Effects of NKT Cells on Metabolic Disorders Caused by High-Fat Diet Using CD1d-Knockout Mice

References

• Morris MJ, Beilharz JE, Maniam J, Reichelt AC, Westbrook RF. Why is obesity such a problem in the 21st century? The intersection of palatable food, cues and reward pathways, stress, and cognition. Neurosci Biobehav Rev. 2015;58:36–45. doi:10.1016/j.neubiorev.2014.12.002
   PubMed Web of Science ®Google Scholar
• Tanaka K, Nakanishi T. Obesity as a risk factor for various diseases: necessity of lifestyle changes for healthy aging. Appl Human Sci. 1996;15(4):139–148. doi:10.2114/jpa.15.139
   PubMedGoogle Scholar
• Esser N, Legrand-Poels S, Piette J, Scheen AJ, Paquot N. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract. 2014;105(2):141–150. doi:10.1016/j.diabres.2014.04.006
   PubMed Web of Science ®Google Scholar
• Fahed G, Aoun L, Bou Zerdan M, et al. Metabolic syndrome: updates on pathophysiology and management in 2021. Int J Mol Sci. 2022;23(2):786. doi:10.3390/ijms23020786
   PubMed Web of Science ®Google Scholar
• Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol. 2003;4(12):1230–1237. doi:10.1038/ni1002
   PubMed Web of Science ®Google Scholar
• Zeissig S, Blumberg RS. Primary immunodeficiency associated with defects in CD1 and CD1-restricted T cells. Ann N Y Acad Sci. 2012;1250(1):14–24. doi:10.1111/j.1749-6632.2011.06380.x
   PubMedGoogle Scholar
• Gao B, Radaeva S, Park O. Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J Leukoc Biol. 2009;86(3):513–528. doi:10.1189/JLB.0309135
   PubMed Web of Science ®Google Scholar
• Martin-Murphy BV, You Q, Wang H, et al. Mice lacking natural killer T cells are more susceptible to metabolic alterations following high fat diet feeding. PLoS One. 2014;9(1):e80949. doi:10.1371/journal.pone.0080949
   PubMed Web of Science ®Google Scholar
• Lynch L, Nowak M, Varghese B, et al. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity. 2012;37(3):574–587. doi:10.1016/j.immuni.2012.06.016
   PubMed Web of Science ®Google Scholar
• Schipper HS, Rakhshandehroo M, van de Graaf SF, et al. Natural killer T cells in adipose tissue prevent insulin resistance. J Clin Invest. 2012;122(9):3343–3354. doi:10.1172/JCI62739
   PubMed Web of Science ®Google Scholar
• Huh JY, Kim JI, Park YJ, et al. A novel function of adipocytes in lipid antigen presentation to iNKT cells. Mol Cell Biol. 2013;33(2):328–339. doi:10.1128/MCB.00552-12
   PubMed Web of Science ®Google Scholar
• Kane H, Lynch L. Innate Immune Control of Adipose Tissue Homeostasis. Trends Immunol. 2019;40(9):857–872. doi:10.1016/j.it.2019.07.006
   PubMed Web of Science ®Google Scholar
• Lynch L. Adipose invariant natural killer T cells. Immunology. 2014;142(3):337–346. doi:10.1111/imm.12269
   PubMed Web of Science ®Google Scholar
• Ji Y, Sun S, Xu A, et al. Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. J Biol Chem. 2012;287(17):13561–13571. doi:10.1074/jbc.M112.350066
   PubMed Web of Science ®Google Scholar
• Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annu Rev Immunol. 2007;25(1):297–336. doi:10.1146/annurev.immunol.25.022106.141711
   PubMedGoogle Scholar
• Exley MA, Hand L, O’Shea D, Lynch L. Interplay between the immune system and adipose tissue in obesity. J Endocrinol. 2014;223(2):R41–R48. doi:10.1530/JOE-13-0516
   PubMed Web of Science ®Google Scholar
• Satoh M, Iwabuchi K. Role of natural killer T cells in the development of obesity and insulin resistance: insights from recent progress. Front Immunol. 2018;9:1314. doi:10.3389/fimmu.2018.01314
   PubMed Web of Science ®Google Scholar
• Lynch LA, O’Connell JM, Kwasnik AK, Cawood TJ, O’Farrelly C, O’Shea DB. Are natural killer cells protecting the metabolically healthy obese patient?. Obesity. 2009;17(3):601–605. doi:10.1038/oby.2008.565
   PubMed Web of Science ®Google Scholar
• Elinav E, Pappo O, Sklair-Levy M, et al. Adoptive transfer of regulatory NKT lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trapping. J Pathol. 2006;209(1):121–128. doi:10.1002/path.1950
   PubMed Web of Science ®Google Scholar
• Smiley ST, Kaplan MH, Grusby MJ. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science. 1997;275(5302):977–979. doi:10.1126/science.275.5302.977
   PubMed Web of Science ®Google Scholar
• Mendiratta SK, Martin WD, Hong S, Boesteanu A, Joyce S, Van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity. 1997;6(4):469–477. doi:10.1016/s1074-7613(00)80290-3
   PubMed Web of Science ®Google Scholar
• Middendorp S, Nieuwenhuis EE. NKT cells in mucosal immunity. Mucosal Immunol. 2009;2(5):393–402. doi:10.1038/mi.2009.99
   PubMed Web of Science ®Google Scholar
• Ishikawa H, Ino S, Nakashima T, et al. Oral administration of trehangelin-A alleviates metabolic disorders caused by a high-fat diet through improvement of lipid metabolism and restored beneficial microbiota. Obes Res Clin Pract. 2020;14(4):360–367. doi:10.1016/j.orcp.2020.06.004
   PubMed Web of Science ®Google Scholar
• Druce I, Abujrad H, Ooi TC. PCSK9 and triglyceride-rich lipoprotein metabolism. J Biomed Res. 2015;29(6):429–436. doi:10.7555/JBR.29.20150052
   PubMed Web of Science ®Google Scholar
• Satoh M, Andoh Y, Clingan CS, et al. Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance. PLoS One. 2012;7(2):e30568. doi:10.1371/journal.pone.0030568
   PubMed Web of Science ®Google Scholar
• Wu L, Parekh VV, Gabriel CL, et al. Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc Natl Acad Sci U S A. 2012;109(19):E1143–52. doi:10.1073/pnas.1200498109
   PubMed Web of Science ®Google Scholar
• Kotas ME, Lee HY, Gillum MP, et al. Impact of CD1d deficiency on metabolism. PLoS One. 2011;6(9):e25478. doi:10.1371/journal.pone.0025478
   PubMed Web of Science ®Google Scholar
• Miyagi T, Takehara T, Uemura A, et al. Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet. J Gastroenterol. 2010;45(12):1247–1254. doi:10.1007/s00535-010-0272-y
   PubMed Web of Science ®Google Scholar
• Hams E, Locksley RM, McKenzie AN, Fallon PG. Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol. 2013;191(11):5349–5353. doi:10.4049/jimmunol.1301176
   PubMed Web of Science ®Google Scholar
• Lynch L, Michelet X, Zhang S, et al. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol. 2015;16(1):85–95. doi:10.1038/ni.3047
   PubMed Web of Science ®Google Scholar
• Lynch L, Hogan AE, Duquette D, et al. iNKT cells induce FGF21 for thermogenesis and are required for maximal weight loss in GLP1 therapy. Cell Metab. 2016;24(3):510–519. doi:10.1016/j.cmet.2016.08.003
   PubMed Web of Science ®Google Scholar
• Kharitonenkov A, Shiyanova TL, Koester A, et al. FGF-21 as a novel metabolic regulator. J Clin Invest. 2005;115(6):1627–1635. doi:10.1172/JCI23606
   PubMed Web of Science ®Google Scholar
• Cai D, Liu T. Hypothalamic inflammation: a double-edged sword to nutritional diseases. Ann N Y Acad Sci. 2011;1243:E1–39. doi:10.1111/j.1749-6632.2011.06388.x
   PubMed Web of Science ®Google Scholar
• Bhattacharjee J, Kirby M, Softic S, et al. Hepatic natural killer T-cell and CD8+ T-cell signatures in mice with nonalcoholic steatohepatitis. Hepatol Commun. 2017;1(4):299–310. doi:10.1002/hep4.1041
   PubMed Web of Science ®Google Scholar
• Brailey PM, Evans L, Lopez-Rodriguez JC, et al. CD1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses. Nat Commun. 2022;13(1):6723. doi:10.1038/s41467-022-34532-x
   PubMed Web of Science ®Google Scholar
• Janani C, Ranjitha Kumari BD. PPAR gamma gene--A review. Diabetes Metab Syndr. 2015;9(1):46–50. doi:10.1016/j.dsx.2014.09.015
   PubMed Web of Science ®Google Scholar
• Christofides A, Konstantinidou E, Jani C, Boussiotis VA. The role of peroxisome proliferator-activated receptors (PPAR) in immune responses. Metabolism. 2021;114:154338. doi:10.1016/j.metabol.2020.154338
   PubMed Web of Science ®Google Scholar
• He W, Barak Y, Hevener A, et al. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003;100(26):15712–15717. doi:10.1073/pnas.2536828100
   PubMed Web of Science ®Google Scholar