Alpha-Linolenic Acid Ameliorates Cognitive Impairment and Liver Damage Caused by Obesity

References

• Dubern B, Mosbah H, Pigeyre M, et al. Rare genetic causes of obesity: diagnosis and management in clinical care. Ann Endocrinol. 2022;83(1):63–72. doi:10.1016/j.ando.2021.12.003
   PubMed Web of Science ®Google Scholar
• Marcelin G, Silveira ALM, Martins LB, et al. Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis. J Clin Invest. 2019;129(10):4032–4040. doi:10.1172/JCI129192
   PubMed Web of Science ®Google Scholar
• Mayoral LP, Andrade G, Mayoral E-C, et al. Obesity subtypes, related biomarkers & heterogeneity. Indian J Med Res. 2020;151(1):11–21. doi:10.4103/ijmr.IJMR_1768_17
   PubMed Web of Science ®Google Scholar
• Piché ME, Tchernof A, Després JP. Obesity phenotypes, diabetes, and cardiovascular diseases. Circ Res. 2020;126(11):1477–1500. doi:10.1161/CIRCRESAHA.120.316101
   PubMed Web of Science ®Google Scholar
• Sandouk Z, Lansang MC. Diabetes with obesity--Is there an ideal diet? Cleve Clin J Med. 2017;84(7 Suppl 1):S4–s14. doi:10.3949/ccjm.84.s1.02
   PubMedGoogle Scholar
• Milić S, Lulić D, Štimac D. Non-alcoholic fatty liver disease and obesity: biochemical, metabolic and clinical presentations. World J Gastroenterol. 2014;20(28):9330–9337. doi:10.3748/wjg.v20.i28.9330
   PubMed Web of Science ®Google Scholar
• Tomlinson DJ, Erskine RM, Morse CI, et al. The impact of obesity on skeletal muscle strength and structure through adolescence to old age. Biogerontology. 2016;17(3):467–483. doi:10.1007/s10522-015-9626-4
   PubMed Web of Science ®Google Scholar
• Kim KB, Nam YA, Kim HS, et al. α-Linolenic acid: nutraceutical, pharmacological and toxicological evaluation. Food Chem Toxicol. 2014;70:163–178. doi:10.1016/j.fct.2014.05.009
   PubMed Web of Science ®Google Scholar
• Burdge G. Alpha-linolenic acid metabolism in men and women: nutritional and biological implications. Curr Opin Clin Nutr Metab Care. 2004;7(2):137–144. doi:10.1097/00075197-200403000-00006
   PubMed Web of Science ®Google Scholar
• Pan A, Chen M, Chowdhury R, et al. α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. Am J Clin Nutr. 2012;96(6):1262–1273. doi:10.3945/ajcn.112.044040
   PubMed Web of Science ®Google Scholar
• Desale SE, Dubey T, Chinnathambi S. α-Linolenic acid inhibits Tau aggregation and modulates Tau conformation. Int J Biol Macromol. 2021;166:687–693. doi:10.1016/j.ijbiomac.2020.10.226
   PubMed Web of Science ®Google Scholar
• de Lorgeril M, Salen P. Alpha-linolenic acid and coronary heart disease. Nutr, Metab Cardiovasc Dis. 2004;14(3):162–169. doi:10.1016/S0939-4753(04)80037-1
   PubMed Web of Science ®Google Scholar
• Hattiangady B, Mishra V, Kodali M, et al. Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness. Front Behav Neurosci. 2014;8:78. doi:10.3389/fnbeh.2014.00078
   PubMed Web of Science ®Google Scholar
• Subhramanyam CS, Wang C, Hu Q, et al. Microglia-mediated neuroinflammation in neurodegenerative diseases. Semin Cell Dev Biol. 2019;94:112–120. doi:10.1016/j.semcdb.2019.05.004
   PubMed Web of Science ®Google Scholar
• Piermartiri T, Pan H, Figueiredo T, et al. α-Linolenic Acid, A nutraceutical with pleiotropic properties that targets endogenous neuroprotective pathways to protect against organophosphate nerve agent-induced neuropathology. Molecules. 2015;20(11):20355–20380. doi:10.3390/molecules201119698
   PubMed Web of Science ®Google Scholar
• Gao H, Yan P, Zhang S, et al. Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: roles of PERK/eIF2α signaling pathway. Brain Behav Immun. 2016;57:314–325. doi:10.1016/j.bbi.2015.09.012
   PubMed Web of Science ®Google Scholar
• Lee AY, Lee MH, Lee S, et al. Neuroprotective effect of alpha-linolenic acid against Aβ-mediated inflammatory responses in C6 glial cell. J Agric Food Chem. 2018;66(19):4853–4861. doi:10.1021/acs.jafc.8b00836
   PubMed Web of Science ®Google Scholar
• Zabolotny JM, Kim Y-B, Welsh LA, et al. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem. 2008;283(21):14230–14241. doi:10.1074/jbc.M800061200
   PubMed Web of Science ®Google Scholar
• Vieira MN, Lyra e Silva NM, Ferreira ST, et al. Protein tyrosine phosphatase 1B (PTP1B): a potential target for alzheimer’s therapy? Front Aging Neurosci. 2017;9:7. doi:10.3389/fnagi.2017.00007
   PubMed Web of Science ®Google Scholar
• Fuentes F, Zimmer D, Atienza M, et al. Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning. PLoS One. 2012;7(7):e41536. doi:10.1371/journal.pone.0041536
   PubMed Web of Science ®Google Scholar
• Pathak NM, Pathak V, Lynch AM, et al. Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice. Mol Cell Endocrinol. 2015;412:95–103. doi:10.1016/j.mce.2015.05.035
   PubMed Web of Science ®Google Scholar
• Spires-Jones TL, Hyman BT. The intersection of amyloid beta and tau at synapses in Alzheimer’s disease. Neuron. 2014;82(4):756–771. doi:10.1016/j.neuron.2014.05.004
   PubMed Web of Science ®Google Scholar
• Jiang Y, Liu Y, Zhu C, et al. Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice. Neurobiol Learn Mem. 2015;121:20–29. doi:10.1016/j.nlm.2015.03.003
   PubMed Web of Science ®Google Scholar
• Head E, Corrada MM, Kahle-Wrobleski K, et al. Synaptic proteins, neuropathology and cognitive status in the oldest-old. Neurobiol Aging. 2009;30(7):1125–1134. doi:10.1016/j.neurobiolaging.2007.10.001
   PubMed Web of Science ®Google Scholar
• Whitfield DR, Vallortigara J, Alghamdi A, et al. Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer’s disease: association with cognitive impairment. Neurobiol Aging. 2014;35(12):2836–2844. doi:10.1016/j.neurobiolaging.2014.06.015
   PubMed Web of Science ®Google Scholar
• Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266–282. doi:10.1038/s41580-020-00324-8
   PubMed Web of Science ®Google Scholar
• Li J, Cao F, Yin H-L, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88. doi:10.1038/s41419-020-2298-2
   PubMed Web of Science ®Google Scholar
• Stockwell BR, Friedmann Angeli JP, Bayir H, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017;171(2):273–285. doi:10.1016/j.cell.2017.09.021
   PubMed Web of Science ®Google Scholar
• Lee JY, Nam M, Son HY, et al. Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer. Proc Natl Acad Sci U S A. 2020;117(51):32433–32442. doi:10.1073/pnas.2006828117
   PubMed Web of Science ®Google Scholar
• Mak HY, Ouyang Q, Tumanov S, et al. AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway. Nat Commun. 2021;12(1):6877. doi:10.1038/s41467-021-27279-4
   PubMed Web of Science ®Google Scholar
• Cautivo KM, Lizama CO, Tapia PJ, et al. AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue. Mol Metab. 2016;5(7):491–505. doi:10.1016/j.molmet.2016.05.004
   PubMed Web of Science ®Google Scholar
• Tapia PJ, Figueroa A-M, Eisner V, et al. Absence of AGPAT2 impairs brown adipogenesis, increases IFN stimulated gene expression and alters mitochondrial morphology. Metabolism. 2020;111:154341. doi:10.1016/j.metabol.2020.154341
   PubMed Web of Science ®Google Scholar