An antibiotic stewardship exercise in the ICU: building a treatment algorithm for the management of ventilator-associated pneumonia based on local epidemiology and the 2016 Infectious Diseases Society of America/American Thoracic Society guidelines

References

• Kollef MH, Chastre J, Fagon JY, et al. Global prospective epidemiologic and surveillance study of ventilator-associated pneumonia due to Pseudomonas aeruginosa. Crit Care Med. 2014;42(10):2178–2187.
   PubMed Web of Science ®Google Scholar
• Chaudhry D, Prajapat B. Intensive care unit bugs in India: how do they differ from the western world? J Assoc Chest Phys. 2017;5(1):10.
   Google Scholar
• Lee CR, Cho IH, Jeong BC, Lee SH. Strategies to minimize antibiotic resistance. Int J Environ Res Public Health. 2013;10(9):4274–4305.
   PubMed Web of Science ®Google Scholar
• Kalil AC, Metersky ML, Klompas M, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016:63(5):e61–e111.
   PubMed Web of Science ®Google Scholar
• WHO (World Health Organization): Introduction to Drug Utilization Research. Geneva: WHO International Working Group for Drug Statistics Methodology, WHO Collaborating Centre for Drug Statistics Methodology, WHO Collaborating Centre for Drug Utilization Research and Clinical Pharmacological Services, 2003.
   Google Scholar
• CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 26th ed. CLSI Supplement M100S. Wayne, PA: Clinical and Laboratory Standards Institute; 2016.
   Google Scholar
• The European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint Tables for Interpretation of MICs and Zone Diameters. Version 6.0. 2016. Available from: http://www.eucast.org. Accessed September 30, 2016.
   Google Scholar
• Jones RN, Ferraro MJ, Reller LB, et al. Multicenter studies of tigecycline disk diffusion susceptibility results for Acinetobacter spp. J Clin Microbiol. 2007;45(1):227–230.
   PubMed Web of Science ®Google Scholar
• Sınırtaş M, Akalın H, Gedikoğlu S. Investigation of colistin sensitivity via three different methods in Acinetobacter baumannii isolates with multiple antibiotic resistance. Int J Infect Dis. 2009;13(5):e217–e220.
   PubMed Web of Science ®Google Scholar
• Magiorakos AP, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3):268–281.
   PubMed Web of Science ®Google Scholar
• Tacconelli E, Cataldo MA, Dancer SJ, et al. ESCMID guidelines for the management of the infection control measures to reduce transmission of multidrug-resistant Gram-negative bacteria in hospitalized patients. Clin Microbiol Infect. 2014;20(s1):1–55.
   PubMed Web of Science ®Google Scholar
• Kanafani ZA, Kara L, Hayek S, Kanj SS. Ventilator-associated pneumonia at a tertiary-care center in a developing Country: incidence, microbiology, and susceptibility patterns of isolated microorganisms. Infect Control Hosp Epidemiol. 2003;24(11):864–869.
   PubMed Web of Science ®Google Scholar
• Chamoun K, Farah M, Araj G, et al. Surveillance of antimicrobial resistance in Lebanese hospitals: retrospective nationwide compiled data. Int J Infect Dis. 2016;46:64–70.
   PubMed Web of Science ®Google Scholar
• Moghnieh R, Siblani L, Ghadban D, et al. Extensively drug-resistant Acinetobacter baumannii in a Lebanese intensive care unit: risk factors for acquisition and determination of a colonization score. J Hosp Infect. 2016;92(1):47–53.
   PubMed Web of Science ®Google Scholar
• Hurley JC. World-wide variation in incidence of Acinetobacter associated ventilator associated pneumonia: a meta-regression. BMC Infect Dis. 2016;16(1):577.
   PubMedGoogle Scholar
• Villalón P, Valdezate S, Cabezas T, et al. Endemic and epidemic Acinetobacter baumannii clones: a twelve-year study in a tertiary care hospital. BMC Microbiol. 2015;15(1):47.
   PubMedGoogle Scholar
• Buhl M, Peter S, Willmann M. Prevalence and risk factors associated with colonization and infection of extensively drug-resistant Pseudomonas aeruginosa: a systematic review. Expert Rev Anti Infect Ther. 2015;13(9):1159–1170.
   PubMed Web of Science ®Google Scholar
• Gillon SA, Wyncoll DL. In a financially driven quest for antibiotic stewardship, does intensive care hold the key? Expert Rev Anti Infect Ther. 2017;15(1):1–3.
   PubMed Web of Science ®Google Scholar
• Iskandar K, Hanna PA, Salameh P, Raad EB. Antibiotic consumption in non-teaching Lebanese hospitals: a cross-sectional study. J Infect Public Health. 2016;9(5):618–625.
   PubMed Web of Science ®Google Scholar
• Moghnieh R, Estaitieh N, Mugharbil A, et al. Third generation cephalosporin resistant Enterobacteriaceae and multidrug resistant Gram-negative bacteria causing bacteremia in febrile neutropenia adult cancer patients in Lebanon, broad spectrum antibiotics use as a major risk factor, and correlation with poor prognosis. Front Cell Infect Microbiol. 2015;5:11.
   PubMed Web of Science ®Google Scholar
• Hammoudi D, Moubareck CA, Aires J, Adaime A, Barakat A, Fayad N. Countrywide spread of OXA-48 carbapenemase in Lebanon: surveillance and genetic characterization of carbapenem-non-susceptible Enterobacteriaceae in 10 hospitals over a one-year period. Int J Infect Dis. 2014;29:139–144.
   PubMed Web of Science ®Google Scholar
• Dandachi I, Sokhn ES, Najem E, Azar E, Daoud Z. Carriage of beta-lactamase-producing Enterobacteriaceae among nursing home residents in north Lebanon. Int J Infect Dis. 2016;45:24–31.
   PubMed Web of Science ®Google Scholar
• Ferrer R, Martin-Loeches I, Phillips G, et al. Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med. 2014;42(8):1749–1755.
   PubMed Web of Science ®Google Scholar
• Pogue JM, Alaniz C, Carver PL, Pleva M, Newton D, DePestel DD. Role of unit-specific combination antibiograms for improving the selection of appropriate empiric therapy for Gram-negative pneumonia. Infect Control Hosp Epidemiol. 2011;32(3):289–292.
   PubMed Web of Science ®Google Scholar
• Chuang YC, Cheng CY, Sheng WH, et al. Effectiveness of tigecycline-based versus colistin- based therapy for treatment of pneumonia caused by multidrug- resistant Acinetobacter baumannii in a critical setting: a matched cohort analysis. BMC Infect Dis. 2014;14:102.
   PubMed Web of Science ®Google Scholar
• Kassamali Z, Jain R, Danziger LH. An update on the arsenal for multidrug-resistant Acinetobacter infections: polymyxin antibiotics. Int J Infect Dis. 2015;30:125–132.
   PubMed Web of Science ®Google Scholar
• Tumbarello M, De Pascale G, Trecarichi EM, et al. Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible Gram-negative bacteria. Chest. 2013;144(6):1768–1775.
   PubMed Web of Science ®Google Scholar
• Durante-Mangoni E, Signoriello G, Andini R, et al. Colistin and rifampicin compared with colistin alone for the treatment of serious infections due to extensively drug-resistant Acinetobacter baumannii. A multicentre, randomised, clinical trial. Clin Infect Dis. 2013;57:349–358.
   PubMed Web of Science ®Google Scholar
• Zilberberg MD, Chen J, Mody SH, Ramsey AM, Shorr AF. Imipenem resistance of Pseudomonas in pneumonia: a systematic literature review. BMC Pulm Med. 2010;10:45.
   PubMed Web of Science ®Google Scholar
• Mombelli G, Coppens L, Thys JP, Klastersky J. Anti-Pseudomonas activity in bronchial secretions of patients receiving amikacin or tobramycin as a continuous infusion. Antimicrob Agents Chemother. 1981;19:72–75.
   PubMed Web of Science ®Google Scholar
• Bauer KA, West JE, O’Brien JM, Goff DA. Extended-infusion cefepime reduces mortality in patients with Pseudomonas aeruginosa infections. Antimicrob Agents Chemother. 2013;57(7):2907–2912.
   PubMed Web of Science ®Google Scholar
• Sader HS, Farrell DJ, Flamm RK, Jones RN. Antimicrobial susceptibility of Gram-negative organisms isolated from patients hospitalised with pneumonia in US and European hospitals: results from the SENTRY Antimicrobial Surveillance Program, 2009–2012. Int J Antimicrob Agents. 2014;43(4):328–334.
   PubMed Web of Science ®Google Scholar
• Perez F, Bonomo RA. Editorial commentary: bloodstream infection caused by extended-spectrum beta-lactamase-producing Gram-negative bacteria: how to define the best treatment regimen? Clin Infect Dis. 2015;60(9):1326–1329.
   PubMedGoogle Scholar
• Vardakas KZ, Tansarli GS, Rafailidis PI, Falagas ME. Carbapenems versus alternative antibiotics for the treatment of bacteraemia due to Enterobacteriaceae producing extended- spectrum beta-lactamases: a systematic review and meta-analysis. J Antimicrob Chemother. 2012;67(12):2793–2803.
   PubMed Web of Science ®Google Scholar
• van Duin D, Kaye KS, Neuner EA, Bonomo RA. Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes. Diagn Microbiol Infect Dis. 2013;75(2):115–120.
   PubMed Web of Science ®Google Scholar
• Bassetti M, Peghin M, Pecori D. The management of multidrug-resistant Enterobacteriaceae. Curr Opin Infect Dis. 2016;29(6):583–594.
   PubMed Web of Science ®Google Scholar
• Arizpe A, Reveles KR, Patel SD, Aitken SL. Updates in the management of cephalosporin-resistant Gram-negative bacteria. Curr Infect Dis Rep. 2016;18(12):39.
   PubMed Web of Science ®Google Scholar
• Harris PN, Tambyah PA, Paterson DL. β-lactam and β-lactamase inhibitor combinations in the treatment of extended-spectrum β-lactamase producing Enterobacteriaceae: time for a reappraisal in the era of few antibiotic options? Lancet Infect Dis. 2015;15(4):475–485.
   PubMed Web of Science ®Google Scholar
• Tamma PD, Han JH, Rock C, et al. Carbapenem therapy is associated with improved survival compared to Piperacillin-Tazobactam for patients with ESBL bacteremia. Clin Infect Dis. 2015;60:1319–1325.
   PubMed Web of Science ®Google Scholar
• Gutiérrez-Gutiérrez B, Pérez-Galera S, Salamanca E, et al. A multinational, preregistered cohort study of b-lactam/b-lactamase inhibitor combinations for treatment of bloodstream infections due to extended-spectrum-b-lactamase- producing Enterobacteriaceae. Antimicrob Agents Chemother. 2016;60:4159–4169.
   PubMed Web of Science ®Google Scholar
• Harris PN, Peleg AY, Iredell J, et al. Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non-susceptible Escherichia coli and Klebsiella spp (the MERINO trial): study protocol for a randomised controlled trial. Trials. 2015;16(1):24.
   PubMed Web of Science ®Google Scholar
• Kang CI, Cha MK, Kim SH, et al. Extended-spectrum cephalosporins and the inoculum effect in tests with CTX-M-type extended-spectrum beta-lactamase- producing Escherichia coli: potential clinical implications of the revised CLSI interpretive criteria. Int J Antimicrob Agents. 2014;43(5):456–459.
   PubMed Web of Science ®Google Scholar
• Chopra T, Marchaim D, Veltman J, et al. Impact of cefepime therapy on mortality among patients with bloodstream infections caused by extended-spectrum-beta- lactamase-producing Klebsiella pneumoniae and Escherichia coli. Antimicrob Agents Chemother. 2012;56(7):3936–3942.
   PubMed Web of Science ®Google Scholar
• Lee NY, Lee CC, Huang WH, Tsui KC, Hsueh PR, Ko WC. Cefepime therapy for monomicrobial bacteremia caused by cefepime-susceptible extended-spectrum beta-lactamase- producing Enterobacteriaceae: MIC matters. Clin Infect Dis. 2013;56(4):488–495.
   PubMed Web of Science ®Google Scholar
• Wang R, Cosgrove SE, Tschudin-Sutter S, et al. Cefepime therapy for cefepime-susceptible extended-spectrum beta-lactamase-producing Enterobacteriaceae bacteremia. Open Forum Infect Dis. 2016;3(3):ofw132.
   Web of Science ®Google Scholar
• Scholte JB, Zhou TL, Bergmans DC, et al. Stenotrophomonas maltophilia ventilator-associated pneumonia. A retrospective matched case-control study. Infect Dis. 2016;48(10):738–743.
   PubMed Web of Science ®Google Scholar
• Abbott IJ, Slavin MA, Turnidge JD, Thursky KA, Worth LJ. Stenotrophomonas maltophilia: emerging disease patterns and challenges for treatment. Expert Rev Anti Infect Ther. 2011;9(4):471–488.
   PubMed Web of Science ®Google Scholar