Preexposure prophylaxis-related stigma: strategies to improve uptake and adherence – a narrative review

References

• 10 facts on HIV/AIDS [webpage on the Internet]GenevaWorld Health Organization Available from: http://www.who.int/features/factfiles/hiv/facts/en/index2.htmlAccessed July 22, 2015
   Google Scholar
• HaireBConsidering Pre-Exposure Prophylaxis: Do the Pros Outweigh the Cons as an HIV Prevention Strategy?LGBT Health201414253255
   Web of Science ®Google Scholar
• FlashCLandovitzRGilerRMTwo years of Truvada for pre-exposure prophylaxis utilization in the USJ Int AIDS Soc2014174 Suppl 31973025397476
   PubMed Web of Science ®Google Scholar
• HunterPHIV prevention drug Truvada focus of controversy [webpage on the Internet]TorontoThestar.com2014 [updated November 23, 2014]. Available from: http://www.thestar.com/life/health_wellness/2014/11/23/hiv_prevention_drug_truvada_focus_of_controversy.htmlAccessed July 22, 2015
   Google Scholar
• PetersonLTaylorDRoddyRTenofovir disoproxil fumarate for prevention of HIV infection in women: a phase 2, double-blind, randomized, placebo-controlled trialPLoS Clin Trials200725e2717525796
   PubMedGoogle Scholar
• BaetenJMDonnellDNdasePAntiretroviral prophylaxis for HIV prevention in heterosexual men and womenNew Engl J Med2012367539941022784037
   PubMed Web of Science ®Google Scholar
• ChoopanyaKMartinMSuntharasamaiPAntiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trialLancet201338198832083209023769234
   PubMed Web of Science ®Google Scholar
• Abdool KarimQAbdool KarimSSFrohlichJAEffectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in womenScience201032959961168117420643915
   PubMed Web of Science ®Google Scholar
• FDA approves first drug for reducing the risk of Sexually Acquired HIV Infection (News release) [webpage on the Internet]Silver SpringUS Food and Drug Administration2012 [updated July 17, 2012]. Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm312210.htmAccessed July 10, 2015
   Google Scholar
• Consolidated guidelines on HIV prevention, diagnosis, treatment and care for key populations [webpage on the Internet]GenevaWorld Health Organization2014 Available from: http://who.int/hiv/pub/guidelines/keypopulations/enAccessed July 2, 2015
   Google Scholar
• Ongoing and Planned PrEP Demonstration and Implementation Studies [webpage on the Internet]AVAC Global Advocacy for HIV Prevention2015 Available from: http://www.avac.org/resource/ongoing-and-planned-prep-demonstration-and-implementation-studiesAccessed July 22, 2015
   Google Scholar
• YoungIMcDaidLHow acceptable are antiretrovirals for the prevention of sexually transmitted HIV?: A review of research on the acceptability of oral pre-exposure prophylaxis and treatment as preventionAIDS Behav201418219521623897125
   PubMed Web of Science ®Google Scholar
• PrEP Update for HIV Clinicians [webpage on the Internet]Surry HillsAustralasian Society for HIV Medicine2015 Available from: http://www.ashm.org.au/PrEPAccessed July 17, 2015
   Google Scholar
• GrantRMLamaJRAndersonPLPreexposure chemoprophylaxis for HIV prevention in men who have sex with menNew Engl J Med2010363272587259921091279
   PubMed Web of Science ®Google Scholar
• AndersonPLGliddenDVLiuAEmtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men. Science Translational MedicineSci Transl Med20124151151ra125
   PubMed Web of Science ®Google Scholar
• WoodLVWhy I voted “no” to Truvada PrEPAnn Intern Med2012157751952022821402
   PubMed Web of Science ®Google Scholar
• Van DammeLCorneliAAhmedKPreexposure prophylaxis for HIV infection among African womenNew Engl J Med2012367541142222784040
   PubMed Web of Science ®Google Scholar
• MarrazzoJMRamjeeGRichardsonBATenofovir-based pre-exposure prophylaxis for HIV Infection among African womenNew Engl J Med2015372650951825651245
   PubMed Web of Science ®Google Scholar
• CorneliALDeeseJWangMFEM-PrEP: adherence patterns and factors associated with adherence to a daily oral study product for pre-exposure prophylaxisJ Acquir Immune Defic Synd2014663324331
   PubMed Web of Science ®Google Scholar
• van der StratenAVan DammeLHabererJEBangsbergDRUnraveling the divergent results of pre-exposure prophylaxis trials for HIV preventionAIDS2012267F13F1922333749
   PubMed Web of Science ®Google Scholar
• van der StratenAStadlerJLueckeEPerspectives on use of oral and vaginal antiretrovirals for HIV prevention: the VOICE-C qualitative study in Johannesburg, South AfricaJ Int AIDS Soc2014173 Supp 21914625224610
   PubMedGoogle Scholar
• ThigpenMCKebaabetswePMPaxtonLAAntiretroviral pre-exposure prophylaxis for heterosexual HIV transmission in BotswanaNew Engl J Med2012367542343422784038
   PubMed Web of Science ®Google Scholar
• MolinaJMCapitantCSpireBOn Demand PrEP With Oral TDF-FTC in MSM: Results of the ANRS Ipergay TrialPresented at: 2015 CROIFebruary 23–26, 2015Seattle Abstract 23
   Google Scholar
• GliddenDVBuchbinderSPAndersonPLPrEP Engagement for HIV Prevention: Results From the iPrEx Open Label Extension (OLE)Presented at: 2015 CROIFebruary 23–26, 2015Seattle Abstract 970
   Google Scholar
• BaetenJHeffronRKidoguchiLNear elimination of HIV transmission in a demonstration project of PrEP and ARTPresented at: 2015 CROIFebruary 23–26, 2015Seattle Abstract 24
   Google Scholar
• McCormackSDunnDPragmatic open-label randomised trial of pre-exposure prophylaxis: The PROUD studyPresented at: 2015 CROIFebruary 23–26, 2015Seattle Abstract 22LB
   Google Scholar
• AmicoKRAdherence to preexposure chemoprophylaxis: The behavioral bridge from efficacy to effectivenessCurr Opin HIV AIDS20127654254822964887
   PubMed Web of Science ®Google Scholar
• KippaxSStephensonNBeyond the distinction between biomedical and social dimensions of HIV prevention through the lens of a social public healthAm J Public Health2012102578979922493997
   PubMed Web of Science ®Google Scholar
• ParkerRAggletonPHIV and AIDS-related stigma and discrimination: a conceptual framework and implications for actionSoc Sci Med2003571132412753813
   PubMed Web of Science ®Google Scholar
• GoffmanEStigma: Notes on the Management of a Spoiled IdentityEnglewood CliffsPrentice-Hall Inc1963
   Google Scholar
• BayerRPrivate Acts, Social ConsequencesNew YorkThe Free Press1989
   Google Scholar
• WeeksJThe Sexual CitizenTheory Cult Soc19981533552
   Web of Science ®Google Scholar
• YoungSPanel recommends approving Truvada to prevent HIV infection [webpage on the Internet]AtlantaCable News Network2012 [updated July 17, 2012]. Available from: http://edition.cnn.com/2012/05/10/health/hiv-drugAccessed July 17, 2015
   Google Scholar
• GarciaMWhy Michael Weinstein gets blamed for PrEP Myths [web-page on the Internet]Advocate.com2014 Available from: http://www.advocate.com/31-days-prep/2014/10/31/why-michael-weinstein-gets-blamed-prep-mythsAccessed July 7, 2015
   Google Scholar
• GlazekCWhy I am a Truvada whore [webpage on the Internet]. Out.com2014 Available from: http://www.out.com/entertainment/popnography/2014/05/20/why-i-am-truvada-whoreAccessed July 17, 2015Accessed July 7, 2015
   Google Scholar
• BurressJ‘Truvada Whore’ Stigma Endures Among Doctors and LGBTs [webpage on the Internet]. Advocate.com2014 Available from: http://www.advocate.com/health/2014/08/11/truvada-whore-stigma-endures-among-doctors-and-lgbtsAccessed July 7, 2015
   Google Scholar
• GalinskyADHugenbergKGroomCGalenBVThe reappropriation of stigmatizing labels: Implications for social identityIdentity Issues in Groups (Research on Managing Groups and Teams)20035221256
   Google Scholar
• LiuACohenSFollansbeeSEarly experiences implementing pre-exposure prophylaxis (PrEP) for HIV prevention in San FranciscoPLoS Med2014113e100161324595035
   PubMed Web of Science ®Google Scholar
• TangmunkongvorakulAChariyalertsakSAmicoKRFacilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, ThailandAIDS Care201325896196723252473
   PubMed Web of Science ®Google Scholar
• Van der ElstEMMboguaJOperarioDHigh acceptability of HIV pre-exposure prophylaxis but challenges in adherence and use: qualitative insights from a phase I trial of intermittent and daily PrEP in at-risk populations in KenyaAIDS Behav20131762162217223080358
   PubMed Web of Science ®Google Scholar
• WareNCWyattMAHabererJEWhat’s love got to do with it? Explaining adherence to oral antiretroviral pre-exposure prophylaxis for hiv serodiscordant couplesJ Acquir Immune Defic Synd2012595463468
   PubMed Web of Science ®Google Scholar
• HoaglandBGrinsztejnBpresenterPre-exposure prophylaxis (PrEP) uptake and associated factors among MSM and TGW in the PrEP Brasil demonstration projectPresented at: Eighth IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015), VancouverJuly 19–22, 2015Vancouver, BC Abstract TUAC0205LB
   Google Scholar
• HendersonFTaylorAWChirwaLICharacteristics and oral PrEP adherence in the TDF2 open-label extension in BotswanaPresented at: Eighth IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015), VancouverJuly 19–22, 2015Vancouver, BC Abstract TUAC0203
   Google Scholar
• BaetenJCelumCHIV Prevention at IAS 2015 Vancouver [webpage on the Internet] Available from: http://www.natap.org/2015/IAS/IAS_93.htmAccessed August 19, 2015
   Google Scholar
• LiuACohenSVittinghoffEAdherence, sexual behavior and HIV/STI incidence among men who have sex with men (MSM) and transgender women (TGW) in the US PrEP demonstration (Demo) projectPresented at: Eighth International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, VancouverJuly 19–22, 2015Vancouver, BC Abstract TUAC0202
   Google Scholar
• HosekSRudyBLandowitzRAn HIV pre-exposure prophylaxis (PrEP) demonstration project and safety study for young men who have sex with men in the United States (ATN 110)Presented at: Eighth International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015), VancouverJuly 19–22, 2015Vancouver, BC Abstract no TUAC0204LB
   Google Scholar
• LiuAYKittredgePVVittinghoffELimited knowledge and use of HIV post- and pre-exposure prophylaxis among gay and bisexual menJ Acquir Immune Defic Syndr200847224124718340656
   PubMed Web of Science ®Google Scholar
• BarashEAGoldenMAwareness and use of HIV pre-exposure prophylaxis among attendees of a seattle gay pride event and sexually transmitted disease clinicAIDS Patient Care STDS2010241168969120863247
   PubMed Web of Science ®Google Scholar
• GolubSAKowalczykWWeinbergerCLParsonsJTPreexposure prophylaxis and predicted condom use among high-risk men who have sex with menJ Acquir Immune Defic Syndr201054554855520512046
   PubMed Web of Science ®Google Scholar
• MimiagaMJCasePJohnsonCVSafrenSAMayerKHPreexposure antiretroviral prophylaxis attitudes in high-risk Boston area men who report having sex with men: limited knowledge and experience but potential for increased utilization after educationJ Acquir Immune Defic Synd20095017783
   PubMed Web of Science ®Google Scholar
• LeonardiMLeeETanDHSAwareness of, usage of and willingness to use HIV pre-exposure prophylaxis among men in downtown Toronto, CanadaInt J STD AIDS2011221273874122174057
   PubMed Web of Science ®Google Scholar
• NodinNCarballo-DiéguezAVentuneacAMBalanICRemienRKnowledge and acceptability of alternative HIV prevention bio-medical products among MSM who barebackAIDS Care200820110611518278621
   PubMed Web of Science ®Google Scholar
• PoyntenIMJinFPrestageGPKaldorJMImrieJGrulichAEAttitudes towards new HIV biomedical prevention technologies among a cohort of HIV-negative gay men in Sydney, AustraliaHIV Med201011428228820015220
   PubMed Web of Science ®Google Scholar
• HoltMHIV pre-exposure prophylaxis and treatment as prevention: a review of awareness and acceptability among men who have sex with men in the Asia-Pacific region and the AmericasSex Health201411216617023866853
   PubMed Web of Science ®Google Scholar
• SmithDKToledoLSmithDJAdamsMARothenbergRAttitudes and program preferences of African-American urban young adults about pre-exposure prophylaxis (PrEP)AIDS Educ Prev201224540842123016502
   PubMed Web of Science ®Google Scholar
• GaleaJTKinslerJJSalazarXAcceptability of pre-exposure prophylaxis as an HIV prevention strategy: barriers and facilitators to pre-exposure prophylaxis uptake among at-risk Peruvian populationsInt J STD AIDS201122525626221571973
   PubMed Web of Science ®Google Scholar
• MimiagaMJClossonEFKotharyVMittyJASexual partnerships and considerations for HIV antiretroviral pre-exposure prophylaxis utilization among high-risk substance using men who have sex with menArch Sex Behav20144319910624243002
   PubMed Web of Science ®Google Scholar
• RawlingsKMeraRPechonkinaAStatus of Truvada (TVD) for HIV pre-exposure prophylaxis in the United States: an early drug utilization analysisPresented at: 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2013)September 10–13, 2013Denver Abstract H-663a
   Google Scholar
• IdokoJFolayanMODademNYKolawoleGOAnenihJAlhassanE“Why should I take drugs for your infection?”: outcomes of formative research on the use of HIV pre-exposure prophylaxis in NigeriaBMC Public Health201515134925881087
   PubMed Web of Science ®Google Scholar
• JacksonTHuangAChenHGaoXZhongXZhangYCognitive, psychosocial, and sociodemographic predictors of willingness to use HIV pre-exposure prophylaxis among Chinese men who have sex with menAIDS Behav20121671853186122538373
   PubMed Web of Science ®Google Scholar
• Populations at Higher Risk for HIV: Racial and Ethnic Health Inequities [webpage on the Internet]AtlantaCenters for Disease Control and Prevention2014 [updated December 9, 2014]. Available from: http://www.cdc.gov/nchhstp/newsroom/HIVFactSheets/Epidemic/inequities.htmAccessed September 30, 2015
   Google Scholar
• KrakowerDMayerKHEngaging healthcare providers to implement HIV pre-exposure prophylaxisCurr Opin HIV AIDS20127659359923032736
   PubMed Web of Science ®Google Scholar
• WhiteJMMimiagaMJKrakowerDSMayerKHEvolution of Mas-sachusetts physician attitudes, knowledge, and experience regarding the use of antiretrovirals for HIV preventionAIDS Patient Care STDS20122639540522694239
   PubMed Web of Science ®Google Scholar
• MaznaviKHDBredeekFPre-exposure prophylaxis (PrEP) for HIV: an online survey of HIV healthcare providers evaluating their knowledge, perception, and prescription of PrEP49th Annual Meeting of the Infectious Diseases Society of America2011Boston, MA Abstract 011
   Google Scholar
• KarrisMYBeekmannSEMehtaSRAndersonCMPolgreenPMAre we prepped for preexposure prophylaxis (PrEP)? Provider opinions on the real-world use of PrEP in the United States and CanadaClin Infect Dis201458570471224319083
   PubMed Web of Science ®Google Scholar
• SachdevDDStojanovskiKLiuAYBuchbinderSPMacalinoGEIntentions to prescribe preexposure prophylaxis are associated with self-efficacy and normative beliefsClin Infect Dis201458121786178724729556
   PubMed Web of Science ®Google Scholar
• MimiagaMJWhiteJMKrakowerDSBielloKBMayerKHSuboptimal awareness and comprehension of published pre-exposure prophylaxis efficacy results among physicians in MassachusettsAIDS Care201426668469324116985
   PubMed Web of Science ®Google Scholar
• CalabreseSKEarnshawVAUnderhillKHansenNBDovidioJFThe impact of patient race on clinical decisions related to prescribing HIV pre-exposure prophylaxis (PrEP): assumptions about sexual risk compensation and implications for accessAIDS Behav201418222624024366572
   PubMed Web of Science ®Google Scholar
• VissersDCVoetenHANagelkerkeNJHabbemaJDde VlasSJThe impact of pre-exposure prophylaxis (PrEP) on HIV epidemics in Africa and India: a simulation studyPLoS One200835e207718461185
   PubMed Web of Science ®Google Scholar
• MarcusJLGliddenDVMayerKHNo evidence of sexual risk compensation in the iPrEx trial of daily oral HIV pre-exposure prophylaxisPLoS One2013812e8199724367497
   PubMed Web of Science ®Google Scholar
• MartinMVanichseniSSuntharasamaiPRisk behaviors and risk factors for HIV infection among participants in the Bangkok tenofovir study, an HIV pre-exposure prophylaxis trial among people who inject drugsPLoS One201493e9280924667938
   PubMed Web of Science ®Google Scholar
• LiuAYVittinghoffEChillagKSexual risk behavior among HIV-uninfected men who have sex with men participating in a tenofovir preexposure prophylaxis randomized trial in the United StatesJ Acquir Immune Defic Synd20136418794
   PubMed Web of Science ®Google Scholar
• WiltonJSennHSharmaMTanDHSPre-exposure prophylaxis for sexually-acquired HIV risk management: a reviewHIV AIDS (Auckl)2015712513625987851
   PubMedGoogle Scholar
• GrantRMAndersonPLMcMahanVUptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort studyLancet Infect Dis201414982082925065857
   PubMed Web of Science ®Google Scholar
• SmithDKHerbstJHZhangXRoseCECondom effectiveness for HIV prevention by consistency of use among men who have sex with men in the United StatesJ Acquir Immune Defic Syndr201568333734425469526
   PubMed Web of Science ®Google Scholar
• CáceresCFKoechlinFGoicocheaPThe promises and challenges of pre-exposure prophylaxis as part of the emerging paradigm of combination HIV preventionJ Int AIDS Soc2015184 Suppl 31994926198341
   PubMed Web of Science ®Google Scholar