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Original Research

Evaluation of Platelet Activation by HIV Protease Inhibitors – The HIV-PLA II Study

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Pages 789-800 | Published online: 06 Aug 2021

References

  • Gresele P, Falcinelli E, Sebastiano M, Baldelli F. Endothelial and platelet function alterations in HIV-infected patients. Thromb Res. 2012;129(3):301–308. doi:10.1016/j.thromres.2011.11.022
  • Zahler S, Massoudy P, Hartl H, Hahnel C, Meisner H, Becker BF. Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass. Cardiovasc Res. 1999;41(3):722–730. doi:10.1016/S0008-6363(98)00229-6
  • Furie B, Furie BC. The molecular basis of platelet and endothelial cell interaction with neutrophils and monocytes: role of P-selectin and the P-selectin ligand, PSGL-1. Thromb Haemost. 1995;74(1):224–227. doi:10.1055/s-0038-1642681
  • Evangelista V, Manarini S, Rotondo S, et al. Platelet/polymorphonuclear leukocyte interaction in dynamic conditions: evidence of adhesion cascade and cross talk between P-selectin and the beta 2 integrin CD11b/CD18. Blood. 1996;88(11):4183–4194. doi:10.1182/blood.V88.11.4183.4183
  • Graff J, Klinkhardt U, Schini-Kerth VB, et al. Close relationship between the platelet activation marker CD62 and the granular release of platelet-derived growth factor. J Pharmacol Exp Ther. 2002;300(3):952–957. doi:10.1124/jpet.300.3.952
  • Abedi H, Zachary I. Signalling mechanisms in the regulation of vascular cell migration. Cardiovasc Res. 1995;30(4):544–556. doi:10.1016/S0008-6363(95)00092-5
  • Schini-Kerth VB, Bassus S, Fisslthaler B, Kirchmaier CM, Busse R. Aggregating human platelets stimulate the expression of thrombin receptors in cultured vascular smooth muscle cells via the release of transforming growth factor-beta1 and platelet-derived growth factorAB. Circulation. 1997;96(11):3888–3896. doi:10.1161/01.CIR.96.11.3888
  • Hamburger SA, McEver RP. GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood. 1990;75(3):550–554. doi:10.1182/blood.V75.3.550.550
  • Neumann FJ, Marx N, Gawaz M, et al. Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets. Circulation. 1997;95(10):2387–2394. doi:10.1161/01.CIR.95.10.2387
  • Ott I, Neumann FJ, Gawaz M, Schmitt M, Schomig A. Increased neutrophil-platelet adhesion in patients with unstable angina. Circulation. 1996;94(6):1239–1246. doi:10.1161/01.CIR.94.6.1239
  • Mathew JP, Rinder CS, Tracey JB, et al. Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1995;109(3):448–456. doi:10.1016/S0022-5223(95)70275-X
  • Gawaz MP. Das Blutplättchen: Physiologie, Pathophysiologie, Membranrezeptoren, antithrombozytäre Wirkstoffe und antithrombozytäre Therapie bei koronarer Herzerkrankung. Stuttgart [u.a.]: Thieme; 1999.
  • Friis-Moller N, Weber R, Reiss P, et al. Cardiovascular disease risk factors in HIV patients--association with antiretroviral therapy. Results from the DAD study. Aids. 2003;17(8):1179–1193. doi:10.1097/00002030-200305230-00010
  • Friis-Moller N, Sabin C, Weber R, et al. Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med. 2003;349(21):1993–2003.
  • Desvarieux M, Boccara F, Meynard JL, et al. Infection duration and inflammatory imbalance are associated with atherosclerotic risk in HIV-infected never-smokers independent of antiretroviral therapy. Aids. 2013;27(16):2603–2614. doi:10.1097/QAD.0b013e3283634819
  • Kristoffersen US, Kofoed K, Kronborg G, Benfield T, Kjaer A, Lebech AM. Changes in biomarkers of cardiovascular risk after a switch to abacavir in HIV-1-infected individuals receiving combination antiretroviral therapy. HIV Med. 2009;10(10):627–633. doi:10.1111/j.1468-1293.2009.00733.x
  • Falcinelli E, Francisci D, Belfiori B, et al. In vivo platelet activation and platelet hyperreactivity in abacavir-treated HIV-infected patients. Thromb Haemost. 2013;110(08):349–357. doi:10.1160/TH12-07-0504
  • Nordell AD, McKenna M, Borges AH, et al. Severity of cardiovascular disease outcomes among patients with HIV is related to markers of inflammation and coagulation. J Am Heart Assoc. 2014;3(3):e000844. doi:10.1161/JAHA.114.000844
  • Westhorpe CL, Schneider HG, Dunne M, et al. C-reactive protein as a predictor of cardiovascular risk in HIV-infected individuals. Sex Health. 2014;11(6):580–582. doi:10.1071/SH14130
  • Lacerda HR, Falcao Mda C, de Albuquerque VM, et al. Association of inflammatory cytokines and endothelial adhesion molecules with immunological, virological, and cardiometabolic disease in HIV-infected individuals. J Interferon Cytokine Res. 2014;34(5):385–393. doi:10.1089/jir.2013.0029
  • Moyle G, Hardy H, Uy J, et al. Changes in biomarkers in HIV-1-infected treatment-naive patients treated with tenofovir DF/emtricitabine plus atazanavir/ritonavir or lopinavir/ritonavir for 96 weeks: the CASTLE biomarker substudy. Antivir Ther. 2014;19(7):693–699. doi:10.3851/IMP2778
  • Rasmussen TA, Tolstrup M, Melchjorsen J, et al. Evaluation of cardiovascular biomarkers in HIV-infected patients switching to abacavir or tenofovir based therapy. BMC Infect Dis. 2011;11:267. doi:10.1186/1471-2334-11-267
  • Duprez DA, Neuhaus J, Kuller LH, et al. Inflammation, coagulation and cardiovascular disease in HIV-infected individuals. PLoS One. 2012;7(9):e44454. doi:10.1371/journal.pone.0044454
  • Kuller LH, Tracy R, Belloso W, et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med. 2008;5(10):e203. doi:10.1371/journal.pmed.0050203
  • Ikeda H, Nakayama H, Oda T, et al. Neutrophil activation after percutaneous transluminal coronary angioplasty. Am Heart J. 1994;128(6):1091–1098. doi:10.1016/0002-8703(94)90738-2
  • Mann KG, Butenas S, Brummel K. The dynamics of thrombin formation. Arterioscler Thromb Vasc Biol. 2003;23(1):17–25. doi:10.1161/01.ATV.0000046238.23903.FC
  • Hemker HC, Al Dieri R, Beguin S. Thrombin generation assays: accruing clinical relevance. Curr Opin Hematol. 2004;11(3):170–175. doi:10.1097/01.moh.0000130314.33410.d7
  • Baglin T. The measurement and application of thrombin generation. Br J Haematol. 2005;130(5):653–661. doi:10.1111/j.1365-2141.2005.05612.x
  • von Hentig N, Forster AK, Kuczka K, et al. Platelet-leucocyte adhesion markers before and after the initiation of antiretroviral therapy with HIV protease inhibitors. J Antimicrob Chemother. 2008;62(5):1118–1121. doi:10.1093/jac/dkn333
  • Angdujar I, Collado-Diaz V, Ordem S, et al. Prothrombotic effects of abacavir in an in-vivo model. Conference on Retroviruses and Opportunistic Infections. 2017; Seattle, USA (Feb 13–16). Poster609.
  • Wohl DA, Arnoczy G, Fichtenbaum CJ, et al. Comparison of cardiovascular disease risk markers in HIV-infected patients receiving abacavir and tenofovir: the nucleoside inflammation, coagulation and endothelial function (NICE) study. Antivir Ther. 2014;19(2):141–147. doi:10.3851/IMP2681
  • Rinder HM, Bonan JL, Rinder CS, Ault KA, Smith BR. Activated and unactivated platelet adhesion to monocytes and neutrophils. Blood. 1991;78(7):1760–1769. doi:10.1182/blood.V78.7.1760.1760
  • Schmitz G, Rothe G, Ruf A, et al. European Working Group on Clinical Cell Analysis: consensus protocol for the flow cytometric characterisation of platelet function. Thromb Haemost. 1998;79(5):885–896. doi:10.1055/s-0037-1615088
  • Barbaro G. Vascular injury, hypertension and coronary artery disease in human immunodeficiency virus infection. Clin Ter. 2008;159(1):51–55.
  • McComsey GA, O’Riordan M, Hazen SL, et al. Increased carotid intima media thickness and cardiac biomarkers in HIV infected children. Aids. 2007;21(8):921–927. doi:10.1097/QAD.0b013e328133f29c
  • Masia M, Padilla S, Bernal E, et al. Influence of antiretroviral therapy on oxidative stress and cardiovascular risk: a prospective cross-sectional study in HIV-infected patients. Clin Ther. 2007;29(7):1448–1455. doi:10.1016/j.clinthera.2007.07.025
  • Wang X, Chai H, Yao Q, Chen C. Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction. J Acquir Immune Defic Syndr. 2007;44(5):493–499. doi:10.1097/QAI.0b013e3180322542
  • Cotter BR. Endothelial dysfunction in HIV infection. Curr HIV/AIDS Rep. 2006;3(3):126–131. doi:10.1007/BF02696656
  • Barbaro G, Barbarini G. Highly active antiretroviral therapy-associated metabolic syndrome and cardiovascular risk. Chemotherapy. 2006;52(4):161–165. doi:10.1159/000093034
  • Spieker LE, Karadag B, Binggeli C, Corti R. Rapid progression of atherosclerotic coronary artery disease in patients with human immunodeficiency virus infection. Heart Vessels. 2005;20(4):171–174. doi:10.1007/s00380-004-0790-8
  • Zhou H, Pandak WM, Lyall V, Natarajan R, Hylemon PB. HIV protease inhibitors activate the unfolded protein response in macrophages: implication for atherosclerosis and cardiovascular disease. Mol Pharmacol. 2005;68(3):690–700. doi:10.1124/mol.105.012898
  • Carr A. Cardiovascular risk factors in HIV-infected patients. J Acquir Immune Defic Syndr. 2003;34(Suppl 1):S73–78. doi:10.1097/00126334-200309011-00011
  • Baker J, Sharma S, Grund B; Group ISS. The effect of ART on inflammation, coagulation, and vascular injury in START. Conference on Retroviruses and Opportunistic Infections. 2017; Seattle, USA (Feb 13–16). Poster608.
  • Baker J, Sharma S, Grund B; Group ISS. Association of inflammation and coagulation with clinical risk in the START trial. Conference on Retroviruses and Opportunistic Infections. 2017; Seattle, USA (Feb 13–16). Poster623.
  • Ryom L, Lunsgren J, el-Sadr W, et al. Associations between cardiovascular disease and contemporarily used protease inhibitors. Conference on Retroviruses and Opportunistic Infections. 2017; Seattle, USA (Feb 13–16). OP128LB.
  • Ryom L, Lundgren JD, El-Sadr W, et al. Cardiovascular disease and use of contemporary protease inhibitors: the D:A:D international prospective multicohort study. Lancet HIV. 2018;5(6):e291–e300. doi:10.1016/S2352-3018(18)30043-2