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ORIGINAL RESEARCH

Gender Differences in the Incidence of Nephropathy and Changes in Renal Function in Patients with Type 2 Diabetes Mellitus: A Retrospective Cohort Study

ORCID Icon, , & ORCID Icon
Pages 943-957 | Received 05 Dec 2023, Accepted 19 Feb 2024, Published online: 25 Feb 2024

References

  • Collaborators GBDD. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2023;402(10397):203–234.
  • Cole JB, Florez JC. Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol. 2020;16(7):377–390.
  • American Diabetes A. 11. Microvascular Complications and Foot Care: standards of Medical Care in Diabetes-2019. Diabetes Care. 2019;42(Suppl 1):S124–S138.
  • de Boer IH. Kidney disease and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. Diabetes Care. 2014;37(1):24–30.
  • Anders HJ, Huber TB, Isermann B, Schiffer M. CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease. Nat Rev Nephrol. 2018;14(6):361–377.
  • Cockwell P, Fisher LA. The global burden of chronic kidney disease. Lancet. 2020;395(10225):662–664.
  • Bonner R, Albajrami O, Hudspeth J, Upadhyay A. Diabetic Kidney Disease. Prim Care. 2020;47(4):645–659.
  • Umanath K, Lewis JB. Update on Diabetic Nephropathy: core Curriculum 2018. Am J Kidney Dis. 2018;71(6):884–895.
  • Afkarian M, Zelnick LR, Hall YN, et al. Clinical Manifestations of Kidney Disease Among US Adults With Diabetes, 1988-2014. JAMA. 2016;316(6):602–610.
  • Flyvbjerg A. The role of the complement system in diabetic nephropathy. Nat Rev Nephrol. 2017;13(5):311–318.
  • Selby NM, Taal MW. An updated overview of diabetic nephropathy: diagnosis, prognosis, treatment goals and latest guidelines. Diabetes Obes Metab. 2020;22(Suppl 1):3–15.
  • Li J, Albajrami O, Zhuo M, Hawley CE, Paik JM. Decision Algorithm for Prescribing SGLT2 Inhibitors and GLP-1 Receptor Agonists for Diabetic Kidney Disease. Clin J Am Soc Nephrol. 2020;15(11):1678–1688.
  • Duru OK, Middleton T, Tewari MK, Norris K. The Landscape of Diabetic Kidney Disease in the United States. Curr Diab Rep. 2018;18(3):14.
  • Zou Y, Zhao L, Zhang J, et al. Development and internal validation of machine learning algorithms for end-stage renal disease risk prediction model of people with type 2 diabetes mellitus and diabetic kidney disease. Ren Fail. 2022;44(1):562–570.
  • Johansen KL, Chertow GM, Foley RN, et al. US Renal Data System 2020 Annual Data Report: epidemiology of Kidney Disease in the United States. Am J Kidney Dis. 2021;77(4 Suppl 1):67.
  • Andresdottir G, Jensen ML, Carstensen B, et al. Improved survival and renal prognosis of patients with type 2 diabetes and nephropathy with improved control of risk factors. Diabetes Care. 2014;37(6):1660–1667.
  • Adler AI, Stevens RJ, Manley SE, Bilous RW, Cull CA, Holman RR. Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64). Kidney Int. 2003;63(1):225–232.
  • de Boer IH, Khunti K, Sadusky T, et al. Diabetes Management in Chronic Kidney Disease: a Consensus Report by the American Diabetes Association (ADA) and Kidney Disease: improving Global Outcomes (KDIGO). Diabetes Care. 2022;45(12):3075–3090.
  • Harreiter J, Fadl H, Kautzky-Willer A, Simmons D. Do Women with Diabetes Need More Intensive Action for Cardiovascular Reduction than Men with Diabetes? Curr Diab Rep. 2020;20(11):61.
  • Huxley R, Barzi F, Woodward M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ. 2006;332(7533):73–78.
  • Prospective Studies C, Asia Pacific Cohort Studies C. Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies. Lancet Diabetes Endocrinol. 2018;6(7):538–546.
  • Peters SAE, Woodward M. Sex Differences in the Burden and Complications of Diabetes. Curr Diab Rep. 2018;18(6):33.
  • de Ritter R, Sep SJS, van der Kallen CJH, et al. Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: the Maastricht Study. Cardiovasc Diabetol. 2021;20(1):102.
  • Retnakaran R, Cull CA, Thorne KI, Adler AI, Holman RR, Group US. Risk factors for renal dysfunction in type 2 diabetes: u.K. Prospective Diabetes Study 74. Diabetes. 2006;55(6):1832–1839.
  • Shen Y, Cai R, Sun J, et al. Diabetes mellitus as a risk factor for incident chronic kidney disease and end-stage renal disease in women compared with men: a systematic review and meta-analysis. Endocrine. 2017;55(1):66–76.
  • Parizadeh D, Rahimian N, Akbarpour S, Azizi F, Hadaegh F. Sex-specific clinical outcomes of impaired glucose status: a long follow-up from the Tehran Lipid and Glucose Study. Eur J Prev Cardiol. 2019;26(10):1080–1091.
  • Pradhan AD, Everett BM, Cook NR, Rifai N, Ridker PM. Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial. JAMA. 2009;302(11):1186–1194.
  • Guerrero-Romero F, Simental-Mendia LE, Gonzalez-Ortiz M, et al. The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. J Clin Endocrinol Metab. 2010;95(7):3347–3351.
  • Kahn HS. The “lipid accumulation product” performs better than the body mass index for recognizing cardiovascular risk: a population-based comparison. BMC Cardiovasc Disord. 2005;5:26.
  • Campesi I, Franconi F, Seghieri G, Meloni M. Sex-gender-related therapeutic approaches for cardiovascular complications associated with diabetes. Pharmacol Res. 2017;119:195–207.
  • Sun H, Saeedi P, Karuranga S, et al. IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabet Res Clin Pract. 2022;183:109119.
  • Molitch ME, DeFronzo RA, Franz MJ, et al. Diabetic nephropathy. Diabetes Care. 2003;26(Suppl 1):S94–98.
  • Kautzky-Willer A, Harreiter J, Pacini G. Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus. Endocr Rev. 2016;37(3):278–316.
  • Mauvais-Jarvis F, Bairey Merz N, Barnes PJ, et al. Sex and gender: modifiers of health, disease, and medicine. Lancet. 2020;396(10250):565–582.
  • Gomez-Marcos MA, Recio-Rodriguez JI, Gomez-Sanchez L, et al. Gender differences in the progression of target organ damage in patients with increased insulin resistance: the LOD-DIABETES study. Cardiovasc Diabetol. 2015;14:132.
  • Yu MK, Lyles CR, Bent-Shaw LA, Young BA, Pathways A. Risk factor, age and sex differences in chronic kidney disease prevalence in a diabetic cohort: the pathways study. Am J Nephrol. 2012;36(3):245–251.
  • de Hauteclocque A, Ragot S, Slaoui Y, et al. The influence of sex on renal function decline in people with Type 2 diabetes. Diabet Med. 2014;31(9):1121–1128.
  • Roche MM, Wang PP. Factors associated with a diabetes diagnosis and late diabetes diagnosis for males and females. J Clin Transl Endocrinol. 2014;1(3):77–84.
  • Radcliffe NJ, Seah JM, Clarke M, MacIsaac RJ, Jerums G, Ekinci EI. Clinical predictive factors in diabetic kidney disease progression. J Diabetes Investig. 2017;8(1):6–18.
  • Mu X, Wu A, Hu H, Zhou H, Yang M. Prediction of Diabetic Kidney Disease in Newly Diagnosed Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2023;16:2061–2075.
  • Abdelhafiz AH. Diabetic Kidney Disease in Older People with Type 2 Diabetes Mellitus: improving Prevention and Treatment Options. Drugs Aging. 2020;37(8):567–584.
  • Cederholm J, Eliasson B, Nilsson PM, Weiss L, Gudbjörnsdottir S. Microalbuminuria and risk factors in type 1 and type 2 diabetic patients. Diabet Res Clin Pract. 2005;67(3):258–266.
  • Su S, Wang W, Sun T, et al. Smoking as a risk factor for diabetic nephropathy: a meta-analysis. Int Urol Nephrol. 2017;49(10):1801–1807.
  • Choung HG, Bomback AS, Stokes MB, et al. The spectrum of kidney biopsy findings in patients with morbid obesity. Kidney Int. 2019;95(3):647–654.
  • Chung HF, Al Mamun A, Huang MC, et al. Obesity, weight change, and chronic kidney disease in patients with type 2 diabetes mellitus: a longitudinal study in Taiwan. J Diabetes. 2017;9(11):983–993.
  • Kumar S, Khatri M, Memon RA, et al. Effects of testosterone therapy in adult males with hypogonadism and T2DM: a meta-analysis and systematic review. Diabetes Metab Syndr. 2022;16(8):102588.
  • Turkmen K. Inflammation, oxidative stress, apoptosis, and autophagy in diabetes mellitus and diabetic kidney disease: the Four Horsemen of the Apocalypse. Int Urol Nephrol. 2017;49(5):837–844.
  • Thomas MC, Brownlee M, Susztak K, et al. Diabetic kidney disease. Nat Rev Dis Primers. 2015;1:15018.
  • Thomas B. The Global Burden of Diabetic Kidney Disease: time Trends and Gender Gaps. Curr Diab Rep. 2019;19(4):18.
  • Kumari K, Kumar R, Memon A, et al. Treatment with Testosterone Therapy in Type 2 Diabetic Hypogonadal Adult Males: a Systematic Review and Meta-Analysis. Clin Pract. 2023;13(2):454–469.
  • Committee ADAPP. C11. Chronic Kidney Disease and Risk Management: standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45(Suppl 1):S175–s184.
  • Maric C, Sullivan S. Estrogens and the diabetic kidney. Gend Med. 2008;5 Suppl A(Suppl A):S103–113.
  • Coll-de-Tuero G, Mata-Cases M, Rodriguez-Poncelas A, et al. Chronic kidney disease in the type 2 diabetic patients: prevalence and associated variables in a random sample of 2642 patients of a Mediterranean area. BMC Nephrol. 2012;13:87.
  • Carrero JJ, de Mutsert R, Axelsson J, et al. Sex differences in the impact of diabetes on mortality in chronic dialysis patients. Nephrol Dial Transplant. 2011;26(1):270–276.
  • Hecking M, Bieber BA, Ethier J, et al. Sex-specific differences in hemodialysis prevalence and practices and the male-to-female mortality rate: the Dialysis Outcomes and Practice Patterns Study (DOPPS). PLoS Med. 2014;11(10).
  • Villar E, Chang SH, McDonald SP. Incidences, treatments, outcomes, and sex effect on survival in patients with end-stage renal disease by diabetes status in Australia and New Zealand. Diabetes Care. 2007;30(12):3070–3076.
  • Huxley RR, Peters SA, Mishra GD, Woodward M. Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2015;3(3):198–206.
  • Valdivielso JM, Jacobs-Cacha C, Soler MJ. Sex hormones and their influence on chronic kidney disease. Curr Opin Nephrol Hypertens. 2019;28(1):1–9.
  • Kovats S. Estrogen receptors regulate innate immune cells and signaling pathways. Cell Immunol. 2015;294(2):63–69.
  • Gale EA, Gillespie KM. Diabetes and gender. Diabetologia. 2001;44(1):3–15.
  • Earle KA, Ng L, White S, Zitouni K. Sex differences in vascular stiffness and relationship to the risk of renal functional decline in patients with type 2 diabetes. Diab Vasc Dis Res. 2017;14(4):304–309.
  • Maric C. Sex, diabetes and the kidney. Am J Physiol Renal Physiol. 2009;296(4).
  • Kramer HU, Raum E, Ruter G, et al. Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA study. Cardiovasc Diabetol. 2012;11:88.
  • Tran HV, Waring ME, McManus DD, et al. Underuse of Effective Cardiac Medications Among Women, Middle-Aged Adults, and Racial/Ethnic Minorities With Coronary Artery Disease (from the National Health and Nutrition Examination Survey 2005 to 2014). Am J Cardiol. 2017;120(8):1223–1229.
  • Gouni-Berthold I, Berthold HK, Mantzoros CS, Bohm M, Krone W. Sex disparities in the treatment and control of cardiovascular risk factors in type 2 diabetes. Diabetes Care. 2008;31(7):1389–1391.