108
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Roux-en-Y Gastric Bypass Improves Insulin Sensitivity in Obese Rats with Type 2 Diabetes Mellitus by Regulating the Grin3a/AMPK Signal Axis in Hypothalamic Arcuate Nucleus

, , , &
Pages 3617-3629 | Received 10 Aug 2023, Accepted 21 Oct 2023, Published online: 09 Nov 2023

References

  • Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6–10. doi:10.1016/j.metabol.2018.09.005
  • Wondmkun YT. Obesity, insulin resistance, and type 2 diabetes: associations and therapeutic implications. Diabetes Metab Syndr Obes. 2020;13:3611–3616. doi:10.2147/DMSO.S275898
  • Golay A, Ybarra J. Link between obesity and type 2 diabetes. Best Pract Res Clin Endocrinol Metab. 2005;19(4):649–663. doi:10.1016/j.beem.2005.07.010
  • Choi K, Kim YB. Molecular mechanism of insulin resistance in obesity and type 2 diabetes. Korean J Intern Med. 2010;25(2):119–129. doi:10.3904/kjim.2010.25.2.119
  • Yan Y, Sha Y, Yao G, et al. Roux-en-Y gastric bypass versus medical treatment for type 2 diabetes mellitus in obese patients: a systematic review and meta-analysis of randomized controlled trials. Medicine. 2016;95(17):e3462. doi:10.1097/MD.0000000000003462
  • Camastra S, Gastaldelli A, Mari A, et al. Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes. Diabetologia. 2011;54(8):2093–2102. doi:10.1007/s00125-011-2193-6
  • Fabbrini E, Tamboli RA, Magkos F, et al. Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults. Gastroenterology. 2010;139(2):448–455. doi:10.1053/j.gastro.2010.04.056
  • Hardie DG. Sensing of energy and nutrients by AMP-activated protein kinase. Am J Clin Nutr. 2011;93(4):891S–896S. doi:10.3945/ajcn.110.001925
  • Entezari M, Hashemi D, Taheriazam A, et al. AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: a pre-clinical and clinical investigation. Biomed Pharmacother. 2022;146:112563. doi:10.1016/j.biopha.2021.112563
  • Zgheib NK, El-Khoury H, Maamari D, Basbous M, Saab R, Muwakkit SA. A GRIN3A polymorphism may be associated with glucocorticoid-induced symptomatic osteonecrosis in children with acute lymphoblastic leukemia. Per Med. 2021;18(5):431–439. doi:10.2217/pme-2020-0167
  • Shi X, Lu L, Jin X, et al. GRIN3A and MAPT stimulate nerve overgrowth in macrodactyly. Mol Med Rep. 2016;14(6):5637–5643. doi:10.3892/mmr.2016.5923
  • Fujihara C, Yamada S, Ozaki N, et al. Role of mechanical stress-induced glutamate signaling-associated molecules in cytodifferentiation of periodontal ligament cells. J Biol Chem. 2010;285(36):28286–28297. doi:10.1074/jbc.M109.097303
  • Zhang LH, Wang J, Tan BH, Yin YB, Kang YM. The association of lncRNA and mRNA changes in adipose tissue with improved insulin resistance in type 2 obese diabetes mellitus rats after Roux-en-Y gastric bypass. Dis Markers. 2022;2022:8902916. doi:10.1155/2022/8902916
  • Nagao H, Nishizawa H, Bamba T, et al. Increased dynamics of tricarboxylic acid cycle and glutamate synthesis in obese adipose tissue: in vivo metabolic turnover analysis. J Biol Chem. 2017;292(11):4469–4483. doi:10.1074/jbc.M116.770172
  • Zhou H, Li YJ, Wang M, et al. Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes. Acta Pharmacol Sin. 2011;32(8):999–1008. doi:10.1038/aps.2011.54
  • Fang XK, Gao J, Zhu DN. Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci. 2008;82(11–12):615–622. doi:10.1016/j.lfs.2007.12.021
  • Petersen MC, Shulman GI. Mechanisms of Insulin Action and Insulin Resistance. Physiol Rev. 2018;98(4):2133–2223. doi:10.1152/physrev.00063.2017
  • Yan Y, Zhou Z, Kong F, et al. Roux-en-Y gastric bypass surgery suppresses hepatic gluconeogenesis and increases intestinal gluconeogenesis in a T2DM rat model. Obes Surg. 2016;26(11):2683–2690. doi:10.1007/s11695-016-2157-5
  • Yan Y, Sha Y, Huang X, et al. Roux-en-Y gastric bypass improves metabolic conditions in association with increased serum bile acids level and hepatic farnesoid X receptor expression in a T2DM rat model. Obes Surg. 2019;29(9):2912–2922. doi:10.1007/s11695-019-03918-0
  • Christian DT, Stefanik MT, Bean LA, et al. GluN3-containing NMDA receptors in the rat nucleus accumbens core contribute to incubation of cocaine craving. J Neurosci. 2021;41(39):8262–8277. doi:10.1523/JNEUROSCI.0406-21.2021
  • De Berardis D, Tomasetti C, Pompili M, et al. An update on glutamatergic system in suicidal depression and on the role of esketamine. Curr Top Med Chem. 2020;20(7):554–584. doi:10.2174/1568026620666200131100316
  • Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013;123(7):2764–2772. doi:10.1172/JCI67227
  • Zhang R, Qin X, Zhang T, et al. Astragalus polysaccharide improves insulin sensitivity via AMPK activation in 3T3-L1 adipocytes. Molecules. 2018;23(10):2711. doi:10.3390/molecules23102711
  • Li X, Hu X, Pan T, et al. Kanglexin, a new anthraquinone compound, attenuates lipid accumulation by activating the AMPK/SREBP-2/PCSK9/LDLR signalling pathway. Biomed Pharmacother. 2021;133:110802. doi:10.1016/j.biopha.2020.110802
  • Agius L, Ford BE, Chachra SS. The metformin mechanism on gluconeogenesis and AMPK activation: the metabolite perspective. Int J Mol Sci. 2020;21(9):3240. doi:10.3390/ijms21093240
  • Shamshoum H, Vlavcheski F, MacPherson REK, Tsiani E. Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance. Appl Physiol Nutr Metab. 2021;46(7):819–827. doi:10.1139/apnm-2020-0592
  • Xu XJ, Apovian C, Hess D, Carmine B, Saha A, Ruderman N. Improved insulin sensitivity 3 months after RYGB surgery is associated with increased subcutaneous adipose tissue AMPK activity and decreased oxidative stress. Diabetes. 2015;64(9):3155–3159. doi:10.2337/db14-1765
  • Huang H, Aminian A, Hassan M, et al. Gastric bypass surgery improves the skeletal muscle ceramide/S1P ratio and upregulates the AMPK/SIRT1/PGC-1α pathway in Zucker diabetic fatty rats. Obes Surg. 2019;29(7):2158–2165. doi:10.1007/s11695-019-03800-z
  • Krssak M, Roden M. The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humans. Rev Endocr Metab Disord. 2004;5(2):127–134. doi:10.1023/B:REMD.0000021434.98627.dc
  • Ribeiro MBT, Guzzoni V, Hord JM, et al. Resistance training regulates gene expression of molecules associated with intramyocellular lipids, glucose signaling and fiber size in old rats. Sci Rep. 2017;7(1):8593. doi:10.1038/s41598-017-09343-6
  • Madsen MS, Siersbaek R, Boergesen M, Nielsen R, Mandrup S. Peroxisome proliferator-activated receptor gamma and C/EBPalpha synergistically activate key metabolic adipocyte genes by assisted loading. Mol Cell Biol. 2014;34(6):939–954. doi:10.1128/MCB.01344-13
  • John CM, Arockiasamy S. Sinapic acid prevents adipogenesis by regulating transcription factors and exerts an anti-ROS effect by modifying the intracellular anti-oxidant system in 3T3-L1 adipocytes. Iran J Basic Med Sci. 2022;25(5):611–620. doi:10.22038/IJBMS.2022.62590.13847