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Original Research

Virological Suppression and Its Associated Factors of Dolutegravir Based Regimen in a Resource-Limited Setting: An Observational Retrospective Study in Ethiopia

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Pages 709-717 | Published online: 29 Jun 2021

References

  • Cohen MS, Chen YQ, McCauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505. doi:10.1056/NEJMoa1105243
  • Oguntibeju OO. Quality of life of people living with HIV and AIDS and antiretroviral therapy. HIV/AIDS. 2012;4:117.
  • Organization WH.. Updated Recommendations on First-Line and Second-Line Antiretroviral Regimens and Post-Exposure Prophylaxis and Recommendations on Early Infant Diagnosis of HIV: Interim Guidelines: Supplement to the 2016 Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection. World Health Organization; 2018.
  • Walmsley SL, Antela A, Clumeck N, et al. Dolutegravir plus abacavir–lamivudine for the treatment of HIV-1 infection. N Engl J Med. 2013;369(19):1807–1818. doi:10.1056/NEJMoa1215541
  • Oliveira M, Mesplede T, Quashie PK, Moïsi D, Wainberg MA. Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors. AIDS. 2014;28(6):813–819. doi:10.1097/QAD.0000000000000199
  • Treviño A, Cabezas T, Lozano AB, et al. Dolutegravir for the treatment of HIV-2 infection. J Clin Virol. 2015;64:12–15. doi:10.1016/j.jcv.2015.01.001
  • Cahn P, Pozniak AL, Mingrone H, et al. Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study. Lancet. 2013;382(9893):700–708. doi:10.1016/S0140-6736(13)61221-0
  • Trottier B, Lake JE, Logue K, et al. Dolutegravir/abacavir/lamivudine versus current ART in virally suppressed patients (STRIIVING): a 48-week, randomized, non-inferiority, open-label, phase IIIb study. Antivir Ther. 2017;22(4):295–305. doi:10.3851/IMP3166
  • Snedecor SJ, Radford M, Kratochvil D, Grove R, Punekar YS. Comparative efficacy and safety of dolutegravir relative to common core agents in treatment-naïve patients infected with HIV-1: a systematic review and network meta-analysis. BMC Infect Dis. 2019;19(1):484. doi:10.1186/s12879-019-3975-6
  • Cruciani M, Parisi SG. Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: a systematic review and meta-analysis. PLoS One. 2019;14(9):e0222229. doi:10.1371/journal.pone.0222229
  • McCormack PL. Dolutegravir: a review of its use in the management of HIV-1 infection in adolescents and adults. Drugs. 2014;74(11):1241–1252. doi:10.1007/s40265-014-0256-y
  • HIV W. AIDS. Monitoring Response to ART and Diagnosis of Treatment Failure. 2013 ed. June, 2013.
  • Organization WH. Adherence to Long-Term Therapies: Evidence for Action. World Health Organization; 2003.
  • Sangeda RZ, Mosha F, Prosperi M, et al. Pharmacy refill adherence outperforms self-reported methods in predicting HIV therapy outcome in resource-limited settings. BMC Public Health. 2014;14(1):1035. doi:10.1186/1471-2458-14-1035
  • Evaluation FD. Human Immunodeficiency Virus-1 Infection: Developing Antiretroviral drugs for Treatment. Guidance for industry; 2015.
  • O’brien RM. A caution regarding rules of thumb for variance inflation factors. Qual Quant. 2007;41(5):673–690. doi:10.1007/s11135-006-9018-6
  • Hosmer DW Jr, Lemeshow S, Sturdivant RX. Applied Logistic Regression. Vol. 398. John Wiley & Sons; 2013.
  • Nabitaka VM, Nawaggi P, Campbell J, et al. High acceptability and viral suppression of patients on dolutegravir-based first-line regimens in pilot sites in Uganda: a mixed-methods prospective cohort study. PLoS One. 2020;15(5):e0232419. doi:10.1371/journal.pone.0232419
  • Group NAS. Dolutegravir-based or low-dose efavirenz–based regimen for the treatment of HIV-1. N Engl J Med. 2019;381(9):816–826. doi:10.1056/NEJMoa1904340
  • Venter W, Moorhouse M, Sokhela S, et al. The ADVANCE trial: phase 3, randomized comparison of TAF/FTC/DTG, TDF/FTC/DTG or TDF/FTC/EFV for first-line treatment of HIV-1 infection. Paper presented at: Journal of the International Aids Society; 2019.
  • Norwood J, Turner M, Bofill C, et al. Weight gain in persons with HIV switched from efavirenz-based to integrase strand transfer inhibitor-based regimens. J Acquir Immune Defic Syndr. 2017;76(5):527. doi:10.1097/QAI.0000000000001525
  • Bourgi K, Rebeiro PF, Turner M, et al. Greater weight gain in treatment-naive persons starting dolutegravir-based antiretroviral therapy. Clin Infect Dis. 2020;70(7):1267–1274. doi:10.1093/cid/ciz407
  • Rizzardo S, Lanzafame M, Lattuada E, et al. Dolutegravir monotherapy and body weight gain in antiretroviral naive patients. AIDS. 2019;33(10):1673–1674. doi:10.1097/QAD.0000000000002245
  • Wohl DA, Yazdanpanah Y, Baumgarten A, et al. Bictegravir combined with emtricitabine and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection: week 96 results from a randomised, double-blind, multicentre, phase 3, non-inferiority trial. Lancet HIV. 2019;6(6):e355–e363. doi:10.1016/S2352-3018(19)30077-3
  • Burns JE, Stirrup OT, Dunn D, et al. No overall change in the rate of weight gain after switching to an integrase-inhibitor in virologically suppressed adults with HIV. AIDS. 2020;34(1):109–114. doi:10.1097/QAD.0000000000002379
  • Blair SN, Church TS. The fitness, obesity, and health equation: is physical activity the common denominator? JAMA. 2004;292(10):1232–1234. doi:10.1001/jama.292.10.1232
  • Bodnar LM, Siega-Riz AM, Simhan HN, Himes KP, Abrams B. Severe obesity, gestational weight gain, and adverse birth outcomes. Am J Clin Nutr. 2010;91(6):1642–1648. doi:10.3945/ajcn.2009.29008
  • Desta AA, Woldearegay TW, Futwi N, et al. HIV virological non-suppression and factors associated with non-suppression among adolescents and adults on antiretroviral therapy in northern Ethiopia: a retrospective study. BMC Infect Dis. 2020;20(1):1–10. doi:10.1186/s12879-019-4732-6
  • Bayu B, Tariku A, Bulti AB, Habitu YA, Derso T, Teshome DF. Determinants of virological failure among patients on highly active antiretroviral therapy in University of Gondar Referral Hospital, Northwest Ethiopia: a case–control study. HIV/AIDS. 2017;9:153.
  • Maina E, Mureithi H, Adan A, Muriuki J, Lwembe R, Bukusi E. Incidences and factors associated with viral suppression or rebound among HIV patients on combination antiretroviral therapy from three counties in Kenya. Int J Infect Dis. 2020. doi:10.1016/j.ijid.2020.05.097
  • Kiweewa F, Esber A, Musingye E, et al. HIV virologic failure and its predictors among HIV-infected adults on antiretroviral therapy in the African Cohort Study. PLoS One. 2019;14(2):e0211344. doi:10.1371/journal.pone.0211344
  • Casado JL, Sabido R, Perez-Elías MJ, et al. Percentage of adherence correlates with the risk of protease inhibitor (PI) treatment failure in HIV-infected patients. Antivir Ther. 1999;4:157–162.
  • Omooja J, Nannyonjo M, Sanyu G, et al. Rates of HIV-1 virological suppression and patterns of acquired drug resistance among fisherfolk on first-line antiretroviral therapy in Uganda. J Antimicrob Chemother. 2019;74(10):3021–3029. doi:10.1093/jac/dkz261
  • Hanna DB, Felsen UR, Ginsberg MS, et al. Increased antiretroviral therapy use and virologic suppression in the bronx in the context of multiple HIV prevention strategies. AIDS Res Hum Retroviruses. 2016;32(10–11):955–963. doi:10.1089/aid.2015.0345
  • Lokpo SY, Ofori-Attah PJ, Ameke LS, et al. Viral suppression and its associated factors in HIV patients on Highly Active Antiretroviral Therapy (HAART): a Retrospective Study in the Ho Municipality, Ghana. AIDS Res Treat. 2020;2020:1–7. doi:10.1155/2020/9247451
  • Resino S, Resino R, Micheloud D, et al. Long-term effects of highly active antiretroviral therapy in pretreated, vertically HIV type 1-infected children: 6 years of follow-up. Clin Infect Dis. 2006;42(6):862–869. doi:10.1086/500412