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ORIGINAL RESEARCH

Adiponectin Paradox More Evident in Non-Obese Than in Obese Patients with Diabetic Microvascular Complications

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Pages 201-212 | Received 02 Sep 2022, Accepted 11 Jan 2023, Published online: 23 Jan 2023

References

  • Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes. 2005;54(6):1615–1625. doi:10.2337/diabetes.54.6.1615
  • Nathan DM, Genuth S, Lachin J, et al. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329(14):977–986.
  • Man REK, Gan ATL, Fenwick EK, et al. The relationship between generalized and abdominal obesity with diabetic kidney disease in type 2 diabetes: a multiethnic asian study and meta-analysis. Nutrients. 2018;10(11):1685. doi:10.3390/nu10111685
  • Carr DB, Utzschneider KM, Hull RL, et al. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes. 2004;53(8):2087–2094. doi:10.2337/diabetes.53.8.2087
  • Suzuki T, Gao J, Ishigaki Y, et al. ER stress protein CHOP mediates insulin resistance by modulating adipose tissue macrophage polarity. Cell Rep. 2017;18(8):2045–2057. doi:10.1016/j.celrep.2017.01.076
  • Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest. 1996;97(11):2601–2610. doi:10.1172/JCI118709
  • Purdy JC, Shatzel JJ. The hematologic consequences of obesity. Eur J Haematol. 2021;106(3):306–319. doi:10.1111/ejh.13560
  • Kovesdy CP, Furth SL, Zoccali C. Obesity and kidney disease: hidden consequences of the epidemic. Am J Nephrol. 2017;45(3):283–291. doi:10.1159/000458467
  • Zhou Y, Zhang Y, Shi K, Wang C. Body mass index and risk of diabetic retinopathy: a meta-analysis and systematic review. Medicine. 2017;96(22):e6754. doi:10.1097/MD.0000000000006754
  • Man RE, Sabanayagam C, Chiang PP, et al. Differential association of generalized and abdominal obesity with diabetic retinopathy in asian patients with type 2 diabetes. JAMA Ophthalmol. 2016;134(3):251–257. doi:10.1001/jamaophthalmol.2015.5103
  • Sampath Kumar A, Arun Maiya G, Shastry BA, Vaishali K, Maiya S, Umakanth S. Correlation between basal metabolic rate, visceral fat and insulin resistance among type 2 diabetes mellitus with peripheral neuropathy. Diabetes Metab Syndr. 2019;13(1):344–348. doi:10.1016/j.dsx.2018.10.005
  • Oh TJ, Lee JE, Choi SH, Jang HC. Association between body fat and diabetic peripheral neuropathy in middle-aged adults with type 2 diabetes mellitus: a preliminary report. J Obes Metab Syndr. 2019;28(2):112–117. doi:10.7570/jomes.2019.28.2.112
  • Matsushita Y, Hasegawa Y, Takebe N, et al. Serum C-X-C motif chemokine ligand 14 levels are associated with serum C-peptide and fatty liver index in type 2 diabetes mellitus patients. J Diabetes Investig. 2021;12(6):1042–1049. doi:10.1111/jdi.13438
  • Maeda N, Funahashi T, Matsuzawa Y, Shimomura I. Adiponectin, a unique adipocyte-derived factor beyond hormones. Atherosclerosis. 2020;292:1–9. doi:10.1016/j.atherosclerosis.2019.10.021
  • Ouchi N, Walsh K. Adiponectin as an anti-inflammatory factor. Clin Chim Acta. 2007;380(1–2):24–30. doi:10.1016/j.cca.2007.01.026
  • Aljafary MA, Al-Suhaimi EA. Adiponectin system (rescue hormone): the missing link between metabolic and cardiovascular diseases. Pharmaceutics. 2022;14(7):1430. doi:10.3390/pharmaceutics14071430
  • Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24(1):29–33. doi:10.1161/01.ATV.0000099786.99623.EF
  • Menzaghi C, Trischitta V. The adiponectin paradox for all-cause and cardiovascular mortality. Diabetes. 2018;67(1):12–22. doi:10.2337/dbi17-0016
  • Rodríguez AJ, Nunes Vdos S, Mastronardi CA, Neeman T, Paz-Filho GJ. Association between circulating adipocytokine concentrations and microvascular complications in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of controlled cross-sectional studies. J Diabetes Complications. 2016;30(2):357–367. doi:10.1016/j.jdiacomp.2015.11.004
  • Yang HS, Choi YJ, Han HY, et al. Serum and aqueous humor adiponectin levels correlate with diabetic retinopathy development and progression. PLoS One. 2021;16(11):e0259683. doi:10.1371/journal.pone.0259683
  • Nigro E, Scudiero O, Monaco ML, et al. New insight into adiponectin role in obesity and obesity-related diseases. Biomed Res Int. 2014;2014:658913. doi:10.1155/2014/658913
  • Consultation, WHO Expert. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157–163. doi:10.1016/S0140-6736(03)15268-3
  • Takebe N, Tanno K, Ohmomo H, et al. Weight gain after 20 years of age is associated with unfavorable lifestyle and increased prevalence of metabolic disorders. Diabetes Metab Syndr Obes. 2021;14:2065–2075. doi:10.2147/DMSO.S300250
  • Wilkinson CP, Ferris FL, Klein RE, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110(9):1677–1682. doi:10.1016/S0161-6420(03)00475-5
  • Araki E, Goto A, Kondo T, et al. Japanese clinical practice guideline for diabetes 2019. Diabetol Int. 2020;11(3):165–223. doi:10.1007/s13340-020-00439-5
  • Hangai M, Takebe N, Honma H, et al. Association of advanced glycation end products with coronary artery calcification in Japanese subjects with type 2 diabetes as assessed by skin autofluorescence. J Atheroscler Thromb. 2016;23(10):1178–1187. doi:10.5551/jat.30155
  • Wei L, Li Y, Yu Y, et al. Obesity-related glomerulopathy: from mechanism to therapeutic target. Diabetes Metab Syndr Obes. 2021;14:4371–4380. doi:10.2147/DMSO.S334199
  • Borges MC, Lawlor DA, de Oliveira C, White J, Horta BL, Barros AJ. Role of adiponectin in coronary heart disease risk: a Mendelian randomization study. Circ Res. 2016;119(3):491–499. doi:10.1161/CIRCRESAHA.116.308716
  • Dieplinger B, Haltmayer M, Poelz W, Mueller T. Value of adiponectin as predictor of 5-year all-cause mortality in patients with symptomatic peripheral arterial disease: results from the Linz Peripheral Arterial Disease (LIPAD) study. Clin Chim Acta. 2009;408(1–2):87–91. doi:10.1016/j.cca.2009.07.014
  • Kizer JR, Benkeser D, Arnold AM, et al. Associations of total and high-molecular-weight adiponectin with all-cause and cardiovascular mortality in older persons: the Cardiovascular Health Study. Circulation. 2012;126(25):2951–2961. doi:10.1161/CIRCULATIONAHA.112.135202
  • Chong DQ, Mehta RS, Song M, et al. Prediagnostic plasma adiponectin and survival among patients with colorectal cancer. Cancer Prevent Res. 2015;8(12):1138–1145. doi:10.1158/1940-6207.CAPR-15-0175
  • Frystyk J, Tarnow L, Hansen TK, Parving HH, Flyvbjerg A. Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications. Diabetologia. 2005;48(9):1911–1918. doi:10.1007/s00125-005-1850-z
  • Fan X, Wu Q, Li Y, et al. Association between adiponectin concentrations and diabetic retinopathy in patients with type 2 diabetes: a meta analysis. Chin Med J. 2014;127(4):765–771.
  • Matsuda M, Shimomura I, Sata M, et al. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem. 2002;277(40):37487–37491. doi:10.1074/jbc.M206083200
  • Aubert CE, Liabeuf S, Amouyal C, et al. Serum concentration and vascular expression of adiponectin are differentially associated with the diabetic calcifying peripheral arteriopathy. Diabetol Metab Syndr. 2019;11:32. doi:10.1186/s13098-019-0429-7
  • Higuchi A, Ohashi K, Kihara S, Walsh K, Ouchi N. Adiponectin suppresses pathological microvessel formation in retina through modulation of tumor necrosis factor-alpha expression. Circ Res. 2009;104(9):1058–1065. doi:10.1161/CIRCRESAHA.109.194506
  • Bushra S, Al-Sadeq DW, Bari R, Sahara A, Fadel A, Rizk N. Adiponectin ameliorates hyperglycemia-induced retinal endothelial dysfunction, highlighting pathways, regulators, and networks. J Inflamm Res. 2022;15:3135–3166. doi:10.2147/JIR.S358594
  • Fujishima Y, Maeda N, Matsuda K, et al. Adiponectin association with T-cadherin protects against neointima proliferation and atherosclerosis. FASEB j. 2017;31(4):1571–1583. doi:10.1096/fj.201601064R
  • Sakaue TA, Fujishima Y, Fukushima Y, et al. Adiponectin accumulation in the retinal vascular endothelium and its possible role in preventing early diabetic microvascular damage. Sci Rep. 2022;12(1):4159. doi:10.1038/s41598-022-08041-2
  • Sharma K, Ramachandrarao S, Qiu G, et al. Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest. 2008;118(5):1645–1656. doi:10.1172/JCI32691
  • Esmaili S, Hemmati M, Karamian M. Physiological role of adiponectin in different tissues: a review. Arch Physiol Biochem. 2020;126(1):67–73. doi:10.1080/13813455.2018.1493606
  • Ma OK, Ronsisvalle S, Basile L, et al. Identification of a novel adiponectin receptor and opioid receptor dual acting agonist as a potential treatment for diabetic neuropathy. Biomed Pharmacother. 2022;158:114141. doi:10.1016/j.biopha.2022.114141
  • Parida S, Siddharth S, Sharma D. Adiponectin, obesity, and cancer: clash of the bigwigs in health and disease. Int J Mol Sci. 2019;20(10):2519. doi:10.3390/ijms20102519
  • Maeda N, Takahashi M, Funahashi T, et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes. 2001;50(9):2094–2099. doi:10.2337/diabetes.50.9.2094
  • Fasshauer M, Kralisch S, Klier M, et al. Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2003;301(4):1045–1050. doi:10.1016/S0006-291X(03)00090-1
  • Yamauchi T, Kamon J, Waki H, et al. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem. 2001;276(44):41245–41254. doi:10.1074/jbc.M103241200
  • Drolet R, Bélanger C, Fortier M, et al. Fat depot-specific impact of visceral obesity on adipocyte adiponectin release in women. Obesity. 2009;17(3):424–430. doi:10.1038/oby.2008.555
  • Van Berendoncks AM, Garnier A, Beckers P, et al. Functional adiponectin resistance at the level of the skeletal muscle in mild to moderate chronic heart failure. Circ Heart Fail. 2010;3(2):185–194. doi:10.1161/CIRCHEARTFAILURE.109.885525
  • Wang Y, Ma XL, Lau WB. Cardiovascular Adiponectin resistance: the critical role of adiponectin receptor modification. Trends Endocrinol Metabol. 2017;28(7):519–530. doi:10.1016/j.tem.2017.03.004
  • Matsuda K, Fujishima Y, Maeda N, et al. Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice. Endocrinology. 2015;156(3):934–946. doi:10.1210/en.2014-1618
  • Obata Y, Yamada Y, Takahi Y, et al. Relationship between serum adiponectin levels and age in healthy subjects and patients with type 2 diabetes. Clin Endocrinol. 2013;79(2):204–210. doi:10.1111/cen.12041