Circulating MicroRNA-30a, Beclin1 and Their Association with Different Variables in Females with Metabolically Healthy /Unhealthy Obesity

References

• Afshin A, Forouzanfar MH. GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13–27. doi:10.1056/NEJMoa1614362
   PubMed Web of Science ®Google Scholar
• Jakubiak GK, Osadnik K, Lejawa M, et al. “Obesity and insulin resistance” is the component of the metabolic syndrome most strongly associated with oxidative stress. Antioxidants. 2021;11(1):79. PMID: 35052583; PMCID: PMC8773170. doi:10.3390/antiox11010079
   Web of Science ®Google Scholar
• Kwon H, Kim D, Kim JS. Body fat distribution and the risk of incident metabolic syndrome: a longitudinal cohort study. Sci Rep. 2017;7(1):10955. doi:10.1038/s41598-017-09723-y
   PubMedGoogle Scholar
• Fathi Dizaji B. The investigations of genetic determinants of the metabolic syndrome. Diabetes Metab Syndr. 2018;12(5):783–789. doi:10.1016/j.dsx.2018.04.009
   PubMed Web of Science ®Google Scholar
• Jiménez-Lucena R, Camargo A, Alcalá-Diaz JF, et al. A plasma circulating miRNAs profile predicts type 2 diabetes mellitus and prediabetes: from the CORDIOPREV study. Exp Mol Med. 2018;50(12):1–12. doi:10.1038/s12276-018-0194-y
   PubMed Web of Science ®Google Scholar
• Kuramoto K, He C. The secretory function of BECN1 in metabolic regulation. Autophagy. 2021;17(10):3262–3263. doi:10.1080/15548627.2021.1953849
   PubMed Web of Science ®Google Scholar
• Gonzalez CD, Lee MS, Marchetti P, et al. The emerging role of autophagy in the pathophysiology of diabetes mellitus. Autophagy. 2011;7(1):2–11. doi:10.4161/auto.7.1.13044
   PubMed Web of Science ®Google Scholar
• Jin Y, Ji Y, Song Y, et al. Depletion of adipocyte Becn1 leads to lipodystrophy and metabolic dysregulation. Diabetes. 2021;70(1):182–195. doi:10.2337/db19-1239
   PubMed Web of Science ®Google Scholar
• Akkoc Y, Gozuacik D. MicroRNAs as major regulators of the autophagy pathway. Biochim Biophys Acta Mol Cell Res. 2020;1867(5):118662. doi:10.1016/j.bbamcr.2020.118662
   PubMed Web of Science ®Google Scholar
• Miranda K, Yang X, Bam M, Murphy EA, Nagarkatti PS, Nagarkatti M. MicroRNA-30 modulates metabolic inflammation by regulating Notch signaling in adipose tissue macrophages. Int J Obes. 2018;42(6):1140–1150. doi:10.1038/s41366-018-0114-1
   Web of Science ®Google Scholar
• Zhang T, Tian F, Wang J, Jing J, Zhou SS, Chen YD. Endothelial cell autophagy in atherosclerosis is regulated by miR-30-mediated translational control of ATG6. Cell Physiol Biochem. 2015;37(4):1369–1378. doi:10.1159/000430402
   PubMed Web of Science ®Google Scholar
• Zhang X, Dong S, Jia Q, et al. The microRNA in ventricular remodeling: the miR-30 family. Biosci Rep. 2019;39(8):BSR20190788. doi:10.1042/BSR20190788
   PubMedGoogle Scholar
• Hintze J. PASS 11. NCSS, LLC. Kaysville, Utah, USA; 2011. Available from: www.ncss.com. Accessed September 29, 2023.
   Google Scholar
• Naguib M, Tarabay A, ElSaraf N, Rashed L, ElMeligy A. Beclin1 circulating level as predictor of carotid intima-media thickness in patients with type 2 diabetes mellitus. Medicine. 2021;100(28):e26630. doi:10.1097/MD.0000000000026630
   PubMed Web of Science ®Google Scholar
• Alberti KG, Zimmet P, Shaw J. IDF Epidemiology Task Force Consensus Group. The metabolic syndrome--a new worldwide definition. Lancet. 2005;366(9491):1059–1062. PMID: 16182882. doi:10.1016/S0140-6736(05)67402-8
   PubMed Web of Science ®Google Scholar
• Washko ME, Rice EW. Determination of glucose by an improved enzymatic procedure. Clin Chem. 1961;7(5):542–545. PMID: 14005104. doi:10.1093/clinchem/7.5.542
   PubMed Web of Science ®Google Scholar
• Lassale C, Tzoulaki I, Moons KGM, et al. Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis. Eur Heart J. 2018;39(5):397–406. PMID: 29020414; PMCID: PMC6198928. doi:10.1093/eurheartj/ehx448
   PubMed Web of Science ®Google Scholar
• Xu J, Kitada M, Ogura Y, Koya D. Relationship between autophagy and metabolic syndrome characteristics in the pathogenesis of atherosclerosis. Front Cell Dev Biol. 2021;9:641852. doi:10.3389/fcell.2021.641852
   PubMed Web of Science ®Google Scholar
• Liu HY, Han J, Cao SY, et al. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J Biol Chem. 2009;284(45):31484–31492. PMID: 19758991; PMCID: PMC2781544. doi:10.1074/jbc.M109.033936
   PubMed Web of Science ®Google Scholar
• Ignacio-Souza LM, Bombassaro B, Pascoal LB, et al. Defective regulation of the ubiquitin/proteasome system in the hypothalamus of obese male mice. Endocrinology. 2014;155(8):2831–2844. doi:10.1210/en.2014-1090
   PubMed Web of Science ®Google Scholar
• Kovsan J, Blüher M, Tarnovscki T, et al. Altered autophagy in human adipose tissues in obesity. J Clin Endocrinol Metab. 2011;96(2):E268–E277. doi:10.1210/jc.2010-1681
   PubMed Web of Science ®Google Scholar
• Kim KH, Jeong YT, Oh H, et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med. 2013;19(1):83–92. doi:10.1038/nm.3014
   PubMed Web of Science ®Google Scholar
• Yang X, Bai F, Xu Y, Chen Y, Chen L. Intensified beclin-1 mediated by low expression of mir-30a-5p promotes chemoresistance in human small cell lung cancer. Cell Physiol Biochem. 2017;43(3):1126–1139. doi:10.1159/000481754
   PubMed Web of Science ®Google Scholar
• Fang Y, Zou L, He W. miR-30a-5p mitigates autophagy by regulating the Beclin-1/ATG16 pathway in renal ischemia/reperfusion injury. Int J Mol Med. 2021;48(1):144. doi:10.3892/ijmm.2021.4977
   PubMed Web of Science ®Google Scholar
• Brandão-Lima PN, de Carvalho GB, Payolla TB, et al. Circulating microRNAs showed specific responses according to metabolic syndrome components and sex of adults from a population-based study. Metabolites. 2022;13(1):2. doi:10.3390/metabo13010002
   PubMed Web of Science ®Google Scholar
• Koh EH, Chernis N, Saha PK, et al. miR-30a remodels subcutaneous adipose tissue inflammation to improve insulin sensitivity in obesity. Diabetes. 2018;67(12):2541–2553. doi:10.2337/db17-1378
   PubMed Web of Science ®Google Scholar
• Kim JW, You YH, Jung S, et al. MiRNA-30a-5p-mediated silencing of beta2/neurod expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models. Diabetologia. 2013;56(4):847–855. doi:10.1007/s00125-012-2812-x
   PubMed Web of Science ®Google Scholar
• Weale CJ, Matshazi DM, Davids SFG, et al. Circulating miR-30a-5p and miR-182-5p in prediabetes and screen-detected diabetes mellitus. Diabetes Metab Syndr Obes. 2020;13:5037–5047. doi:10.2147/DMSO.S286081
   PubMed Web of Science ®Google Scholar
• Rocha EPAA, Vogel M, Stanik J, et al. Serum uric acid levels as an indicator for metabolically unhealthy obesity in children and adolescents. Horm Res Paediatr. 2018;90(1):19–27. doi:10.1159/000490113
   PubMed Web of Science ®Google Scholar
• Wan Mohd Zin RM, Jalaludin MY, Yahya A, et al. Prevalence and clinical characteristics of metabolically healthy obese versus metabolically unhealthy obese school children. Front Endocrinol. 2022;13:971202. doi:10.3389/fendo.2022.971202
   PubMed Web of Science ®Google Scholar
• Zhang P, Liao J, Wang X, Feng Z. High glucose promotes apoptosis and autophagy of MC3T3-E1 osteoblasts. Arch Med Sci. 2020;19(1):138–150. doi:10.5114/aoms.2020.101307
   PubMedGoogle Scholar
• Zhang L, Cheng R, Huang Y. MiR-30a inhibits BECN1-mediated autophagy in diabetic cataract. Oncotarget. 2017;8(44):77360–77368. PMID: 29100392; PMCID: PMC5652784. doi:10.18632/oncotarget.20483
   PubMedGoogle Scholar
• Jiang Q, Lagos-Quintana M, Liu D, et al. miR-30a regulates endothelial tip cell formation and arteriolar branching. Hypertension. 2013;62(3):592–598. doi:10.1161/HYPERTENSIONAHA.113.0176723
   PubMed Web of Science ®Google Scholar
• Saito T, Kuma A, Sugiura Y, et al. Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nat Commun. 2019;10(1):1567. doi:10.1038/s41467-019-08829-3
   PubMed Web of Science ®Google Scholar
• Sumner AD, Sardi GL, Reed JF. Components of the metabolic syndrome differ between young and old adults in the US population. J Clin Hypertens. 2012;14(8):502–506. doi:10.1111/j.1751-7176.2012.00647.x
   Web of Science ®Google Scholar
• Leidal AM, Levine B, Debnath J. Autophagy and the cell biology of age-related disease. Nat Cell Biol. 2018;20(12):1338–1348. PMID: 30482941. doi:10.1038/s41556-018-0235-8
   PubMed Web of Science ®Google Scholar
• Deshmukh V, Farishta F, Bhole M. Thyroid dysfunction in patients with metabolic syndrome: a cross-sectional, epidemiological, Pan-India study. Int J Endocrinol. 2018;2018:2930251. PMID: 30675157; PMCID: PMC6323507. doi:10.1155/2018/2930251
   PubMed Web of Science ®Google Scholar
• Xin W, Yu Y, Ma Y, et al. Thyroid-stimulating hormone stimulation downregulates autophagy and promotes apoptosis in chondrocytes. Endocr J. 2017;64(7):749–757. doi:10.1507/endocrj.EJ16-0534
   PubMed Web of Science ®Google Scholar
• Paschos P, Paletas K. Non alcoholic fatty liver disease and metabolic syndrome. Hippokratia. 2009;13(1):9–19. PMID: 19240815; PMCID: PMC2633261.
   PubMed Web of Science ®Google Scholar
• Galle-Treger L, Helou DG, Quach C, et al. Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23. Nat Commun. 2022;13(1):1440. doi:10.1038/s41467-022-29174-y
   PubMed Web of Science ®Google Scholar
• Khambu B, Yan S, Huda N, Liu G, Yin XM. Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease. Liver Res. 2018;2(3):112–119. PMID: 31123622; PMCID: PMC6528826. doi:10.1016/j.livres.2018.09.004
   PubMedGoogle Scholar
• Hochreuter MY, Dall M, Treebak JT, Barrès R. MicroRNAs in non-alcoholic fatty liver disease: progress and perspectives. Mol Metab. 2022;65:101581. PMID: 36028120; PMCID: PMC9464960. doi:10.1016/j.molmet.2022.101581
   PubMed Web of Science ®Google Scholar
• Soussi H, Clément K, Dugail I. Adipose tissue autophagy status in obesity: expression and flux--two faces of the picture. Autophagy. 2016;12(3):588–589. PMID: 26565777; PMCID: PMC4835957. doi:10.1080/15548627.2015.1106667
   PubMed Web of Science ®Google Scholar