A Gender-, Age-, and Weight Status-Specific Analysis of the High Prevalence of Hyperuricemia Among Chinese Children and Adolescents with Obesity

References

• Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol. 2021;9(6):373–392. doi:10.1016/S2213-8587(21)00045-0
   PubMed Web of Science ®Google Scholar
• Reilly JJ. Health effects of overweight and obesity in 195 countries. N Engl J Med. 2017;377:1496.
   PubMedGoogle Scholar
• Okronipa H, Arimond M, Young RR, et al. Exposure to a slightly sweet lipid-based nutrient supplement during early life does not increase the preference for or consumption of sweet foods and beverages by 4–6-y-old Ghanaian preschool children: follow-up of a randomized controlled trial. J Nutr. 2019;149(3):532–541. doi:10.1093/jn/nxy293
   PubMed Web of Science ®Google Scholar
• Cali AM, Caprio S. Obesity in children and adolescents. J Clin Endocrinol Metab. 2008;93:S31–S36. doi:10.1210/jc.2008-1363
   PubMed Web of Science ®Google Scholar
• Morales CW, Molina DJ, Plata OS, Plata OJ, Morales CM, Calderón BP. Childhood obesity: aetiology, comorbidities, and treatment. Diabetes Metab Res Rev. 2019;35(8):e3203. doi:10.1002/dmrr.3203
   PubMed Web of Science ®Google Scholar
• Su J, Wei Y, Liu M, et al. Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice. Arch Pharm Res. 2014;37(10):1336–1344. doi:10.1007/s12272-014-0413-6
   PubMed Web of Science ®Google Scholar
• Rao J, Ye P, Lu J, et al. Prevalence and related factors of hyperuricaemia in Chinese children and adolescents: a pooled analysis of 11 population-based studies. Ann Med. 2022;54(1):1608–1615. doi:10.1080/07853890.2022.2083670
   PubMed Web of Science ®Google Scholar
• Chen YC, Liu YH, Wu PY, et al. Synergetic association between anemia and hyperuricemia on new-onset chronic kidney disease in a large Taiwanese population follow-up study. Int J Environ Res Public Health. 2023;4:20.
   Google Scholar
• Singh SK, Singh R, Singh SK, Iquebal MA, Jaiswal S, Singh A. Prevalence of hyperuricemia and the relationship between serum uric acid and hypertension in new onset diabetic patients: a cross-sectional Indian Study. Diabetes Metab Syndr Obes. 2022;15:1809–1817. doi:10.2147/DMSO.S363311
   PubMed Web of Science ®Google Scholar
• Molla NH, Kathak RR, Sumon AH, et al. Assessment of the relationship between serum uric acid levels and liver enzymes activity in Bangladeshi adults. Sci Rep. 2021;11(1):20114. doi:10.1038/s41598-021-99623-z
   PubMed Web of Science ®Google Scholar
• Ali N, Miah R, Hasan M, et al. Association between serum uric acid and metabolic syndrome: a cross-sectional study in Bangladeshi adults. Sci Rep. 2020;10(1):7841. doi:10.1038/s41598-020-64884-7
   PubMed Web of Science ®Google Scholar
• Haque T, Rahman S, Islam S, Molla NH, Ali N. Assessment of the relationship between serum uric acid and glucose levels in healthy, prediabetic and diabetic individuals. Diabetol Metab Syndr. 2019;11(1):49. doi:10.1186/s13098-019-0446-6
   PubMed Web of Science ®Google Scholar
• Ali N, Mahmood S, Islam F, et al. Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults. Sci Rep. 2019;9(1):9061. doi:10.1038/s41598-019-45680-4
   PubMed Web of Science ®Google Scholar
• Ali N, Rahman S, Islam S, et al. The relationship between serum uric acid and lipid profile in Bangladeshi adults. BMC Cardiovasc Disord. 2019;19(1):42. doi:10.1186/s12872-019-1026-2
   PubMed Web of Science ®Google Scholar
• Duan Y, Liang W, Zhu L, et al. Association between serum uric acid levels and obesity among university students (China). Nutr Hosp. 2015;31(6):2407–2411. doi:10.3305/nh.2015.31.6.8734
   PubMed Web of Science ®Google Scholar
• Qin L, Yang Z, Gu H, et al. Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals. BMC Cardiovasc Disord. 2014;14(1):26. doi:10.1186/1471-2261-14-26
   PubMedGoogle Scholar
• Dehghan A, van Hoek M, Sijbrands EJ, Hofman A, Witteman JC. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care. 2008;31(2):361–362. doi:10.2337/dc07-1276
   PubMed Web of Science ®Google Scholar
• Cardoso AS, Gonzaga NC, Medeiros CC, Carvalho DF. Association of uric acid levels with components of metabolic syndrome and non-alcoholic fatty liver disease in overweight or obese children and adolescents. J Pediatr. 2013;89(4):412–418. doi:10.1016/j.jped.2012.12.008
   Google Scholar
• Kubota M. Hyperuricemia in children and adolescents: present knowledge and future directions. J Nutr Metab. 2019;2019:3480718. doi:10.1155/2019/3480718
   PubMed Web of Science ®Google Scholar
• Guo X, Xiao N, Jing X, Zhu Z, Zhang H. Analysis of the prevalence and influencing factors of hyperuricemia in children and adolescents aged 6–17 years in northeastern Sichuan Province. J Pediatr. 2023;99(6):604–609. doi:10.1016/j.jped.2023.05.001
   Google Scholar
• Kuczmarski RJ, Ogden CL, Guo SS, et al. CDC Growth Charts for the United States: Methods and Development. National Center for Health Statistics; 2000:1–190.
   Google Scholar
• Xie L, Mo P, Tang Q, et al. Skeletal muscle mass has stronger association with the risk of hyperuricemia than body fat mass in obese children and adolescents. Front Nutr. 2022;9:792234. doi:10.3389/fnut.2022.792234
   PubMed Web of Science ®Google Scholar
• Skinner AC, Skelton JA. Prevalence and trends in obesity and severe obesity among children in the United States, 1999–2012. JAMA Pediatr. 2014;168(6):561–566. doi:10.1001/jamapediatrics.2014.21
   PubMed Web of Science ®Google Scholar
• Skinner AC, Ravanbakht SN, Skelton JA, Perrin EM, Armstrong SC. Prevalence of obesity and severe obesity in US Children, 1999–2016. Pediatrics. 2018;4:141.
   Google Scholar
• Huang YF, Yang KH, Chen SH, et al. 高尿酸血症/痛风患者实践指南[Practice guideline for patients with hyperuricemia/gout]. Zhonghua Nei Ke Za Zhi. 2020;59(7):519–527. Chinese. doi:10.3760/cma.j.cn112138-20200505-00449
   PubMedGoogle Scholar
• Qian Y, Kong YW, Wan NJ, Yan YK. Associations between body mass index in different childhood age periods and hyperuricemia in young adulthood: the China Health and Nutrition Survey cohort study. World J Pediatr. 2022;18(10):680–686. doi:10.1007/s12519-022-00573-x
   PubMed Web of Science ®Google Scholar
• Lee JH. Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016–2017 Korea National Health and Nutrition Examination Survey. Korean J Pediatr. 2019;62(8):317–323. doi:10.3345/kjp.2019.00444
   PubMedGoogle Scholar
• Wei Y, Zhu J, Wetzstein SA. Plasma and water fluoride levels and hyperuricemia among adolescents: a cross-sectional study of a nationally representative sample of the United States for 2013–2016. Ecotoxicol Environ Saf. 2021;208:111670. doi:10.1016/j.ecoenv.2020.111670
   PubMed Web of Science ®Google Scholar
• Tang L, Kubota M, Nagai A, Mamemoto K, Tokuda M. Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome. Pediatr Rep. 2010;2(1):e12. doi:10.4081/pr.2010.e12
   PubMedGoogle Scholar
• Liang XJ, Gong CX, Liu Y, Liu M, Gu Y. Association study of children type 2 diabetes mellitus with hyperuricemia and insulin resistance, lipid. Chin J Diabetes. 2015;23:726–729.
   Google Scholar
• Moulin-Mares S, Oliosa PR, Faria ER, Zago-Gomes MP, Mill JG. Association of uric acid with cardiovascular risk in Brazilian children and adolescents. Nutr, Metab Cardiovasc Dis. 2021;31(1):314–321. doi:10.1016/j.numecd.2020.09.012
   PubMed Web of Science ®Google Scholar
• Jørgensen RM, Bøttger B, Vestergaard ET, et al. Uric acid is elevated in children with obesity and decreases after weight loss. Front Pediatr. 2021;9:814166. doi:10.3389/fped.2021.814166
   PubMed Web of Science ®Google Scholar
• Krzystek-Korpacka M, Patryn E, Kustrzeba-Wojcicka I, Chrzanowska J, Gamian A, Noczynska A. The effect of a one-year weight reduction program on serum uric acid in overweight/obese children and adolescents. Clin Chem Lab Med. 2011;49(5):915–921. doi:10.1515/CCLM.2011.130
   PubMed Web of Science ®Google Scholar
• Weihrauch-Blüher S, Wiegand S, Weihe P, et al. Uric acid and gamma-glutamyl-transferase in children and adolescents with obesity: association to anthropometric measures and cardiometabolic risk markers depending on pubertal stage, sex, degree of weight loss and type of patient care: evaluation of the adiposity patient follow-up registry. Pediatr Obes. 2023;18(3):e12989. doi:10.1111/ijpo.12989
   PubMed Web of Science ®Google Scholar
• Yun M, Zhang T, Li S, et al. Temporal relationship between body mass index and uric acid and their joint impact on blood pressure in children and adults: the Bogalusa Heart Study. Int J Obes. 2021;45(7):1457–1463. doi:10.1038/s41366-021-00810-9
   Web of Science ®Google Scholar
• Luciano R, Shashaj B, Spreghini M, et al. Percentiles of serum uric acid and cardiometabolic abnormalities in obese Italian children and adolescents. Ital J Pediatr. 2017;43(1):3. doi:10.1186/s13052-016-0321-0
   PubMedGoogle Scholar
• Krzystek-Korpacka M, Patryn E, Kustrzeba-Wojcicka I, Chrzanowska J, Gamian A, Noczynska A. Gender-specific association of serum uric acid with metabolic syndrome and its components in juvenile obesity. Clin Chem Lab Med. 2011;49(1):129–136. doi:10.1515/CCLM.2011.011
   PubMed Web of Science ®Google Scholar
• Tsouli SG, Liberopoulos EN, Mikhailidis DP, Athyros VG, Elisaf MS. Elevated serum uric acid levels in metabolic syndrome: an active component or an innocent bystander? Metabolism. 2006;55(10):1293–1301. doi:10.1016/j.metabol.2006.05.013
   PubMed Web of Science ®Google Scholar
• Özalp KD, Şen S, Ersoy B. Associations between serum uric acid concentrations and cardiometabolic risk and renal injury in obese and overweight children. J Clin Res Pediatr Endocrinol. 2019;11(3):262–269. doi:10.4274/jcrpe.galenos.2018.2019.0241
   PubMed Web of Science ®Google Scholar
• Wun YT, Chan CS, Lui CS. Hyperuricaemia in Type 2 diabetes mellitus. Diabetes Nutr Metab. 1999;12(4):286–291.
   PubMedGoogle Scholar
• Hou X, Guan Y, Tang Y, et al. A correlation study of the relationships between nonalcoholic fatty liver disease and serum triglyceride concentration after an oral fat tolerance test. Lipids Health Dis. 2021;20(1):54. doi:10.1186/s12944-021-01483-z
   PubMed Web of Science ®Google Scholar
• Zhou X, Lin X, Chen J, et al. Clinical spectrum transition and prediction model of nonalcoholic fatty liver disease in children with obesity. Front Endocrinol. 2022;13:986841. doi:10.3389/fendo.2022.986841
   PubMed Web of Science ®Google Scholar
• Liang XJ, Gong CX, Liu Y, et al. Characteristics and related factors of type 2 diabetes mellitus with non-alcoholic fatty liver disease in children. Chin J Diabetes Mellitus. 2018;10:482–486.
   Google Scholar
• Afzali A, Weiss NS, Boyko EJ, Ioannou GN. Association between serum uric acid level and chronic liver disease in the United States. Hepatology. 2010;52(2):578–589. doi:10.1002/hep.23717
   PubMed Web of Science ®Google Scholar
• Fathallah-Shaykh SA, Cramer MT. Uric acid and the kidney. Pediatr Nephrol. 2014;29(6):999–1008. doi:10.1007/s00467-013-2549-x
   PubMed Web of Science ®Google Scholar
• Viazzi F, Leoncini G, Ratto E, Pontremoli R. Hyperuricemia and renal risk. High Blood Press Cardiovasc Prev. 2014;21(3):189–194. doi:10.1007/s40292-014-0042-7
   PubMedGoogle Scholar
• Yahyaoui R, Esteva I, Haro-Mora JJ, et al. Effect of long-term administration of cross-sex hormone therapy on serum and urinary uric acid in transsexual persons. J Clin Endocrinol Metab. 2008;93(6):2230–2233. doi:10.1210/jc.2007-2467
   PubMed Web of Science ®Google Scholar
• Harlan WR, Cornoni-Huntley J, Leaverton PE. Physiologic determinants of serum urate levels in adolescence. Pediatrics. 1979;63(4):569–575. doi:10.1542/peds.63.4.569
   PubMed Web of Science ®Google Scholar
• Dai C, Wang C, Xia F, et al. Age and gender-specific reference intervals for uric acid level in children aged 5–14 years in southeast Zhejiang province of china: hyperuricemia in children may need redefinition. Front Pediatr. 2021;9:560720. doi:10.3389/fped.2021.560720
   PubMed Web of Science ®Google Scholar
• Wells JC. Sexual dimorphism of body composition. Best Pract Res Clin Endocrinol Metab. 2007;21(3):415–430. doi:10.1016/j.beem.2007.04.007
   PubMed Web of Science ®Google Scholar