Autophagy, Pyroptosis and Ferroptosis are Rising Stars in the Pathogenesis of Diabetic Nephropathy

References

• Demir Y, Ceylan H, Türkeş C, et al. Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes. J Biomol Struct Dyn. 2022;40(22):12008–12021. doi:10.1080/07391102.2021.1967195
   PubMed Web of Science ®Google Scholar
• Sever B, Altıntop MD, Demir Y, et al. Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds. Bioorg Chem. 2020;102:104110. doi:10.1016/j.bioorg.2020.104110
   PubMed Web of Science ®Google Scholar
• Sun H, Saeedi P, Karuranga S, et al. IDF diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2021:109119. doi:10.1016/j.diabres.2021.109119
   PubMed Web of Science ®Google Scholar
• Bjornstad P, Drews KL; TODAY Study Group. Long-term complications in youth-onset type 2 diabetes. N Engl J Med. 2021;385(5):416–426. doi:10.1056/NEJMoa2100165
   PubMed Web of Science ®Google Scholar
• Sever B, Altıntop MD, Demir Y, et al. Identification of a new class of potent aldose reductase inhibitors: design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines. Chem Biol Interact. 2021;345:109576. doi:10.1016/j.cbi.2021.109576
   PubMed Web of Science ®Google Scholar
• Sinha N, Kumar V, Puri V, et al. Urinary exosomes: potential biomarkers for diabetic nephropathy. Nephrology. 2020;25(12):881–887. doi:10.1111/nep.13720
   PubMed Web of Science ®Google Scholar
• Dong C, Liu S, Cui Y, et al. 12-Lipoxygenase as a key pharmacological target in the pathogenesis of diabetic nephropathy. Eur J Pharmacol. 2020;879:173122. doi:10.1016/j.ejphar.2020.173122
   PubMed Web of Science ®Google Scholar
• Tokalı FS, Demir Y, Türkeş C, et al. Novel acetic acid derivatives containing quinazolin-4(3H)-one ring: synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors. Drug Dev Res. 2023;84(2):275–295. doi:10.1002/ddr.22031
   PubMed Web of Science ®Google Scholar
• Koch EAT, Nakhoul R, Nakhoul F, et al. Autophagy in diabetic nephropathy: a review. Int Urol Nephrol. 2020;52(9):1705–1712. doi:10.1007/s11255-020-02545-4
   PubMed Web of Science ®Google Scholar
• Sun H, Yuan Y, Sun Z. Update on mechanisms of renal tubule injury caused by advanced glycation end products. Biomed Res Int. 2016;2016:5475120. doi:10.1155/2016/5475120
   PubMed Web of Science ®Google Scholar
• Ke R, Wang Y, Hong S, Xiao L. Endoplasmic reticulum stress related factor IRE1α regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy. Exp Cell Res. 2020;396(2):112293. doi:10.1016/j.yexcr.2020.112293
   PubMed Web of Science ®Google Scholar
• Wu X, Li H, Wan Z, et al. The combination of ursolic acid and empagliflozin relieves diabetic nephropathy by reducing inflammation, oxidative stress and renal fibrosis. Biomed Pharmacother. 2021;144:112267. doi:10.1016/j.biopha.2021.112267
   PubMed Web of Science ®Google Scholar
• Demir Y, Tokalı FS, Kalay E, et al. Synthesis and characterization of novel acyl hydrazones derived from vanillin as potential aldose reductase inhibitors. Mol Divers. 2023;27(4):1713–1733. doi:10.1007/s11030-022-10526-1
   PubMed Web of Science ®Google Scholar
• Liang Q, Liu T, Guo T, et al. ATF4 promotes renal tubulointerstitial fibrosis by suppressing autophagy in diabetic nephropathy. Life Sci. 2021;264:118686. doi:10.1016/j.lfs.2020.118686
   PubMed Web of Science ®Google Scholar
• Wen S, Deng F, Li L, et al. VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation. J Diabetes Investig. 2022;13(1):22–33. doi:10.1111/jdi.13660
   PubMed Web of Science ®Google Scholar
• Jia Y, Xu H, Yu Q, et al. Identification and verification of vascular cell adhesion protein 1 as an immune-related hub gene associated with the tubulointerstitial injury in diabetic kidney disease. Bioengineered. 2021;12(1):6655–6673. doi:10.1080/21655979.2021.1976540
   PubMed Web of Science ®Google Scholar
• Eftekhari A, Vahed SZ, Kavetskyy T, et al. Cell junction proteins: crossing the glomerular filtration barrier in diabetic nephropathy. Int J Biol Macromol. 2020;148:475–482. doi:10.1016/j.ijbiomac.2020.01.168
   PubMed Web of Science ®Google Scholar
• Lee YH, Kim J, Park K, et al. β-cell autophagy: mechanism and role in β-cell dysfunction. Mol Metab. 2019;27S(Suppl):S92–S103. doi:10.1016/j.molmet.2019.06.014
   PubMedGoogle Scholar
• New J, Thomas SM. Autophagy-dependent secretion: mechanism, factors secreted, and disease implications. Autophagy. 2019;15(10):1682–1693. doi:10.1080/15548627.2019.1596479
   PubMed Web of Science ®Google Scholar
• Li XD, He SS, Wan TT, et al. Liraglutide protects palmitate-induced INS-1 cell injury by enhancing autophagy mediated via FoxO1. Mol Med Rep. 2021;23(2):147. doi:10.3892/mmr.2020.11786
   PubMed Web of Science ®Google Scholar
• Gong W, Shi Y, Ren J. Research progresses of molecular mechanism of pyroptosis and its related diseases. Immunobiology. 2020;225(2):151884. doi:10.1016/j.imbio.2019.11.019
   PubMed Web of Science ®Google Scholar
• Kesavardhana S, Malireddi RKS, Kanneganti TD. Caspases in Cell Death, Inflammation, and Pyroptosis. Annu Rev Immunol. 2020;38:567–595. doi:10.1146/annurev-immunol-073119-095439
   PubMed Web of Science ®Google Scholar
• Feng S, Fox D, Man SM. Mechanisms of gasdermin family members in inflammasome signaling and cell death. J Mol Biol. 2018;430(18 Pt B):3068–3080. doi:10.1016/j.jmb.2018.07.002
   PubMed Web of Science ®Google Scholar
• Sharma BR, Kanneganti TD. NLRP3 inflammasome in cancer and metabolic diseases. Nat Immunol. 2021;22(5):550–559. doi:10.1038/s41590-021-00886-5
   PubMed Web of Science ®Google Scholar
• Li Z, Lange M, Dixon SJ, et al. Lipid quality control and ferroptosis: from concept to mechanism. Annu Rev Biochem. 2023. doi:10.1146/annurev-biochem-052521-033527
   Google Scholar
• Xia D, Zang J. Telmisartan combined with calcitriol enhances therapeutic efficacy for diabetic nephropathy while inhibiting inflammation and renal interstitial fibrosis. Am J Transl Res. 2023;15(11):6543–6550.
   PubMed Web of Science ®Google Scholar
• Kocak MZ, Aktas G, Duman TT, et al. Monocyte lymphocyte ratio as a predictor of diabetic kidney injury in type 2 diabetes mellitus; the MADKID Study. J Diabetes Metab Disord. 2020;19(2):997–1002. doi:10.1007/s40200-020-00595-0
   PubMed Web of Science ®Google Scholar
• Kocak MZ, Aktas G, Duman TT, et al. Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy? Rev Assoc Med Bras. 2019;65(9):1155–1160. doi:10.1590/1806-9282.65.9.1156
   PubMed Web of Science ®Google Scholar
• Taslamacioglu Duman T, Ozkul FN, Balci B. Could systemic inflammatory index predict diabetic kidney injury in type 2 diabetes mellitus? Diagnostics. 2023;13(12):2063. doi:10.3390/diagnostics13122063
   Web of Science ®Google Scholar
• Kimura T, Isaka Y, Yoshimori T. Autophagy and kidney inflammation. Autophagy. 2017;13(6):997–1003. doi:10.1080/15548627.2017.1309485
   PubMed Web of Science ®Google Scholar
• Lin L, Zhang MX, Zhang L, et al. Autophagy, pyroptosis, and ferroptosis: new regulatory mechanisms for atherosclerosis. Front Cell Dev Biol. 2022;9:809955. doi:10.3389/fcell.2021.809955
   PubMed Web of Science ®Google Scholar
• Aktas G, Atak Tel BM, Tel R, et al. Treatment of type 2 diabetes patients with heart conditions. Expert Rev Endocrinol Metab. 2023;18(3):255–265. doi:10.1080/17446651.2023.2204941;
   PubMed Web of Science ®Google Scholar
• Aktas G. Association between the prognostic nutritional index and chronic microvascular complications in patients with type 2 diabetes mellitus. J Clin Med. 2023;12(18):5952. doi:10.3390/jcm12185952
   PubMed Web of Science ®Google Scholar
• Hu Y, Wang SX, Wu FY, et al. Effects and mechanism of ganoderma lucidum polysaccharides in the treatment of diabetic nephropathy in streptozotocin-induced diabetic rats. Biomed Res Int. 2022;2022:4314415. doi:10.1155/2022/4314415
   PubMed Web of Science ®Google Scholar
• Zhong Y, Liu J, Sun D, et al. Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control. Food Funct. 2022;13(6):3660–3673. doi:10.1039/d1fo02733f
   PubMed Web of Science ®Google Scholar
• Zhang X, Zhang L, Chen Z, et al. Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway. Int J Mol Med. 2021;47(3):27. doi:10.3892/ijmm.2021.4860
   PubMed Web of Science ®Google Scholar
• Di Tu Q, Jin J, Hu X, et al. Curcumin improves the renal autophagy in rat experimental membranous nephropathy via regulating the PI3K/AKT/mTOR and Nrf2/HO-1 signaling pathways. Biomed Res Int. 2020;2020:7069052. doi:10.1155/2020/7069052
   PubMed Web of Science ®Google Scholar
• Xu J, Deng Y, Wang Y, et al. SPAG5-AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway. Cell Prolif. 2020;53(2):e12738. doi:10.1111/cpr.12738
   PubMed Web of Science ®Google Scholar
• Jin J, Shi Y, Gong J, et al. Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte. Stem Cell Res Ther. 2019;10(1):95. doi:10.1186/s13287-019-1177-1
   PubMed Web of Science ®Google Scholar
• Xu L, Fan Q, Wang X, et al. Ursolic acid improves podocyte injury caused by high glucose. Nephrol Dial Transplant. 2017;32(8):1285–1293. doi:10.1093/ndt/gfv382
   PubMed Web of Science ®Google Scholar
• Wang X, Gao Y, Tian N, et al. Astragaloside IV inhibits glucose-induced epithelial-mesenchymal transition of podocytes through autophagy enhancement via the SIRT-NF-κB p65 axis. Sci Rep. 2019;9(1):323. doi:10.1038/s41598-018-36911-1
   PubMed Web of Science ®Google Scholar
• Barbosa AA, Zhou H, Hültenschmidt D, et al. Inhibition of cellular autophagy in proximal tubular cells of the kidney in streptozotocin-diabetic and uninephrectomized rats. Virchows Arch B Cell Pathol Incl Mol Pathol. 1992;61(6):359–366. doi:10.1007/BF02890439
   PubMedGoogle Scholar
• Yoshibayashi M, Kume S, Yasuda-Yamahara M, et al. Protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes. Biochem Biophys Res Commun. 2020;525(2):319–325. doi:10.1016/j.bbrc.2020.02.088
   PubMed Web of Science ®Google Scholar
• Lenoir O, Jasiek M, Hénique C, et al. Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis. Autophagy. 2015;11(7):1130–1145. doi:10.1080/15548627.2015.1049799
   PubMed Web of Science ®Google Scholar
• Wang L, Law HKW. Immune complexes suppressed autophagy in glomerular endothelial cells. Cell Immunol. 2018;328:1–8. doi:10.1016/j.cellimm.2018.02.013
   PubMed Web of Science ®Google Scholar
• Lim JH, Kim HW, Kim MY, et al. Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy. Cell Death Dis. 2018;9(3):270. doi:10.1038/s41419-018-0324-4
   PubMedGoogle Scholar
• Li D, Lu Z, Xu Z, et al. Spironolactone promotes autophagy via inhibiting PI3K/AKT/mTOR signalling pathway and reduce adhesive capacity damage in podocytes under mechanical stress. Biosci Rep. 2016;36(4):e00355. doi:10.1042/BSR20160086
   PubMedGoogle Scholar
• Yun J, Ren J, Liu Y, et al. Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy. Diabetol Metab Syndr. 2021;13(1):72. doi:10.1186/s13098-021-00692-x
   PubMed Web of Science ®Google Scholar
• Wang X, Gao Y, Tian N, et al. Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB p65 subunit. Drug Des Devel Ther. 2018;12:2971–2980. doi:10.2147/DDDT.S174058
   PubMed Web of Science ®Google Scholar
• Shi M, Yang S, Zhu X, et al. The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells. Cell Signal. 2019;62:109334. doi:10.1016/j.cellsig.2019.05.019
   PubMed Web of Science ®Google Scholar
• Ren H, Shao Y, Wu C, et al. Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway. Mol Cell Endocrinol. 2020;500:110628. doi:10.1016/j.mce.2019.110628
   PubMed Web of Science ®Google Scholar
• Meng F, Cao Y, Khoso MH, et al. Therapeutic effect and mechanism of combined use of FGF21 and insulin on diabetic nephropathy. Arch Biochem Biophys. 2021;713:109063. doi:10.1016/j.abb.2021.109063
   PubMed Web of Science ®Google Scholar
• Chen C, Ma J, Miao CS, et al. Trigonelline induces autophagy to protect mesangial cells in response to high glucose via activating the miR-5189-5p-AMPK pathway. Phytomedicine. 2021;92:153614. doi:10.1016/j.phymed.2021.153614
   PubMed Web of Science ®Google Scholar
• Wei L, Jian P, Erjiong H, et al. Ginkgetin alleviates high glucose-evoked mesangial cell oxidative stress injury, inflammation, and extracellular matrix (ECM) deposition in an AMPK/mTOR-mediated autophagy axis. Chem Biol Drug Des. 2021;98(4):620–630. doi:10.1111/cbdd.13915
   PubMed Web of Science ®Google Scholar
• Palabıyık E, Sulumer AN, Uguz H, et al. Assessment of hypolipidemic and anti-inflammatory properties of walnut (Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton WR-1339-induced hyperlipidemia in rat kidney, liver, and heart. J Mol Recognit. 2023;36(3):e3004. doi:10.1002/jmr.3004
   PubMed Web of Science ®Google Scholar
• Demir Y, Türkeş C, Çavuş MS, et al. Enzyme inhibition, molecular docking, and density functional theory studies of new thiosemicarbazones incorporating the 4-hydroxy-3,5-dimethoxy benzaldehyde motif. Arch Pharm. 2023;356(4):e2200554. doi:10.1002/ardp.202200554
   PubMed Web of Science ®Google Scholar
• Thomas K, Zondler L, Ludwig N, et al. Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells. JCI Insight. 2022;7(21):e163161. doi:10.1172/jci.insight.163161
   PubMed Web of Science ®Google Scholar
• Widjaja AA, Viswanathan S, Shekeran SG, et al. Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease. Nat Commun. 2022;13(1):7497. doi:10.1038/s41467-022-35306-1
   PubMed Web of Science ®Google Scholar
• Zheng Y, Zhang Z, Zheng D, et al. METTL14 promotes the development of diabetic kidney disease by regulating m6A modification of TUG1. Acta Diabetol. 2023;60(11):1567–1580. doi:10.1007/s00592-023-02145-5
   PubMed Web of Science ®Google Scholar
• Jiang A, Liu J, Wang Y, Zhang C. cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis. Free Radic Biol Med. 2023;208:516–529. doi:10.1016/j.freeradbiomed.2023.09.011
   PubMed Web of Science ®Google Scholar
• Li A, Yi B, Han H, et al. Vitamin D-VDR (vitamin D receptor) regulates defective autophagy in renal tubular epithelial cell in streptozotocin-induced diabetic mice via the AMPK pathway. Autophagy. 2022;18(4):877–890. doi:10.1080/15548627.2021.1962681
   PubMed Web of Science ®Google Scholar
• Suzuki C, Tanida I, Oliva Trejo JA, et al. Autophagy deficiency in renal proximal tubular cells leads to an increase in cellular injury and apoptosis under normal fed conditions. Int J Mol Sci. 2019;21(1):155. doi:10.3390/ijms21010155
   PubMed Web of Science ®Google Scholar
• Zhuang J, Nie G, Hu R, et al. Inhibition of autophagy aggravates molybdenum-induced mitochondrial dysfunction by aggravating oxidative stress in duck renal tubular epithelial cells. Ecotoxicol Environ Saf. 2021;209:111771. doi:10.1016/j.ecoenv.2020.111771
   PubMed Web of Science ®Google Scholar
• Wang F, Sun H, Zuo B, et al. Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy. Sci Rep. 2021;11(1):16362. doi:10.1038/s41598-021-95827-5
   PubMed Web of Science ®Google Scholar
• Karunasagara S, Hong GL, Park SR, et al. Korean red ginseng attenuates hyperglycemia-induced renal inflammation and fibrosis via accelerated autophagy and protects against diabetic kidney disease. J Ethnopharmacol. 2020;254:112693. doi:10.1016/j.jep.2020.112693
   PubMed Web of Science ®Google Scholar
• Yang S, Lin C, Zhuo X, et al. Glucagon-like peptide-1 alleviates diabetic kidney disease through activation of autophagy by regulating AMP-activated protein kinase-mammalian target of rapamycin pathway. Am J Physiol Endocrinol Metab. 2020;319(6):E1019–E1030. doi:10.1152/ajpendo.00195.2019
   PubMed Web of Science ®Google Scholar
• Tong MQ, Luo LZ, Xue PP, et al. Glucose-responsive hydrogel enhances the preventive effect of insulin and liraglutide on diabetic nephropathy of rats. Acta Biomater. 2021;122:111–132. doi:10.1016/j.actbio.2021.01.007
   PubMed Web of Science ®Google Scholar
• Zhu W, Li YY, Zeng HX, et al. Carnosine alleviates podocyte injury in diabetic nephropathy by targeting caspase-1-mediated pyroptosis. Int Immunopharmacol. 2021;101(Pt B):108236. doi:10.1016/j.intimp.2021.108236
   PubMedGoogle Scholar
• Han J, Zuo Z, Shi X, et al. Hirudin ameliorates diabetic nephropathy by inhibiting Gsdmd-mediated pyroptosis. Cell Biol Toxicol. 2023;39(3):573–589. doi:10.1007/s10565-021-09622-z
   PubMed Web of Science ®Google Scholar
• Zhan JF, Huang HW, Huang C, et al. Long non-coding RNA NEAT1 regulates pyroptosis in diabetic nephropathy via mediating the miR-34c/NLRP3 axis. Kidney Blood Press Res. 2020;45(4):589–602. doi:10.1159/000508372
   PubMed Web of Science ®Google Scholar
• Liu C, Zhuo H, Ye MY, et al. LncRNA MALAT1 promoted high glucose-induced pyroptosis of renal tubular epithelial cell by sponging miR-30c targeting for NLRP3. Kaohsiung J Med Sci. 2020;36(9):682–691. doi:10.1002/kjm2.12226
   PubMed Web of Science ®Google Scholar
• Cheng Q, Pan J, Zhou ZL, et al. Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy. Acta Pharmacol Sin. 2021;42(6):954–963. doi:10.1038/s41401-020-00525-z
   PubMed Web of Science ®Google Scholar
• Dong W, Jia C, Li J, et al. Fisetin attenuates diabetic nephropathy-induced podocyte injury by inhibiting NLRP3 inflammasome. Front Pharmacol. 2022;13:783706. doi:10.3389/fphar.2022.783706
   PubMed Web of Science ®Google Scholar
• Zuo Y, Chen L, He X, et al. Atorvastatin regulates MALAT1/miR-200c/NRF2 activity to protect against podocyte pyroptosis induced by high glucose. Diabetes Metab Syndr Obes. 2021;14:1631–1645. doi:10.2147/DMSO.S298950
   PubMed Web of Science ®Google Scholar
• Li F, Chen Y, Li Y, et al. Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway. Eur J Pharmacol. 2020;886:173449. doi:10.1016/j.ejphar.2020.173449
   PubMed Web of Science ®Google Scholar
• Wang T, Gao Y, Yue R, et al. Ginsenoside Rg1 alleviates podocyte injury induced by hyperlipidemia via targeting the mTOR/NF-κB/NLRP3 axis. Evid Based Complement Alternat Med. 2020;2020:2735714. doi:10.1155/2020/2735714
   PubMed Web of Science ®Google Scholar
• Liu BH, Tu Y, Ni GX, et al. Total flavones of abelmoschus manihot ameliorates podocyte pyroptosis and injury in high glucose conditions by targeting METTL3-dependent m6a modification-mediated NLRP3-inflammasome activation and PTEN/PI3K/Akt signaling. Front Pharmacol. 2021;12:667644. doi:10.3389/fphar.2021.667644
   PubMed Web of Science ®Google Scholar
• Song Y, Yang L, Guo R, et al. Long noncoding RNA MALAT1 promotes high glucose-induced human endothelial cells pyroptosis by affecting NLRP3 expression through competitively binding miR-22. Biochem Biophys Res Commun. 2019;509(2):359–366. doi:10.1016/j.bbrc.2018.12.139
   PubMed Web of Science ®Google Scholar
• Gu J, Huang W, Zhang W, et al. Sodium butyrate alleviates high-glucose-induced renal glomerular endothelial cells damage via inhibiting pyroptosis. Int Immunopharmacol. 2019;75:105832. doi:10.1016/j.intimp.2019.105832
   PubMed Web of Science ®Google Scholar
• Du Y, Feng Y, Cai Y, et al. CircLARP1B promotes pyroptosis of high glucose-induced renal mesangial cells by regulating the miR-578/TLR4 axis. Int Urol Nephrol. 2024;56(1):283–293. doi:10.1007/s11255-023-03672-4
   PubMed Web of Science ®Google Scholar
• Xie Y, J E, Cai H, et al. Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells. Kidney Int. 2022;102(2):293–306. doi:10.1016/j.kint.2022.02.038
   PubMed Web of Science ®Google Scholar
• Eleftheriadis T, Pissas G, Golfinopoulos S, et al. Routes of albumin overload toxicity in renal tubular epithelial cells. Int J Mol Sci. 2023;24(11):9640. doi:10.3390/ijms24119640
   PubMed Web of Science ®Google Scholar
• El-Lateef AEA, El-Shemi AGA, Alhammady MS, et al. LncRNA NEAT2 modulates pyroptosis of renal tubular cells induced by high glucose in Diabetic Nephropathy (DN) by via miR-206 regulation. Biochem Genet. 2022;60(5):1733–1747. doi:10.1007/s10528-021-10164-6
   PubMed Web of Science ®Google Scholar
• Zhu B, Cheng X, Jiang Y, et al. Silencing of KCNQ1OT1 decreases oxidative stress and pyroptosis of renal tubular epithelial cells. Diabetes Metab Syndr Obes. 2020;13:365–375. doi:10.2147/DMSO.S225791
   PubMed Web of Science ®Google Scholar
• Wei Z, Nie G, Yang F, et al. Inhibition of ROS/NLRP3/Caspase-1 mediated pyroptosis attenuates cadmium-induced apoptosis in duck renal tubular epithelial cells. Environ Pollut. 2020;273:115919. doi:10.1016/j.envpol.2020.115919
   PubMed Web of Science ®Google Scholar
• Sun Y, Guo LQ, Wang DG, et al. Metformin alleviates glucolipotoxicity-induced pancreatic β cell ferroptosis through regulation of the GPX4/ACSL4 axis. Eur J Pharmacol. 2023;956:175967. doi:10.1016/j.ejphar.2023.175967
   PubMed Web of Science ®Google Scholar
• Li X, Li Z, Dong X, et al. Astragaloside IV attenuates myocardial dysfunction in diabetic cardiomyopathy rats through downregulation of CD36-mediated ferroptosis. Phytother Res. 2023;37(7):3042–3056. doi:10.1002/ptr.7798
   PubMed Web of Science ®Google Scholar
• Fang X, Song J, Chen Y, et al. LncRNA SNHG1 knockdown inhibits hyperglycemia induced ferroptosis via miR-16-5p/ACSL4 axis to alleviate diabetic nephropathy. J Diabetes Investig. 2023;14(9):1056–1069. doi:10.1111/jdi.14036
   PubMed Web of Science ®Google Scholar
• Li S, Lu S, Wang L, et al. Effects of amygdalin on ferroptosis and oxidative stress in diabetic retinopathy progression via the NRF2/ARE signaling pathway. Exp Eye Res. 2023;234:109569. doi:10.1016/j.exer.2023.109569
   PubMed Web of Science ®Google Scholar
• Tsai YC, Kuo MC, Huang JC, et al. Single-cell transcriptomic profiles in the pathophysiology within the microenvironment of early diabetic kidney disease. Cell Death Dis. 2023;14(7):442. doi:10.1038/s41419-023-05947-1
   PubMed Web of Science ®Google Scholar
• Wei M, Liu X, Tan Z, et al. Ferroptosis: a new strategy for Chinese herbal medicine treatment of diabetic nephropathy. Front Endocrinol. 2023;14:1188003. doi:10.3389/fendo.2023.1188003
   PubMed Web of Science ®Google Scholar
• Zhang Q, Hu Y, Hu JE, et al. Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis. Life Sci. 2021;278:119529. doi:10.1016/j.lfs.2021.119529
   PubMed Web of Science ®Google Scholar
• Cao M, Li Y, Famurewa AC, et al. Antidiabetic and nephroprotective effects of polysaccharide extract from the seaweed Caulerpa racemosa in high fructose-streptozotocin induced diabetic nephropathy. Diabetes Metab Syndr Obes. 2021;14:2121–2131. doi:10.2147/DMSO.S302748
   PubMed Web of Science ®Google Scholar
• Wu WY, Wang ZX, Li TS, et al. SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway. Redox Biol. 2022;52:102303. doi:10.1016/j.redox.2022.102303
   PubMed Web of Science ®Google Scholar
• Chen J, Ou Z, Gao T, et al. Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy. Biomed Pharmacother. 2022;156:113953. doi:10.1016/j.biopha.2022.113953
   PubMed Web of Science ®Google Scholar
• Jin J, Wang Y, Zheng D, et al. A novel identified circular RNA, mmu_mmu_circRNA_0000309, involves in germacrone-mediated improvement of diabetic nephropathy through regulating ferroptosis by targeting miR-188-3p/GPX4 signaling axis. Antioxid Redox Signal. 2022;36(10–12):740–759. doi:10.1089/ars.2021.0063
   PubMed Web of Science ®Google Scholar
• Rong J, Li C, Zhang Q, et al. Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11. Pharm Biol. 2023;61(1):404–415. doi:10.1080/13880209.2023.2225543
   PubMed Web of Science ®Google Scholar
• Cui S, Liu X, Liu Y, et al. Autophagosomes defeat ferroptosis by decreasing generation and increasing discharge of free Fe2+ in skin repair cells to accelerate diabetic wound healing. Adv Sci. 2023;10(25):e2300414. doi:10.1002/advs.202300414
   Web of Science ®Google Scholar
• Bai T, Li M, Liu Y, et al. The promotion action of AURKA on post-ischemic angiogenesis in diabetes-related limb ischemia. Mol Med. 2023;29(1):39. doi:10.1186/s10020-023-00635-4
   PubMed Web of Science ®Google Scholar
• Wang X, Li Q, Sui B, et al. Schisandrin A from schisandra chinensis attenuates ferroptosis and NLRP3 inflammasome-mediated pyroptosis in diabetic nephropathy through mitochondrial damage by AdipoR1 ubiquitination. Oxid Med Cell Longev. 2022;2022:5411462. doi:10.1155/2022/5411462
   PubMed Web of Science ®Google Scholar
• Luo EF, Li HX, Qin YH, et al. Role of ferroptosis in the process of diabetes-induced endothelial dysfunction. World J Diabetes. 2021;12(2):124–137. doi:10.4239/wjd.v12.i2.124
   PubMed Web of Science ®Google Scholar
• Wu Y, Zhao Y, Yang HZ, et al. HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose. Biosci Rep. 2021;41(2):BSR20202924. doi:10.1042/BSR20202924
   PubMed Web of Science ®Google Scholar
• Wu J, Shao X, Shen J, et al. Downregulation of PPARα mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells. Int J Biol Sci. 2022;18(14):5438–5458. doi:10.7150/ijbs.74675
   PubMed Web of Science ®Google Scholar
• Shen S, Ji C, Wei K. Cellular senescence and regulated cell death of tubular epithelial cells in diabetic kidney disease. Front Endocrinol. 2022;13:924299. doi:10.3389/fendo.2022.924299
   PubMed Web of Science ®Google Scholar
• Han Y, Su Y, Han M, et al. Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice. J Ethnopharmacol. 2023;302(Pt A):115923. doi:10.1016/j.jep.2022.115923
   PubMedGoogle Scholar
• Yang S, Pei T, Wang L, et al. Salidroside alleviates renal fibrosis in SAMP8 mice by inhibiting ferroptosis. Molecules. 2022;27(22):8039. doi:10.3390/molecules27228039
   PubMed Web of Science ®Google Scholar
• Tan H, Chen J, Li Y, et al. Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways. Mol Med. 2022;28(1):58. doi:10.1186/s10020-022-00481-w
   PubMed Web of Science ®Google Scholar
• Li Q, Meng X, Hua Q. Circ ASAP2 decreased inflammation and ferroptosis in diabetic nephropathy through SOX2/SLC7A11 by miR-770-5p. Acta Diabetol. 2023;60(1):29–42. doi:10.1007/s00592-022-01961-5
   PubMed Web of Science ®Google Scholar