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Infection and Drug Resistance Volume 12, 2019 - Issue
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Original Research

Enhancing the antibacterial activity of polymyxins using a nonantibiotic drug

Malathy Krishnamurthy1 Department of Target Discovery and Experimental Microbiology, Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA
,
Margaret M Lemmon1 Department of Target Discovery and Experimental Microbiology, Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA
,
Evan M Falcinelli1 Department of Target Discovery and Experimental Microbiology, Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA
,
Reuel A Sandy1 Department of Target Discovery and Experimental Microbiology, Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA
,
Jennifer N Dootz1 Department of Target Discovery and Experimental Microbiology, Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA
,
Tiffany M Mott1 Department of Target Discovery and Experimental Microbiology, Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA
,
Sathish Rajamani1 Department of Target Discovery and Experimental Microbiology, Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA;2 General Dynamics Information Technology, Frederick, MD, USA
,
Kurt E Schaecher3 Department of Pathology, Walter Reed National Military Medical Center, Bethesda, MD, USA
,
Allen J Duplantier1 Department of Target Discovery and Experimental Microbiology, Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA;4 Cherokee Nation Assurance, Frederick, MD, USA
&
Rekha G Panchal1 Department of Target Discovery and Experimental Microbiology, Division of Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, USACorrespondence[email protected]
 show all
Pages 1393-1405 | Published online: 27 May 2019

References

  • O’Neill J. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. Rev Antimicrob Resist. 2014. Available from: https://amr-review.org/. Accessed April 23, 2019.
  • Mehrad B, Clark NM, Zhanel GG, Lynch JP 3rd. Antimicrobial resistance in hospital-acquired gram-negative bacterial infections. Chest. 2015;147(5):1413–1421. doi:10.1378/chest.14-217125940252
  • Al-Tawfiq JA, Laxminarayan R, Mendelson M. How should we respond to the emergence of plasmid-mediated colistin resistance in humans and animals? Int J Infect Dis. 2017;54:77–84. doi:10.1016/j.ijid.2016.11.41527915108
  • Poirel L, Jayol A, Nordmann P. Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes. Clin Microbiol Rev. 2017;30(2):557–596. doi:10.1128/CMR.00064-1628275006
  • Olaitan AO, Morand S, Rolain JM. Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria. Front Microbiol. 2014;5:643. doi:10.3389/fmicb.2014.0054725505462
  • Liu YY, Wang Y, Walsh TR, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16(2):161–168. doi:10.1016/S1473-3099(15)00424-726603172
  • Ejim L, Farha MA, Falconer SB, et al. Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nat Chem Biol. 2011;7(6):348–350. doi:10.1038/nchembio.55921516114
  • Worthington RJ, Melander C. Combination approaches to combat multidrug-resistant bacteria. Trends Biotechnol. 2013;31(3):177–184. doi:10.1016/j.tibtech.2012.12.00623333434
  • Ball P. The clinical development and launch of amoxicillin/clavulanate for the treatment of a range of community-acquired infections. Int J Antimicrob Agents. 2007;30(Suppl 2):S113–S117. doi:10.1016/j.ijantimicag.2007.07.03717997283
  • Annamanedi M, Varma GYN, Anuradha K, Kalle AM. Celecoxib enhances the efficacy of low-dose antibiotic treatment against polymicrobial sepsis in mice and clinical isolates of ESKAPE pathogens. Front Microbiol. 2017;8:805. doi:10.3389/fmicb.2017.0080528533769
  • Stokes JM, MacNair CR, Ilyas B, et al. Pentamidine sensitizes gram-negative pathogens to antibiotics and overcomes acquired colistin resistance. Nat Microbiol. 2017;2:17028. doi:10.1038/nmicrobiol.2016.25128263303
  • Harris TL, Worthington RJ, Hittle LE, Zurawski DV, Ernst RK, Melander C. Small molecule downregulation of PmrAB reverses lipid A modification and breaks colistin resistance. ACS Chem Biol. 2014;9(1):122–127. doi:10.1021/cb400490k24131198
  • Zhu J, Huang JW, Tseng PH, et al. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 2004;64(12):4309–4318. doi:10.1158/0008-5472.CAN-03-406315205346
  • Weng SC, Kashida Y, Kulp SK, et al. Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. Mol Cancer Ther. 2008;7(4):800–808. doi:10.1158/1535-7163.MCT-07-043418413793
  • Chiu HC, Soni S, Kulp SK, et al. Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agent. J Biomed Sci. 2009;16:110. doi:10.1186/1423-0127-16-11020003180
  • Booth L, Robert JL, Cash DR, et al. GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease. J Cell Physiol. 2015;230(7):1661–1676.
  • Campos MA, Morey P, Bengoechea JA. Quinolones sensitize gram-negative bacteria to antimicrobial peptides. Antimicrob Agents Chemother. 2006;50(7):2361–2367. doi:10.1128/AAC.01437-0516801413
  • Ortega X, Silipo A, Saldias MS, Bates CC, Molinaro A, Valvano MA. Biosynthesis and structure of the Burkholderia cenocepacia K56-2 lipopolysaccharide core oligosaccharide: truncation of the core oligosaccharide leads to increased binding and sensitivity to polymyxin B. J Biol Chem. 2009;284(32):21738–21751. doi:10.1074/jbc.M109.00853219525227
  • Helander IM, Mattila-Sandholm T. Fluorometric assessment of gram-negative bacterial permeabilization. J Appl Microbiol. 2000;88(2):213–219.10735988
  • Hancock REW, Wong PGW. Compounds which increase the permeability of the pseudomonas-aeruginosa outer-membrane. Antimicrob Agents Ch. 1984;26(1):48–52. doi:10.1128/AAC.26.1.48
  • Peleg AY, Hooper DC. Hospital-acquired infections due to gram-negative bacteria. N Engl J Med. 2010;362(19):1804–1813. doi:10.1056/NEJMra090412420463340

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