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Diabetes, Metabolic Syndrome and Obesity Volume 14, 2021 - Issue
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Original Research

A-FABP-PTEN/AKT Regulates Insulin Resistance in Preadipocyte Cell 3T3-L1 Cells

Rensiqin Wu1 Department of Endocrinology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, Inner Mongolia, People’s Republic of ChinaView further author information
,
Hui Wang1 Department of Endocrinology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, Inner Mongolia, People’s Republic of ChinaView further author information
,
Jian Huangfu1 Department of Endocrinology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, Inner Mongolia, People’s Republic of ChinaCorrespondence[email protected]
View further author information
&
Rui Xiao2 Key Laboratory of Molecular Pathology, Inner Mongolia Medical University, Huhhot, 010000, Inner Mongolia, People’s Republic of ChinaCorrespondence[email protected]
View further author information
Pages 2103-2110 | Published online: 11 May 2021

References

  • Hammarstedt A , Gogg S , Hedjazifar S , et al. Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity. Physiol Rev . 2018;98(4):1911–1941. doi:10.1152/physrev.00034.2017 30067159
  • Yongmei L , Jianying D , Zhu E , et al. Liraglutide suppresses proliferation and induces adipogenic differentiation of 3T3-L1 cells via the hippo-YAP signaling pathway. Mol Med Rep . 2018;17(3):4499–4507. doi:10.3892/mmr.2018.8438 29344656
  • Furuhashi M . Fatty acid-binding protein 4 in cardiovascular and metabolic diseases. J Atheroscler Thromb . 2019;26(3):216–232. doi:10.5551/jat.48710 30726793
  • Ghallab A , Seddek A . PPARG as therapeutic target for antifibrotic therapy. EXCLI J . 2020;19:227–229. doi:10.17179/excli2020-1136 32256268
  • Yang R , Castriota G , Chen Y , et al. RNAi-mediated germline knockdown of FABP4 increases body weight but does not improve the deranged nutrient metabolism of diet-induced obese mice. Int J Obes (Lond) . 2011;35(2):217–225. doi:10.1038/ijo.2010.128 20603627
  • Floresta G , Pistarà V , Amata E , et al. Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. a comprehensive systematic review. Eur J Med Chem . 2017;138:854–873. doi:10.1016/j.ejmech.2017.07.022 28738306
  • Xu A , Wang Y , Xu YJ , et al. Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin Chem . 2006;52(3):405–413. doi:10.1373/clinchem.2005.062463 16423904
  • Hopkins BD , Hodakoski C , Barrows D , Mense SM , Parsons RE . PTEN function: the long and the short of it. Trends Biochem Sci . 2014;39(4):183–190. doi:10.1016/j.tibs.2014.02.006 24656806
  • Gorbenko O , Panayotou G . Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4. Mol Cell Biochem . 2010;337(1–2):299–305. doi:10.1007/s11010-009-0312-1 19911253
  • Tsuda M , Inoue-Narita T , Suzuki A , et al. Induction of gene encoding FABP4 in Pten-null keratinocytes. FEBS Lett . 2009;583(8):1319–1322. doi:10.1016/j.febslet.2009.03.030 19303874
  • Yuan-yuan LI , Rui XIAO , Jiang-feng MAO , et al. Increased plasma levels of FABP4 and PTEN Is associated with more severe insulin resistance in women with gestational diabetes mellitus. Med Sci Monit . 2015;21:426–431. doi:10.12659/MSM.892431 25659997
  • Su D , Zhang C-L , Jian H-F , et al. Gene expression and correlation of Pten and Fabp4 in liver, muscle, and adipose tissues of type 2 diabetes rats. Med Sci Monit . 2015;21:3616–3621. doi:10.12659/MSM.895490 26591002
  • Ngeow J , Eng C . PTEN in hereditary and sporadic cancer. Cold Spring Harb Perspect Med . 2020;10(4):a036087. doi:10.1101/cshperspect.a036087 31570378
  • Yang J , Yin Y . PTEN in chromatin remodeling. Cold Spring Harb Perspect Med . 2020;10(2):a036160. doi:10.1101/cshperspect.a036160 31570373
  • Glenn RM , Roger LW . Structural mechanisms of PTEN regulation. Cold Spring Harb Perspect Med . 2020;10(3):a036152. doi:10.1101/cshperspect.a036152 31636093
  • Deng T , Wang Y , Wang C , et al. FABP4 silencing ameliorates hypoxia reoxygenation injury through the attenuation of endoplasmic reticulum stress-mediated apoptosis by activating PI3K/Akt Pathway. Life Sci . 2019;224:149–156. doi:10.1016/j.lfs.2019.03.046 30904493

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