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ORIGINAL RESEARCH

The Application of the Insulin to C-Peptide Molar Ratio (ICPR) in Primary Screening for Insulin Antibodies in Type 2 Diabetes Mellitus Patients: A Further Quantitative Study on the Relationship Between ICPR and Insulin Antibodies

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Pages 1121-1132 | Received 20 Jan 2023, Accepted 15 Apr 2023, Published online: 22 Apr 2023

References

  • Tomic D, Shaw JE, Magliano DJ. The burden and risks of emerging complications of diabetes mellitus. Nat Rev Endocrinol. 2022;18(9):525–539. doi:10.1038/s41574-022-00690-7
  • Wilson LM, Castle JR. Recent advances in insulin therapy. Diabetes Technol Ther. 2020;22(12):929–936. doi:10.1089/dia.2020.0065
  • Fineberg SE, Kawabata TT, Finco-Kent D, Fountaine RJ, Finch GL, Krasner AS. Immunological responses to exogenous insulin. Endocr Rev. 2007;28(6):625–652. doi:10.1210/er.2007-0002
  • Shen Y, Song X, Ren Y. Insulin autoimmune syndrome induced by exogenous insulin injection: a four-case series. BMC Endocr Disord. 2019;19(1):148. doi:10.1186/s12902-019-0482-0
  • Oak S, Phan T-HT, Gilliam LK, Hirsch IB, Hampe CS. Animal insulin therapy induces a biased insulin antibody response that persists for years after introduction of human insulin. Acta Diabetol. 2010;47(2):131–135. doi:10.1007/s00592-009-0135-2
  • Lee YY, Lin CW, Chen IW. Exogenous insulin injection-induced stiff-person syndrome in a patient with latent autoimmune diabetes: a case report and literature review. Front Endocrinol. 2020;11:594. doi:10.3389/fendo.2020.00594
  • Xiao Y, Li X, Chao C, et al. Severe insulin resistance due to insulin antibodies. J Diabetes. 2018;10(7):611–613. doi:10.1111/1753-0407.12657
  • Kalant N, Gomberg C, Schucher R. The effect of insulin-binding antibodies on insulin sensitivity. Lancet. 1958;2(7047):614–617. doi:10.1016/s0140-6736(58)90337-4
  • Barnett AH, Lange P, Dreyer M, Serdarevic-Pehar M. Long-term tolerability of inhaled human insulin (Exubera) in patients with poorly controlled type 2 diabetes. Int J Clin Pract. 2007;61(10):1614–1625. doi:10.1111/j.1742-1241.2007.01522.x
  • Gordis E. Detection of insulin-binding antibodies and separation of free and antibody-bound insulin by rapid chemical procedure. Proc Soc Exp Biol Med. 1960;103(3):542–544. doi:10.3181/00379727-103-25589
  • Elias D, Cohen IR, Schechter Y, Spirer Z, Golander A. Antibodies to insulin receptor followed by anti-idiotype. Antibodies to insulin in child with hypoglycemia. Diabetes. 1987;36(3):348–354. doi:10.2337/diabetes.36.3.348
  • Rosenstock J, Zinman B, Murphy LJ, et al. Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy in type 2 diabetes: a randomized, controlled trial. Ann Intern Med. 2005;143(8):549–558. doi:10.7326/0003-4819-143-8-200510180-00005
  • Ishizuka T, Ogawa S, Mori T, et al. Characteristics of the antibodies of two patients who developed daytime hyperglycemia and morning hypoglycemia because of insulin antibodies. Diabetes Res Clin Pract. 2009;84(2):e21–e23. doi:10.1016/j.diabres.2009.02.007
  • Hu X, Chen F. Exogenous insulin antibody syndrome (EIAS): a clinical syndrome associated with insulin antibodies induced by exogenous insulin in diabetic patients. Endocr Connect. 2018;7(1):R47–R55. doi:10.1530/EC-17-0309
  • Censi S, Mian C, Betterle C. Insulin autoimmune syndrome: from diagnosis to clinical management. Ann Transl Med. 2018;6(17):335. doi:10.21037/atm.2018.07.32
  • Barnett AH, Dreyer M, Lange P, Serdarevic-Pehar M. An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with glibenclamide as adjunctive therapy in patients with type 2 diabetes poorly controlled on metformin. Diabetes Care. 2006;29(8):1818–1825. doi:10.2337/dc05-1880
  • Lebowitz MR, Blumenthal SA. The molar ratio of insulin to C-peptide. An aid to the diagnosis of hypoglycemia due to surreptitious (or inadvertent) insulin administration. Arch Intern Med. 1993;153(5):650–655. doi:10.1001/archinte.1993.00410050082011
  • Quan H, Tan H, Li Q, Li J, Li S. Immunological hypoglycemia associated with insulin antibodies induced by exogenous insulin in 11 Chinese patients with diabetes. J Diabetes Res. 2015;2015:746271. doi:10.1155/2015/746271
  • Hua KF, Zhang MY, Zhang Y, Ren BJ, Wu YH. Characteristics of OGTT and correlation between the insulin to C-peptide molar ratio, HOMA-IR, and insulin antibodies in T2DM patients. Diabetes Metab Syndr Obes. 2022;15:2417–2425. doi:10.2147/DMSO.S373475
  • World Medical A. World medical association declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191–2194. doi:10.1001/jama.2013.281053
  • Colagiuri S, Falavigna M, Agarwal MM, et al. Strategies for implementing the WHO diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. Diabetes Res Clin Pract. 2014;103(3):364–372. doi:10.1016/j.diabres.2014.02.012
  • Bartoli E, Fra GP, Carnevale Schianca GP. The oral glucose tolerance test (OGTT) revisited. Eur J Intern Med. 2011;22(1):8–12. doi:10.1016/j.ejim.2010.07.008
  • Kicsiny R. Improved multiple linear regression based models for solar collectors. Renew Energy. 2016;91:224–232. doi:10.1016/j.renene.2016.01.056
  • Schnurr TM, Jakupovic H, Carrasquilla GD, et al. Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study. Diabetologia. 2020;63(7):1324–1332. doi:10.1007/s00125-020-05140-5
  • Bellary S, Kyrou I, Brown JE, Bailey CJ. Type 2 diabetes mellitus in older adults: clinical considerations and management. Nat Rev Endocrinol. 2021;17(9):534–548. doi:10.1038/s41574-021-00512-2
  • Jansson AK, Chan LX, Lubans DR, Duncan MJ, Plotnikoff RC. Effect of resistance training on HbA1c in adults with type 2 diabetes mellitus and the moderating effect of changes in muscular strength: a systematic review and meta-analysis. BMJ Open Diabetes Res Care. 2022;10(2):e002595. doi:10.1136/bmjdrc-2021-002595
  • Zhu J, Yuan L, Ni WJ, Luo Y, Ma JH. Association of higher circulating insulin antibody with increased mean amplitude glycemic excursion in patients with type 2 diabetes mellitus: a cross-sectional, retrospective case-control study. J Diabetes Res. 2019;2019:7304140. doi:10.1155/2019/7304140
  • Liu LH, Xu LJ, Ke WJ, et al. Time-in-range during short-term intensive insulin therapy is associated with clinical outcomes in patients with newly diagnosed type 2 diabetes. Diabetes. 2020;69:2. doi:10.2337/db20-1032-P
  • Chen P, Ma X, Chen H, Wang K, Zhou L. Delays in insulin initiation among patients with type 2 diabetes mellitus in southeast china: a retrospective, real-world study. Diabetes Metab Syndr Obes. 2020;13:3059–3068. doi:10.2147/DMSO.S256381
  • Wong SL, Priestman A, Holmes DT. Recurrent hypoglycemia from insulin autoimmune syndrome. J Gen Intern Med. 2014;29(1):250–254. doi:10.1007/s11606-013-2588-9
  • Krysiak R, Kowalcze K, Okopien B. The impact of exogenous vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and early-onset androgenic alopecia. Pharmacol Rep. 2021;73(5):1439–1447. doi:10.1007/s43440-021-00295-3
  • Zhao TY, Li F, Xiong ZY. Frequent reoccurrence of hypoglycemia in a type 2 diabetic patient with insulin antibodies. Mol Diagn Ther. 2010;14(4):237–241. doi:10.1007/bf03256379
  • Stumvoll M, Mitrakou A, Pimenta W, et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 2000;23(3):295–301. doi:10.2337/diacare.23.3.295
  • Boyko EJ, Keane EM, Marshall JA, Hamman RF. Higher insulin and C-peptide concentrations in Hispanic population at high risk for NIDDM. San Luis valley diabetes study. Diabetes. 1991;40(4):509–515. doi:10.2337/diab.40.4.509
  • Goldman J, Baldwin D, Rubenstein AH, et al. Characterization of circulating insulin and proinsulin-binding antibodies in autoimmune hypoglycemia. J Clin Invest. 1979;63(5):1050–1059. doi:10.1172/JCI109374
  • Ionescu-Tîrgovişte C, Mincu I, Simionescu L, et al. Disappearance rate of insulin antibodies after discontinuing insulin treatment in 42 type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1984;27(6):592–595. doi:10.1007/bf00276974
  • Hirai H, Ogata E, Kikuchi N, et al. The effects of liraglutide on both hypereosinophilic insulin allergy and the characteristics of anti-insulin antibodies in type 2 diabetes mellitus: a case report. J Med Case Rep. 2016;10:202. doi:10.1186/s13256-016-0994-4
  • Yuan T, Li J, Li M, et al. Insulin autoimmune syndrome diagnosis and therapy in a single Chinese center. Clin Ther. 2019;41(5):920–928. doi:10.1016/j.clinthera.2019.03.009
  • Jones AG, Hattersley AT. The clinical utility of C-peptide measurement in the care of patients with diabetes. Diabet Med. 2013;30(7):803–817. doi:10.1111/dme.12159
  • Iwase H, Kobayashi M, Nakajima M, Takatori T. The ratio of insulin to C-peptide can be used to make a forensic diagnosis of exogenous insulin overdosage. Forensic Sci Int. 2001;115(1–2):123–127. doi:10.1016/s0379-0738(00)00298-x
  • Kahleova H, Hlozkova A, Fleeman R, Fletcher K, Holubkov R, Barnard ND. Fat quantity and quality, as part of a low-fat, vegan diet, are associated with changes in body composition, insulin resistance, and insulin secretion. A 16-week randomized controlled trial. Nutrients. 2019;11(3):615. doi:10.3390/nu11030615