016/j.jcjd.2019.07.151
   Web of Science ®Google Scholar
• Ortega FJ , Mercader JM , Moreno-Navarrete JM , et al. Profiling of circulating microRNAs reveals common microRNAs linked to type 2 diabetes that change with insulin sensitization. Diabetes Care . 2014;37(5):1375–1383. doi:10.2337/dc13-1847 24478399
   PubMed Web of Science ®Google Scholar
• Ortega FJ , Mercader JM , Catalán V , et al. Targeting the circulating microRNA signature of obesity. Clin Chem . 2013;59(5):781–792. doi:10.1373/clinchem.2012.195776 23396142
   PubMed Web of Science ®Google Scholar
• Ding X , Jian T , Wu Y , et al. Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1-Nrf2 pathway. Biomed Pharmacother . 2019;110::85–94. doi:10.1016/j.biopha.2018.11.018
   Web of Science ®Google Scholar
• Ding XQ , Gu TT , Wang W . Curcumin protects against fructose-induced podocyte insulin signaling impairment through upregulation of miR-206. Mol Nutr Food Res . 2015;59(12):2355–2370. doi:10.1002/mnfr.201500370 26395192
   PubMed Web of Science ®Google Scholar
• Eliasson L , Esguerra JLS . MicroRNA Networks in Pancreatic Islet Cells: normal Function and Type 2 Diabetes. Diabetes . 2020;69(5):804–812. doi:10.2337/dbi19-0016 32312896
   PubMed Web of Science ®Google Scholar
• Savage DB , Zhai L , Ravikumar B , et al. A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. PLoS Med . 2008;5(1):e27. doi:10.1371/journal.pmed.0050027 18232732
   PubMed Web of Science ®Google Scholar
• Nitschke S , Chown EE , Zhao X , et al. An inducible glycogen synthase-1 knockout halts but does not reverse Lafora disease progression in mice. J Biol Chem . 2020;296.31900378
   PubMed Web of Science ®Google Scholar
• Zhao M , Shen L , Ouyang Z , et al. Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis. J Mol Cell Biol . 2020;12(4):277–290. doi:10.1093/jmcb/mjz050 31169879
   PubMed Web of Science ®Google Scholar
• Kang HW , Lim WC , Lee JK , Ho JN , Lim EJ , Cho HY . Germinated waxy black rice ameliorates hyperglycemia and dyslipidemia in streptozotocin-induced diabetic rats. Biol Pharm Bull . 2017;40(11):1846–1855. doi:10.1248/bpb.b17-00239 29093331
   PubMed Web of Science ®Google Scholar
• Hu X , Li Z , Ding Y , et al. Chk1 modulates the interaction between myosin phosphatase targeting protein 1 (MYPT1) and protein phosphatase 1cβ (PP1cβ). Cell Cycle . 2018;17(4):421–427. doi:10.1080/15384101.2017.1418235 29262732
   PubMed Web of Science ®Google Scholar
• Felgueiras J , Jerónimo C , Fardilha M . Protein phosphatase 1 in tumorigenesis: is it worth a closer look? Biochimica Et Biophysica Acta Rev Cancer . 2020;1874(2):188433. doi:10.1016/j.bbcan.2020.188433
   Web of Science ®Google Scholar
• Salvi F , Hoermann B , Del Pino García J , et al. Towards dissecting the mechanism of protein phosphatase-1 inhibition by its C-terminal phosphorylation. Chembiochem . 2021;22(5):834–838. doi:10.1002/cbic.202000669 33085143
   PubMed Web of Science ®Google Scholar
• Luo C , Wu M , Su X , et al. Protein phosphatase 1α interacts with a novel ciliary targeting sequence of polycystin-1 and regulates polycystin-1 trafficking. FASEB j . 2019;33(9):9945–9958. doi:10.1096/fj.201900338R 31157564
   PubMed Web of Science ®Google Scholar
• Chown EE , Wang P , Zhao X , et al. GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease. Ann Clin Translational Neurol . 2020;7(11):2186–2198. doi:10.1002/acn3.51211
   Web of Science ®Google Scholar