The Influence of SLC22A3 Genetic Polymorphisms on Susceptibility to Type 2 Diabetes Mellitus in Chinese Population

References

• Sun H, Saeedi P, Karuranga S, et al. IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. doi:10.1016/j.diabres.2021.109119
   PubMed Web of Science ®Google Scholar
• Chiasson JL, Rabasa-Lhoret R. Prevention of type 2 diabetes: insulin resistance and beta-cell function. Diabetes. 2004;53 Suppl 3:S34–S38.
   PubMedGoogle Scholar
• Li C, Yang Y, Liu X, Li Z, Liu H, Tan Q. Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes. Diabetol Metab Syndr. 2020;12(1):97. doi:10.1186/s13098-020-00604-5
   PubMed Web of Science ®Google Scholar
• Chen EC, Matsson P, Azimi M, et al. High throughput screening of a prescription drug library for inhibitors of organic cation transporter 3, OCT3. Pharm Res. 2022;39(7):1599–1613. doi:10.1007/s11095-022-03171-8
   PubMed Web of Science ®Google Scholar
• Gasser PJ. Roles for the uptake(2) transporter OCT3 in regulation of dopaminergic neurotransmission and behavior. Neurochem Int. 2019;123:46–49.
   PubMed Web of Science ®Google Scholar
• Huang KM, Zavorka TM, Magdy T, et al. Targeting OCT3 attenuates doxorubicin-induced cardiac injury. Proc Natl Acad Sci U S A. 2021;118(5). doi:10.1073/pnas.2020168118
   Web of Science ®Google Scholar
• Fu L, Qin YR, Ming XY, et al. RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer. Proc Natl Acad Sci U S A. 2017;114(23):E4631–E4640. doi:10.1073/pnas.1703178114
   PubMed Web of Science ®Google Scholar
• Xiong JX, Wang YS, Sheng J, et al. Epigenetic alterations of a novel antioxidant gene SLC22A3 predispose susceptible individuals to increased risk of esophageal cancer. Int J Biol Sci. 2018;14(12):1658–1668. doi:10.7150/ijbs.28482
   PubMed Web of Science ®Google Scholar
• Cervenkova L, Vycital O, Bruha J, et al. Protein expression of ABCC2 and SLC22A3 associates with prognosis of pancreatic adenocarcinoma. Sci Rep. 2019;9(1):19782. doi:10.1038/s41598-019-56059-w
   PubMedGoogle Scholar
• Gu Y, Xu ZJ, Zhou JD, et al. SLC22A3 methylation-mediated gene silencing predicts adverse prognosis in acute myeloid leukemia. Clin Epigenetics. 2022;14(1):162. doi:10.1186/s13148-022-01373-w
   PubMed Web of Science ®Google Scholar
• Mahrooz A, Alizadeh A, Hashemi-Soteh MB, Ghaffari-Cherati M, Hosseyni-Talei SR. Polymorphic variants rs3088442 and rs2292334 in the Organic Cation Transporter 3 (OCT3) gene and susceptibility against type 2 diabetes: role of their interaction. Arch Med Res. 2017;48(2):162–168. doi:10.1016/j.arcmed.2017.03.010
   PubMed Web of Science ®Google Scholar
• Koepsell H. Organic cation transporters in health and disease. Pharmacol Rev. 2020;72(1):253–319. doi:10.1124/pr.118.015578
   PubMed Web of Science ®Google Scholar
• Shirasaka Y, Lee N, Zha W, Wagner D, Wang J. Involvement of organic cation transporter 3 (Oct3/Slc22a3) in the bioavailability and pharmacokinetics of antidiabetic metformin in mice. Drug Metab Pharmacokinet. 2016;31(5):385–388. doi:10.1016/j.dmpk.2016.04.005
   PubMed Web of Science ®Google Scholar
• Chen EC, Liang X, Yee SW, et al. Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin. Mol Pharmacol. 2015;88(1):75–83. doi:10.1124/mol.114.096776
   PubMed Web of Science ®Google Scholar
• Kwon EY, Chung JY, Park HJ, Kim BM, Kim M, Choi JH. OCT3 promoter haplotype is associated with metformin pharmacokinetics in Koreans. Sci Rep. 2018;8(1):16965. doi:10.1038/s41598-018-35322-6
   PubMedGoogle Scholar
• Care, Diabetes. Diabetes: standards of medical care in diabetes-2022. Diabetes Care. 2022;45(Suppl 1):S17–S38. doi:10.2337/dc22-S002
   PubMedGoogle Scholar
• Li Z, Zhang Z, He Z, et al. A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis. Cell Res. 2009;19(4):519–523. doi:10.1038/cr.2009.33
   PubMed Web of Science ®Google Scholar
• Ren A, Sun S, Li S, et al. Genetic variants in SLC22A3 contribute to the susceptibility to colorectal cancer. Int J Cancer. 2019;145(1):154–163. doi:10.1002/ijc.32079
   PubMed Web of Science ®Google Scholar
• Wang L, Chen J, Zeng Y, et al. Functional variant in the SLC22A3-LPAL2-LPA gene cluster contributes to the severity of coronary artery disease. Arterioscler Thromb Vasc Biol. 2016;36(9):1989–1996. doi:10.1161/ATVBAHA.116.307311
   PubMed Web of Science ®Google Scholar
• Taheri R, Kazerouni F, Mirfakhraei R, Kalbasi S, Shahrokhi SZ, Rahimipour A. The influence of SLC22A3 rs543159 and rs1317652 genetic variants on metformin therapeutic efficacy in newly diagnosed patients with type 2 diabetes mellitus: 25 weeks follow-up study. Gene. 2022;823:146382. doi:10.1016/j.gene.2022.146382
   PubMed Web of Science ®Google Scholar
• Huang LO, Rauch A, Mazzaferro E, et al. Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 2021;3(2):228–243.
   PubMedGoogle Scholar
• Paquette M, Bernard S, Baass A. SLC22A3 is associated with lipoprotein (a) concentration and cardiovascular disease in familial hypercholesterolemia. Clin Biochem. 2019;66:44–48. doi:10.1016/j.clinbiochem.2019.02.008
   PubMed Web of Science ®Google Scholar
• Hosseyni-Talei SR, Mahrooz A, Hashemi-Soteh MB, Ghaffari-Cherati M, Alizadeh A. Association between the synonymous variant organic cation transporter 3 (OCT3)-1233G>A and the glycemic response following metformin therapy in patients with type 2 diabetes. Iran J Basic Med Sci. 2017;20(3):250–255. doi:10.22038/IJBMS.2017.8351
   PubMed Web of Science ®Google Scholar
• Ghaffari-Cherati M, Mahrooz A, Hashemi-Soteh MB, Hosseyni-Talei SR, Alizadeh A, Nakhaei SM. Allele frequency and genotype distribution of a common variant in the 3 -untranslated region of the SLC22A3 gene in patients with type 2 diabetes: association with response to metformin. J Res Med Sci. 2016;21:92. doi:10.4103/1735-1995.192508
   PubMed Web of Science ®Google Scholar
• Ghasan AAS, Ramachandran V, Inche ML, Mohamad NA, Mohamed MH, Wan SW. Analysis of OCT1, OCT2 and OCT3 gene polymorphisms among type 2 diabetes mellitus subjects in Indian ethnicity, Malaysia. Saudi J Biol Sci. 2022;29(1):453–459. doi:10.1016/j.sjbs.2021.09.008
   PubMed Web of Science ®Google Scholar
• Moeez S, Riaz S, Masood N, et al. Evaluation of the rs3088442 G>A SLC22A3 gene polymorphism and the role of microRNA 147 in groups of adult Pakistani populations with type 2 diabetes in response to metformin. Can J Diabetes. 2019;43(2):128–135.
   PubMed Web of Science ®Google Scholar
• Karthi S, Rajeshwari M, Francis A, et al. 3’-UTR SNP rs2229611 in G6PC1 affects mRNA stability, expression and glycogen storage disease type-Ia risk. Clin Chim Acta. 2017;471:46–54. doi:10.1016/j.cca.2017.05.016
   PubMed Web of Science ®Google Scholar