Riluzole: real-world evidence supports significant extension of median survival times in patients with amyotrophic lateral sclerosis

References

• BrayfieldAMartindale: The Complete Drug Reference37th edLondon, England, UKPharmaceutical Press2011 Available from https://www.medicinescomplete.comAccessed January 14, 2017
   Google Scholar
• NCBI (National Center for Biotechnology Information) [webpage on the Internet]PubChem Compound Database; CID=5070 (Riluzole) Available from: https://pubchem.ncbi.nlm.nih.gov/compound/riluzole#section=TopAccessed January 14, 2017
   Google Scholar
• Drugs.com [webpage on the Internet]Riluzole Information from Drugs.comc2000–17 Available from: https://www.drugs.com/cdi/riluzoleAccessed January 14, 2017
   Google Scholar
• eMC [webpage on the Internet]Rilutek 50 mg film-coated tablets – summary of product characteristics (SPC) (Sanofi) Available from: http://www.medicines.org.uk/emc/medicine/1672Accessed January 14, 2017
   Google Scholar
• KuhnleinPGdyniaHJSperfeldADDiagnosis and treatment of bulbar symptoms in amyotrophic lateral sclerosisNat Clin Pract Neurol20084736637418560390
   PubMedGoogle Scholar
• WijesekeraLCLeighPNAmyotrophic lateral sclerosisOrphanet J Rare Dis20094319192301
   PubMed Web of Science ®Google Scholar
• AndersenPMAbrahamsSBorasioGDEFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS) – revised report of an EFNS task forceEur J Neurol201219336037521914052
   PubMed Web of Science ®Google Scholar
• MillerRGMitchellJDMooreDHRiluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)Cochrane Database Syst Rev20123CD00144722419278
   PubMed Web of Science ®Google Scholar
• PrattAJGetzoffEDPerryJJAmyotrophic lateral sclerosis: update and new developmentsDegener Neurol Neuromuscul Dis2012211423019386
   PubMedGoogle Scholar
• CalvoACManzanoRMendoncaDMMunozMJZaragozaPOstaRAmyotrophic lateral sclerosis: a focus on disease progressionBiomed Res Int2014201492510125157374
   PubMed Web of Science ®Google Scholar
• NicholsNLVan DykeJNasholdLSatriotomoISuzukiMMitchellGSVentilatory control in ALSRespir Physiol Neurobiol2013189242943723692930
   PubMed Web of Science ®Google Scholar
• IngreCRoosPMPiehlFKamelFFangFRisk factors for amyotrophic lateral sclerosisClin Epidemiol2015718119325709501
   PubMed Web of Science ®Google Scholar
• ChioALogroscinoGTraynorBJGlobal epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literatureNeuroepidemiology201341211813023860588
   PubMed Web of Science ®Google Scholar
• MehtaPKayeWBryanLPrevalence of amyotrophic lateral sclerosis – United States, 2012–2013MMWR Surveill Summ201665SS–8112
   Web of Science ®Google Scholar
• ArthurKCCalvoAPriceTRGeigerJTChiòATraynorBJProjected increase in amyotrophic lateral sclerosis from 2015 to 2040Nat Commun201671240827510634
   PubMed Web of Science ®Google Scholar
• GordonPHAmyotrophic lateral sclerosis: pathophysiology, diagnosis and managementCNS Drugs2011251115
   Web of Science ®Google Scholar
• BealMFBioenergetics in oxidative damage in neurodegenerative diseasesFiskumGNeurodegenerative Diseases: Molecular and Cellular Mechanisms and Therapeutic AdvancesProceedings of the Fifteenth Washington International Spring Symposium at The George Washington UniversityMay 15–17, 1995Washington, DCNew York, NYSpringer Science+Business Media1996171180
   Google Scholar
• PlattSRThe role of glutamate in central nervous system health and disease – a reviewVet J2007173227828616376594
   PubMed Web of Science ®Google Scholar
• LudolphADroryVHardimanOA revision of the El Escorial criteria – 2015Amyotroph Lateral Scler Frontotemporal Degener2015165–629129226121170
   PubMed Web of Science ®Google Scholar
• GaberTA-ZKMehmoodZSiringwaniHRiluzoleProg Neurol Psychiatry2016203233
   Google Scholar
• NICE (National Institute for Clincal Excellence)Guidance on the Use of Riluzole (Rilutek) for the Treatment of Motor Neurone Disease202001Technology Appraisal Guidance Available from: https://www.nice.org.uk/Guidance/ta20Accessed January 14, 2017
   Google Scholar
• ZarateCAManjiHKRiluzole in psychiatry: a systematic review of the literatureExpert Opin Drug Metab Toxicol2008491223123418721116
   PubMed Web of Science ®Google Scholar
• Medicines.org [database on the Internet]DataPharm, UK: electronic medicines compendium (eMC) for riluzole Available from: https://www.medicines.org.uk/emc/searchAccessed January 14, 2017
   Google Scholar
• DyerAMSmithARiluzole 5 mg/mL oral suspension: for optimized drug delivery in amyotrophic lateral sclerosisDrug Des Devel Ther2017115964
   PubMed Web of Science ®Google Scholar
• KeatingGMRiluzole oral suspension in amyotrophic lateral sclerosis: a guide to its useDrugs Ther Perspect2016327282286
   Google Scholar
• BensimonGLacomblezLMeiningerVA controlled trial of riluzole in amyotrophic lateral sclerosisN Engl J Med199433095855918302340
   PubMed Web of Science ®Google Scholar
• LacomblezLBensimonGLeighPNGuilletPMeiningerVDose-ranging study of riluzole in amyotrophic lateral sclerosisLancet1996347142514318676624
   PubMed Web of Science ®Google Scholar
• YanagisawaNTashiroKTohgiHEfficacy and safety of riluzole in patients with amyotrophic lateral sclerosis: double-blind placebo-controlled study in JapanIgakuno Ayumi1997182851866
   Google Scholar
• BensimonGLacomblezLDelumeauJCet al; Riluzole/ALS Study GroupIIA study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosisJ Neurol2002249560961512021952
   PubMed Web of Science ®Google Scholar
• GhaleihaAMohammadiEMohammadiM-RRiluzole as an adjunctive therapy to risperidone for the treatment of irritability in children with autistic disorder: a double-blind, placebo-controlled, randomized trialPediatric Drugs201315650551423821414
   PubMed Web of Science ®Google Scholar
• FarokhniaMSabzabadiMPourmahmoudHA double-blind, placebo controlled, randomized trial of riluzole as an adjunct to ris-peridone for treatment of negative symptoms in patients with chronic schizophreniaPsychopharmacology2014231353354224013610
   PubMed Web of Science ®Google Scholar
• RajasekaranSAiyerSNShettyAPKannaRMMaheswaranAShettyJYEffectiveness of riluzole as a pharmacotherapeutic treatment option for early cervical myelopathy: a double-blinded, placebo-controlled randomised controlled trialEur Spine J20162561830183526596730
   PubMed Web of Science ®Google Scholar
• StewartASandercockJBryanSThe clinical effectiveness and cost-effectiveness of riluzole for motor neurone disease: a rapid and systematic reviewHealth Technol Assess200152197
   Google Scholar
• StandaertDGRobersonEDTreatment of central nervous system degenerative disordersBruntonLChabnerBAKnollmanBGoodman and Gilman’s The Pharmacological Basis of Therapeutics12 ed Chap. 22McGraw-Hill2011
   Google Scholar
• MooreAMcQuayHJWhat is an NNT?11EnglandHayward Medical Communications Ltd Available from: http://www.bandolier.org.uk/painres/download/whatis%20copy/NNT.pdfAccessed March 30, 2017
   Google Scholar
• AbsherJRRiluzole increased survival in amyotrophic lateral sclerosisACP J Club19941219
   Google Scholar
• DemaerschalkBUWO Evidence Based Neurology GroupRiluzole Appears to Minimally Improve Survival in ALS. All Other Therapeutic Trials of Anti-Glutamatergic and Anti-Excitotoxicity Agents Reveal no Significant Effect1999 Available from: http://www.cnsuwo.ca/ebn/downloads/cats/2010/CNS-EBN_cat-document_2010-07-JUL-30_riluzole-appears-to-minimally-improve-survival-in-als-all-other-therapeutic-trials-of_1FFE9.pdfAccessed March 30, 2017
   Google Scholar
• ABPI (The Association of the British Pharmaceutical Industry)The Vision for Real World Data – Harnessing the Opportunities in the UKLondon, UKABPI2011 Available from: http://www.abpi.org.uk/our-work/library/industry/documents/vision-for-real-world-data.pdfAccessed January 12, 2017
   Google Scholar
• IOM (Institute of Medicine)Crossing the Quality Chasm: A New Health System for the 21^st CenturyWashington, DCNational Academy Press2001
   Google Scholar
• BoothCMTannockIFRandomised controlled trials and population-based observational research: partners in the evolution of medical evidenceBr J Cancer2014110355155524495873
   PubMed Web of Science ®Google Scholar
• TraynorBJAlexanderMCorrBFrostEHardimanOAn outcome study of riluzole in amyotrophic lateral sclerosis – a population-based study in Ireland, 1996-2000J Neurol2003250447347912700914
   PubMed Web of Science ®Google Scholar
• FleurenceRLNaciHJansenJPThe critical role of observational evidence in comparative effectiveness researchHealth Aff (Millwood)201029101826183320921482
   PubMed Web of Science ®Google Scholar
• ClayRAMore than one way to measure – randomized clinical trials have their place, but critics argue that researchers would get better results if they also embraced other methodologiesMonitor Psychol201041852
   Google Scholar
• BonnelyeGMiniuksAGoncalvesA webpage on the InternetThe importance of real-world data to the pharma industryPMlive2015 http://www.pmlive.com/pharma_thought_leadership/the_importance_of_real-world_data_to_the_pharma_industry_740092Accessed January 12, 2017
   Google Scholar
• FiminskaZ webpage on the InternetReal world evidence: maximize benefits to healthcareEye Pharma2015 Available from: http://social.eyeforpharma.com/market-access/real-world-evidence-maximize-benefits-healthcareAccessed January 12, 2017
   Google Scholar
• HubbardTEParadisRReal World Evidence: A New Era for Health Care InnovationMassachusettsThe Network For Excellence In Health Innovation2015 Available from: http://www.nehi.net/publications/66-real-world-evidence-a-new-era-for-health-care-innovation/viewAccessed December 18, 2016
   Google Scholar
• FellowsMReal world evidence: a reality check for pharma?Pharmafocus20161891417
   Google Scholar
• MeiningerVLacomblezLSalachasFWhat has changed with riluzole?J Neurol2000247suppl 6VI/1922
   Google Scholar
• BrooksBRBeldenDSRoelkeKSurvival in non-riluzole treated amyotrophic lateral sclerosis (ALS) – motor neuron disease (MND) patients with disease onset before and since 1996 is identical: a clinic-based epidemiological studyAmyotroph Lateral Scler Other Motor Neuron Disord200126061
   Google Scholar
• TurnerMRBakkerMShamPShawCELeighPNAl-ChalabiAPrognostic modelling of therapeutic interventions in amyotrophic lateral sclerosisAmyotroph Lateral Scler Other Motor Neuron Disord200231152112061944
   PubMed Web of Science ®Google Scholar
• MitchellJDO’BrienMRJoshiMAudit of outcomes in motor neuron disease (MND) patients treated with riluzoleAmyotroph Lateral Scler200672677116753969
   PubMed Web of Science ®Google Scholar
• ZoccolellaSBeghiEPalaganoGSLAP RegistryRiluzole and amyotrophic lateral sclerosis survival: a population-based study in southern ItalyEur J Neurol200714326226817355545
   PubMed Web of Science ®Google Scholar
• LeeCT-CChiuY-WWangK-CRiluzole and prognostic factors in amyotrophic lateral sclerosis long-term and short-term survival: a population-based study of 1149 Cases in TaiwanJ Epidemiol2013231354023117224
   PubMed Web of Science ®Google Scholar
• GeorgoulopoulouEFiniNVincetiMThe impact of clinical factors, riluzole and therapeutic interventions on ALS survival: a population based study in Modena, ItalyAmyotroph Lateral Scler Frontotemporal Degener2013145–633834523373475
   PubMed Web of Science ®Google Scholar
• KnibbJAKerenNKulkaAA clinical tool for predicting survival in ALSJ Neurol Neurosurg Psychiatry201687121361136727378085
   PubMed Web of Science ®Google Scholar
• ChenLLiuXTangLZhangNFanDLong-term use of riluzole could improve the prognosis of sporadic amyotrophic lateral sclerosis patients: a real-world cohort study in ChinaFront Aging Neurosci2016824627822184
   PubMed Web of Science ®Google Scholar
• ArmonCGuiloffRJBedlackRLimitations of inferences from observational databases in amyotrophic lateral sclerosis: all that glitters is not goldAmyotroph Lateral Scler Other Motor Neuron Disord20023310911212495570
   PubMed Web of Science ®Google Scholar
• MeiningerVDatabase analyses: a replyAmyotroph Lateral Scler Other Motor Neuron Disord20023311312495571
   PubMed Web of Science ®Google Scholar
• LacomblezLBensimonGLeighPNGuilletPMeiningerVRiluzole and amyotrophic lateral sclerosis (Authors reply)Lancet1996348336337
   Web of Science ®Google Scholar
• RiviereMMeiningerVZeisserPMunsatTAn analysis of extended survival in patients with amyotrophic lateral sclerosis treated with riluzoleArch Neurol19985545265289561981
   PubMed Web of Science ®Google Scholar