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ORIGINAL RESEARCH

Associations Between Serum TNF-α, IL-6, hs-CRP and GLMD in Obese Children and Adolescents: A Cross-Sectional Study

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Pages 3915-3923 | Received 08 Aug 2023, Accepted 22 Nov 2023, Published online: 02 Dec 2023

References

  • Cifuentes L, Camilleri M, Acosta A. Gastric sensory and motor functions and energy intake in health and obesity-therapeutic implications. Nutrients. 2021;13(4):1158–1187. doi:10.3390/nu13041158
  • Jebeile H, Kelly AS, O’Malley G, et al. Obesity in children and adolescents: epidemiology, causes, assessment, and management. Lancet Diabetes Endocrinol. 2022;10(5):351–365. doi:10.1016/S2213-8587(22)00047-X
  • Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol. 2021;9(6):373–392. doi:10.1016/S2213-8587(21)00045-0
  • Halbach SM, Flynn J. Treatment of obesity-related hypertension in children and adolescents. Curr Hypertens Rep. 2013;15(3):224–231. doi:10.1007/s11906-013-0334-7
  • Pulgaron ER, Delamater AM. Obesity and type 2 diabetes in children: epidemiology and treatment. Curr Diab Rep. 2014;14(8):508–519. doi:10.1007/s11892-014-0508-y
  • Zhu WF, Wang CL, Liang L, et al. Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents. Lipids Health Dis. 2014;13(1):93–99. doi:10.1186/1476-511X-13-93
  • Di Genova L, Penta L, Biscarini A, et al. Children with obesity and asthma: which are the best options for their management? Nutrients. 2018;10(11):1634–1647. doi:10.3390/nu10111634
  • Shaunak M, Byrne CD, Davis N, et al. Non-alcoholic fatty liver disease and childhood obesity. Arch Dis Child. 2021;106(1):3–8. doi:10.1136/archdischild-2019-318063
  • Small L, Aplasca A. Child obesity and mental health: a complex interaction. Child Adolesc Psychiatr Clin N Am. 2016;25(2):269–282. doi:10.1016/j.chc.2015.11.008
  • Liang XH, Xiao L, Chen JY, et al. The determinants of adolescent glycolipid metabolism disorder: a cohort study. Int J Endocrinol. 2022;2022:6214785. doi:10.1155/2022/6214785
  • Hosick P, McMurray R, Hackney AC, et al. Resting IL-6 and TNF-α level in children of different weight and fitness status. Pediatr Exerc Sci. 2013;25(2):238–247. doi:10.1123/pes.25.2.238
  • Jürimäe J, Võsoberg K, Tamm AL, et al. Body composition and inflammatory markers in pubertal girls: comparison between athletes and non-athletic controls. Eur J Sport Sci. 2017;17(7):867–873. doi:10.1080/17461391.2017.1315177
  • Utsal L, Tillmann V, Zilmer M, et al. Elevated serum IL-6, IL-8, MCP-1, CRP, and IFN-γ levels in 10- to 11-year-old boys with increased BMI. Horm Res Paediatr. 2012;78(1):31–39. doi:10.1159/000339831
  • Alvarez JA, Higgins PB, Oster RA, et al. Fasting and postprandial markers of inflammation in lean and overweight children. Am J Clin Nutr. 2009;89(4):1138–1144. doi:10.3945/ajcn.2008.26926
  • Bastard JP, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006;17(1):4–12.
  • Esteve E, Ricart W, Fernández-Real JM. Dyslipidemia and inflammation: an evolutionary conserved mechanism. Clin Nutr. 2005;24(1):16–31. doi:10.1016/j.clnu.2004.08.004
  • Shin SH, Lee YJ, Lee YA, et al. High-sensitivity C-reactive protein is associated with prediabetes and adiposity in Korean Youth. Metab Syndr Relat Disord. 2020;18(1):47–55. doi:10.1089/met.2019.0076
  • Kong Y, Zhang S, Wu R, et al. New insights into different adipokines in linking the pathophysiology of obesity and psoriasis. Lipids Health Dis. 2019;18(1):171–182. doi:10.1186/s12944-019-1115-3
  • Roth CL, Kratz M, Ralston MM, et al. Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children. Metabolism. 2011;60(4):445–452. doi:10.1016/j.metabol.2010.03.023
  • Sönmez HE, Canpolat N, Ağbaş A, et al. The relationship between the waist circumference and increased carotid intima thickness in obese children. Child Obes. 2019;15(7):468–475. doi:10.1089/chi.2019.0022
  • Jain V, Kumar A, Agarwala A, et al. Adiponectin, Interleukin-6 and high-sensitivity C-reactive protein levels in overweight/obese Indian children. Indian Pediatr. 2017;54(10):848–850. doi:10.1007/s13312-017-1148-5
  • Kamada Y, Takehara T, Hayashi N. Adipocytokines and liver disease. J Gastroenterol. 2008;43(11):811–822. doi:10.1007/s00535-008-2213-6
  • Grimble RF. Inflammatory status and insulin resistance. Curr Opin Clin Nutr Metab Care. 2002;5(5):551–559. doi:10.1097/00075197-200209000-00015
  • Patel R, Palit SP, Rathwa N, et al. Genetic variants of tumor necrosis factor-α and its levels: a correlation with dyslipidemia and type 2 diabetes susceptibility. Clin Nutr. 2019;38(3):1414–1422. doi:10.1016/j.clnu.2018.06.962
  • O’Neill BJ. Effect of low-carbohydrate diets on cardiometabolic risk, insulin resistance, and metabolic syndrome. Curr Opin Endocrinol Diabetes Obes. 2020;27(5):301–307. doi:10.1097/MED.0000000000000569
  • Nieto-Vazquez I, Fernández-Veledo S, Krämer DK, et al. Insulin resistance associated to obesity: the link TNF-alpha. Arch Physiol Biochem. 2008;114(3):183–194. doi:10.1080/13813450802181047
  • Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord. 2003;27(Suppl 3):S53–S55. doi:10.1038/sj.ijo.0802502
  • Nisar M, Iqbal MU. Influence of hs-CRP, IL-6 and TNF-α and it’s role in dyslipidemia and type 2 diabetes in population of Karachi, Pakistan. Pak J Pharm Sci. 2021;34(3(Special):1217–1225.
  • Marques-Vidal P, Bastardot F, von Känel R, et al. Association between circulating cytokine levels, diabetes and insulin resistance in a population-based sample (CoLaus study). Clin Endocrinol (Oxf). 2013;78(2):232–241. doi:10.1111/j.1365-2265.2012.04384.x
  • Lainampetch J, Panprathip P, Phosat C, et al. Association of tumor necrosis factor alpha, Interleukin 6, and C-Reactive protein with the risk of developing type 2 diabetes: a retrospective cohort study of rural Thais. J Diabetes Res. 2019;2019:9051929. doi:10.1155/2019/9051929