Association of Serum Leptin and Adiponectin Concentrations with Type 2 Diabetes Biomarkers and Complications Among Saudi Women

References

• Alhowaish AK. Economic costs of diabetes in Saudi Arabia. J Family Community Med. 2013;20(1):1. doi:10.4103/2230-8229.108174
   PubMedGoogle Scholar
• IDF. The international diabetes federation Available from: https://idf.org/our-network/regions-members/middle-east-and-north-africa/members/46-saudi-arabia.html. Accessed June 26, 2023.
   Google Scholar
• Saati S, Dehghan P, Azizi-Soleiman F, Mobasseri M. The effect of bitter almond (Amygdalus communis L. var. Amara) gum as a functional food on metabolic profile, inflammatory markers, and mental health in type 2 diabetes women: a blinded randomized controlled trial protocol. Trials. 2023;24(1):1–10. doi:10.1186/s13063-023-07085-7
   PubMedGoogle Scholar
• Abou-Gamel M, Abdul-Nassir M, Rajeh A, et al. The prevalence of diabetes mellitus among working personnel in the faculty of science, Taibah University, Almadinah Almunawwarah, KSA. J Taibah Univ Med Sci. 2014;9(1):85–88. doi:10.1016/j.jtumed.2013.07.007
   Google Scholar
• Alqarni SSM. A review of prevalence of obesity in Saudi Arabia. J Obes Eat Disord. 2016;2(2):1–6.
   Google Scholar
• WHO. Noncommunicable diseases. Available from: https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases. Accessed June 26, 2023.
   Google Scholar
• Scheja L, Heeren J. The endocrine function of adipose tissues in health and cardiometabolic disease. Nat Rev Endocrinol. 2019;15(9):507–524. doi:10.1038/s41574-019-0230-6
   PubMed Web of Science ®Google Scholar
• Mohammadzadeh G, Zarghami N. Serum leptin level is reduced in non-obese subjects with type 2 diabetes. Int j Endocrinol Metab. 2013;11(1):3. doi:10.5812/ijem.6535
   PubMedGoogle Scholar
• Zhang L, Li -M-M, Corcoran M, Zhang S, Cooper GJ. Essential roles of insulin, AMPK signaling and lysyl and prolyl hydroxylases in the biosynthesis and multimerization of adiponectin. Mol Cell Endocrinol. 2015;399:164–177. doi:10.1016/j.mce.2014.09.014
   PubMed Web of Science ®Google Scholar
• Tang Q, Li X, Song P, Xu L. Optimal cut-off values for the homeostasis model assessment of insulin resistance (HOMA-IR) and pre-diabetes screening: developments in research and prospects for the future. Drug Discov Ther. 2015;9(6):380–385. doi:10.5582/ddt.2015.01207
   PubMed Web of Science ®Google Scholar
• Ho -C-C, Tseng C-Y, Chen H-W, et al. Coenzyme Q10 status, glucose parameters, and antioxidative capacity in college athletes. J Int Soc Sports Nutr. 2020;17(1):5. doi:10.1186/s12970-020-0334-3
   PubMed Web of Science ®Google Scholar
• Wekesa C, Asiki G, Kasamba I, et al. Atherogenic risk assessment among persons living in rural Uganda. J Trop Med. 2016;2016:1–8. doi:10.1155/2016/7073894
   Google Scholar
• Davis SK, Gebreab SY, Xu R, et al. Association of adiponectin with type 2 diabetes and hypertension in African American men and women: the Jackson Heart Study. BMC Cardiovasc Disord. 2015;15(1):1–10. doi:10.1186/s12872-015-0005-5
   PubMedGoogle Scholar
• Agarwal T, Lyngdoh T, Dudbridge F, et al. Causal relationships between lipid and glycemic levels in an Indian population: a bidirectional Mendelian randomization approach. PLoS One. 2020;15(1):e0228269. doi:10.1371/journal.pone.0228269
   PubMed Web of Science ®Google Scholar
• de Abreu VG, Martins C, de Oliveira PAC, Francischetti EA. High-molecular weight adiponectin/HOMA-IR ratio as a biomarker of metabolic syndrome in urban multiethnic Brazilian subjects. PLoS One. 2017;12(7):e0180947. doi:10.1371/journal.pone.0180947
   PubMed Web of Science ®Google Scholar
• Keska A, Lutoslawska G, Czajkowska A, Tkaczyk J, Mazurek K. Variability in HOMA-IR, lipoprotein profile and selected hormones in young active men. Sci World J. 2013;2013:1–6. doi:10.1155/2013/412764
   Google Scholar
• Guarino D, Nannipieri M, Iervasi G, Taddei S, Bruno RM. The role of the autonomic nervous system in the pathophysiology of obesity. Front Physiol. 2017;8:665. doi:10.3389/fphys.2017.00665
   PubMed Web of Science ®Google Scholar
• Russo B, Menduni M, Borboni P, Picconi F, Frontoni S. Autonomic nervous system in obesity and insulin-resistance—The complex interplay between leptin and central nervous system. Int J Mol Sci. 2021;22(10):5187. doi:10.3390/ijms22105187
   PubMed Web of Science ®Google Scholar
• Konstantinidou SK, Argyrakopoulou G, Tentolouris N, Karalis V, Kokkinos A. Interplay between baroreflex sensitivity, obesity and related cardiometabolic risk factors. Exp Ther Med. 2022;23(1):1–13. doi:10.3892/etm.2021.10923
   PubMed Web of Science ®Google Scholar
• Paiva ES, Andretta A, Batista ED, et al. Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity. Arch Endocrinol Metab. 2017;61:249–256. doi:10.1590/2359-3997000000248
   PubMed Web of Science ®Google Scholar
• Karayannis G, Giamouzis G, Tziolas N, et al. Association between epicardial fat thickness and weight homeostasis hormones in patients with noncachectic heart failure. Angiology. 2013;64(3):173–180. doi:10.1177/0003319712447978
   PubMed Web of Science ®Google Scholar
• Koleva DI, Orbetzova MM, Nikolova JG, Deneva TI. Pathophysiological role of adiponectin, leptin and asymmetric dimethylarginine in the process of atherosclerosis. Folia Med (Plovdiv). 2016;58(4):234. doi:10.1515/folmed-2016-0039
   PubMedGoogle Scholar
• Pérez-Pérez A, Vilariño-García T, Fernández-Riejos P, Martín-González J, Segura-Egea JJ, Sánchez-Margalet V. Role of leptin as a link between metabolism and the immune system. Cytokine Growth Factor Rev. 2017;35:71–84. doi:10.1016/j.cytogfr.2017.03.001
   PubMed Web of Science ®Google Scholar
• Andrade-Oliveira V, Câmara NO, Moraes-Vieira PM. Adipokines as drug targets in diabetes and underlying disturbances. J Diabetes Res. 2015;2015:1–11. doi:10.1155/2015/681612
   Web of Science ®Google Scholar
• Kurajoh M, Koyama H, Kadoya M, et al. Plasma leptin level is associated with cardiac autonomic dysfunction in patients with type 2 diabetes: HSCAA study. Cardiovasc Diabetol. 2015;14(1):1–8. doi:10.1186/s12933-015-0280-6
   PubMedGoogle Scholar
• Liu X, Li X, Li C, Gong C, Liu S, Shi Y. Study on regulation of adipokines on body fat distribution and its correlation with metabolic syndrome in type 2 diabetes mellitus. Minerva Endocrinol. 2017;44(3):259–263. doi:10.23736/S0391-1977.17.02773-0
   PubMed Web of Science ®Google Scholar
• Morioka T, Emoto M, Yamazaki Y, et al. Leptin is associated with vascular endothelial function in overweight patients with type 2 diabetes. Cardiovasc Diabetol. 2014;13(1):1–9. doi:10.1186/1475-2840-13-10
   PubMedGoogle Scholar
• Tang Y, Fung E, Xu A, Lan HY. C‐reactive protein and ageing. Clin Exp Pharmacol Physiol. 2017;44:9–14. doi:10.1111/1440-1681.12758
   PubMed Web of Science ®Google Scholar
• DeBoer MD, Gurka MJ, Morrison JA, Woo JG. Inter-relationships between the severity of metabolic syndrome, insulin and adiponectin and their relationship to future type 2 diabetes and cardiovascular disease. Int J Obes. 2016;40(9):1353–1359. doi:10.1038/ijo.2016.81
   Web of Science ®Google Scholar
• Kanhai D, Kranendonk M, Uiterwaal C, Van Der Graaf Y, Kappelle L, Visseren F. Adiponectin and incident coronary heart disease and stroke. A systematic review and meta‐analysis of prospective studies. Obesity Rev. 2013;14(7):555–567. doi:10.1111/obr.12027
   PubMed Web of Science ®Google Scholar
• Al-Hamodi Z, Al-Habori M, Al-Meeri A, Saif-Ali R. Association of adipokines, leptin/adiponectin ratio and C-reactive protein with obesity and type 2 diabetes mellitus. Diabetol Metab Syndr. 2014;6(1):1–8. doi:10.1186/1758-5996-6-99
   PubMedGoogle Scholar
• De Rosa A, Monaco ML, Capasso M, et al. Adiponectin oligomers as potential indicators of adipose tissue improvement in obese subjects. Eur J Endocrinol. 2013;169(1):37–43. doi:10.1530/EJE-12-1039
   PubMed Web of Science ®Google Scholar
• Meyer LK, Ciaraldi TP, Henry RR, Wittgrove AC, Phillips SA. Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity. Adipocyte. 2013;2(4):217–226. doi:10.4161/adip.24953
   PubMedGoogle Scholar
• Wander PL, Christophi CA, Araneta MRG, et al. Adiposity, related biomarkers, and type 2 diabetes after gestational diabetes: the Diabetes Prevention Program. Obesity. 2022;30(1):221–228. doi:10.1002/oby.23291
   PubMed Web of Science ®Google Scholar
• Liao P-J, Ting M-K, Wu I-W, Chen S-W, Yang N-I, Hsu K-H. Higher Leptin-to-Adiponectin Ratio Strengthens the Association Between Body Measurements and Occurrence of Type 2 Diabetes Mellitus. Front Public Health. 2021;9:1006. doi:10.3389/fpubh.2021.678681
   Web of Science ®Google Scholar
• Lee KW, Shin D. Prospective associations of serum adiponectin, leptin, and leptin-adiponectin ratio with incidence of metabolic syndrome: the Korean Genome and Epidemiology Study. Int J Environ Res Public Health. 2020;17(9):3287. doi:10.3390/ijerph17093287
   PubMed Web of Science ®Google Scholar
• Liu W, Zhou X, Li Y, et al. Serum leptin, resistin, and adiponectin levels in obese and non-obese patients with newly diagnosed type 2 diabetes mellitus: a population-based study. Medicine. 2020;99(6):e19052. doi:10.1097/MD.0000000000019052
   PubMed Web of Science ®Google Scholar
• Wang L-K, Wang H, Wu X-L, Shi L, Yang R-M, Wang Y-C. Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus. J Int Med Res. 2020;48(4):0300060519870407. doi:10.1177/0300060519870407
   PubMedGoogle Scholar