MRI-Measured Pancreatic Fat Correlates with Increased Arterial Stiffness in Patients Who are Overweight and Obese

References

• Powell-Wiley TM, Poirier P, Burke LE, et al. Obesity and cardiovascular disease: a scientific statement from the American heart association. Circulation. 2021;143(21):e984–e1010. doi:10.1161/cir.0000000000000973
   PubMed Web of Science ®Google Scholar
• Shah RV, Murthy VL, Abbasi SA, et al. Visceral adiposity and the risk of metabolic syndrome across body mass index: the Mesa Study. JACC Cardiovasc Imaging. 2014;7(12):1221–1235. doi:10.1016/j.jcmg.2014.07.017
   PubMed Web of Science ®Google Scholar
• Kaess BM, Pedley A, Massaro JM, Murabito J, Hoffmann U, Fox CS. The ratio of visceral to subcutaneous fat, a metric of body fat distribution, is a unique correlate of cardiometabolic risk. Diabetologia. 2012;55(10):2622–2630. doi:10.1007/s00125-012-2639-5
   PubMed Web of Science ®Google Scholar
• Singh RG, Yoon HD, Wu LM, Lu J, Plank LD, Petrov MS. Ectopic fat accumulation in the pancreas and its clinical relevance: a systematic review, meta-analysis, and meta-regression. Metabolism. 2017;69:1–13. doi:10.1016/j.metabol.2016.12.012
   PubMed Web of Science ®Google Scholar
• Kim MK, Chun HJ, Park JH, et al. The association between ectopic fat in the pancreas and subclinical atherosclerosis in type 2 diabetes. Diabetes Res Clin Pract. 2014;106(3):590–596. doi:10.1016/j.diabres.2014.09.005
   PubMed Web of Science ®Google Scholar
• Ozturk K, Dogan T, Celikkanat S, et al. The association of fatty pancreas with subclinical atherosclerosis in nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2018;30(4):411–417. doi:10.1097/meg.0000000000001059
   PubMed Web of Science ®Google Scholar
• Sahin S, Karadeniz A. Pancreatic fat accumulation is associated with subclinical atherosclerosis. Angiology. 2022;73(6):508–513. doi:10.1177/00033197211038334
   PubMedGoogle Scholar
• Kul S, Karadeniz A, Dursun İ, et al. Non-alcoholic fatty pancreas disease is associated with increased epicardial adipose tissue and aortic intima-media thickness. Acta Cardiologica Sinica. 2019;35(2):118–125. doi:10.6515/acs.201903_35(2).20181009a
   PubMed Web of Science ®Google Scholar
• Sun P, Fan C, Wang R, et al. Computed tomography-estimated pancreatic steatosis is associated with carotid plaque in type 2 diabetes mellitus patients: a cross-sectional study from China. Diabete Metab Synd Obes. 2021;14:1329–1337. doi:10.2147/dmso.S299060
   PubMed Web of Science ®Google Scholar
• Koo BK, Denenberg JO, Wright CM, Criqui MH, Allison MA. The association between pancreatic fat and systemic calcified atherosclerosis. Pancreas. 2020;49(1):e16–e18. doi:10.1097/mpa.0000000000001447
   PubMed Web of Science ®Google Scholar
• Idilman IS, Tuzun A, Savas B, et al. Quantification of liver, pancreas, kidney, and vertebral body MRI-PDFF in non-alcoholic fatty liver disease. Abdominal Imaging. 2015;40(6):1512–1519. doi:10.1007/s00261-015-0385-0
   PubMedGoogle Scholar
• Kameda F, Tanabe M, Onoda H, et al. Quantification of pancreas fat on dual-energy computed tomography: comparison with six-point Dixon magnetic resonance imaging. Abdom Radiol. 2020;45(9):2779–2785. doi:10.1007/s00261-020-02583-7
   PubMed Web of Science ®Google Scholar
• Femia R, Kozakova M, Nannipieri M, et al. Carotid intima-media thickness in confirmed prehypertensive subjects: predictors and progression. Arteriosclerosis Thrombosis Vasc Biol. 2007;27(10):2244–2249. doi:10.1161/atvbaha.107.149641
   PubMed Web of Science ®Google Scholar
• Wang Y, Yuan Y, Gao WH, et al. Predictors for progressions of brachial-ankle pulse wave velocity and carotid intima-media thickness over a 12-year follow-up: hanzhong adolescent hypertension study. J Hypertens. 2019;37(6):1167–1175. doi:10.1097/hjh.0000000000002020
   PubMed Web of Science ®Google Scholar
• Sheng S. Mean arterial pressure and arterial stiffness in Japanese population: a secondary analysis based on a cross-sectional study. Blood Pressu Monit. 2020;25(6):310–317. doi:10.1097/mbp.0000000000000471
   PubMed Web of Science ®Google Scholar
• Zhou BF. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci. 2002;15(1):83–96.
   PubMed Web of Science ®Google Scholar
• Lopes-Vicente WRP, Rodrigues S, Cepeda FX, et al. Arterial stiffness and its association with clustering of metabolic syndrome risk factors. Diabetol Metab Syndr. 2017;9:87. doi:10.1186/s13098-017-0286-1
   PubMed Web of Science ®Google Scholar
• Hill H, Elliot CA, Lizamore CA, Hamlin MJ. Physical activity has a stronger correlation with arterial stiffness than strength, balance, or BMI in an older population. Front Aging. 2023;4:1279479. doi:10.3389/fragi.2023.1279479
   PubMedGoogle Scholar
• Saisho Y, Butler AE, Meier JJ, et al. Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes. Clin Anat. 2007;20(8):933–942. doi:10.1002/ca.20543
   PubMed Web of Science ®Google Scholar
• Murakami R, Saisho Y, Watanabe Y, et al. Pancreas fat and β cell mass in humans with and without diabetes: an analysis in the Japanese population. J Clin Endocrinol Metab. 2017;102(9):3251–3260. doi:10.1210/jc.2017-00828
   PubMed Web of Science ®Google Scholar
• Hisamatsu T, Miura K, Arima H, et al. Smoking, smoking cessation, and measures of subclinical atherosclerosis in multiple vascular beds in Japanese men. J Am Heart Assoc. 2016;5:9.
   Web of Science ®Google Scholar
• Laguzzi F, Baldassarre D, Veglia F, et al. Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study. Eur J Nutr. 2021;60(1):123–134. doi:10.1007/s00394-020-02220-5
   PubMed Web of Science ®Google Scholar
• Stuart CE, Ko J, Modesto AE, et al. Implications of tobacco smoking and alcohol consumption on ectopic fat deposition in individuals after pancreatitis. Pancreas. 2020;49(7):924–934. doi:10.1097/mpa.0000000000001600
   PubMed Web of Science ®Google Scholar
• Hung CS, Tseng PH, Tu CH, et al. Increased pancreatic echogenicity with US: relationship to glycemic progression and incident diabetes. Radiology. 2018;287(3):853–863. doi:10.1148/radiol.2018170331
   PubMed Web of Science ®Google Scholar
• Koç U, Taydaş O. Evaluation of pancreatic steatosis prevalence and anthropometric measurements using non-contrast computed tomography. Turk J Gastroenterol. 2020;31(9):640–648. doi:10.5152/tjg.2020.19434
   PubMed Web of Science ®Google Scholar
• Chen Y, Long L, Jiang Z, Zhang L, Zhong D, Huang X. Quantification of pancreatic proton density fat fraction in diabetic pigs using MR imaging and IDEAL-IQ sequence. BMC Med Imaging. 2019;19(1):38. doi:10.1186/s12880-019-0336-2
   PubMedGoogle Scholar
• Van Bortel LM, Laurent S, Boutouyrie P, et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012;30(3):445–448. doi:10.1097/HJH.0b013e32834fa8b0
   PubMed Web of Science ®Google Scholar
• Tanaka H, Munakata M, Kawano Y, et al. Comparison between carotid-femoral and brachial-ankle pulse wave velocity as measures of arterial stiffness. J Hypertens. 2009;27(10):2022–2027. doi:10.1097/HJH.0b013e32832e94e7
   PubMed Web of Science ®Google Scholar
• Sánchez Bacaicoa C, Rico-Martín S, Morales E, et al. Brachial-ankle pulse wave velocity with a custom device. Rev Clin Esp. 2021;221(3):145–150. doi:10.1016/j.rceng.2019.12.008
   Web of Science ®Google Scholar
• Fernández-Alvarez V, Linares Sánchez M, López Alvarez F, et al. Evaluation of Intima-media thickness and arterial stiffness as early ultrasound biomarkers of carotid artery atherosclerosis. Cardiol Ther. 2022;11(2):231–247. doi:10.1007/s40119-022-00261-x
   PubMed Web of Science ®Google Scholar
• Johri AM, Nambi V, Naqvi TZ, et al. Recommendations for the assessment of carotid arterial plaque by ultrasound for the characterization of atherosclerosis and evaluation of cardiovascular risk: from the American society of echocardiography. J Am Soc Echocardiography. 2020;33(8):917–933. doi:10.1016/j.echo.2020.04.021
   PubMed Web of Science ®Google Scholar
• Kurkowska-Jastrzebska I, Karlinski MA, Błazejewska-Hyzorek B, Sarzynska-Dlugosz I, Filipiak KJ, Czlonkowska A. Carotid intima media thickness and blood biomarkers of atherosclerosis in patients after stroke or myocardial infarction. Croatian Med J. 2016;57(6):548–557. doi:10.3325/cmj.2016.57.548
   PubMed Web of Science ®Google Scholar
• Simon A, Gariepy J, Chironi G, Megnien JL, Levenson J. Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens. 2002;20(2):159–169. doi:10.1097/00004872-200202000-00001
   PubMed Web of Science ®Google Scholar
• Wong VW, Wong GL, Yeung DK, et al. Fatty pancreas, insulin resistance, and β-cell function: a population study using fat-water magnetic resonance imaging. Am J Gastroenterol. 2014;109(4):589–597. doi:10.1038/ajg.2014.1
   PubMed Web of Science ®Google Scholar
• Zhou J, Li ML, Zhang DD, et al. The correlation between pancreatic steatosis and metabolic syndrome in a Chinese population. Pancreatology. 2016;16(4):578–583. doi:10.1016/j.pan.2016.03.008
   PubMed Web of Science ®Google Scholar
• Lesmana CR, Pakasi LS, Inggriani S, Aidawati ML, Lesmana LA. Prevalence of Non-Alcoholic Fatty Pancreas Disease (NAFPD) and its risk factors among adult medical check-up patients in a private hospital: a large cross sectional study. BMC Gastroenterol. 2015;15:174. doi:10.1186/s12876-015-0404-1
   PubMed Web of Science ®Google Scholar
• Sepe PS, Ohri A, Sanaka S, et al. A prospective evaluation of fatty pancreas by using EUS. Gastrointest Endosc. 2011;73(5):987–993. doi:10.1016/j.gie.2011.01.015
   PubMed Web of Science ®Google Scholar
• Lê KA, Ventura EE, Fisher JQ, et al. Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers. Diabetes Care. 2011;34(2):485–490. doi:10.2337/dc10-0760
   PubMed Web of Science ®Google Scholar
• Szczepaniak LS, Victor RG, Mathur R, et al. Pancreatic steatosis and its relationship to β-cell dysfunction in humans: racial and ethnic variations. Diabetes Care. 2012;35(11):2377–2383. doi:10.2337/dc12-0701
   PubMed Web of Science ®Google Scholar
• Roh E, Kim KM, Park KS, et al. Comparison of pancreatic volume and fat amount linked with glucose homeostasis between healthy Caucasians and Koreans. Diabetes Obesity Metab. 2018;20(11):2642–2652. doi:10.1111/dom.13447
   PubMed Web of Science ®Google Scholar
• Hakim O, Bonadonna RC, Mohandas C, et al. Associations between pancreatic lipids and β-cell function in black African and White European men with type 2 diabetes. J Clin Endocrinol Metab. 2019;104(4):1201–1210. doi:10.1210/jc.2018-01809
   PubMed Web of Science ®Google Scholar