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ORIGINAL RESEARCH

The Metabolic Score for Insulin Resistance Index is Superior to the Triglyceride and Glucose Index in Identifying Nonalcoholic Fatty Liver Disease in Hyperuricemia Subjects

, ORCID Icon & ORCID Icon
Pages 4235-4246 | Received 02 Oct 2023, Accepted 13 Dec 2023, Published online: 27 Dec 2023

References

  • Younossi Z, Tacke F, Arrese M, et al. Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis. Hepatology. 2019;69(6):2672–2682. doi:10.1002/hep.30251
  • Yang C, Yang S, Xu W, Zhang J, Fu W, Feng C. Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population: a retrospective cohort study. PLoS One. 2017;12(5):e0177249. doi:10.1371/journal.pone.0177249
  • Zhou F, Zhou J, Wang W, et al. Unexpected rapid increase in the burden of NAFLD in China from 2008 to 2018: a Systematic review and meta-analysis. Hepatology. 2019;70(4):1119–1133. doi:10.1002/hep.30702
  • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55(6):2005–2023. doi:10.1002/hep.25762
  • Yang C, He Q, Chen Z, et al. A bidirectional relationship between hyperuricemia and metabolic dysfunction-associated fatty liver disease. Front Endocrinol. 2022;13:821689. doi:10.3389/fendo.2022.821689
  • Duell PB, Welty FK, Miller M, et al. Nonalcoholic fatty liver disease and cardiovascular risk: a scientific statement from the American Heart Association. Arterioscler Thromb Vasc Biol. 2022;42(6):e168–e185. doi:10.1161/ATV.0000000000000153
  • Hediger MA, Johnson RJ, Miyazaki H, Endou H. Molecular physiology of urate transport. Physiology. 2005;20:125–133.
  • Yanai H, Adachi H, Hakoshima M, Katsuyama H. Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome, cardiovascular diseases and chronic kidney disease. Int J Mol Sci. 2021;22(17):9221. doi:10.3390/ijms22179221
  • Helget LN, Mikuls TR. Environmental triggers of hyperuricemia and gout. Rheum Dis Clin North Am. 2022;48(4):891–906. doi:10.1016/j.rdc.2022.06.009
  • Wang J, Qin T, Chen J, et al. Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. PLoS One. 2014;9(12):e114259. doi:10.1371/journal.pone.0114259
  • Peng L-H, He Y, Xu W-D, et al. Carotid intima-media thickness in patients with hyperuricemia: a systematic review and meta-analysis. Aging Clin Exp Res. 2021;33(11):2967–2977. doi:10.1007/s40520-021-01850-x
  • Li Y, Xu C, Yu C, Xu L, Miao M. Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study. J Hepatol. 2009;50(5):1029–1034. doi:10.1016/j.jhep.2008.11.021
  • Wan X, Xu C, Lin Y, et al. Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism. J Hepatol. 2016;64(4):925–932. doi:10.1016/j.jhep.2015.11.022
  • Choi Y-J, Shin H-S, Choi HS, et al. Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. Lab Invest. 2014;94(10):1114–1125. doi:10.1038/labinvest.2014.98
  • Li X, Huang W, Gu J, et al. SREBP-1c overactivates ROS-mediated hepatic NF-κB inflammatory pathway in dairy cows with fatty liver. Cell Signal. 2015;27(10):2099–2109. doi:10.1016/j.cellsig.2015.07.011
  • Xu C. Hyperuricemia and nonalcoholic fatty liver disease: from bedside to bench and back. Hepatol Internat. 2016;10(2):286–293. doi:10.1007/s12072-015-9682-5
  • Wang F-S, Fan J-G, Zhang Z, Gao B, Wang H-Y. The global burden of liver disease: the major impact of China. Hepatology. 2014;60(6):2099–2108. doi:10.1002/hep.27406
  • Bello-Chavolla OY, Almeda-Valdes P, Gomez-Velasco D, et al. METS-IR, a novel score to evaluate insulin sensitivity, is predictive of visceral adiposity and incident type 2 diabetes. Eur J Endocrinol. 2018;178(5):533–544. doi:10.1530/EJE-17-0883
  • Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008;6(4):299–304. doi:10.1089/met.2008.0034
  • Liu XZ, Fan J, Pan SJ. METS-IR, a novel simple insulin resistance indexes, is associated with hypertension in normal-weight Chinese adults. J Clin Hypertens. 2019;21(8):1075–1081. doi:10.1111/jch.13591
  • Tao L-C, J-N X, Wang -T-T, Hua F, Li -J-J. Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations. Cardiovasc Diabetol. 2022;21(1):68. doi:10.1186/s12933-022-01511-x
  • Petrescu M, Vlaicu SI, Ciumărnean L, et al. Chronic inflammation-a link between Nonalcoholic Fatty Liver Disease (NAFLD) and dysfunctional adipose tissue. Medicina. 2022;58(5):641. doi:10.3390/medicina58050641
  • Aktas G, Khalid A, Kurtkulagi O, et al. Poorly controlled hypertension is associated with elevated serum uric acid to HDL-cholesterol ratio: a cross-sectional cohort study. Postgrad Med. 2022;134(3):297–302. doi:10.1080/00325481.2022.2039007
  • Kurtkulagi O, Tel BMA, Kahveci G, et al. Hashimoto’s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio. Rom J Intern Med. 2021;59(4):403–408. doi:10.2478/rjim-2021-0023
  • Kocak MZ, Aktas G, Erkus E, Sincer I, Atak B, Duman T. Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus. Rev Assoc Med Bras. 2019;65(1). doi:10.1590/1806-9282.65.1.9
  • Aktas G, Kocak MZ, Bilgin S, Atak BM, Duman TT, Kurtkulagi O. Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. Aging Male. 2020;23(5):1098–1102. doi:10.1080/13685538.2019.1678126
  • Zhou C, Liu M, Zhang Z, et al. Positive association of serum uric acid with new-onset diabetes in Chinese women with hypertension in a retrospective analysis of the China Stroke Primary Prevention Trial. Diabetes Obes Metab. 2020;22(9):1598–1606. doi:10.1111/dom.14072
  • Aktas G, Yilmaz S, Kantarci DB, et al. Is serum uric acid-to-HDL cholesterol ratio elevation associated with diabetic kidney injury? Postgrad Med. 2023;135(5):519–523. doi:10.1080/00325481.2023.2214058
  • Kosekli MA, Kurtkulagii O, Kahveci G, et al. The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: the abund study. Rev Assoc Med Bras. 2021;67(4):549–554. doi:10.1590/1806-9282.20201005
  • van Buuren S, Groothuis-Oudshoorn K. Mice: multivariate Imputation by Chained Equations in R. Journal of Statistical Software. 2011;45(3):1–67. doi:10.18637/jss.v045.i03
  • Castera L, Friedrich-Rust M, Loomba R. Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease. Gastroenterology. 2019;156(5):1264–1281.e4.
  • Huang X, He J, Wu G, Peng Z, Yang B, Ye L. TyG-BMI and hypertension in Normoglycemia subjects in Japan: a cross-sectional study. Diab Vasc Dis Res. 2023;20(3):14791641231173617. doi:10.1177/14791641231173617
  • Akin F, Altun İ, Ayca B, Kose N, Altun İ. Associations of non-HDL-C and triglyceride/HDL-C ratio with coronary plaque burden and plaque characteristics in young adults. Bosn J Basic Med Sci. 2022;22(6):1025–1032. doi:10.17305/bjbms.2022.7142
  • Al Akl NS, Haoudi EN, Bensmail H, Arredouani A. The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: a cross-sectional study. Front Public Health. 2023;11:1086771. doi:10.3389/fpubh.2023.1086771
  • Zhang S, Du T, Zhang J, et al. The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease. Lipids Health Dis. 2017;16(1):15. doi:10.1186/s12944-017-0409-6
  • Song K, Lee HW, Choi HS, et al. Comparison of the modified TyG indices and other parameters to predict non-alcoholic fatty liver disease in youth. Biology. 2022;11(5):685. doi:10.3390/biology11050685
  • Smiderle CA, Coral GP, De Carli LA, Mattos AAD, Mattos AZD, Tovo CV. Performace of triglyceride-glucose index on diagnosis and staging of nafld in obese patients. Arq Gastroenterol. 2021;58(2):139–144. doi:10.1590/S0004-2803.202100000-24
  • Widjaja NA, Irawan R, Hanindita MH, Ugrasena I, Handajani R. METS-IR vs. HOMA-AD and metabolic syndrome in obese adolescents. J Med Invest. 2023;70(1.2):7–16.
  • Lee J-H, Park K, Lee HS, Park H-K, Han JH, Ahn SB. The usefulness of metabolic score for insulin resistance for the prediction of incident non-alcoholic fatty liver disease in Korean adults. Clin Mol Hepatol. 2022;28(4):814–826. doi:10.3350/cmh.2022.0099
  • Han T, Lan L, Qu R, et al. Temporal relationship between hyperuricemia and insulin resistance and its impact on future risk of hypertension. Hypertension. 2017;70(4):703–711. doi:10.1161/HYPERTENSIONAHA.117.09508
  • Mazidi M, Katsiki N, Mikhailidis DP, Banach M. The link between insulin resistance parameters and serum uric acid is mediated by adiposity. Atherosclerosis. 2018;270:180–186. doi:10.1016/j.atherosclerosis.2017.12.033
  • Gastaldelli A. Insulin resistance and reduced metabolic flexibility: cause or consequence of NAFLD? Clin Sci. 2017;131(22):2701–2704. doi:10.1042/CS20170987
  • Zhang M, Zhu X, Wu J, et al. Prevalence of hyperuricemia among Chinese adults: findings from two nationally representative cross-sectional surveys in 2015–16 and 2018–19. Front Immunol. 2021;12:791983. doi:10.3389/fimmu.2021.791983
  • Chen Z, Qin H, Qiu S, Chen G, Chen Y. Correlation of triglyceride to high-density lipoprotein cholesterol ratio with nonalcoholic fatty liver disease among the non-obese Chinese population with normal blood lipid levels: a retrospective cohort research. Lipids Health Dis. 2019;18(1):162. doi:10.1186/s12944-019-1104-6
  • Perumpail BJ, Khan MA, Yoo ER, Cholankeril G, Kim D, Ahmed A. Clinical epidemiology and disease burden of nonalcoholic fatty liver disease. World J Gastroenterol. 2017;23(47):8263–8276. doi:10.3748/wjg.v23.i47.8263
  • Yen P-C, Chou Y-T, Li C-H, et al. Hyperuricemia is associated with significant liver fibrosis in subjects with nonalcoholic fatty liver disease, but not in subjects without it. J Clin Med. 2022;11(5):1445. doi:10.3390/jcm11051445