294
Views
2
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Ginsenoside Rg1 Ameliorates Pancreatic Injuries via the AMPK/mTOR Pathway in vivo and in vitro

, , , , & ORCID Icon
Pages 779-794 | Received 15 Dec 2022, Accepted 21 Feb 2023, Published online: 15 Mar 2023

References

  • Cloete L. Diabetes mellitus: an overview of the types, symptoms, complications and management. Nurs Stand. 2022;37(1):61–66. doi:10.7748/ns.2021.e11709
  • Syed FZ. Type 1 Diabetes Mellitus. Ann Intern Med. 2022;175(3):ITC33–ITC48. doi:10.7326/AITC202203150
  • Patterson CC, Karuranga S, Salpea P, et al. Worldwide estimates of incidence, prevalence and mortality of type 1 diabetes in children and adolescents: results from the international diabetes federation diabetes atlas. Diabetes Res Clin Pract. 2019;157:107842. doi:10.1016/j.diabres.2019.107842
  • Zhao X, Hilton A, Watson R, et al. Development and validity testing of a type 1 diabetes resource for 10–19-years old adolescents in China. J Pediatr Nurs. 2021;60:e96–e103. doi:10.1016/j.pedn.2021.03.029
  • Chellappan DK, Sivam NS, Teoh KX, et al. Gene therapy and type 1 diabetes mellitus. Biomed Pharmacother. 2018;108:1188–1200. doi:10.1016/j.biopha.2018.09.138
  • Chen S, Du K, Zou C. Current progress in stem cell therapy for type 1 diabetes mellitus. Stem Cell Res Ther. 2020;11(1):275. doi:10.1186/s13287-020-01793-6
  • Chen X, Affinati AH, Lee Y, et al. Immune checkpoint inhibitors and risk of type 1 diabetes. Diabetes Care. 2022;45(5):1170–1176. doi:10.2337/dc21-2213
  • Stamati A, Karagiannis T, Tsapas A, et al. Efficacy and safety of ultra-rapid insulin analogues in insulin pumps in patients with type 1 diabetes mellitus: a systematic review and meta-analysis. Diabetes Res Clin Pract. 2022;193:110144. doi:10.1016/j.diabres.2022.110144
  • Kumar K, Baliga G, Babu N, et al. Clinical features and surgical outcomes of complications of proliferative diabetic retinopathy in young adults with type 1 diabetes mellitus versus type 2 diabetes mellitus - A comparative observational study. Indian J Ophthalmol. 2021;69(11):3289–3295. doi:10.4103/ijo.IJO_1293_21
  • Chalakova T, Yotov Y, Tzotchev K, et al. Type 1 diabetes mellitus - risk factor for cardiovascular disease morbidity and mortality. Curr Diabetes Rev. 2021;17(1):37–54. doi:10.2174/18756417MTA2pNTAa1
  • Yang B, Gan MS, Lin ZY, et al. Identification of autophagy-related genes as potential biomarkers for type 1 diabetes mellitus. Ann Transl Med. 2022;10(11):637. doi:10.21037/atm-22-1812
  • Bokhary K, Aljaser F, Abudawood M, et al. Role of oxidative stress and severity of diabetic retinopathy in type 1 and type 2 diabetes. Ophthalmic Res. 2021;64(4):613–621. doi:10.1159/000514722
  • Zhang J, Xiao Y, Hu J, et al. Lipid metabolism in type 1 diabetes mellitus: pathogenetic and therapeutic implications. Front Immunol. 2022;13:999108. doi:10.3389/fimmu.2022.999108
  • Muralidharan C, Linnemann AK. β-Cell autophagy in the pathogenesis of type 1 diabetes. Am J Physiol Endocrinol Metab. 2021;321(3):E410–E416. doi:10.1152/ajpendo.00151.2021
  • Oh SJ, Lee MS. Role of autophagy in the pathogenesis of diabetes and therapeutic potential of autophagy modulators in the treatment of diabetes and metabolic syndrome. J Korean Med Sci. 2022;37(37):e276. doi:10.3346/jkms.2022.37.e276
  • Šrámek J, Němcová-Fürstová V, Kovář J. Molecular mechanisms of apoptosis induction and its regulation by fatty acids in pancreatic β-cells. Int J Mol Sci. 2021;22(8):4285. doi:10.3390/ijms22084285
  • Saikia R, Joseph J. AMPK: a key regulator of energy stress and calcium-induced autophagy. J Mol Med. 2021;99(11):1539–1551. doi:10.1007/s00109-021-02125-8
  • Ji S, Zhu C, Gao S, et al. Morus alba leaves ethanol extract protects pancreatic islet cells against dysfunction and death by inducing autophagy in type 2 diabetes. Phytomedicine. 2021;83:153478. doi:10.1016/j.phymed.2021.153478
  • Zhou B, Leng Y, Lei SQ, et al. AMPK activation restores ischemic post‑conditioning cardioprotection in STZ‑induced type 1 diabetic rats: role of autophagy. Mol Med Rep. 2017;16(3):3648–3656. doi:10.3892/mmr.2017.7033
  • Yang F, Qin Y, Wang Y, et al. Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy. Int J Biol Sci. 2019;15(5):1010–1019. doi:10.7150/ijbs.29680
  • Varshney R, Varshney R, Mishra R, et al. Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic β-cell dysfunction through AMPK/mTOR-mediated lipophagy. J Nutr Biochem. 2018;57:212–227. doi:10.1016/j.jnutbio.2018.02.017
  • Wang XY, Zhu BR, Jia Q, et al. Cinnamtannin D1 protects pancreatic β-cells from glucolipotoxicity-induced apoptosis by enhancement of autophagy in vitro and in vivo. J Agric Food Chem. 2020;68(45):12617–12630. doi:10.1021/acs.jafc.0c04898
  • Liu H, Chen W, Lu P, et al. Ginsenoside Rg1 attenuates the inflammation and oxidative stress induced by diabetic nephropathy through regulating the PI3K/AKT/FOXO3 pathway. Ann Transl Med. 2021;9(24):1789. doi:10.21037/atm-21-6234
  • Yang Y, Wang L, Zhang C, et al. Ginsenoside Rg1 improves Alzheimer’s disease by regulating oxidative stress, apoptosis, and neuroinflammation through Wnt/GSK-3β/β-catenin signaling pathway. Chem Biol Drug Des. 2022;99(6):884–896. doi:10.1111/cbdd.14041
  • Gao Y, Li J, Chu S, et al. Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetic by modulating the NLRP3 and Keap1/Nrf2/HO-1 pathways. Eur J Pharmacol. 2020;866:172801. doi:10.1016/j.ejphar.2019.172801
  • Yang P, Ling L, Sun W, et al. Ginsenoside Rg1 inhibits apoptosis by increasing autophagy via the AMPK/mTOR signaling in serum deprivation macrophages. Acta Biochim Biophys Sin (Shanghai). 2018;50(2):144–155. doi:10.1093/abbs/gmx136
  • Samarghandian S, Azimi-Nezhad M, Samini F, et al. Chrysin treatment improves diabetes and its complications in liver, brain, and pancreas in streptozotocin-induced diabetic rats. Can J Physiol Pharmacol. 2016;94(4):388–393. doi:10.1139/cjpp-2014-0412
  • Lan ZJ, Lei Z, Nation L, et al. Oral administration of NPC43 counters hyperglycemia and activates insulin receptor in streptozotocin-induced type 1 diabetic mice. BMJ Open Diabetes Res Care. 2020;8(1):e001695. doi:10.1136/bmjdrc-2020-001695
  • Liu H, Wang J, Liu M, et al. Antiobesity Effects of Ginsenoside Rg1 on 3T3-L1 Preadipocytes and high fat diet-induced obese mice mediated by AMPK. Nutrients. 2018;10(7):830. doi:10.3390/nu10070830
  • Xiao Y, Wu QQ, Duan MX, et al. TAX1BP1 overexpression attenuates cardiac dysfunction and remodeling in STZ-induced diabetic cardiomyopathy in mice by regulating autophagy. Biochim Biophys Acta Mol Basis Dis. 2018;1864(5 Pt A):1728–1743. doi:10.1016/j.bbadis.2018.02.012
  • Baeyens A, Pérol L, Fourcade G, et al. Limitations of IL-2 and rapamycin in immunotherapy of type 1 diabetes. Diabetes. 2013;62(9):3120–3131. doi:10.2337/db13-0214
  • Wang W, Xu AL, Li ZC, et al. Combination of probiotics and salvia miltiorrhiza polysaccharide alleviates hepatic steatosis via gut microbiota modulation and insulin resistance improvement in high fat-induced NAFLD mice. Diabetes Metab J. 2020;44(2):336–348. doi:10.4093/dmj.2019.0042
  • Rao X, Huang X, Zhou Z, et al. An improvement of the 2ˆ(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis. Biostat Bioinforma Biomath. 2013;3(3):71–85.
  • Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas. Diabetes Res Clin Pract. 2019;157:107843. doi:10.1016/j.diabres.2019.107843
  • Marasco MR, Linnemann AK. β-Cell Autophagy in Diabetes Pathogenesis. Endocrinology. 2018;159(5):2127–2141. doi:10.1210/en.2017-03273
  • Peng M, Wang L, Su H, et al. Ginsenoside Rg1 improved diabetes through regulating the intestinal microbiota in high-fat diet and streptozotocin-induced type 2 diabetes rats. J Food Biochem. 2022;46(10):e14321. doi:10.1111/jfbc.14321
  • Shi Y, Gao Y, Wang T, et al. Ginsenoside Rg1 Alleviates Podocyte EMT Passage by Regulating AKT/GSK3 β/β-Catenin Pathway by Restoring Autophagic Activity. Evid Based Complement Alternat Med. 2020;2020:1903627. doi:10.1155/2020/1903627
  • Zhao J, He B, Zhang S, et al. Ginsenoside Rg1 alleviates acute liver injury through the induction of autophagy and suppressing NF-κB/NLRP3 inflammasome signaling pathway. Int J Med Sci. 2021;18(6):1382–1389. doi:10.7150/ijms.50919
  • Huang C, Xue X, Gong N, et al. Ginsenoside Rg1 suppresses paraquat-induced epithelial cell senescence by enhancing autophagy in an ATG12-dependent manner. Environ Toxicol. 2022;37(9):2302–2313. doi:10.1002/tox.23597
  • Muralidharan C, Conteh AM, Marasco MR, et al. Pancreatic beta cell autophagy is impaired in type 1 diabetes. Diabetologia. 2021;64(4):865–877. doi:10.1007/s00125-021-05387-6
  • Chwalba A, Pilśniak A, Otto-Buczkowska E. β-cell self-destruction and extremely complicated and still unknown etiopathogenesis of type 1 diabetes. Proces autodestrukcji komórek β trzustki oraz niezwykle skomplikowana i wciąż nieznana etiopatogeneza cukrzycy typu 1. Pediatr Endocrinol Diabetes Metab. 2021;27(1):47–50. doi:10.5114/pedm.2020.103058
  • Demirtas L, Guclu A, Erdur FM, et al. Apoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitus. Indian J Med Res. 2016;144(4):515–524. doi:10.4103/0971-5916.200887
  • Li Y, Chen Y. AMPK and Autophagy. Adv Exp Med Biol. 2019;1206:85–108.
  • Moore MN. Lysosomes, Autophagy, and Hormesis in Cell Physiology, Pathology, and Age-Related Disease. Dose Response. 2020;18(3):1559325820934227. doi:10.1177/1559325820934227
  • Wang Y, Liu Z, Shu S, et al. AMPK/mTOR signaling in autophagy regulation during cisplatin-induced acute kidney injury. Front Physiol. 2020;11:619730. doi:10.3389/fphys.2020.619730
  • Li Y, Sun R, Zou J, et al. Dual roles of the AMP-activated protein kinase pathway in angiogenesis. Cells. 2019;8(7):752. doi:10.3390/cells8070752
  • Chen M, Jing D, Ye R, et al. PPARβ/δ accelerates bone regeneration in diabetic mellitus by enhancing AMPK/mTOR pathway-mediated autophagy. Stem Cell Res Ther. 2021;12(1):566. doi:10.1186/s13287-021-02628-8
  • Zhang Y, Ling Y, Yang L, et al. Liraglutide relieves myocardial damage by promoting autophagy via AMPK-mTOR signaling pathway in zucker diabetic fatty rat. Mol Cell Endocrinol. 2017;448:98–107. doi:10.1016/j.mce.2017.03.029
  • Zhu Y, Su Y, Zhang J, et al. Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy. Mol Med Rep. 2021;23(6):437. doi:10.3892/mmr.2021.12076