Interaction between leucine and phosphodiesterase 5 inhibition in modulating insulin sensitivity and lipid metabolism

References

• CantóCAuwerxJPGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditureCurr Opin Lipidol200920298 10519276888
   PubMed Web of Science ®Google Scholar
• GomesAPPriceNLLingAJDeclining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during agingCell201315571624 163824360282
   PubMed Web of Science ®Google Scholar
• PriceNLGomesAPLingAJSIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial functionCell Metab201215675 69022560220
   PubMed Web of Science ®Google Scholar
• GowansGJHawleySARossFAHardieDGAMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylationCell Metab2013184556 56624093679
   PubMed Web of Science ®Google Scholar
• JägerSHandschinCSt-PierreJSpiegelmanBMAMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alphaProc Natl Acad Sci U S A20071042912017 1202217609368
   PubMed Web of Science ®Google Scholar
• BrenmoehlJHoeADual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3Mitochondrion201313755 76123583953
   PubMed Web of Science ®Google Scholar
• CoughlanKAValentineRJRudermanNBSahaAKAMPK activation: a therapeutic target for type 2 diabetes?Diabetes Metab Syndr Obes20147241 25325018645
   PubMedGoogle Scholar
• PflugerPTHerranzDVelasco-miguelSSerranoMTschoMHSirt1 protects against high-fat diet-induced metabolic damagePNAS2008105289793 979818599449
   PubMed Web of Science ®Google Scholar
• MilneJCLambertPDSchenkSSmall molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetesNature20074507170712 71618046409
   PubMed Web of Science ®Google Scholar
• BruckbauerAZemelMBSynergistic effects of polyphenols and methylxanthines with leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytesPLoS One201492e8916624551237
   PubMed Web of Science ®Google Scholar
• LiangCCurryBJBrownPLZemelMBLeucine modulates mitochondrial biogenesis and SIRT1-AMPK signaling in C2C12 myotubesJ Nutr Metab2014201423975025400942
   PubMedGoogle Scholar
• BruckbauerAZemelMBThorpeTSynergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and miceNutr Metab (Lond)2012917722913271
   PubMed Web of Science ®Google Scholar
• BruckbauerAZemelMBSynergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivityDiabetes Metab Syndr Obes2013693 10223430507
   PubMedGoogle Scholar
• XueBFuLLiFLeucine amplifies the effects of metformin on insulin sensitivity and glycemicDiabetes201463Suppl 1A288
   Google Scholar
• ShiHFuLLiFSynergy between metformin and leucine in sirtuin signaling and fat oxidation in vitro, and in reducing lipid accumulation in diet-induced obese miceDiabetes201463Suppl 1A463
   Google Scholar
• NisoliETonelloCCardileACalorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOSScience20053105746314 31716224023
   PubMed Web of Science ®Google Scholar
• ShinmuraKTamakiKBolliRImpact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1Am J Physiol Heart Circ Physiol20082956H2348 H235518931029
   PubMed Web of Science ®Google Scholar
• MattagajasinghIKimCSNaqviASIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthaseProc Natl Acad Sci U S A20071043714855 1486017785417
   PubMed Web of Science ®Google Scholar
• SpallottaFCencioniCStrainoSA nitric oxide-dependent crosstalk between class I and III histone deacetylases accelerates skin repairJ Biol Chem20132881611004 1101223463510
   PubMed Web of Science ®Google Scholar
• ChenZPMitchelhillKIMichellBJAMP-activated protein kinase phosphorylation of endothelial NO synthaseFEBS Lett1999443285 28910025949
   PubMed Web of Science ®Google Scholar
• ZhangYLeeTSKolbEMAMP-activated protein kinase is involved in endothelial NO synthase activation in response to shear stressArterioscler Thromb Vasc Biol2006261281 128716601232
   PubMed Web of Science ®Google Scholar
• FrancisSHBuschJLCorbinJDSibleyDcGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP actionPharmacol Rev2010623525 56320716671
   PubMed Web of Science ®Google Scholar
• SchluesenerJKSchluesenerHPlant polyphenols in the treatment of age-associated diseases: revealing the pleiotropic effects of icariin by network analysisMol Nutr Food Res201458149 6024311544
   PubMed Web of Science ®Google Scholar
• MusickiBBivalacquaTJChampionHCBurnettALSildenafil promotes eNOS activation and inhibits NADPH oxidase in the transgenic sickle cell mouse penisJ Sex Med2014112424 43024251665
   PubMed Web of Science ®Google Scholar
• DasAXiLKukrejaRCPhosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signalingJ Biol Chem20052801312944 1295515668244
   PubMed Web of Science ®Google Scholar
• ShalwalaMZhuS-GDasASalloumFNXiLKukrejaRCSirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in micePLoS One201491e8697724466304
   PubMed Web of Science ®Google Scholar
• KokaSAluriHSXiLLesnefskyEJKukrejaRCChronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signalingAm J Physiol Heart Circ Physiol201430611H1558 H156824727492
   PubMed Web of Science ®Google Scholar
• AyalaJBracyDJulienBChronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious miceDiabetes20075641025 103317229936
   PubMed Web of Science ®Google Scholar
• ColmanRJBeasleyTMKemnitzJWJohnsonSCWeindruchRAndersonRMCaloric restriction reduces age-related and all-cause mortality in rhesus monkeysNat Commun20145355724691430
   PubMed Web of Science ®Google Scholar
• ColmanRJAndersonRMJohnsonSCCaloric restriction delays disease onset and mortality in rhesus monkeysScience20093255937201 20419590001
   PubMed Web of Science ®Google Scholar
• JovéMNaudíARamírez-NúñezOCaloric restriction reveals a metabolomic and lipidomic signature in liver of male miceAging Cell2014131 1024433409
   PubMed Web of Science ®Google Scholar
• MitchellSJMartin-MontalvoAMerckenEMThe SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard dietCell Rep201465836 84324582957
   PubMed Web of Science ®Google Scholar
• MerckenEMHuJKrzysik-WalkerSSIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted miceAging Cell2014131193 19623941528
   PubMed Web of Science ®Google Scholar
• ChangH-CGuarenteLSIRT1 and other sirtuins in metabolismTrends Endocrinol Metab2014253138 14524388149
   PubMed Web of Science ®Google Scholar
• KimFPhamMMaloneyEVascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistanceArterioscler Thromb Vasc Biol200828111982 198818772497
   PubMed Web of Science ®Google Scholar
• HandaPTateyaSRizzoNOReduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feedingArterioscler Thromb Vasc Biol201131122827 283521903940
   PubMed Web of Science ®Google Scholar
• SabatiniSSgròPDurantiGCeciRDi LuigiLTadalafil alters energy metabolism in C2C12 skeletal muscle cellsActa Biochim Pol2011582237 24121681286
   PubMed Web of Science ®Google Scholar
• JanssonPAMurdoloGSjögrenLTadalafil increases muscle capillary recruitment and forearm glucose uptake in women with type 2 diabetesDiabetologica201053102205 2208
   Web of Science ®Google Scholar
• ImaiSGuarenteLTen years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseasesTrends Pharmacol Sci2010315212 22020226541
   PubMed Web of Science ®Google Scholar
• XuFGaoZZhangJLack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/− mice: a role of lipid mobilization and inflammationEndocrinology201015162504 251420339025
   PubMed Web of Science ®Google Scholar
• XuFLiZZhengXSirt1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosisDiabetes201463113637 364624947350
   PubMed Web of Science ®Google Scholar
• LeeJHongSWChaeSWExendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J micePLoS One201272e3139422363635
   PubMed Web of Science ®Google Scholar
• TateyaSRizzoNOHandaPEndothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feedingDiabetes201160112792 280121911751
   PubMed Web of Science ®Google Scholar
• RizzoNOMaloneyEPhamMReduced NO–cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feedingArterioscler Thromb Vasc Biol2010304758 76520093624
   PubMed Web of Science ®Google Scholar