230
Views
3
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Association Analysis of Triglyceride Glucose-Body Mass Index and Bone Turnover Markers in Patients with Type 2 Diabetes Mellitus

, , ORCID Icon, , & ORCID Icon
Pages 1435-1447 | Received 20 Feb 2023, Accepted 24 Apr 2023, Published online: 18 May 2023

References

  • Zimmet P, Alberti KG, Magliano DJ, Bennett PH. Diabetes mellitus statistics on prevalence and mortality: facts and fallacies. Nat Rev Endocrinol. 2016;12(10):616–622. doi:10.1038/nrendo.2016.105
  • Sellmeyer DE, Civitelli R, Hofbauer LC, Khosla S, Lecka-Czernik B, Schwartz AV. Skeletal metabolism, fracture risk, and fracture outcomes in type 1 and type 2 diabetes. Diabetes. 2016;65(7):1757–1766. doi:10.2337/db16-0063
  • Walsh JS, Obesity VT. Type 2 diabetes and bone in adults. Calcif Tissue Int. 2017;100(5):528–535. doi:10.1007/s00223-016-0229-0
  • Picke AK, Campbell G, Napoli N, Hofbauer LC, Rauner M. Update on the impact of type 2 diabetes mellitus on bone metabolism and material properties. Endocr Connect. 2019;8(3):R55–r70. doi:10.1530/EC-18-0456
  • Purnamasari D, Puspitasari MD, Setiyohadi B, Nugroho P, Isbagio H. Low bone turnover in premenopausal women with type 2 diabetes mellitus as an early process of diabetes-associated bone alterations: a cross-sectional study. BMC Endocr Disord. 2017;17(1):72. doi:10.1186/s12902-017-0224-0
  • Li YM, Schilling T, Benisch P, et al. Effects of high glucose on mesenchymal stem cell proliferation and differentiation. Biochem Biophys Res Commun. 2007;363(1):209–215. doi:10.1016/j.bbrc.2007.08.161
  • Wittrant Y, Gorin Y, Woodruff K, et al. High d(+)glucose concentration inhibits RANKL-induced osteoclastogenesis. Bone. 2008;42(6):1122–1130. doi:10.1016/j.bone.2008.02.006
  • Chiodini I, Catalano A, Gennari L, Gaudio A. Osteoporosis and fragility fractures in type 2 diabetes. J Diabetes Res. 2020;2020:9342696. doi:10.1155/2020/9342696
  • Imerb N, Thonusin C, Chattipakorn N, Chattipakorn SC. Aging, obese-insulin resistance, and bone remodeling. Mech Ageing Dev. 2020;191:111335. doi:10.1016/j.mad.2020.111335
  • Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab. 2008;294(1):E15–26. doi:10.1152/ajpendo.00645.2007
  • Er LK, Wu S, Chou HH, et al. Triglyceride glucose-body mass index is a simple and clinically useful surrogate marker for insulin resistance in nondiabetic individuals. PLoS One. 2016;11(3):e0149731. doi:10.1371/journal.pone.0149731
  • Zheng S, Shi S, Ren X, et al. Triglyceride glucose-waist circumference, a novel and effective predictor of diabetes in first-degree relatives of type 2 diabetes patients: cross-sectional and prospective cohort study. J Transl Med. 2016;14(1):260. doi:10.1186/s12967-016-1020-8
  • Zeng ZY, Liu SX, Xu H, Xu X, Liu XZ, Zhao XX. Association of triglyceride glucose index and its combination of obesity indices with prehypertension in lean individuals: a cross-sectional study of Chinese adults. J Clin Hypertens. 2020;22(6):1025–1032. doi:10.1111/jch.13878
  • Jiang C, Yang R, Kuang M, Yu M, Zhong M, Zou Y. Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes. Lipids Health Dis. 2021;20(1):161. doi:10.1186/s12944-021-01594-7
  • Wang X, Liu J, Cheng Z, Zhong Y, Chen X, Song W. Triglyceride glucose-body mass index and the risk of diabetes: a general population-based cohort study. Lipids Health Dis. 2021;20(1):99. doi:10.1186/s12944-021-01532-7
  • Li Y, You A, Tomlinson B, et al. Insulin resistance surrogates predict hypertension plus hyperuricemia. J Diabetes Investig. 2021;12(11):2046–2053. doi:10.1111/jdi.13573
  • Sheng G, Lu S, Xie Q, Peng N, Kuang M, Zou Y. The usefulness of obesity and lipid-related indices to predict the presence of Non-alcoholic fatty liver disease. Lipids Health Dis. 2021;20(1):134. doi:10.1186/s12944-021-01561-2
  • Du Z, Xing L, Lin M, Sun Y. Estimate of prevalent ischemic stroke from triglyceride glucose-body mass index in the general population. BMC Cardiovasc Disord. 2020;20(1):483. doi:10.1186/s12872-020-01768-8
  • Cosman F, de Beur SJ, LeBoff MS, et al. Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int. 2014;25(10):2359–2381. doi:10.1007/s00198-014-2794-2
  • Greenblatt MB, Tsai JN, Wein MN. Bone turnover markers in the diagnosis and monitoring of metabolic bone disease. Clin Chem. 2017;63(2):464–474. doi:10.1373/clinchem.2016.259085
  • Conte C, Epstein S, Napoli N. Insulin resistance and bone: a biological partnership. Acta Diabetol. 2018;55(4):305–314. doi:10.1007/s00592-018-1101-7
  • Thrailkill KM, Lumpkin CK Jr, Bunn RC, Kemp SF, Fowlkes JL. Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab. 2005;289(5):E735–745. doi:10.1152/ajpendo.00159.2005
  • Li Z, Qi C, Pan X, et al. The relationship between estimated glucose disposal rate and bone turnover markers in type 2 diabetes mellitus. Endocrine. 2022;77(2):242–251. doi:10.1007/s12020-022-03090-z
  • Aktas G, Kocak MZ, Taslamacioglu Duman T, et al. Mean Platelet Volume (MPV) as an inflammatory marker in type 2 diabetes mellitus and obesity. Bali Med J. 2018;7:3. doi:10.15562/bmj.v7i3.806
  • Boden G. Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes. 2011;18(2):139–143. doi:10.1097/MED.0b013e3283444b09
  • Mittendorfer B. Origins of metabolic complications in obesity: adipose tissue and free fatty acid trafficking. Curr Opin Clin Nutr Metab Care. 2011;14(6):535–541. doi:10.1097/MCO.0b013e32834ad8b6
  • Yuzefovych L, Wilson G, Rachek L. Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Am J Physiol Endocrinol Metab. 2010;299(6):E1096–1105. doi:10.1152/ajpendo.00238.2010
  • Waqas K, Chen J, Koromani F, et al. Skin autofluorescence, a noninvasive biomarker for advanced glycation end-products, is associated with prevalent vertebral and major osteoporotic fractures: the Rotterdam study. J Bone Miner Res. 2020;35(10):1904–1913. doi:10.1002/jbmr.4096
  • Wang F, He T, Wang G, Han T, Yao Z. Association of triglyceride glucose-body mass index with non-small cell lung cancer risk: a case-control study on Chinese adults. Front Nutr. 2022;9:1004179. doi:10.3389/fnut.2022.1004179
  • Wu D, Cline-Smith A, Shashkova E, Perla A, Katyal A, Aurora R. T-Cell mediated inflammation in postmenopausal osteoporosis. Front Immunol. 2021;12:687551. doi:10.3389/fimmu.2021.687551
  • Muñoz J, Akhavan NS, Mullins AP, Arjmandi BH. Macrophage polarization and osteoporosis: a review. Nutrients. 2020;12:10. doi:10.3390/nu12102999
  • Zhao C, Liu G, Zhang Y, et al. Association between serum levels of bone turnover markers and bone mineral density in men and women with type 2 diabetes mellitus. J Clin Lab Anal. 2020;34(4):e23112. doi:10.1002/jcla.23112
  • Jiao H, Xiao E, Graves DT. Diabetes and its effect on bone and fracture healing. Curr Osteoporos Rep. 2015;13(5):327–335. doi:10.1007/s11914-015-0286-8
  • Yiwan S, Huajun W, Xiaofei Z. Research progress on fracture risk of type 2 diabetes mellitus and its related mechanisms. Chin Orthop J Clin Basic. 2020;12(5):304–311.
  • Oei L, Rivadeneira F, Zillikens MC, Oei EH. Diabetes, diabetic complications, and fracture risk. Curr Osteoporos Rep. 2015;13(2):106–115. doi:10.1007/s11914-015-0260-5
  • Xing Y, Liu J, Liu H, Ma H. Relationship of bone turnover markers with serum uric acid-to-creatinine ratio in men and postmenopausal women with type 2 diabetes. Diabetes Metab Syndr Obes. 2022;15:3205–3217. doi:10.2147/DMSO.S384694
  • Napoli N, Chandran M, Pierroz DD, Abrahamsen B, Schwartz AV, Ferrari SL. Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol. 2017;13(4):208–219. doi:10.1038/nrendo.2016.153
  • He L. Analysis of bone metabolism index and its influencing factors in type 2 diabetic patients with osteoporosis [master’s thesis]. Beijing: North China University of Science and Technology; 2019.
  • Lane NE, Saag K, O’Neill TJ, et al. Real-world bone turnover marker use: impact on treatment decisions and fracture. Osteoporos Int. 2021;32(5):831–840. doi:10.1007/s00198-020-05734-0
  • Jain S. Role of bone turnover markers in osteoporosis therapy. Endocrinol Metab Clin North Am. 2021;50(2):223–237. doi:10.1016/j.ecl.2021.03.007
  • Guo H, Wang C, Jiang B, et al. Association of insulin resistance and β-cell function with bone turnover biomarkers in dysglycemia patients. Front Endocrinol (Lausanne). 2021;12:554604. doi:10.3389/fendo.2021.554604
  • Cho YK, Lee J, Kim HS, et al. Triglyceride glucose-waist circumference better predicts coronary calcium progression compared with other indices of insulin resistance: a longitudinal observational study. J Clin Med. 2020;10:1. doi:10.3390/jcm10010092
  • Shi Y, Wang H, Zheng X. Research progress on fracture risk and related mechanisms in type 2 diabetes mellitus. Chin J Orthop Clin Basic Res. 2020;12(Z1):304–311.
  • Lakatos P, Szili B, Bakos B, Takacs I, Putz Z, Istenes I. Thyroid hormones, glucocorticoids, insulin, and bone. Handb Exp Pharmacol. 2020;262:93–120.
  • Vianna AGD, Sanches CP, Barreto FC. Review article: effects of type 2 diabetes therapies on bone metabolism. Diabetol Metab Syndr. 2017;9:75. doi:10.1186/s13098-017-0274-5
  • Wei J, Ferron M, Clarke CJ, et al. Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Invest. 2014;124(4):1–13. doi:10.1172/JCI72323
  • Nakamura T, Imai Y, Matsumoto T, et al. Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell. 2007;130(5):811–823. doi:10.1016/j.cell.2007.07.025
  • Lean JM, Davies JT, Fuller K, et al. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest. 2003;112(6):915–923. doi:10.1172/JCI200318859
  • Decai C, Eryuan L, Ling X, Zhenlin Z. Guidelines for the clinical application of biochemical markers of bone metabolism. J Bone Miner Res. 2015;8(04):283–293.
  • Zhang M, Zhang X, Deng W, et al. Expert consensus on clinical application of biochemical markers of bone metabolism(2020). Chin Med J. 2020;26(06):781–796.
  • Im JA, Yu BP, Jeon JY, Kim SH. Relationship between osteocalcin and glucose metabolism in postmenopausal women. Clin Chim Acta. 2008;396(1–2):66–69. doi:10.1016/j.cca.2008.07.001
  • Sarkar PD, Choudhury AB. Relationships between serum osteocalcin levels versus blood glucose, insulin resistance and markers of systemic inflammation in central Indian type 2 diabetic patients. Eur Rev Med Pharmacol Sci. 2013;17(12):1631–1635.