76
Views
4
CrossRef citations to date
0
Altmetric
Review

Breaking barriers: insight into the pathogenesis of neovascular age-related macular degeneration

, &
Pages 19-28 | Published online: 27 Sep 2011

References

  • CATT Research GroupRanibizumab and bevacizumab for neovascular age-related macular degenerationN Engl J Med2011364201897190821526923
  • EghojMSSorensenTLTachyphylaxis during treatment of exudative age-related macular degeneration with ranibizumabBr J Ophthalmol Epub762011
  • DiasJRRodriguesEBMaiaMMagalhaesOJrPenhaFMFarahMECytokines in neovascular age-related macular degeneration: fundamentals of targeted combination therapyBr J Ophthalmol Epub552011
  • BhuttoIAKimSYMcLeodDSLocalization of collagen XVIII and the endostatin portion of collagen XVIII in aged human control eyes and eyes with age-related macular degenerationInvest Ophthalmol Vis Sci20044551544155215111613
  • HagemanGSAndersonDHJohnsonLVA common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degenerationProc Natl Acad Sci U S A2005102207227723215870199
  • LamoreauxWJFitzgeraldMECReinerAHastyKACharlesSTVascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitroMicrovasc Res199855129429473407
  • DaySAcquahKMruthyunjayaPGrossmanDSLeePPSloanFAOcular complications after anti-vascular endothelial growth factor therapy in Medicare patients with age-related macular degenerationAm J Ophthalmol Epub692011
  • NishijimaKNgYSZhongLVascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injuryAm J Pathol20071711536717591953
  • ZarbinMAAge-related macular degeneration: review of pathogenesisEur J Ophthalmol1998841992069891890
  • KameiMHollyfieldJGTIMP-3 in Bruch’s membrane: changes during aging and in age-related macular degenerationInvest Ophthalmol Vis Sci199940102367237510476804
  • SheridanCWilliamsRGriersonIBasement membranes and artificial substrates in cell transplantationGraefes Arch Clin Exp Ophthalmol20042421687514628146
  • ZarbinMACurrent concepts in the pathogenesis of age-related macular degenerationArch Ophthalmol2004122459861415078679
  • StoneEMBraunTARussellSRMissense variations in the fibulin 5 gene and age-related macular degenerationN Engl J Med2004351434635315269314
  • MousaALorelliWCampochiaroPARole of hypoxia and extracellular matrix-integrin binding in the modulation of angiogenic growth factors secretion by retinal pigmented epithelial cellsJ Cell Biochem199974113514310381270
  • FrankRNGrowth factors in age-related macular degeneration: pathogenic and therapeutic implicationsOphthalmic Res19972953413539323725
  • RennoRZYoussriAIMichaudNGragoudasESMillerJWExpression of pigment epithelium-derived factor in experimental choroidal neovascularizationInvest Ophthalmol Vis Sci20024351574158011980876
  • HartnettMEElsnerAECharacteristics of exudative age-related macular degeneration determined in vivo with confocal and indirect infrared imagingOphthalmology1996103158718628562
  • HartnettMEWeiterJJStaurenghiGElsnerAEDeep retinal vascular anomalous complexes in advanced age-related macular degenerationOphthalmology199610312204220539003338
  • HartnettMEWeiterJJGarsdAJalkhAEClassification of retinal pigment epithelial detachments associated with drusenGraefes Arch Clin Exper Ophthalmol1992230111191547961
  • YannuzziLANegraoSIidaTRetinal angiomatous proliferation in age-related macular degenerationRetina200121541643411642370
  • StevensTSBresslerNMMaguireMGOccult choroidal neovascularization in age-related macular degeneration: a natural history studyArch Ophthalmol199711533453509076206
  • DardikRLivnatTNisgavYWeinbergerDEnhancement of angiogenic potential of endothelial cells by contact with retinal pigment epithelial cells in a model simulating pathological conditionsInvest Ophthalmol Vis Sci201051126188619520702828
  • Espinosa-HeidmannDGSunerIJCatanutoPHernandezEPMarin-CastanoMECousinsSWCigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMDInvest Ophthalmol Vis Sci200647272973716431974
  • WuTHandaJTGottschJDLight-induced oxidative stress in choroidal endothelial cells in miceInvest Ophthalmol Vis Sci20054641117112315790868
  • AmbatiJAnandAFernandezSAn animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient miceNat Med20039111390139714566334
  • AmbatiJAge-related macular degeneration and the other double helix: the Cogan LectureInvest Ophthalmol Vis Sci201152521662169
  • GeisenPMcColmJRKingBMHartnettMECharacterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term cultureCurr Eye Res200631973974816966147
  • PengSRaoVSAdelmanRARizzoloLJClaudin-19 and the barrier properties of the human retinal pigment epitheliumInvest Ophthalmol Vis Sci20115231392140321071746
  • GeisenPMcColmJRHartnettMEChoroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factorExp Eye Res200682460861916259980
  • HartnettMELappasADarlandDMcColmJRLovejoySD’AmorePARetinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanismExp Eye Res200377559359914550401
  • PetersonLJWittchenESGeisenPBurridgeKHartnettMEHeterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1Exp Eye Res200784473774417292356
  • WangHGeisenPWittchenESThe role of RPE cell-associated VEGF189 in choroidal endothelial cell transmigration across the RPEInvest Ophthalmol Vis Sci201152157057820811045
  • KleinRJZeissCChewEYComplement factor H polymorphism in age-related macular degenerationScience2005308572038538915761122
  • EdwardsAORitterR3rdAbelKJManningAPanhuysenCFarrerLAComplement factor H polymorphism and age-related macular degenerationScience2005308572042142415761121
  • SilveiraACMorrisonMAJiFConvergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approachVision Res201050769871519786043
  • NealeBMFagernessJReynoldsRGenome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)Proc Natl Acad Sci U S A2010107167395740020385826
  • SeddonJMGeorgeSRosnerBRifaiNProgression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkersArch Ophthalmol2005123677478215955978
  • SeddonJMWillettWCSpeizerFEHankinsonSEA prospective study of cigarette smoking and age-related macular degeneration in womenJAMA199627614114111468827966
  • Monaghan-BensonEHartmannJVendrovAEThe role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularizationAm J Pathol201017742091210220802176
  • Age-Related Eye Disease Study Research GroupA randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8Arch Ophthalmol2001119101417143611594942
  • ZhouJJangYPKimSRSparrowJRComplement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epitheliumProc Natl Acad Sci U S A200610344161821618717060630
  • ZhouJKimSRWestlundBSSparrowJRComplement activation by bisretinoid constituents of RPE lipofuscinInvest Ophthalmol Vis Sci20095031392139919029031
  • Ushio-FukaiMVEGF signaling through NADPH oxidase-derived ROSAntioxid Redox Signal20079673173917511588
  • Ushio-FukaiMRedox signaling in angiogenesis: role of NADPH oxidaseCardiovasc Res200671222623516781692
  • Saint-GeniezMKuriharaTSekiyamaEMaldonadoAED’AmorePAAn essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillarisProc Natl Acad Sci U S A200910644187511875619841260
  • TakedaABaffiJZKleinmanMECCR3 is a target for age-related macular degeneration diagnosis and therapyNature2009460725222523019525930
  • BuddSByfieldGMartiniukDGeisenPHartnettMEReduction in endothelial tip cell filopodia corresponds to reduced intravitreous but not intraretinal vascularization in a model of ROPExp Eye Res200989571872719576214
  • HernándezEDe La Mota-PeynadoADharmawardhaneSVlaarCPNovel inhibitors of Rac1 in metastatic breast cancerP R Health Sci J201029434835621261173
  • FiresteinGS‘Rac’-ing upstream to treat rheumatoid arthritisArthritis Res Ther201012110920236447
  • SaitoYUppalAByfieldGBuddSHartnettMEActivated NAD(P)H oxidase from supplemental oxygen induces neovascularization independent of VEGF in retinopathy of prematurity modelInvest Ophthalmol Vis Sci20084941591159818385079
  • BuddSJThompsonHHartnettMEAssociation of retinal vascular endothelial growth factor with avascular retina in a rat model of retinopathy of prematurityArch Ophthalmol201012881014102120697002
  • ByfieldGBuddSHartnettMEThe role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat modelInvest Ophthalmol Vis Sci20095073360336519264880
  • SalleeJLWittchenESBurridgeKRegulation of cell adhesion by protein-tyrosine phosphatases: II. Cell-cell adhesionJ Biol Chem200628124161891619216497667
  • RaoRKBasuroySRaoVUKarnakyKJJrGuptaATyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stressBiochem J2002368Pt 247148112169098
  • PriceLSHajdo-MilasinovicAZhaoJZwartkruisFJCollardJGBosJLRap1 regulates E-cadherin-mediated cell-cell adhesionJ Biol Chem200427934351273513215166221
  • HoganCSerpenteNCogramPRap1 regulates the formation of E-cadherin-based cell-cell contactsMol Cell Biol200424156690670015254236
  • WittchenESWorthylakeRAKellyPCaseyPJQuilliamLABurridgeKRap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier functionJ Biol Chem200528012116751168215661741
  • Chrzanowska-WodnickaMRegulation of angiogenesis by a small GTPase Rap1Vascul Pharmacol2010531–211020302970
  • LiYYanJDePRap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteinsJ Immunol2007179128322833118056377
  • Chrzanowska-WodnickaMSmythSSSchoenwaelderSMFischerTHWhiteGC2ndRap1b is required for normal platelet function and hemostasis in miceJ Clin Invest2005115368068715696195
  • YanJLiFIngramDAQuilliamLARap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functionsMol Cell Biol200828185803581018625726
  • WittchenESHartnettMEThe small GTPase Rap1 is a novel regulator of RPE cell barrier functionInvest Ophthalmol Vis SciIn press2011