The Metabolic Characteristics of Patients at the Risk for Diabetic Foot Ulcer: A Comparative Study of Diabetic Patients with and without Diabetic Foot

References

• van Netten JJ, Bus SA, Apelqvist J, et al. Definitions and criteria for diabetic foot disease. Diabetes Metab Res Rev. 2020;36(Suppl 1):e3268. doi:10.1002/dmrr.3268
   PubMedGoogle Scholar
• McDermott K, Fang M, Boulton AJM, Selvin E, Hicks CW. Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers. Diabetes Care. 2023;46(1):209–221. doi:10.2337/dci22-0043
   PubMed Web of Science ®Google Scholar
• International Diabetes Federation. The Diabetic Foot. Brussels, Belgium: International Diabetes Federation; 2020.
   Google Scholar
• Society CD. Chinese guidelines for the prevention and treatment of type 2 diabetes (2020). Chin J Pract Inter Med. 2021;41(09):668–784.
   Google Scholar
• Wang YZ, Wang AH, Zhao S, et al. 中国南方与北方地区糖尿病足病危险因素分析 [Differences in risk factors of diabetic foot in the patients in South and North China]. Zhonghua Yi Xue Za Zhi. 2007;87(26):1817–1820. Chinese.
   PubMedGoogle Scholar
• ElSayed NA, Aleppo G, Aroda VR, et al. 12. Retinopathy, neuropathy, and foot care: standards of care in diabetes-2023. Diabetes Care. 2023;46(Suppl 1):S203–S215. doi:10.2337/dc23-S012
   PubMedGoogle Scholar
• Fu XL, Ding H, Miao WW, Mao CX, Zhan MQ, Chen HL. Global recurrence rates in diabetic foot ulcers: a systematic review and meta-analysis. Diabetes Metab Res Rev. 2019;35(6):e3160. doi:10.1002/dmrr.3160
   PubMed Web of Science ®Google Scholar
• Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y. Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis (†). Ann Med. 2017;49(2):106–116. doi:10.1080/07853890.2016.1231932
   PubMed Web of Science ®Google Scholar
• Armstrong DG, Boulton AJM, Bus SA, Ingelfinger JR. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376(24):2367–2375. doi:10.1056/NEJMra1615439
   PubMed Web of Science ®Google Scholar
• Soyoye DO, Abiodun OO, Ikem RT, Kolawole BA, Akintomide AO. Diabetes and peripheral artery disease: a review. World J Diabetes. 2021;12(6):827–838. doi:10.4239/wjd.v12.i6.827
   PubMed Web of Science ®Google Scholar
• Lechleitner M, Abrahamian H, Francesconi C, Kofler M, Sturm W, Köhler G. Diabetische Neuropathie und diabetischer Fuß (Update 2019) [Diabetic neuropathy and diabetic foot syndrome (Update 2019)]. Wien Klin Wochenschr. 2019;131(Suppl 1):141–150. German. doi:10.1007/s00508-019-1487-4
   PubMedGoogle Scholar
• Lazzarini PA, Cramb SM, Golledge J, Morton JI, Magliano DJ, Van Netten JJ. Global trends in the incidence of hospital admissions for diabetes-related foot disease and amputations: a review of national rates in the 21st century. Diabetologia. 2023;66(2):267–287. doi:10.1007/s00125-022-05845-9
   PubMed Web of Science ®Google Scholar
• Ezzatvar Y, García-Hermoso A. Global estimates of diabetes-related amputations incidence in 2010–2020: a systematic review and meta-analysis. Diabetes Res Clin Pract. 2023;195:110194. doi:10.1016/j.diabres.2022.110194
   PubMed Web of Science ®Google Scholar
• Armstrong DG, Tan TW, Boulton AJM, Bus SA. Diabetic Foot Ulcers: a Review. JAMA. 2023;330(1):62–75. doi:10.1001/jama.2023.10578
   PubMed Web of Science ®Google Scholar
• Yang L, Rong GC, Wu QN. Diabetic foot ulcer: challenges and future. World J Diabetes. 2022;13(12):1014–1034. doi:10.4239/wjd.v13.i12.1014
   PubMed Web of Science ®Google Scholar
• Naemi R, Balasubramanian G, Darvel T, Chockalingam N. Predicting diabetic foot ulceration using routinely collected data in a foot clinic. What level of prognostic accuracy can be achieved? Diabetes Metab Res Rev. 2023;39(6):e3674. doi:10.1002/dmrr.3674
   PubMed Web of Science ®Google Scholar
• Kaka AS, Landsteiner A, Ensrud KE, et al. Risk prediction models for diabetic foot ulcer development or amputation: a review of reviews. J Foot Ankle Res. 2023;16(1):13. doi:10.1186/s13047-023-00610-6
   PubMed Web of Science ®Google Scholar
• Wang M, Chen D, Fu H, et al. Development and validation of a risk prediction model for the recurrence of foot ulcer in type 2 diabetes in China: a longitudinal cohort study based on a systematic review and meta-analysis. Diabetes Metab Res Rev. 2023;39(4):e3616. doi:10.1002/dmrr.3616
   PubMed Web of Science ®Google Scholar
• Peng B, Min R. Development of predictive nomograms clinical use to quantify the risk of diabetic foot in patients with type 2 diabetes mellitus. Front Endocrinol. 2023;14:1186992. doi:10.3389/fendo.2023.1186992
   PubMed Web of Science ®Google Scholar
• Shao Z, Wang Z, Bi S, Zhang J. Establishment and validation of a nomogram for progression to diabetic foot ulcers in elderly diabetic patients. Front Endocrinol. 2023;14:1107830. doi:10.3389/fendo.2023.1107830
   PubMed Web of Science ®Google Scholar
• ElSayed NA, Aleppo G, Aroda VR, et al. 2. Classification and diagnosis of diabetes: standards of care in diabetes-2023. Diabetes Care. 2023;46(Suppl 1):S19–S40. doi:10.2337/dc23-S002
   PubMed Web of Science ®Google Scholar
• Das SK, Roy P, Singh P, et al. Diabetic foot ulcer identification: a review. Diagnostics. 2023;13(12). doi:10.3390/diagnostics13121998
   Web of Science ®Google Scholar
• Smith S, Normahani P, Lane T, Hohenschurz-Schmidt D, Oliver N, Davies AH. Prevention and management strategies for diabetic neuropathy. Life. 2022;12(8):1185.
   PubMedGoogle Scholar
• Joseph S, Munshi B, Agarini R, Kwok RCH, Green DJ, Jansen S. Near infrared spectroscopy in peripheral artery disease and the diabetic foot: a systematic review. Diabetes Metab Res Rev. 2022;38(7):e3571. doi:10.1002/dmrr.3571
   PubMed Web of Science ®Google Scholar
• Wang X, Yuan CX, Xu B, Yu Z. Diabetic foot ulcers: classification, risk factors and management. World J Diabetes. 2022;13(12):1049–1065. doi:10.4239/wjd.v13.i12.1049
   PubMed Web of Science ®Google Scholar
• Rajab AAH, Hegazy WAH. What’s old is new again: insights into diabetic foot microbiome. World J Diabetes. 2023;14(6):680–704. doi:10.4239/wjd.v14.i6.680
   PubMed Web of Science ®Google Scholar
• Kurze C, Farn CJ, Siow J. The interdisciplinary approach: preventive and therapeutic strategies for diabetic foot ulcers. Foot Ankle Clin. 2022;27(3):529–543. doi:10.1016/j.fcl.2022.03.001
   PubMed Web of Science ®Google Scholar
• Ramsey DJ, Kwan JT, Sharma A. Keeping an eye on the diabetic foot: the connection between diabetic eye disease and wound healing in the lower extremity. World J Diabetes. 2022;13(12):1035–1048. doi:10.4239/wjd.v13.i12.1035
   PubMed Web of Science ®Google Scholar
• Werkman NCC, Driessen JHM, Stehouwer CDA, et al. The use of sodium-glucose co-transporter-2 inhibitors or glucagon-like peptide-1 receptor agonists versus sulfonylureas and the risk of lower limb amputations: a nation-wide cohort study. Cardiovasc Diabetol. 2023;22(1):160. doi:10.1186/s12933-023-01897-2
   PubMed Web of Science ®Google Scholar
• Lu Y, Guo C. Risk of lower limb amputation in diabetic patients using SGLT2 inhibitors versus DPP4 inhibitors or GLP-1 agonists: a meta-analysis of 2 million patients. Ther Adv Drug Saf. 2023;14:20420986231178126. doi:10.1177/20420986231178126
   Web of Science ®Google Scholar
• Caruso P, Maiorino MI, Bellastella G, Esposito K, Giugliano D. Pleiotropic effects of GLP-1 receptor agonists on peripheral artery disease: is there any hope? Diabetes Metab Res Rev. 2023;39(7):e3627. doi:10.1002/dmrr.3627
   PubMed Web of Science ®Google Scholar
• Shao S, Zhang X, Xu Q, Pan R, Chen Y. Emerging roles of Glucagon like peptide-1 in the management of autoimmune diseases and diabetes-associated comorbidities. Pharmacol Ther. 2022;239:108270. doi:10.1016/j.pharmthera.2022.108270
   PubMed Web of Science ®Google Scholar
• Nurmohamed NS, Kraaijenhof JM, Stroes ESG. Lp(a): a new pathway to target? Curr Atheroscler Rep. 2022;24(11):831–838. doi:10.1007/s11883-022-01060-4
   PubMed Web of Science ®Google Scholar
• Berberich AJ, Hegele RA. A modern approach to dyslipidemia. Endocr Rev. 2022;43(4):611–653. doi:10.1210/endrev/bnab037
   PubMed Web of Science ®Google Scholar
• Ulloque-Badaracco JR, Mosquera-Rojas MD, Hernandez-Bustamante EA, et al. Association between lipid profile and apolipoproteins with risk of diabetic foot ulcer: a systematic review and meta-analysis. Int J Clin Pract. 2022;2022:5450173. doi:10.1155/2022/5450173
   PubMed Web of Science ®Google Scholar
• Vlad LG, Grosser JA, Dodenhoff KA, Peoples AE, Aguilo-Seara G, Molnar JA. Examining albumin as a bioindicator of healing capability in patients with diabetic foot ulcers: a retrospective review. Wounds. 2023;35(6):E193–e196. doi:10.25270/wnds/23012
   PubMed Web of Science ®Google Scholar
• Wang Y, Liu B, Pi Y, et al. Risk factors for diabetic foot ulcers mortality and novel negative pressure combined with platelet-rich plasma therapy in the treatment of diabetic foot ulcers. Front Pharmacol. 2022;13:1051299. doi:10.3389/fphar.2022.1051299
   PubMed Web of Science ®Google Scholar
• Lewis S, Raj D, Guzman NJ. Renal failure: implications of chronic kidney disease in the management of the diabetic foot. Semin Vasc Surg. 2012;25(2):82–88. doi:10.1053/j.semvascsurg.2012.04.007
   PubMed Web of Science ®Google Scholar
• Kaminski MR, Raspovic A, McMahon LP, et al. Risk factors for foot ulceration and lower extremity amputation in adults with end-stage renal disease on dialysis: a systematic review and meta-analysis. Nephrol Dial Transplant. 2015;30(10):1747–1766. doi:10.1093/ndt/gfv114
   PubMed Web of Science ®Google Scholar
• Tran SK, Carr JB, Hall MJ, Park JS, Cooper MT. Incidence of thyroid disease in patients with forefoot deformity. Foot Ankle Surg. 2020;26(4):445–448. doi:10.1016/j.fas.2019.05.014
   PubMed Web of Science ®Google Scholar
• Yammine K, Hayek F, Assi C. Is there an association between anemia and diabetic foot ulcers? A systematic review and meta-analysis. Wound Repair Regen. 2021;29(3):432–442. doi:10.1111/wrr.12902
   PubMed Web of Science ®Google Scholar
• Yan P, Zhang Z, Miao Y, Xu Y, Zhu J, Wan Q. Physiological serum total bilirubin concentrations were inversely associated with diabetic peripheral neuropathy in Chinese patients with type 2 diabetes: a cross-sectional study. Diabetol Metab Syndr. 2019;11(1):100. doi:10.1186/s13098-019-0498-7
   PubMed Web of Science ®Google Scholar
• Alqahtani N, Ghazwani EY, Al-Qahtani AM, Elmahboub RA. Correlation of iron levels with glycemia and microvascular complications among type II diabetes mellitus patients in Najran university hospital. J Fam Med Prim Care. 2022;11(6):2690–2694. doi:10.4103/jfmpc.jfmpc_545_21
   PubMedGoogle Scholar
• Reddy S, Anoop S, Jebasingh FK, et al. Differentials in dietary intake of macro and micronutrients in patients with type 2 diabetes and foot ulcers: observations from a pilot study. Clin Nutr ESPEN. 2022;47:170–176. doi:10.1016/j.clnesp.2021.12.023
   PubMed Web of Science ®Google Scholar
• Kulprachakarn K, Ounjaijean S, Wungrath J, Mani R, Rerkasem K. Micronutrients and natural compounds status and their effects on wound healing in the diabetic foot ulcer. Int J Low Extrem Wounds. 2017;16(4):244–250. doi:10.1177/1534734617737659
   PubMed Web of Science ®Google Scholar
• Hong J, Liu WY, Hu X, et al. Free triiodothyronine and free triiodothyronine to free thyroxine ratio predict all-cause mortality in patients with diabetic foot ulcers. Diabetes Metab Syndr Obes. 2022;15:467–476. doi:10.2147/DMSO.S354754
   PubMed Web of Science ®Google Scholar
• Perlstein TS, Pande RL, Beckman JA, Creager MA. Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: national Health and Nutrition Examination Survey (NHANES) 1999 to 2004. Arterioscler Thromb Vasc Biol. 2008;28(1):166–172. doi:10.1161/ATVBAHA.107.153262
   PubMed Web of Science ®Google Scholar
• Lan Y, Liu H, Liu J, Zhao H, Wang H. The relationship between serum bilirubin levels and peripheral arterial disease and gender difference in patients with hypertension: BEST study. Angiology. 2020;71(4):340–348. doi:10.1177/0003319719900734
   PubMed Web of Science ®Google Scholar
• Ozeki M, Morita H, Miyamura M, et al. High serum bilirubin is associated with lower prevalence of peripheral arterial disease among cardiac patients. Clin Chim Acta. 2018;476:60–66. doi:10.1016/j.cca.2017.11.013
   PubMed Web of Science ®Google Scholar
• Kim ES, Mo EY, Moon SD, Han JH, Catapano A. Inverse association between serum bilirubin levels and arterial stiffness in Korean women with type 2 diabetes. PLoS One. 2014;9(10):e109251. doi:10.1371/journal.pone.0109251
   PubMed Web of Science ®Google Scholar
• Inoguchi T, Sonoda N, Maeda Y. Bilirubin as an important physiological modulator of oxidative stress and chronic inflammation in metabolic syndrome and diabetes: a new aspect on old molecule. Diabetol Int. 2016;7(4):338–341. doi:10.1007/s13340-016-0288-5
   PubMedGoogle Scholar
• Zhao CC, Wang JW, Chen MY, Ke JF, Li MF, Li LX. High-normal serum bilirubin decreased the risk of lower limb atherosclerosis in type 2 diabetes: a real-world study. Diabetol Metab Syndr. 2023;15(1):105. doi:10.1186/s13098-023-01088-9
   PubMed Web of Science ®Google Scholar
• Mayer M. Association of serum bilirubin concentration with risk of coronary artery disease. Clin Chem. 2000;46(11):1723–1727. doi:10.1093/clinchem/46.11.1723
   PubMed Web of Science ®Google Scholar
• Kipp ZA, Xu M, Bates EA, Lee WH, Kern PA, Hinds TD. Bilirubin levels are negatively correlated with adiposity in obese men and women, and its catabolized product, urobilin, is positively associated with insulin resistance. Antioxidants. 2023;12(1):170. doi:10.3390/antiox12010170
   Web of Science ®Google Scholar
• Wang P, Shao X, Bao Y, et al. Impact of obese levels on the hepatic expression of nuclear receptors and drug-metabolizing enzymes in adult and offspring mice. Acta Pharm Sin B. 2020;10(1):171–185. doi:10.1016/j.apsb.2019.10.009
   PubMed Web of Science ®Google Scholar
• Stec DE, John K, Trabbic CJ, et al. Bilirubin binding to PPARα inhibits lipid accumulation. PLoS One. 2016;11(4):e0153427. doi:10.1371/journal.pone.0153427
   PubMed Web of Science ®Google Scholar
• Woronyczová J, Nováková M, Leníček M, et al. Serum bilirubin concentrations and the prevalence of gilbert syndrome in elite athletes. Sports Med. 2022;8(1):84.
   Web of Science ®Google Scholar
• Xu MR, Jin CH, Lu JX, Li MF, Li LX. High-normal unconjugated bilirubin is associated with decreased risk of chronic kidney disease in type 2 diabetes: a real-world study. Diabetes Metab Res Rev. 2023;39(6):e3672. doi:10.1002/dmrr.3672
   PubMed Web of Science ®Google Scholar
• Tafese R, Genet S, Addisu S. Association of serum total bilirubin and uric acid with low glomerular filtration rate diabetic kidney disease in type 2 diabetic patients. Diabetes Metab Syndr Obes. 2022;15:3993–3999. doi:10.2147/DMSO.S391777
   PubMed Web of Science ®Google Scholar
• Li S, Li N, Li L, et al. Association of serum bilirubin levels with macro- and microvascular complications in Chinese people with type 2 diabetes mellitus: new insight on gender differences. Diabetes Metab Syndr Obes. 2023;16:597–606. doi:10.2147/DMSO.S403483
   PubMed Web of Science ®Google Scholar
• Kurian SJ, Baral T, Unnikrishnan MK, et al. The association between micronutrient levels and diabetic foot ulcer: a systematic review with meta-analysis. Front Endocrinol. 2023;14:1152854. doi:10.3389/fendo.2023.1152854
   PubMed Web of Science ®Google Scholar
• Leal EC, Carvalho E. Heme Oxygenase-1 as therapeutic target for diabetic foot ulcers. Int J Mol Sci. 2022;23(19). doi:10.3390/ijms231912043
   Web of Science ®Google Scholar
• Deng H, Li B, Shen Q, et al. Mechanisms of diabetic foot ulceration: a review. J Diabetes. 2023;15(4):299–312. doi:10.1111/1753-0407.13372
   PubMed Web of Science ®Google Scholar
• Kosacka J, Woidt K, Toyka KV, et al. The role of dietary non-heme iron load and peripheral nerve inflammation in the development of peripheral neuropathy (PN) in obese non-diabetic leptin-deficient ob/ob mice. Neurol Res. 2019;41(4):341–353. doi:10.1080/01616412.2018.1564191
   PubMed Web of Science ®Google Scholar
• Xu C, Gong M, Wen S, Zhou M, Li Y, Zhou L. The comparative study on the status of bone metabolism and thyroid function in diabetic patients with or without ketosis or ketoacidosis. Diabetes Metab Syndr Obes. 2022;15:779–797. doi:10.2147/DMSO.S349769
   PubMed Web of Science ®Google Scholar
• Gong M, Xu C, Wen S, et al. The effects of obesity on bone turnover markers in diabetic patients with diabetic ketosis or ketoacidosis. Endocr Metab Immune Disord Drug Targets. 2023. doi:10.2174/1871530323666230509101203
   Web of Science ®Google Scholar
• Iwamoto Y, Kimura T, Tatsumi F, et al. Effect of hyperglycemia-related acute metabolic disturbance on thyroid function parameters in adults. Front Endocrinol. 2022;13:869869. doi:10.3389/fendo.2022.869869
   PubMed Web of Science ®Google Scholar
• Ranuve MS, Mohammadnezhad M. Healthcare workers’ perceptions on diabetic foot ulcers (DFU) and foot care in Fiji: a qualitative study. BMJ open. 2022;12(8):e060896. doi:10.1136/bmjopen-2022-060896
   PubMed Web of Science ®Google Scholar
• Kuhnke JL, Keast D, Rosenthal S, Evans RJ. Health professionals’ perspectives on delivering patient-focused wound management: a qualitative study. J Wound Care. 2019;28(Sup7):S4–S13. doi:10.12968/jowc.2019.28.Sup7.S4
   PubMedGoogle Scholar
• Lo ZJ, Tan E, Chandrasekar S, et al. Diabetic foot in primary and tertiary (DEFINITE) Care: a health services innovation in coordination of diabetic foot ulcer (DFU) Care within a healthcare cluster - 18-month results from an observational population health cohort study. Int Wound J. 2023;20(5):1609–1621. doi:10.1111/iwj.14016
   PubMed Web of Science ®Google Scholar