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REVIEW

Global Prevalence of Anemia Among Type 2 Diabetic Adult Patients: A Systematic Review and Meta-Analysis

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 2243-2254 | Received 06 Jun 2023, Accepted 25 Jul 2023, Published online: 31 Jul 2023

References

  • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37(supplement 1):81–90. doi:10.2337/dc14-S081
  • International Diabetes Federation (IDF). IDF Diabetes Atlas. 10th ed. 2021; 141.
  • Agu K. Diabetes mellitus: a review of some of the prognostic markers of response to treatment and management. J Insul Resist. 2018;3(1):1–10. doi:10.4102/jir.v3i1.36
  • Karaman A, Ozturk A, Ph D, et al. Prevalence of metabolic syndrome in the Mediterranean Region of Turkey: evaluation of hypertension, diabetes mellitus, obesity, and dyslipidemia. Metab Syndr Relat Disord. 2009;7(5):427–434. doi:10.1089/met.2008.0068
  • Christian M, Adebayo A, Chinyere N, Wisdom N. Some haematological parameters in diabetic patients in Port Harcourt Nigeria. Asian J Multidiscip Stud. 2015;3(2):21–25.
  • Angelousi A, Larger E. Anaemia, a common but often unrecognized risk in diabetic patients: a review. Diabetes Metab. 2014;1–10.
  • Barbieri J, Fontela PC, Winkelmann ER, et al. Anemia in Patients with Type 2 Diabetes Mellitus. Hindawi Publ Corp. 2015;2015:1–7.
  • Alamri BN, Bahabri A, Aldereihim AA, Alabduljabbar M. Hyperglycemia effect on red blood cells indices. Eur Rev Med Pharmacol Sci. 2019;23:2139–2150. doi:10.26355/eurrev_201903_17259
  • Pretorius E, Bester J, Vermeulen N, et al. Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin- generated fibrin: implications for diagnostics. Cardiovasc Diabetol. 2015;14(30):1–20. doi:10.1186/s12933-015-0192-5
  • Asmah RH, Yeboah G, Archampong TN, Brown CA, Amegatcher G, Adjei DN. Relationship between oxidative stress and haematological indices in patients with diabetes in the Ghanaian population. Clin Diabetes Endocrinol. 2015;1(7):4–8. doi:10.1186/s40842-015-0008-2
  • Sahay M, Kalra S, Badani R, et al. Diabetes and Anemia: international Diabetes Federation (IDF) -Southeast Asian Region (SEAR) position statement. Diabetes Metab Syndr Clin Res Rev. 2017;11:685–695. doi:10.1016/j.dsx.2017.04.026
  • Donnelly LA, Dennis JM, Coleman RL, Sattar N, Hattersley AT, Holman RR. Risk of Anemia With Metformin Use in Type 2 Diabetes: a Mastermind Study. Diabetes Care. 2020;43:2493–2499. doi:10.2337/dc20-1104
  • Duman TT, Aktas G, Atak BM, Kocak Z, Kurtkulagi O, Bilgin S. General characteristics of anemia in postmenopausal women and elderly men. Aging Male. 2020;23(5):780–784. doi:10.1080/13685538.2019.1595571
  • Kurtkulagi O. Neutrophil to Lymphocyte ratio is significantly reduced after Sodium glucose cotransporter-2 inhibitor treatment in patients with type 2 diabetes mellitus. Int J Endocrinol. 2022;18(2):86–89.
  • Parving HH, Cooper ME, Rossing K, Parving HH. Anaemia in diabetes: is there a rationale to treat? Diabetologia. 2006;49:1151–1157. doi:10.1007/s00125-006-0215-6
  • Gauci R, Hunter M, Bruce DG, Davis WA, Davis TME. Anemia complicating type 2 diabetes: prevalence, risk factors and prognosis. J Diabetes Complications. 2017;31(7):1169–1174. doi:10.1016/j.jdiacomp.2017.04.002
  • Thomas S, Rampersad M. Anaemia in diabetes. Acta Diabetol. 2004;41:13–17. doi:10.1007/s00592-004-0132-4
  • Kaushik D, Parashar R, Malik PK. Study of anaemia in type 2 diabetes mellitus. Int J Res Med Sci. 2018;6(5):1529–1533. doi:10.18203/2320-6012.ijrms20181428
  • Stevens E, Nephrologist C, Hospital C. Diabetes and chronic kidney disease: where are we now. J Ren Care. 2012;38(Supp.1):67–77. doi:10.1111/j.1755-6686.2012.00281.x
  • Mazumder H, Islam KF, Rahman F, et al. Prevalence of anemia in diabetes mellitus in South Asia: a systematic review and meta- analysis. PLoS One. 2023;18(5):1–22. doi:10.1371/journal.pone.0285336
  • Pradeepa R, Shreya L, Anjana RM, et al. Frequency of iron deficiency anemia in type 2 diabetes - Insights from tertiary diabetes care centres across India. Diabetes Metab Syndr. 2022;16(11):1026–1032. doi:10.1016/j.dsx.2022.102632
  • Adane T, Getawa S. Anaemia and its associated factors among diabetes mellitus patients in Ethiopia: a systematic review and meta- -analysis. Endocrinol Diabetes Metab. 2021;4:1–10. doi:10.1002/edm2.260
  • Olum R, Bongomin F, Kaggwa MM, Andia-biraro I, Baluku JB. Anemia in diabetes mellitus in Africa: a systematic review and meta-analysis. Diabetes Metab Syndr Clin Res Rev. 2021;15:1–10. doi:10.1016/j.dsx.2021.102260
  • Page MJ, Mckenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372.
  • World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Geneva: world Health Organization. Vitam Miner Nutr Inf Syst. 2011;11(1):1–6.
  • Munn Z, Moola S, Karolina Lisy DR, Tufanaru C. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence. Int J Evid Based Healthc. 2015;13(3):147–153. doi:10.1097/XEB.0000000000000054
  • Awofisoye OI, Adeleye JO, Olaniyi JA, Esan A. Prevalence and correlates of anemia in type 2 diabetes mellitus: a study of a Nigerian outpatient diabetic population. Sahel Med J. 2019;22:55–63.
  • Chung JO, Park S, Chung DJ, Chung MY. Relationship between anemia, serum bilirubin concentrations, and diabetic retinopathy in individuals with type 2 diabetes. Medicine. 2019;98(43):1–5.
  • Chung JO, Park S, Cho DH, Chung DJ, Chung MY. Anemia, bilirubin, and cardiovascular autonomic neuropathy in patients with type 2 diabetes. Medicine. 2017;96(15):1–4. doi:10.1097/MD.0000000000006586
  • Hosseini MS, Rostami Z. Anemia and Microvascular Complications in Patients With Type 2 Diabetes Mellitus. Nephro Urol Mon. 2014;6(4):1–7. doi:10.5812/numonthly.19976
  • Praveen M, Jain N, Raizada N, Sharma S, Narang S, Madhu SV. Anaemia in patients with type 2 diabetes mellitus without nephropathy is related to iron de fi ciency. Diabetes Metab Syndr Clin Res Rev. 2020;14:1837–1840. doi:10.1016/j.dsx.2020.09.020
  • Rathore S, Singh PK, Kumar A. Anemia in Type 2 Diabetes Mellitus (T2dm) and its association with vitamin B12 deficiency. India n J Pathol Oncol. 2018;5(1):51–54.
  • Bekele A, Roba KT, Egata G, Id BG. Anemia and associated factors among type-2 diabetes mellitus patients attending public hospitals in Harari Region, Eastern Ethiopia. PLoS One. 2019;14(12):1–17. doi:10.1371/journal.pone.0225725
  • Arkew M, Yemane T, Mengistu Y, Gemechu K, Tesfaye G. Hematological parameters of type 2 diabetic adult patients at Debre Berhan Referral Hospital, Northeast Ethiopia: a comparative cross-sectional study. PLoS One. 2021;16(6):1–15. doi:10.1371/journal.pone.0253286
  • Ebrahim H, Fiseha T, Ebrahim Y, Bisetegn H. Comparison of hematological parameters between type 2 diabetes mellitus patients and healthy controls at Dessie comprehensive specialized hospital, Northeast Ethiopia: comparative cross-sectional study. PLoS One. 2022;17(7):1–15. doi:10.1371/journal.pone.0272145
  • Kebede SA, Tusa BS, Weldesenbet AB. Prevalence of Anaemia and Its Associated Factors among Type 2 Diabetes Mellitus Patients in University of Gondar Comprehensive Specialized Hospital. Hindawi. 2021;2021:1–5.
  • B-B H, Xu M, Wei L, et al. Relationship between Anemia and Chronic Complications in Chinese Patients with Type 2 Diabetes Mellitus. Arch Iran Med. 2015;18(5):277–283.
  • Wu F, Jing Y, Tang X, Li D, Gong L, Zhao H. Anemia: an independent risk factor of diabetic peripheral neuropathy in type 2 diabetic patients. Acta Diabetol. 2017;54:925–931. doi:10.1007/s00592-017-1025-7
  • Srivastava PM, Thomas MC, Calafiore P, Isaac RJMAC, Jerums G, Burrell LM. Diastolic dysfunction is associated with anaemia in patients with Type II diabetes. Clin Sci. 2006;110:109–116. doi:10.1042/CS20050184
  • Feteh VF, Choukem S, Kengne A, Nebongo DN. Anemia in type 2 diabetic patients and correlation with kidney function in a tertiary care sub-Saharan African hospital: a cross-sectional study. BMC Nephrol. 2016;17(29):1–7. doi:10.1186/s12882-016-0247-1
  • Ezenwaka CE, Jones-lecointe A, Nwagbara E, Seales D, Okali F. Anaemia and kidney dysfunction in Caribbean Type 2 diabetic patients. Cardiovasc Diabetol. 2008;7(25):1–6. doi:10.1186/1475-2840-7-25
  • Brière M, Diedisheim M, Dehghani L, Dubois-laforgue D, Larger E. Anaemia and its risk factors and association with treatments in patients with diabetes: a cross-sectional study. Diabetes Metab. 2020;46:1–20. doi:10.1016/j.diabet.2019.02.003
  • Grossman C, Koren-morag N, Leibowitz A, Saba K. Diabetes mellitus with normal renal function is associated with anaemia. Diabetes Metab Res Rev. 2014;30:291–296. doi:10.1002/dmrr.2491
  • Idris I, Tohid H, Muhammad NA, et al. Anaemia among primary care patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD): a multicentred cross-sectional study. BMJ Open. 2018;8:1–9. doi:10.1136/bmjopen-2018-025125
  • Sarosh I, Ghafoor R, Haseeb A, Saeed J, Shafqat F, Kashif Z. Frequency of Anemia and its Types in Type II Diabetes Mellitus Patients without Renal Insufficiency. PJMHS. 2022;16(6):216–218. doi:10.53350/pjmhs22166216
  • Al-ghazaly J, Al-dubai W. Pattern and causes of anemia in Yemeni patients with type 2 Diabetes Mellitus. Eur J Biomed Pharm Sci. 2019;6(1):57.
  • Chiou TT, Lee J, Wang M, et al. Genetic disposition and modifiable factors independently associated with anemia in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2015;1:1–6.
  • Bonakdaran S, Gharebaghi M, Vahedian M. Prevalence of Anemia in Type 2 Diabetes and Role of Renal Involvement. Saudi J Kidney Dis Transpl. 2011;22(2):286–290.
  • Solomon D, Bekele K, Atlaw D, et al. Prevalence of anemia and associated factors among adult diabetic patients attending Bale zone hospitals, South-East Ethiopia. PLoS One. 2022;17(2):1–14. doi:10.1371/journal.pone.0264007
  • Abate A, Birhan W, Alemu A. Association of anemia and renal function test among diabetes mellitus patients attending Fenote Selam Hospital, West Gojam, Northwest Ethiopia: a cross sectional study. BMC Blood Disord. 2013;13(1):1. doi:10.1186/2052-1839-13-6
  • Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–1558. doi:10.1002/sim.1186
  • Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–634. doi:10.1136/bmj.315.7109.629
  • Begg CB, Mazumdar M. Operating Characteristics of a Rank Correlation Test for Publication Bias. Biometrics. 1994;50(4):1088–1101. doi:10.2307/2533446
  • Gardner W, Kassebaum N. Global, Regional, and National Prevalence of Anemia and Its Causes in 204 Countries and Territories, 1990–2019. Curr Dev Nutr. 2020;4:830.
  • Balarajan Y, Ramakrishnan U, Özaltin E, Shankar AH, Subramanian SV. Anaemia in low-income and middle-income countries. Lancet. 2011;378(9809):2123–2135. doi:10.1016/S0140-6736(10)62304-5
  • Hamer M, Batty GD, Kengne AP, Stamatakis E. Anaemia, Haemoglobin Level and Cause-Specific Mortality in People with and without Diabetes. PLoS One. 2012;7(8):1–8.
  • Atlaw D, Tariku Z. Magnitude and factors associated with anemia among diabetic patients in Ethiopia: a systematic review and meta-analysis. SAGE Open Med. 2021;9:1–11. doi:10.1177/20503121211031126
  • Azevedo M, Alla S. Diabetes in sub-saharan Africa: Kenya, Mali, Mozambique, Nigeria, South Africa and Zambia. Int J Diabetes Dev Ctries. 2008;28(4):101–108. doi:10.4103/0973-3930.45268
  • Deng Y, Li N, Wu Y, et al. Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019. Front Endocrinol (Lausanne). 2021;12:1–15. doi:10.3389/fendo.2021.672350
  • Fishbane S, Spinowitz B. Update on Anemia in ESRD and Earlier Stages of CKD: core Curriculum 2018. Am J Kidney Dis. 2018;71(3):423–435. doi:10.1053/j.ajkd.2017.09.026
  • Kyoung M, Hyun K, Jun D, et al. Erythropoietin response to anemia and its association with autonomic neuropathy in type 2 diabetic patients without advanced renal failure. J Diabetes Complications. 2010;24(2):90–95. doi:10.1016/j.jdiacomp.2009.02.002
  • Neamţu MC, Crăiţoiu Ş, Avramescu ET, et al. The prevalence of the red cell morphology changes in patients with type 2 diabetes mellitus. Rom J Morphol Embryol. 2015;56(1):183–189.
  • Cho YI, Mooney MP, Cho DJ. Hemorheological disorders in diabetes mellitus. J Diabetes Sci Technol. 2008;2(6):1130–1138. doi:10.1177/193229680800200622
  • Abdel N, Hamed M. Alterations in hematological Parameters: could it be a marker in diabetes mellitus ? BAOJ Diabet. 2016;2(1):1–9.
  • Al-sharefi A, Mohammed A, Abdalaziz A, Jayasena CN, Al-sharefi A. Androgens and Anemia: current Trends and Future Prospects. Front Endocrinol (Lausanne). 2019;10:1–5. doi:10.3389/fendo.2019.00754
  • Osterholm EA, Georgieff MK. Chronic Inflammation and Iron Metabolism. J Pediatr. 2016;166(6):1351–1357. doi:10.1016/j.jpeds.2015.01.017
  • Weiss G, Ganz T, Goodnough LT. Anemia of inflammation: iron metabolism and its disorders. Blood. 2019;133(1):40–50. doi:10.1182/blood-2018-06-856500
  • Bilgin S, Kurtkulagi O, Atak Tel BM, et al. Does C-reactive protein to serum Albumin Ratio correlate with diabEtic nephropathy in patients with Type 2 dIabetes MEllitus? The CARE TIME study. Prim Care Diabetes. 2021;15(6):1071–1074. doi:10.1016/j.pcd.2021.08.015
  • Gulali A, Edip E, et al. Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus. Swiss Med Wkly. 2019;149:1–5.
  • Kocak MZ, Aktas G, Duman TT, et al. Monocyte lymphocyte ratio as a predictor of diabetic kidney injury in type 2 diabetes mellitus; The MADKID Study. J Diabetes Metab Disord. 2020;19:997–1002. doi:10.1007/s40200-020-00595-0