295
Views
0
CrossRef citations to date
0
Altmetric
Original Research

Incidence and Predictors of Virological Failure Among Adult HIV/AIDS Patients on Second-Line Anti-Retroviral Therapy, in Selected Public Hospital of Addis Ababa, Ethiopia: Retrospective Follow-Up Study

ORCID Icon, ORCID Icon, , ORCID Icon, ORCID Icon, ORCID Icon, , ORCID Icon & show all
Pages 319-329 | Published online: 08 Jul 2022

References

  • UNAIDS. Fast track strategy to end the AIDS epidemic by 2030; 2014.
  • UNAIDS. UNAIDS data 2019; 2018.
  • Roberts T, Cohn J, Bonner K, Hargreaves S. Scale-up of routine viral load testing in resource-poor settings: current and future implementation challenges. Clin Infect Dis. 2016;62(8):1043–1048. doi:10.1093/cid/ciw001
  • EthiopiaCountry Operational Plan. Strategic direction summary; 2018.
  • Churchill D, Waters L, Ahmed N, et al. British HIV association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2015. HIV Med. 2016;17(Suppl 4):s2–s104. doi:10.1111/hiv.12426
  • World Health Organization. Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a Public Health Approach. World Health Organization; 2016.
  • Boender TS, Hamers RL, Ondoa P, et al. Protease inhibitor resistance in the first 3 years of second-line antiretroviral therapy for HIV-1 in Sub-Saharan Africa. J Infect Dis. 2016;214(6):873–883. doi:10.1093/infdis/jiw219
  • FMOH Ethiopia. National consolidated guidelines for comprehensive HIV prevention, care and treatment; 2018.
  • Assefa Y, Gilks CF, Lynen L, et al. Performance of the Antiretroviral Treatment Program in Ethiopia, 2005–2015: strengths and weaknesses toward ending AIDS. Int J Infect Dis. 2017;60:70–76. doi:10.1016/j.ijid.2017.05.012
  • Edessa D, Sisay M, Asefa F. Second-line HIV treatment failure in sub-Saharan Africa: a systematic review and meta-analysis. PLoS One. 2019;14(7):e0220159. doi:10.1371/journal.pone.0220159
  • Mulugeta A, Assefa H, Tewelde T, Dube L. Determinants of survival among HIV positive children on antiretroviral therapy in public hospitals, Addis Ababa, Ethiopia. Qual Prim Care. 2017;25(4):235–241.
  • Ayana GM, Akalu TY, Ayele TA. Joint modeling of of tuberculosis and change in viral load over time among adult HIV/AIDS patients on anti-retroviral therapy at Zewditu Memorial Hospital in Addis Ababa, Ethiopia. HIV/AIDS. 2021;13:239. doi:10.2147/DHIV.S291872
  • Schoenfeld DA. Sample-size formula for the proportional-hazards regression model. Biometrics. 1983;39(2):499–503. doi:10.2307/2531021
  • Tsegaye AT, Wubshet M, Awoke T, Addis Alene K. Predictors of treatment failure on second-line antiretroviral therapy among adults in northwest Ethiopia: a multicentre retrospective follow-up study. BMJ Open. 2016;6(12):e012537. doi:10.1136/bmjopen-2016-012537
  • Zenebe Haftu ADA, Bezabih NM, Bayray Kahsay A, et al. Incidence and factors associated with treatment failure among HIV infected adolescent and adult patients on second-line antiretroviral therapy in public hospitals of Northern Ethiopia: multicenter retrospective study. PLoS One. 2020;15(9):e0239191. doi:10.1371/journal.pone.0239191
  • Agegnehu CD, Merid MW, Yenit MK. Incidence and predictors of virological failure among adult HIV patients on first-line antiretroviral therapy in Amhara regional referral hospitals; Ethiopia: a retrospective follow-up study. BMC Infect Dis. 2020;20(1):460. doi:10.1186/s12879-020-05177-2
  • Seid A, Cherie N, Ahmed K. Determinants of virologic failure among adults on second line antiretroviral therapy in Wollo, Amhara Regional State, Northeast Ethiopia. HIV/AIDS. 2020;12:697–706.
  • Nsanzimana S, Semakula M, Ndahindwa V, et al. Retention in care and virological failure among adult HIV+ patients on second-line ART in Rwanda: a national representative study. BMC Infect Dis. 2019;19(1):312. doi:10.1186/s12879-019-3934-2
  • Ongubo DM, Lim R, Tweya H, et al. A cross-sectional study to evaluate second line virological failure and elevated bilirubin as a surrogate for adherence to atazanavir/ritonavir in two urban HIV clinics in Lilongwe, Malawi. BMC Infect Dis. 2017;17(1):461. doi:10.1186/s12879-017-2528-0
  • Gunda DW, Kilonzo SB, Mtaki T, Bernard DM, Kalluvya SE, Shao ER. Magnitude and correlates of virological failure among adult HIV patients receiving PI based second line ART regimens in north western Tanzania; a case control study. BMC Infect Dis. 2019;19(1):235. doi:10.1186/s12879-019-3852-3
  • Gunda DWKC, Kidenya BR, Kabangila R, et al. Plasma concentrations of efavirenz and nevirapine among HIV-infected patients with immunological failure attending a tertiary hospital in North-Western Tanzania. PLoS One. 2013;8(9):e75118. doi:10.1371/journal.pone.0075118
  • Alexander G. Chapter 34 Liver and biliary tract. In: Bennett PN, Brown MJ, Sharma P, editors. Clinical Pharmacology 11th ed. Oxford: Churchill Livingstone; 2012:546–556.
  • Collier D, Iwuji C, Derache A, et al. Virological outcomes of second-line protease inhibitor-based treatment for human immunodeficiency virus type 1 in a high-prevalence rural South African setting: a competing-risks prospective cohort analysis. Clin Infect Dis. 2017;64(8):1006–1016. doi:10.1093/cid/cix015
  • Antagonists TN. LiverTox: clinical and research information on drug-induced liver injury [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases, Ed. Rifampin. Bethesda, MD, USA; 2012.
  • Alene M, Awoke T, Yenit MK, Tsegaye AT. Incidence and predictors of second-line antiretroviral treatment failure among adults living with HIV in Amhara region: a multi-centered retrospective follow-up study. BMC Infect Dis. 2019;19(1):599. doi:10.1186/s12879-019-4243-5
  • Etenyi JO, Okalebo FA, Oluka M, et al. Comparison of zidovudine and tenofovir based regimens with regard to health-related quality of life and prevalence of symptoms in HIV patients in a Kenyan Referral Hospital. Front Pharmacol. 2018;9:984. doi:10.3389/fphar.2018.00984
  • Onoya D, Nattey C, Budgell E, et al. Predicting the need for third-line antiretroviral therapy by identifying patients at high risk for failing second-line antiretroviral therapy in South Africa. AIDS Patient Care STDS. 2017;31(5):205–212. doi:10.1089/apc.2016.0291
  • Mwangi A, van Wyk B. Factors associated with viral suppression among adolescents on antiretroviral therapy in Homa Bay County, Kenya: a retrospective cross-sectional study. HIV/AIDS. 2021;13:1111–1118.