Serum MOTS-C Levels are Decreased in Obese Children and Associated with Vascular Endothelial Function

References

• Development Initiatives. 2018 global nutrition report: shining a light to spur action on nutrition. Bristol: Development Initiatives Poverty Research Ltd; 2018. Available from: https://globalnutritionreport.org/. Accessed April 2, 2019.
   Google Scholar
• Daniels SR. Complications of obesity in children and adolescents. Int J Obes. 2009;33(Suppl 1):S60–S65. doi:10.1038/ijo.2009.20
   PubMed Web of Science ®Google Scholar
• Wang H, Sun J, Zhang Z, et al. Waist circumference change and risk of high carotid intima-media thickness in a cohort of Chinese children. J Hypertens. 2021;39(9):1901–1907. doi:10.1097/HJH.0000000000002881
   PubMed Web of Science ®Google Scholar
• Bibbins-Domingo K, Coxson P, Pletcher MJ, et al. Adolescent overweight and future adult coronary heart disease. N Engl J Med. 2007;357(23):2371–2379. doi:10.1056/NEJMsa073166
   PubMed Web of Science ®Google Scholar
• Gimbrone MA Jr, García-Cardeña G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res. 2016;118(4):620–636. doi:10.1161/CIRCRESAHA.115.306301
   PubMed Web of Science ®Google Scholar
• Alexander Y, Osto E, Schmidt-Trucksäss A, et al. Endothelial function in cardiovascular medicine: a consensus paper of the European society of cardiology working groups on atherosclerosis and vascular biology, aorta and peripheral vascular diseases, coronary pathophysiology and microcirculation, and thrombosis. Cardiovasc Res. 2021;117(1):29–42. doi:10.1093/cvr/cvaa085
   PubMed Web of Science ®Google Scholar
• Litwin M, Niemirska A, Sladowska-Kozlowska J, et al. Regression of target organ damage in children and adolescents with primary hypertension. Pediatr Nephrol. 2010;25(12):2489–2499. doi:10.1007/s00467-010-1626-7
   PubMed Web of Science ®Google Scholar
• Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443–454. doi:10.1016/j.cmet.2015.02.009
   PubMed Web of Science ®Google Scholar
• Kim KH, Son JM, Benayoun BA, et al. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metab. 2018;28(3):516–524. doi:10.1016/j.cmet.2018.06.008
   PubMed Web of Science ®Google Scholar
• Shen C, Wang J, Feng M, et al. The mitochondrial-derived peptide MOTS-c attenuates oxidative stress injury and the inflammatory response of H9c2 cells through the Nrf2/ARE and NF-κB pathways. Cardiovasc Eng Technol. 2022;13(5):651–661. doi:10.1007/s13239-021-00589-w
   PubMed Web of Science ®Google Scholar
• Mohtashami Z, Singh MK, Salimiaghdam N, et al. MOTS-c, the most recent mitochondrial derived peptide in human aging and age-related diseases. Int J Mol Sci. 2022;23(19):11991. doi:10.3390/ijms231911991
   PubMed Web of Science ®Google Scholar
• Ramanjaneya M, Bettahi I, Jerobin J, et al. Mitochondrial-derived peptides are down regulated in diabetes subjects. Front Endocrinol. 2019;10:331. doi:10.3389/fendo.2019.00331
   PubMed Web of Science ®Google Scholar
• Du C, Zhang C, Wu W, et al. Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance. Pediatr Diabetes. 2018;19(6):1058–1064. doi:10.1111/pedi.12685
   Web of Science ®Google Scholar
• Liu C, Gidlund EK, Witasp A, et al. Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease. Am J Physiol Renal Physiol. 2019;317(5):F1122–F1131. doi:10.1152/ajprenal.00202.2019
   PubMed Web of Science ®Google Scholar
• Yin Y, Pan Y, He J, et al. The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus. Pharmacol Res. 2022;175:105987. doi:10.1016/j.phrs.2021.105987
   PubMed Web of Science ®Google Scholar
• Qin Q, Delrio S, Wan J, et al. Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. Int J Cardiol. 2018;254:23–27. doi:10.1016/j.ijcard.2017.12.001
   PubMed Web of Science ®Google Scholar
• Yaşar E, Çakmak T, Bayramoğlu A, et al. MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease. Eur Rev Med Pharmacol Sci. 2022;26(16):5676–5682. doi:10.26355/eurrev_202208_29501
   PubMed Web of Science ®Google Scholar
• Li H, Ren K, Jiang T, et al. MOTS-c attenuates endothelial dysfunction via suppressing the MAPK/NF-κB pathway. Int J Cardiol. 2018;268:40. doi:10.1016/j.ijcard.2018.03.031
   PubMed Web of Science ®Google Scholar
• Li H, Zong XN, Ji CY, et al. Body mass index cut-offs for overweight and obesity in Chinese children and adolescents aged 2–18 years. Zhonghua Liu Xing Bing Xue Za Zhi. 2010;31(6):616–620.
   PubMedGoogle Scholar
• Li JY, Wang YD, Qi XY, et al. Serum CCN3 levels are increased in type 2 diabetes mellitus and associated with obesity, insulin resistance and inflammation. Clin Chim Acta. 2019;494:52–57. doi:10.1016/j.cca.2019.03.006
   PubMed Web of Science ®Google Scholar
• Mućka S, Miodońska M, Jakubiak GK, et al. Endothelial function assessment by flow-mediated dilation method: a valuable tool in the evaluation of the cardiovascular system. Int J Environ Res Public Health. 2022;19(18):11242. doi:10.3390/ijerph191811242
   PubMed Web of Science ®Google Scholar
• Starzak M, Stanek A, Jakubiak GK, et al. Arterial stiffness assessment by pulse wave velocity in patients with metabolic syndrome and its components: is it a useful tool in clinical practice? Int J Environ Res Public Health. 2022;19(16):10368. doi:10.3390/ijerph191610368
   PubMed Web of Science ®Google Scholar
• Donald AE, Halcox JP, Charakida M, et al. Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation. J Am Coll Cardiol. 2008;51(20):1959–1964. doi:10.1016/j.jacc.2008.02.044
   PubMed Web of Science ®Google Scholar
• McCrea CE, Skulas-Ray AC, Chow M, et al. Test-retest reliability of pulse amplitude tonometry measures of vascular endothelial function: implications for clinical trial design. Vasc Med. 2012;17(1):29–36. doi:10.1177/1358863X11433188
   PubMed Web of Science ®Google Scholar
• Sedgwick P. A comparison of parametric and non-parametric statistical tests. BMJ. 2015;350(apr17 1):h2053. doi:10.1136/bmj.h2053
   PubMedGoogle Scholar
• Zheng Y, Wei Z, Wang T. MOTS-c: a promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol. 2023;14:1120533. doi:10.3389/fendo.2023.1120533
   PubMed Web of Science ®Google Scholar
• Cataldo LR, Fernández-Verdejo R, Santos JL, et al. Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals. J Investig Med. 2018;66(6):1019–1022. doi:10.1136/jim-2017-000681
   PubMed Web of Science ®Google Scholar
• Matsuzawa Y, Kwon T-G, Lennon RJ, et al. Prognostic value of flow-mediated vasodilation in brachial artery and fingertip artery for cardiovascular events: a systematic review and meta-analysis. J Am Heart Assoc. 2015;4(11):e002270. doi:10.1161/JAHA.115.002270
   PubMed Web of Science ®Google Scholar
• Ikonomidis I, Katogiannis K, Kyriakou E, et al. β-Amyloid and mitochondrial-derived peptide-c are additive predictors of adverse outcome to high-on-treatment platelet reactivity in type 2 diabetics with revascularized coronary artery disease. J Thromb Thrombolysis. 2020;49(3):365–376. doi:10.1007/s11239-020-02060-4
   PubMed Web of Science ®Google Scholar
• Sun HJ, Wu ZY, Nie XW, et al. Role of endothelial dysfunction in cardiovascular diseases: the link between inflammation and hydrogen sulfide. Front Pharmacol. 2020;10:1568. doi:10.3389/fphar.2019.01568
   PubMed Web of Science ®Google Scholar
• Xinqiang Y, Quan C, Yuanyuan J, et al. Protective effect of MOTS-c on acute lung injury induced by lipopolysaccharide in mice. Int Immunopharmacol. 2020;80:106174. doi:10.1016/j.intimp.2019.106174
   PubMed Web of Science ®Google Scholar
• Yin X, Jing Y, Chen Q, et al. The intraperitoneal administration of MOTS-c produces antinociceptive and anti-inflammatory effects through the activation of AMPK pathway in the mouse formalin test. Eur J Pharmacol. 2020;870:172909. doi:10.1016/j.ejphar.2020.172909
   PubMed Web of Science ®Google Scholar
• Zhong P, Peng J, Hu Y, et al. Mitochondrial derived peptide MOTS -c prevents the development of heart failure under pressure overload conditions in mice. J Cell Mol Med. 2022;26(21):5369–5378. doi:10.1111/jcmm.17551
   PubMed Web of Science ®Google Scholar
• Li S, Wang M, Ma J, et al. MOTS-c and exercise restore cardiac function by activating of NRG1-ErbB signaling in diabetic rats. Front Endocrinol. 2022;13:812032. doi:10.3389/fendo.2022.812032
   PubMed Web of Science ®Google Scholar
• Wu J, Xiao D, Yu K, et al. The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy. Acta Biochim Biophys Sin. 2023;55(2):285–294. doi:10.3724/abbs.2023006
   Google Scholar