Identification of a tsRNA Contributor to Impaired Diabetic Wound Healing via High Glucose-Induced Endothelial Dysfunction

References

• Larijani B, Ghahari A, Warnock GL, et al. Human fetal skin fibroblasts: extremely potent and allogenic candidates for treatment of diabetic wounds. Med Hypotheses. 2015;84(6):577–579. doi:10.1016/j.mehy.2015.03.004
   PubMed Web of Science ®Google Scholar
• Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14(2):88–98. doi:10.1038/nrendo.2017.151
   PubMed Web of Science ®Google Scholar
• Frykberg RG, Banks J. Challenges in the treatment of chronic wounds. Adv Wound Care. 2015;4(9):560–582. doi:10.1089/wound.2015.0635
   PubMed Web of Science ®Google Scholar
• Ackermann M, Pabst AM, Houdek JP, et al. Priming with proangiogenic growth factors and endothelial progenitor cells improves revascularization in linear diabetic wounds. Int J Mol Med. 2014;33(4):833–839. doi:10.3892/ijmm.2014.1630
   PubMed Web of Science ®Google Scholar
• Kruger-Genge A, Blocki A, Franke RP, et al. Vascular endothelial cell biology: an update. Int J Mol Sci. 2019;20(18):4411. doi:10.3390/ijms20184411
   PubMed Web of Science ®Google Scholar
• Jiang M, Huang S, Duan W, et al. Inhibition of acid sphingomyelinase activity ameliorates endothelial dysfunction in db/db mice. Biosci Rep. 2019;39(4). doi:10.1042/BSR20182144.
   Google Scholar
• Wen JT, Huang ZH, Li QH, et al. Research progress on the tsRNA classification, function, and application in gynecological malignant tumors. Cell Death Discov. 2021;7(1):388. doi:10.1038/s41420-021-00789-2
   PubMed Web of Science ®Google Scholar
• Liu Q, Ding C, Lang X, et al. Small noncoding RNA discovery and profiling with sRNAtools based on high-throughput sequencing. Brief Bioinform. 2021;22(1):463–473. doi:10.1093/bib/bbz151
   PubMed Web of Science ®Google Scholar
• Yang Y, Yue W, Wang N, et al. Altered expressions of transfer RNA-derived small RNAs and microRNAs in the vitreous humor of proliferative diabetic retinopathy. Front Endocrinol. 2022;13:913370. doi:10.3389/fendo.2022.913370
   PubMed Web of Science ®Google Scholar
• Han X, Cai L, Lu Y, et al. Identification of tRNA-derived fragments and their potential roles in diabetic cataract rats. Epigenomics. 2020;12(16):1405–1418.
   PubMed Web of Science ®Google Scholar
• Cosentino C, Toivonen S, Diaz Villamil E, et al. Pancreatic beta-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes. Nucleic Acids Res. 2018;46(19):10302–10318. doi:10.1093/nar/gky839
   PubMed Web of Science ®Google Scholar
• Jacovetti C, Bayazit MB, Regazzi R. Emerging classes of small non-coding RNAs with potential implications in diabetes and associated metabolic disorders. Front Endocrinol. 2021;12:670719. doi:10.3389/fendo.2021.670719
   PubMed Web of Science ®Google Scholar
• Langmead B, Trapnell C, Pop M, et al. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 2009;10(3):R25. doi:10.1186/gb-2009-10-3-r25
   PubMed Web of Science ®Google Scholar
• Fan Y, Wu W, Lei Y, et al. Edaravone-loaded alginate-based nanocomposite hydrogel accelerated chronic wound healing in diabetic mice. Mar Drugs. 2019;17(5):285. doi:10.3390/md17050285
   PubMed Web of Science ®Google Scholar
• Tang DT, Glazov EA, McWilliam SM, et al. Analysis of the complement and molecular evolution of tRNA genes in cow. BMC Genomics. 2009;10:188. doi:10.1186/1471-2164-10-188
   PubMed Web of Science ®Google Scholar
• Shen L, Gan M, Tan Z, et al. A novel class of tRNA-derived small non-coding RNAs respond to myocardial hypertrophy and contribute to intergenerational inheritance. Biomolecules. 2018;8(3):54. doi:10.3390/biom8030054
   PubMed Web of Science ®Google Scholar
• Ogawa Y, Taketomi Y, Murakami M, et al. Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing. Biol Pharm Bull. 2013;36(1):66–75. doi:10.1248/bpb.b12-00607
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang Y, Shi J, et al. Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection. J Mol Cell Biol. 2014;6(2):172–174. doi:10.1093/jmcb/mjt052
   PubMed Web of Science ®Google Scholar
• Torres AG, Reina O, Stephan-Otto Attolini C, et al. Differential expression of human tRNA genes drives the abundance of tRNA-derived fragments. Proc Natl Acad Sci U S A. 2019;116(17):8451–8456. doi:10.1073/pnas.1821120116
   PubMed Web of Science ®Google Scholar
• Sharma U, Conine CC, Shea JM, et al. Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science. 2016;351(6271):391–396. doi:10.1126/science.aad6780
   PubMed Web of Science ®Google Scholar
• Yan Z, Cui X, Huang M, et al. Integrated analysis of tRNA-derived small RNAs reveals new therapeutic genes of hyperbaric oxygen in diabetic foot ulcers. Epigenomics. 2021;13(22):1817–1829. doi:10.2217/epi-2021-0284
   PubMed Web of Science ®Google Scholar
• Zhang Y, Deng Q, Tu L, et al. tRNAderived small RNAs: a novel class of small RNAs in human hypertrophic scar fibroblasts. Int J Mol Med. 2020;45(1):115–130. doi:10.3892/ijmm.2019.4411
   PubMed Web of Science ®Google Scholar
• Li T, Mo H, Chen W, et al. Role of the PI3K-akt signaling pathway in the pathogenesis of polycystic ovary syndrome. Reprod Sci. 2017;24(5):646–655. doi:10.1177/1933719116667606
   PubMed Web of Science ®Google Scholar
• Wu C, Jiang F, Wei K, et al. Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5alpha-reductase type 1 in PCOS rats. Sci Rep. 2018;8(1):7982. doi:10.1038/s41598-018-26210-0
   PubMedGoogle Scholar
• Huang X, Sun J, Chen G, et al. Resveratrol promotes diabetic wound healing via SIRT1-FOXO1-c-Myc signaling pathway-mediated angiogenesis. Front Pharmacol. 2019;10:421. doi:10.3389/fphar.2019.00421
   PubMed Web of Science ®Google Scholar
• Barrientos S, Stojadinovic O, Golinko MS, et al. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008;16(5):585–601.
   PubMed Web of Science ®Google Scholar
• Cao Y, Gong Y, Liu L, et al. The use of human umbilical vein endothelial cells (HUVECs) as an in vitro model to assess the toxicity of nanoparticles to endothelium: a review. J Appl Toxicol. 2017;37(12):1359–1369. doi:10.1002/jat.3470
   PubMed Web of Science ®Google Scholar
• Bi H, Li H, Zhang C, et al. Stromal vascular fraction promotes migration of fibroblasts and angiogenesis through regulation of extracellular matrix in the skin wound healing process. Stem Cell Res Ther. 2019;10(1):302. doi:10.1186/s13287-019-1415-6
   PubMed Web of Science ®Google Scholar
• Li H, Cai E, Cheng H, et al. FGA controls VEGFA secretion to promote angiogenesis by activating the VEGFR2-FAK signalling pathway. Front Endocrinol. 2022;13:791860. doi:10.3389/fendo.2022.791860
   PubMed Web of Science ®Google Scholar
• Huang MZ, Yang YJ, Liu XW, et al. Aspirin eugenol ester attenuates oxidative injury of vascular endothelial cells by regulating NOS and Nrf2 signalling pathways. Br J Pharmacol. 2019;176(7):906–918. doi:10.1111/bph.14592
   PubMed Web of Science ®Google Scholar
• Chen T, Zhang X, Zhu G, et al. Quercetin inhibits TNF-alpha induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro. Medicine. 2020;99(38):e22241. doi:10.1097/MD.0000000000022241
   PubMed Web of Science ®Google Scholar
• Lin F, Yang Y, Wei S, et al. Hydrogen sulfide protects against high glucose-induced human umbilical vein Endothelial cell injury through activating PI3K/Akt/eNOS pathway. Drug Des Devel Ther. 2020;14::621–633. doi:10.2147/DDDT.S242521
   PubMed Web of Science ®Google Scholar
• Chai M, Gu C, Shen Q, et al. Hypoxia alleviates dexamethasone-induced inhibition of angiogenesis in cocultures of HUVECs and rBMSCs via HIF-1alpha. Stem Cell Res Ther. 2020;11(1):343. doi:10.1186/s13287-020-01853-x
   PubMed Web of Science ®Google Scholar
• Dong G, Yang S, Cao X, et al. Low shear stress-induced autophagy alleviates cell apoptosis in HUVECs. Mol Med Rep. 2017;15(5):3076–3082. doi:10.3892/mmr.2017.6401
   PubMed Web of Science ®Google Scholar
• Maloney E, Sweet IR, Hockenbery DM, et al. Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation. Arterioscler Thromb Vasc Biol. 2009;29(9):1370–1375. doi:10.1161/ATVBAHA.109.188813
   PubMed Web of Science ®Google Scholar
• Cheng AM, Handa P, Tateya S, et al. Apolipoprotein A-I attenuates palmitate-mediated NF-kappaB activation by reducing Toll-like receptor-4 recruitment into lipid rafts. PLoS One. 2012;7(3):e33917. doi:10.1371/journal.pone.0033917
   PubMed Web of Science ®Google Scholar