Phenotypic and Genomic Characterization of Virulence Heterogeneity in Multidrug-Resistant ST11 Klebsiella pneumoniae During Inter-Host Transmission and Evolution

References

• Magill SS, O’Leary E, Janelle SJ, et al. Changes in prevalence of health care-associated infections in U.S. hospitals. N Engl J Med. 2018;379(18):1732–1744. doi:10.1056/NEJMoa180155030380384
   PubMed Web of Science ®Google Scholar
• Russo TA, Marr CM. Hypervirulent Klebsiella pneumoniae. Clin Microbiol Rev. 2019;32(3):e00001–19.31092506
   PubMed Web of Science ®Google Scholar
• Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence. 2013;4(2):107–118. doi:10.4161/viru.2271823302790
   PubMed Web of Science ®Google Scholar
• Catalan-Najera JC, Garza-Ramos U, Barrios-Camacho H. Hypervirulence and hypermucoviscosity: two different but complementary Klebsiella spp. phenotypes? Virulence. 2017;8(7):1111–1123. doi:10.1080/21505594.2017.131741228402698
   PubMed Web of Science ®Google Scholar
• Liu C, Shi J, Guo J. High prevalence of hypervirulent Klebsiella pneumoniae infection in the genetic background of elderly patients in two teaching hospitals in China. Infect Drug Resist. 2018;11:1031–1041. doi:10.2147/IDR.S16107530104891
   PubMed Web of Science ®Google Scholar
• Wang Q, Wang X, Wang J, et al. Phenotypic and genotypic characterization of carbapenem-resistant enterobacteriaceae: data from a longitudinal large-scale CRE study in China (2012–2016). Clin Infect Dis. 2018;67(suppl_2):S196–S205. doi:10.1093/cid/ciy66030423057
   PubMed Web of Science ®Google Scholar
• Toth A, Damjanova I, Puskas E, et al. Emergence of a colistin-resistant KPC-2-producing Klebsiella pneumoniae ST258 clone in Hungary. Eur j Clin Microbiol Infect Dis. 2010;29(7):765–769. doi:10.1007/s10096-010-0921-320401676
   PubMed Web of Science ®Google Scholar
• Qi Y, Wei Z, Ji S, Du X, Shen P, Yu Y. ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China. J Antimicrob Chemother. 2011;66(2):307–312. doi:10.1093/jac/dkq43121131324
   PubMed Web of Science ®Google Scholar
• Li W, Sun G, Yu Y, et al. Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China. Clin Infect Dis. 2014;58(2):225–232. doi:10.1093/cid/cit67524099919
   PubMed Web of Science ®Google Scholar
• Siu LK, Yeh KM, Lin JC, Fung CP, Chang FY. Klebsiella pneumoniae liver abscess: a new invasive syndrome. Lancet Infect Dis. 2012;12(11):881–887. doi:10.1016/S1473-3099(12)70205-023099082
   PubMed Web of Science ®Google Scholar
• Pomakova DK, Hsiao CB, Beanan JM, et al. Clinical and phenotypic differences between classic and hypervirulent Klebsiella pneumonia: an emerging and under-recognized pathogenic variant. Eur j Clin Microbiol Infect Dis. 2012;31(6):981–989. doi:10.1007/s10096-011-1396-621918907
   PubMed Web of Science ®Google Scholar
• Liu C, Guo J. Characteristics of ventilator-associated pneumonia due to hypervirulent Klebsiella pneumoniae genotype in genetic background for the elderly in two tertiary hospitals in China. Antimicrob Resist Infect Control. 2018;7:95. doi:10.1186/s13756-018-0371-830128143
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhao C, Wang Q, et al. High prevalence of hypervirulent Klebsiella pneumoniae infection in China: geographic distribution, clinical characteristics, and antimicrobial resistance. Antimicrob Agents Chemother. 2016;60(10):6115–6120. doi:10.1128/AAC.01127-1627480857
   PubMed Web of Science ®Google Scholar
• Lin YC, Lu MC, Tang HL, et al. Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain. BMC Microbiol. 2011;11:50. doi:10.1186/1471-2180-11-5021385400
   PubMed Web of Science ®Google Scholar
• Russo TA, Olson R, MacDonald U, Beanan J, Davidson BA. Aerobactin, but not yersiniabactin, salmochelin, or enterobactin, enables the growth/survival of hypervirulent (hypermucoviscous) Klebsiella pneumoniae ex vivo and in vivo. Infect Immun. 2015;83(8):3325–3333. doi:10.1128/IAI.00430-1526056379
   PubMed Web of Science ®Google Scholar
• Russo TA, Olson R, Fang CT, et al. Identification of biomarkers for differentiation of hypervirulent Klebsiella pneumoniae from classical K. pneumoniae. J Clin Microbiol. 2018;56(9). doi:10.1128/JCM.00776-18.
   PubMed Web of Science ®Google Scholar
• Wyres KL, Wick RR, Judd LM, et al. Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae. PLoS Genet. 2019;15(4):e1008114. doi:10.1371/journal.pgen.100811430986243
   PubMed Web of Science ®Google Scholar
• Gu D, Dong N, Zheng Z, et al. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018;18(1):37–46. doi:10.1016/S1473-3099(17)30489-928864030
   PubMed Web of Science ®Google Scholar
• Zhang R, Lin D, Chan EW, Gu D, Chen GX, Chen S. Emergence of carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae strains in China. Antimicrob Agents Chemother. 2016;60(1):709–711. doi:10.1128/AAC.02173-1526574010
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zeng J, Liu W, et al. Emergence of a hypervirulent carbapenem-resistant Klebsiella pneumoniae isolate from clinical infections in China. J Infect. 2015;71(5):553–560. doi:10.1016/j.jinf.2015.07.01026304687
   PubMed Web of Science ®Google Scholar
• Gu DX, Huang YL, Ma JH, et al. Detection of colistin resistance gene mcr-1 in hypervirulent Klebsiella pneumoniae and escherichia coli isolates from an infant with diarrhea in China. Antimicrob Agents Chemother. 2016;60(8):5099–5100. doi:10.1128/AAC.00476-1627270278
   PubMed Web of Science ®Google Scholar
• Jousset AB, Bonnin RA, Rosinski-Chupin I, et al. A 4.5-year within-patient evolution of a colistin-resistant Klebsiella pneumoniae carbapenemase-producing K. pneumoniae sequence type 258. Clin Infect Dis. 2018;67(9):1388–1394. doi:10.1093/cid/ciy29329688339
   PubMed Web of Science ®Google Scholar
• Li H, Zhang J, Liu Y, et al. Molecular characteristics of carbapenemase-producing Enterobacteriaceae in China from 2008 to 2011: predominance of KPC-2 enzyme. Diagn Microbiol Infect Dis. 2014;78(1):63–65. doi:10.1016/j.diagmicrobio.2013.10.00224211218
   PubMed Web of Science ®Google Scholar
• Baraniak A, Izdebski R, Fiett J, et al. NDM-producing Enterobacteriaceae in Poland, 2012–14: inter-regional outbreak of Klebsiella pneumoniae ST11 and sporadic cases. J Antimicrob Chemother. 2016;71(1):85–91. doi:10.1093/jac/dkv28226386745
   PubMed Web of Science ®Google Scholar
• Voulgari E, Zarkotou O, Ranellou K, et al. Outbreak of OXA-48 carbapenemase-producing Klebsiella pneumoniae in Greece involving an ST11 clone. J Antimicrob Chemother. 2013;68(1):84–88. doi:10.1093/jac/dks35622945916
   PubMed Web of Science ®Google Scholar
• Yang J, Ye L, Guo L, et al. A nosocomial outbreak of KPC-2-producing Klebsiella pneumoniae in a Chinese hospital: dissemination of ST11 and emergence of ST37, ST392 and ST395. Clinical Microbiol Infect. 2013;19(11):E509–515. doi:10.1111/1469-0691.1227523841705
   PubMed Web of Science ®Google Scholar
• Guo Y, Wang S, Zhan L, et al. Microbiological and clinical characteristics of hypermucoviscous Klebsiella pneumoniae isolates associated with invasive infections in China. Front Cell Infect Microbiol. 2017;7:24. doi:10.3389/fcimb.2017.0002428203549
   PubMed Web of Science ®Google Scholar
• Tanner JR, Kingsley RA. Evolution of salmonella within hosts. Trends Microbiol. 2018;26(12):986–998. doi:10.1016/j.tim.2018.06.00129954653
   PubMed Web of Science ®Google Scholar
• Marvig RL, Damkiaer S, Khademi SM, Markussen TM, Molin S, Jelsbak L. Within-host evolution of Pseudomonas aeruginosa reveals adaptation toward iron acquisition from hemoglobin. mBio. 2014;5(3):e00966–00914. doi:10.1128/mBio.00966-1424803516
   PubMed Web of Science ®Google Scholar
• Yang X, Wai-Chi Chan E, Zhang R, Chen S. A conjugative plasmid that augments virulence in Klebsiella pneumoniae. Nature Microbiol. 2019;4(12):2039–2043. doi:10.1038/s41564-019-0566-731570866
   PubMed Web of Science ®Google Scholar
• Shu L, Dong N, Lu J, et al. Emergence of OXA-232 carbapenemase-producing Klebsiella pneumoniae that carries a pLVPK-like virulence plasmid among elderly patients in China. Antimicrob Agents Chemother. 2018;63. doi:10.1128/AAC.02246-18.
   Web of Science ®Google Scholar
• Eyre DW, Sheppard AE, Madder H, et al. A Candida auris outbreak and its control in an intensive care setting. N Engl J Med. 2018;379(14):1322–1331. doi:10.1056/NEJMoa171437330281988
   PubMed Web of Science ®Google Scholar
• Epstein L, Hunter JC, Arwady MA, et al. New Delhi metallo-beta-lactamase-producing carbapenem-resistant Escherichia coli associated with exposure to duodenoscopes. JAMA. 2014;312(14):1447–1455. doi:10.1001/jama.2014.1272025291580
   PubMed Web of Science ®Google Scholar
• Kizny Gordon AE, Mathers AJ, Cheong EYL, et al. The hospital water environment as a reservoir for carbapenem-resistant organisms causing hospital-acquired infections-a systematic review of the literature. Clin Infect Dis. 2017;64(10):1435–1444. doi:10.1093/cid/cix13228200000
   PubMed Web of Science ®Google Scholar