Molecular Epidemiology and Mechanisms of High-Level Resistance to Meropenem and Imipenem in Pseudomonas aeruginosa

References

• Micek ST, Wunderink RG, Kollef MH, et al. An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: impact of multidrug resistance. Crit Care. 2015;19:219. doi:10.1186/s13054-015-0926-525944081
   PubMed Web of Science ®Google Scholar
• Castanheira M, Deshpande LM, Costello A, Davies TA, Jones RN. Epidemiology and carbapenem resistance mechanisms of carbapenem-non-susceptible Pseudomonas aeruginosa collected during 2009-11 in 14 European and Mediterranean countries. J Antimicrob Chemother. 2014;69(7):1804–1814. doi:10.1093/jac/dku04824603963
   PubMed Web of Science ®Google Scholar
• Morita Y, Tomida J, Kawamura Y. Responses of Pseudomonas aeruginosa to antimicrobials. Front Microbiol. 2014;4:422. doi:10.3389/fmicb.2013.0042224409175
   PubMed Web of Science ®Google Scholar
• Lee JY, Ko KS. OprD mutations and inactivation, expression of efflux pumps and AmpC, and metallo-beta-lactamases in carbapenem-resistant Pseudomonas aeruginosa isolates from South Korea. Int J Antimicrob Agents. 2012;40(2):168–172. doi:10.1016/j.ijantimicag.2012.04.00422633564
   PubMed Web of Science ®Google Scholar
• Ocampo-Sosa AA, Cabot G, Rodriguez C, et al. Alterations of OprD in carbapenem-intermediate and -susceptible strains of Pseudomonas aeruginosa isolated from patients with bacteremia in a Spanish multicenter study. Antimicrob Agents Chemother. 2012;56(4):1703–1713. doi:10.1128/AAC.05451-1122290967
   PubMed Web of Science ®Google Scholar
• Lister PD, Wolter DJ, Hanson ND. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin Microbiol Rev. 2009;22(4):582–610. doi:10.1128/CMR.00040-0919822890
   PubMed Web of Science ®Google Scholar
• Dantas RCC, Silva RTE, Ferreira ML, et al. Molecular epidemiological survey of bacteremia by multidrug resistant Pseudomonas aeruginosa: the relevance of intrinsic resistance mechanisms. PLoS One. 2017;12(5):e0176774. doi:10.1371/journal.pone.017677428481953
   PubMed Web of Science ®Google Scholar
• Li XZ, Barre N, Poole K. Influence of the MexA-MexB-oprM multidrug efflux system on expression of the MexC-MexD-oprJ and MexE-MexF-oprN multidrug efflux systems in Pseudomonas aeruginosa. J Antimicrob Chemother. 2000;46(6):885–893. doi:10.1093/jac/46.6.88511102405
   PubMed Web of Science ®Google Scholar
• Riera E, Cabot G, Mulet X, et al. Pseudomonas aeruginosa carbapenem resistance mechanisms in Spain: impact on the activity of imipenem, meropenem and doripenem. J Antimicrob Chemother. 2011;66(9):2022–2027. doi:10.1093/jac/dkr23221653605
   PubMed Web of Science ®Google Scholar
• Masuda N, Sakagawa E, Ohya S, et al. Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2000;44(12):3322–3327. doi:10.1128/AAC.44.12.3322-3327.200011083635
   PubMed Web of Science ®Google Scholar
• Khosravi AD, Mihani F. Detection of metallo-beta-lactamase-producing Pseudomonas aeruginosa strains isolated from burn patients in Ahwaz, Iran. Diagn Microbiol Infect Dis. 2008;60(1):125–128. doi:10.1016/j.diagmicrobio.2007.08.00317900848
   PubMed Web of Science ®Google Scholar
• Cornaglia G, Giamarellou H, Rossolini GM. Metallo-beta-lactamases: a last frontier for beta-lactams? Lancet Infect Dis. 2011;11(5):381–393. doi:10.1016/S1473-3099(11)70056-121530894
   PubMed Web of Science ®Google Scholar
• Palzkill T. Metallo-beta-lactamase structure and function. Ann N Y Acad Sci. 2013;1277:91–104. doi:10.1111/j.1749-6632.2012.06796.x23163348
   PubMed Web of Science ®Google Scholar
• Poirel L, Walsh TR, Cuvillier V, Nordmann P. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Inf Dis. 2011;70(1):119–123. doi:10.1016/j.diagmicrobio.2010.12.002
   PubMed Web of Science ®Google Scholar
• Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing. PA: Clinical and Laboratory Standards Institute 27th M100: 2018.
   Google Scholar
• Rostami S, Farajzadeh Sheikh A, Shoja S, et al. Investigating of four main carbapenem-resistance mechanisms in high-level carbapenem resistant Pseudomonas aeruginosa isolated from burn patients. J Chin Med Assoc. 2018;81(2):127–132. doi:10.1016/j.jcma.2017.08.01629033110
   PubMed Web of Science ®Google Scholar
• Senda K, Arakawa Y, Ichiyama S, et al. PCR detection of metallo-beta-lactamase gene (blaIMP) in gram-negative rods resistant to broad-spectrum beta-lactams. J Clin Microbiol. 1996;34(12):2909–2913. doi:10.1128/JCM.34.12.2909-2913.19968940421
   PubMed Web of Science ®Google Scholar
• Shibata N, Doi Y, Yamane K, et al. PCR typing of genetic determinants for metallo-beta-lactamases and integrases carried by gram-negative bacteria isolated in Japan, with focus on the class 3 integron. J Clin Microbiol. 2003;41(12):5407–5413. doi:10.1128/JCM.41.12.5407-5413.200314662918
   PubMed Web of Science ®Google Scholar
• Tsakris A, Pournaras S, Woodford N, et al. Outbreak of infections caused by Pseudomonas aeruginosa producing VIM-1 carbapenemase in Greece. J Clin Microbiol. 2000;38(3):1290–1292. doi:10.1128/JCM.38.3.1290-1292.200010699045
   PubMed Web of Science ®Google Scholar
• Poirel L, Naas T, Nicolas D, et al. Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France. Antimicrob Agents Chemother. 2000;44(4):891–897. doi:10.1128/AAC.44.4.891-897.200010722487
   PubMed Web of Science ®Google Scholar
• Nordmann P, Poirel L, Carrer A, Toleman MA, Walsh TR. How to detect NDM-1 producers. J Clin Microbiol. 2011;49(2):718–721. doi:10.1128/JCM.01773-1021123531
   PubMed Web of Science ®Google Scholar
• Queenan AM, Bush K. Carbapenemases: the versatile beta-lactamases. Clin Microbiol Rev. 2007;20(3):440–458. doi:10.1128/CMR.00001-0717630334
   PubMed Web of Science ®Google Scholar
• Quale J, Bratu S, Gupta J, Landman D. Interplay of efflux system, ampC, and oprD expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother. 2006;50(5):1633–1641. doi:10.1128/AAC.50.5.1633-1641.200616641429
   PubMed Web of Science ®Google Scholar
• Yoneda K, Chikumi H, Murata T, et al. Measurement of Pseudomonas aeruginosa multidrug efflux pumps by quantitative real-time polymerase chain reaction. FEMS Microbiol Lett. 2005;243(1):125–131. doi:10.1016/j.femsle.2004.11.04815668010
   PubMed Web of Science ®Google Scholar
• Shigemura K, Osawa K, Kato A, et al. Association of overexpression of efflux pump genes with antibiotic resistance in Pseudomonas aeruginosa strains clinically isolated from urinary tract infection patients. J Antibiot (Tokyo). 2015;68(9):568–572. doi:10.1038/ja.2015.3425850341
   PubMed Web of Science ®Google Scholar
• Cabot G, Ocampo-Sosa AA, Tubau F, et al. Overexpression of AmpC and efflux pumps in Pseudomonas aeruginosa isolates from bloodstream infections: prevalence and impact on resistance in a Spanish multicenter study. Antimicrob Agents Chemother. 2011;55(5):1906–1911. doi:10.1128/AAC.01645-1021357294
   PubMed Web of Science ®Google Scholar
• Rodriguez-Martinez JM, Poirel L, Nordmann P. Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2009;53(11):4783–4788. doi:10.1128/AAC.00574-0919738025
   PubMed Web of Science ®Google Scholar
• Takata I, Yamagishi Y, Mikamo H. Association of the exoU genotype with a multidrug non-susceptible phenotype and mRNA expressions of resistance genes in Pseudomonas aeruginosa.. J Infect Chemother. 2018;24(1):45–52. doi:10.1016/j.jiac.2017.08.01829107652
   PubMed Web of Science ®Google Scholar
• Mahenthiralingam E, Campbell ME, Foster J, Lam JS, Speert DP. Random amplified polymorphic DNA typing of Pseudomonas aeruginosa isolates recovered from patients with cystic fibrosis. J Clin Microbiol. 1996;34(5):1129–1135. doi:10.1128/JCM.34.5.1129-1135.19968727889
   PubMed Web of Science ®Google Scholar
• Vaez H, Moghim S, Nasr Esfahani B, Ghasemian Safaei H. Clonal relatedness among imipenem-resistant Pseudomonas aeruginosa isolated from ICU-hospitalized patients. Crit Care Res Pract. 2015;2015:5.
   Google Scholar
• Marian RR, Mohamed S, Hazim AR, Noha Anwar H. High incidence of MBL-mediated imipenem resistance among Pseudomonas aeruginosa from surgical site infections in Egypt. J Infect Developing Country. 2018;12:07.
   Web of Science ®Google Scholar
• Chalhoub H, Saenz Y, Rodriguez-Villalobos H, et al. High-level resistance to meropenem in clinical isolates of Pseudomonas aeruginosa in the absence of carbapenemases: role of active efflux and porin alterations. Int J Antimicrob Agents. 2016;48(6):740–743. doi:10.1016/j.ijantimicag.2016.09.01228128097
   PubMed Web of Science ®Google Scholar
• Fam N, Gamal D, El Said M, et al. Occurrence of VIM-2 Metallo-ß-Lactamases in imipenem resistant and susceptible Pseudomonas aeruginosa clinical isolates from Egypt. Afr J Microbiol Res. 2013;7:4465–4472.
   Google Scholar
• Zafer MM, Al-Agamy MH, El-Mahallawy HA, Amin MA, El Din Ashour S, El Din Ashour S. Dissemination of VIM-2 producing Pseudomonas aeruginosa ST233 at tertiary care hospitals in Egypt. BMC Infect Dis. 2015;15(1):122. doi:10.1186/s12879-015-0861-825880997
   PubMed Web of Science ®Google Scholar
• Tsakris A, Poulou A, Kristo I, et al. Large dissemination of VIM-2-metallo-[4]-lactamase-producing Pseudomonas aeruginosa strains causing health care-associated community-onset infections. J Clin Microbiol. 2009;47(11):3524–3529. doi:10.1128/JCM.01099-0919776233
   PubMed Web of Science ®Google Scholar
• Gaballah A, Elbaradei A, Elsheredy A, Kader O. Emergence of blaVEB and blaGES among VIM-producing Pseudomonas aeruginosa clinical isolates in Alexandria, Egypt. Acta Microbiolog Immunolog Hungar. 2019;66(1):131–142. doi:10.1556/030.65.2018.044
   Web of Science ®Google Scholar
• Zafer M, Amin M, El-Mahallawy H, Ashour S, Al-agamy M. First report of NDM-1-producing Pseudomonas aeruginosa in Egypt. Int J Infect Dis. 2014;29C:80–81. doi:10.1016/j.ijid.2014.07.008
   Web of Science ®Google Scholar
• Nikaido H, Pages JM. Broad-specificity efflux pumps and their role in multidrug resistance of gram-negative bacteria. FEMS Microbiol Rev. 2012;36(2):340–363. doi:10.1111/j.1574-6976.2011.00290.x21707670
   PubMed Web of Science ®Google Scholar
• Bubonja-Sonje M, Matovina M, Skrobonja I, Bedenic B, Abram M. Mechanisms of carbapenem resistance in multidrug-resistant clinical isolates of Pseudomonas aeruginosa from a Croatian hospital. Microb Drug Resist. 2015;21(3):261–269. doi:10.1089/mdr.2014.017225565041
   PubMed Web of Science ®Google Scholar
• Poole K. Efflux-Mediated Antimicrobial Resistance In: Dougherty TJ, Pucci MJ, editors. Antibiotic Discovery and Development. Boston, MA: Springer US; 2012:349–395.
   Google Scholar
• Morita Y, Tomida J, Kawamura Y. MexXY-OprM multidrug efflux system of Pseudomonas aeruginosa. Front Microbiol. 2012;3:408. doi:10.3389/fmicb.2012.0040823233851
   PubMed Web of Science ®Google Scholar
• Rostami S, Farajzadeh Sheikh A, Shoja S, et al. Investigating of four main carbapenem-resistance mechanisms in high-level carbapenem resistant Pseudomonas aeruginosa isolated from burn patients. J Chin Med Ass. 2018;81(2):127–132. doi:10.1016/j.jcma.2017.08.01629033110
   PubMed Web of Science ®Google Scholar
• Tuba M, Rıza D, Birsen O, et al. Role of efflux pump and OprD porin expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates. J Inf Develop Country. 2018;12:01. doi:10.3855/jidc.9486
   Google Scholar
• Xavier DE, Picão RC, Girardello R, Fehlberg LC, Gales AC. Efflux pumps expression and its association with porin down-regulation and β-lactamase production among Pseudomonas aeruginosa causing bloodstream infections in Brazil. BMC Microbiol. 2010;10(1):217. doi:10.1186/1471-2180-10-21720704733
   PubMed Web of Science ®Google Scholar
• Muderris T, Durmaz R, Ozdem B. et al. Role of efflux pump and OprD porin expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates. J Infect Dev Ctries. 2018;12(1):1–8. doi:10.3855/jidc.948631628827
   PubMed Web of Science ®Google Scholar
• Onteniente L, Brisse S, Tassios PT, Vergnaud G. Evaluation of the polymorphisms associated with tandem repeats for Pseudomonas aeruginosa strain typing. J Clin Microbiol. 2003;41(11):4991–4997. doi:10.1128/JCM.41.11.4991-4997.200314605129
   PubMed Web of Science ®Google Scholar
• Dawson SL, Fry JC, Dancer BN. A comparative evaluation of five typing techniques for determining the diversity of fluorescent pseudomonads. J Microbiol Methods. 2002;50(1):9–22. doi:10.1016/S0167-7012(02)00003-911943354
   PubMed Web of Science ®Google Scholar