Relationship Between Index of Cardiac Electrophysiological Balance, Frontal QRS-T Angle and Retinopathy in People with Type 2 Diabetes

References

• Cho N, Shaw J, Karuranga S, et al. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–281. doi:10.1016/j.diabres.2018.02.023
   PubMed Web of Science ®Google Scholar
• Akawi N, Checa A, Antonopoulos A, et al. Fat-secreted ceramides regulate vascular redox state and influence outcomes in patients with cardiovascular disease. J Am Coll Cardiol. 2021;77(20):2494–2513. doi:10.1016/j.jacc.2021.03.314
   PubMed Web of Science ®Google Scholar
• Vedel-Larsen E, Iepsen E, Lundgren J, et al. Major rapid weight loss induces changes in cardiac repolarization. J Electrocardiol. 2016;49(3):467–472. doi:10.1016/j.jelectrocard.2016.02.005
   PubMed Web of Science ®Google Scholar
• Hyltén-Cavallius L, Iepsen EW, Albrechtsen NJ, et al. Patients with long-QT syndrome caused by impaired hERG -Encoded K v 11.1 potassium channel have exaggerated endocrine pancreatic and incretin function associated with reactive hypoglycemia. Circulation. 2017;135(18):1705–1719. doi:10.1161/CIRCULATIONAHA.116.024279
   PubMed Web of Science ®Google Scholar
• El-Atat F, McFarlane S, Sowers J, Bigger J. Sudden cardiac death in patients with diabetes. Curr Diab Rep. 2004;4(3):187–193.
   PubMedGoogle Scholar
• Walker A, Cubbon R. Sudden cardiac death in patients with diabetes mellitus and chronic heart failure. Diab Vasc Dis Res. 2015;12(4):228–233 doi:10.1177/1479164115573225.
   PubMed Web of Science ®Google Scholar
• Huikuri HV, Castellanos A, Myerburg RJ. Sudden death due to cardiac arrhythmias. N Engl J Med. 2001;345(20):1473–1482 doi:10.1056/NEJMra000650.
   PubMed Web of Science ®Google Scholar
• Balkau B, Jouven, X, Ducimetière, P, Eschwège, E. Diabetes as a risk factor for sudden death. Lancet. 1999;354(9194):1968–1969 doi:10.1016/S0140-6736(99)04383-4.
   PubMed Web of Science ®Google Scholar
• Albert CM. Prospective study of sudden cardiac death among women in the United States. Circulation. 2003;107(16):2096–2101 doi:10.1161/01.CIR.0000065223.21530.11.
   PubMed Web of Science ®Google Scholar
• Albert C, Mittleman M, Chae C, Lee I, Hennekens C, Manson J. Triggering of sudden death from cardiac causes by vigorous exertion. N Engl J Med. 2000;343(19):1355–1361 doi:10.1056/NEJM200011093431902.
   PubMed Web of Science ®Google Scholar
• Aune D, Schlesinger S, Norat T, Riboli E. Diabetes mellitus and the risk of sudden cardiac death: a systematic review and meta-analysis of prospective studies. NMCD. 2018;28(6):543–556 doi:10.1016/j.numecd.2018.02.011.
   PubMed Web of Science ®Google Scholar
• Hendrick A, Gibson M, Kulshreshtha A. Diabetic Retinopathy. Prim Care. 2015;42(3):451–464 doi:10.1016/j.pop.2015.05.005.
   PubMed Web of Science ®Google Scholar
• Jouven X, Lemaître RN, Rea TD, Sotoodehnia N, Empana J-P, Siscovick DS. Diabetes, glucose level, and risk of sudden cardiac death. Eur Heart J. 2005;26(20):2142–2147 doi:10.1093/eurheartj/ehi376.
   PubMed Web of Science ®Google Scholar
• Vrtovec B, Delgado R, Zewail A, Thomas C, Richartz B, Radovancevic B. Prolonged QTc interval and high B-type natriuretic peptide levels together predict mortality in patients with advanced heart failure. Circulation. 2003;107(13):1764–1769 doi:10.1161/01.CIR.0000057980.84624.95.
   PubMed Web of Science ®Google Scholar
• Panikkath R, Reinier K, Uy-Evanado A, et al. Prolonged Tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. Circ Arrhythm Electrophysiol. 2011;4(4):441–447 doi:10.1161/CIRCEP.110.960658.
   PubMed Web of Science ®Google Scholar
• Tse G, Yan B. Traditional and novel electrocardiographic conduction and repolarization markers of sudden cardiac death. Europace. 2017;19(5):712–721 doi:10.1093/europace/euw280.
   PubMed Web of Science ®Google Scholar
• Erken Pamukcu H, Hepşen S, Şahan H, et al. Diabetic microvascular complications associated with myocardial repolarization heterogeneity evaluated by Tp-e interval and Tp-e/QTc ratio. J Diabetes Complications. 2020;34(12):107726 doi:10.1016/j.jdiacomp.2020.107726.
   PubMed Web of Science ®Google Scholar
• Kobayashi S, Nagao M, Asai A, Fukuda I, Oikawa S, Sugihara H. Severity and multiplicity of microvascular complications are associated with QT interval prolongation in patients with type 2 diabetes. J Diabetes Investig. 2018;9(4):946–951 doi:10.1111/jdi.12772.
   PubMed Web of Science ®Google Scholar
• Lu HR, Yan GX, Gallacher DJ. A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs). J Pharmacol Toxicol Methods. 2013;68(2):250–259 doi:10.1016/j.vascn.2013.01.003.
   PubMed Web of Science ®Google Scholar
• Yücetas S, Kaya H, Kafadar S, Kafadar H, Tibilli H, Akcay A. Evaluation of index of cardiac-electrophysiological balance in patients with subarachnoid hemorrhage. BMC Cardiovasc Disord. 2022;22(1):477 doi:10.1186/s12872-022-02924-y.
   PubMed Web of Science ®Google Scholar
• Ucar F, Ozturk C, Yılmaztepe M. Evaluation of Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with acute myocarditis. BMC Cardiovasc Disord. 2019;19(1):232 doi:10.1186/s12872-019-1207-z.
   PubMed Web of Science ®Google Scholar
• Lin M, Sun Y. Obstacles to the clinical application of the QRS-T angle. J Electrocardiol. 2020;58:27–28 doi:10.1016/j.jelectrocard.2019.09.028.
   PubMed Web of Science ®Google Scholar
• Lipponen JA, Kurl S, Laukkanen JA. Global electrical heterogeneity as a predictor of cardiovascular mortality in men and women. EP Europace. 2018;20(11):1841–1848 doi:10.1093/europace/euy113.
   PubMed Web of Science ®Google Scholar
• Aro AL, Huikuri HV, Tikkanen JT, et al. QRS-T angle as a predictor of sudden cardiac death in a middle-aged general population. Europace. 2012;14(6):872–876 doi:10.1093/europace/eur393.
   PubMed Web of Science ®Google Scholar
• May O, Graversen C, Johansen M, Arildsen H. A large frontal QRS-T angle is a strong predictor of the long-term risk of myocardial infarction and all-cause mortality in the diabetic population. J Diabetes Complications. 2017;31(3):551–555 doi:10.1016/j.jdiacomp.2016.12.001.
   PubMed Web of Science ®Google Scholar
• Nguyen TT, Wong TY. Retinal vascular manifestations of metabolic disorders. Trends Endocrinol Metab. 2006;17(7):262–268 doi:10.1016/j.tem.2006.07.006.
   PubMed Web of Science ®Google Scholar
• Targher G, Bertolini L, Zoppini G, Zenari L, Falezza G. Increased plasma markers of inflammation and endothelial dysfunction and their association with microvascular complications in type1 diabetic patients without clinically manifest macroangiopathy. Diabet Med. 2005;22(8):999–1004 doi:10.1111/j.1464-5491.2005.01562.x.
   PubMed Web of Science ®Google Scholar
• van Hecke M, Dekker J, Nijpels G, et al. Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn study. Diabetologia. 2005;48(7):1300–1306 doi:10.1007/s00125-005-1799-y.
   PubMed Web of Science ®Google Scholar
• Stratton I, Kohner E, Aldington S, et al. UKPDS 50: risk factors for incidence and progression of retinopathy in Type II diabetes over 6 years from diagnosis. Diabetologia. 2001;44(2):156–163 doi:10.1007/s001250051594.
   PubMed Web of Science ®Google Scholar
• Alberti K, Zimmet P. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic Med. 1998;15(7):539–553 doi:10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S.
   PubMed Web of Science ®Google Scholar
• Hao XY, Chen X. Expert consensus on the diagnosis and management of diabetic kidney disease. Chin Med J. 2020;133(19):2333–2334 doi:10.1097/CM9.0000000000001049.
   PubMed Web of Science ®Google Scholar
• Boulton A, Vinik A, Arezzo J, et al. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005;28(4):956–962 doi:10.2337/diacare.28.4.956.
   PubMed Web of Science ®Google Scholar
• Sasongko M, Widyaputri F, Agni A, et al. Prevalence of diabetic retinopathy and blindness in Indonesian adults with type 2 diabetes. Am J Ophthalmol. 2017;181:79–87 doi:10.1016/j.ajo.2017.06.019.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Prineas R, Case D, Soliman E, Rautaharju P. Comparison of the prognostic significance of the electrocardiographic QRS/T angles in predicting incident coronary heart disease and total mortality (from the atherosclerosis risk in communities study). Am J Cardiol. 2007;100(5):844–849 doi:10.1016/j.amjcard.2007.03.104.
   PubMed Web of Science ®Google Scholar
• May O, Graversen C, Johansen M, Arildsen H. The prognostic value of the frontal QRS-T angle is comparable to cardiovascular autonomic neuropathy regarding long-term mortality in people with diabetes. A population based study. Diabetes Res Clin Pract. 2018;142:264–268 doi:10.1016/j.diabres.2018.05.018.
   PubMed Web of Science ®Google Scholar
• Davis M. Vitreous contraction in proliferative diabetic retinopathy. Arch Ophthalmol. 1965;74(6):741–751 doi:10.1001/archopht.1965.00970040743003.
   PubMedGoogle Scholar
• Fiorentini A, Perciaccante A, Valente R, Paris A, Serra P, Tubani L. The correlation among QTc interval, hyperglycaemia and the impaired autonomic activity. Auton Neurosci. 2010;154:94–98 doi:10.1016/j.autneu.2009.11.006.
   PubMed Web of Science ®Google Scholar
• Zima A, Blatter L. Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res. 2006;71(2):310–321 doi:10.1016/j.cardiores.2006.02.019.
   PubMed Web of Science ®Google Scholar
• Tamayo M, Fulgencio-Covián A, Navarro-García J, Val-Blasco A, Fernández-Velasco M. Intracellular calcium mishandling leads to cardiac dysfunction and ventricular arrhythmias in a mouse model of propionic acidemia. BBA. 2019;1866(1):165586 doi:10.1016/j.bbadis.2019.165586.
   PubMed Web of Science ®Google Scholar
• Huang C, Lee J, Lin T, et al. Diabetic retinopathy is strongly predictive of cardiovascular autonomic neuropathy in type 2 diabetes. J Diabetes Res. 2016;2016:6090749 doi:10.1155/2016/6090749.
   PubMed Web of Science ®Google Scholar
• Voulgari C, Moyssakis I, Perrea D, Kyriaki D, Katsilambros N, Tentolouris N. The association between the spatial QRS-T angle with cardiac autonomic neuropathy in subjects with Type 2 diabetes mellitus. Diabetic Med. 2010;27(12):1420–1429 doi:10.1111/j.1464-5491.2010.03120.x.
   PubMed Web of Science ®Google Scholar
• Bell D. Detecting and treating the protean manifestations of diabetic autonomic neuropathy. Diabetes Obes Metab. 2023;2023:1. doi:10.1111/dom.15004
   Google Scholar
• Whitsel E, Boyko E, Siscovick D. Reassessing the role of QTc in the diagnosis of autonomic failure among patients with diabetes: a meta-analysis. Diabetes Care. 2000;23(2):241–247 doi:10.2337/diacare.23.2.241.
   PubMed Web of Science ®Google Scholar
• Perciaccante A, Fiorentini A, Paris A, Serra P, Tubani L. Circadian rhythm of the autonomic nervous system in insulin resistant subjects with normoglycemia, impaired fasting glycemia, impaired glucose tolerance, type 2 diabetes mellitus. BMC Cardiovasc Disord. 2006;6:19 doi:10.1186/1471-2261-6-19.
   PubMedGoogle Scholar
• Martinez R. Diabetic cardiomyopathy: possible pathogenetic role of coronary microcirculation. Minerva Cardioangiol. 1992;40(1–2):1–5.
   PubMedGoogle Scholar
• Rosenson R, Fioretto P, Dodson P. Does microvascular disease predict macrovascular events in type 2 diabetes? Atherosclerosis. 2011;218(1):13–18 doi:10.1016/j.atherosclerosis.2011.06.029.
   PubMed Web of Science ®Google Scholar
• Watabe D, Hashimoto J, Hatanaka R, et al. Electrocardiographic left ventricular hypertrophy and arterial stiffness: the Ohasama study. Am J Hypertens. 2006;19(12):1199–1205 doi:10.1016/j.amjhyper.2006.05.001.
   PubMed Web of Science ®Google Scholar
• Gillow J, Gibson J, Dodson P. Hypertension and diabetic retinopathy—what’s the story? Br J Ophthalmol. 1999;83(9):1083–1087 doi:10.1136/bjo.83.9.1083.
   PubMed Web of Science ®Google Scholar
• Unger T. The role of the renin-angiotensin system in the development of cardiovascular disease. Am J Cardiol. 2002;89(2A):3A–9A doi:10.1016/s0002-9149(01)02321-9.
   PubMed Web of Science ®Google Scholar