Serotyping of Klebsiella pneumoniae and Its Relation with Capsule-Associated Virulence Genes, Antimicrobial Resistance Pattern, and Clinical Infections: A Descriptive Study in Medical Practice

References

• Ko W-C, Paterson DL, Sagnimeni AJ, et al. Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns. Emerg Infect Dis. 2002;8(2):160–166. doi:10.3201/eid0802.01002511897067
   PubMed Web of Science ®Google Scholar
• Woldu M. Klebsiella pneumoniae and its growing concern in healthcare settings. Clin Exp Pharmacol Physiol. 2016;6(199):2161. doi:10.4172/2161-1459.1000199
   Google Scholar
• Derakhshan S, Najar Peerayeh S, Bakhshi B. Association between presence of virulence genes and antibiotic resistance in clinical klebsiella pneumoniae isolates. Lab Med. 2016;47(4):306–311. doi:10.1093/labmed/lmw03027498999
   PubMed Web of Science ®Google Scholar
• Brisse S, Passet V, Haugaard AB, et al. wzi gene sequencing, a rapid method for determination of capsular type for Klebsiella strains. J Clin Microbiol. 2013;51(12):4073–4078. doi:10.1128/JCM.01924-1324088853
   PubMed Web of Science ®Google Scholar
• Pan Y-J, Lin T-L, Chen C-T, et al. Genetic analysis of capsular polysaccharide synthesis gene clusters in 79 capsular types of Klebsiella spp. Sci Rep. 2015;5(1):15573. doi:10.1038/srep1557326493302
   PubMed Web of Science ®Google Scholar
• Turton JF, Englender H, Gabriel SN, et al. Genetically similar isolates of Klebsiella pneumoniae serotype K1 causing liver abscesses in three continents. J Med Microbiol. 2007;56(Pt5):593–597. doi:10.1099/jmm.0.46964-017446279
   PubMed Web of Science ®Google Scholar
• Jian-li W, Yuan-yuan S, Shou-yu G, et al. Serotype and virulence genes of Klebsiella pneumoniae isolated from mink and its pathogenesis in mice and mink. Sci Rep. 2017;7(1):17291. doi:10.1038/s41598-017-17681-829230010
   PubMed Web of Science ®Google Scholar
• Cortés G, Borrell N, de Astorza B, et al. Molecular analysis of the contribution of the capsular polysaccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine model of pneumonia. Infect Immun. 2002;70(5):2583–2590. doi:10.1128/IAI.70.5.2583-2590.200211953399
   PubMed Web of Science ®Google Scholar
• Turton JF, Perry C, Elgohari S, et al. PCR characterization and typing of Klebsiella pneumoniae using capsular type-specific, variable number tandem repeat and virulence gene targets. J Med Microbiol. 2010;59(5):541–547. doi:10.1099/jmm.0.015198-020110386
   PubMed Web of Science ®Google Scholar
• Candan ED, Aksöz N. Klebsiella pneumoniae: characteristics of carbapenem resistance and virulence factors. Acta Biochim Pol. 2015;62(4):867–874. doi:10.18388/abp.2015_114826637376
   PubMed Web of Science ®Google Scholar
• Victor LY, Hansen DS, Ko WC, et al. Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections. Emerg Infect Dis. 2007;13(7):986. doi:10.3201/eid1307.07018718214169
   PubMed Web of Science ®Google Scholar
• Tsay R-W, Siu L, Fung C-P, et al. Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as a herald for community-acquired infection. Arch Intern Med. 2002;162(9):1021–1027. doi:10.1001/archinte.162.9.102111996612
   PubMedGoogle Scholar
• Wayne P. Clinical and laboratory standards institute. Performance standards for antimicrobial susceptibility testing. 2017;142–158.
   Google Scholar
• Magiorakos AP, Srinivasan A, Carey R, et al. Multidrug‐resistant, extensively drug‐resistant and pandrug‐resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18(3):268–281. doi:10.1111/j.1469-0691.2011.03570.x21793988
   PubMed Web of Science ®Google Scholar
• Phu VD, Wertheim HF, Larsson M, et al. Burden of hospital acquired infections and antimicrobial use in Vietnamese adult intensive care units. PLoS One. 2016;11(1):e0147544. doi:10.1371/journal.pone.014754426824228
   PubMed Web of Science ®Google Scholar
• Erdem H, Inan A, Altindis S, et al. Surveillance, control and management of infections in intensive care units in Southern Europe, Turkey and Iran – a prospective multicenter point prevalence study. J Infect. 2014;68(2):131–140. doi:10.1016/j.jinf.2013.11.00124269951
   PubMed Web of Science ®Google Scholar
• Daikos GL, Tsaousi S, Tzouvelekis LS, et al. Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems. Antimicrob Agents Chemother. 2014;58(4):2322–2328. doi:10.1128/aac.02166-1324514083
   PubMed Web of Science ®Google Scholar
• Machuca I, Gutierrez-Gutierrez B, Gracia-Ahufinger I, et al. Mortality associated with bacteremia due to colistin-resistant klebsiella pneumoniae with high-level meropenem resistance: importance of combination therapy without colistin and carbapenems. Antimicrob Agents Chemother. 2017;61(8):e00406–e00417. doi:10.1128/aac.00406-1728559247
   PubMed Web of Science ®Google Scholar
• Tumbarello M, Viale P, Viscoli C, et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase–producing K. pneumoniae: importance of combination therapy. Clin Infect Dis. 2012;55(7):943–950. doi:10.1093/cid/cis58822752516
   PubMed Web of Science ®Google Scholar
• Kang C-I, Kim S-H, Park WB, et al. Bloodstream infections due to extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for mortality and treatment outcome, with special emphasis on antimicrobial therapy. Antimicrob Agents Chemother. 2004;48(12):4574–4581. doi:10.1128/AAC.48.12.4574-4581.200415561828
   PubMed Web of Science ®Google Scholar
• Tumbarello M, Spanu T, Sanguinetti M, et al. Bloodstream infections caused by extended-spectrum-β-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome. Antimicrob Agents Chemother. 2006;50(2):498–504. doi:10.1128/AAC.50.2.498-504.200616436702
   PubMed Web of Science ®Google Scholar
• Xu L, Sun X, Ma X. Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae. Ann Clin Microbiol Antimicrob. 2017;16(1):18. doi:10.1186/s12941-017-0191-328356109
   PubMed Web of Science ®Google Scholar
• Shankar C, Veeraraghavan B, Nabarro LEB, et al. Whole genome analysis of hypervirulent Klebsiella pneumoniae isolates from community and hospital acquired bloodstream infection. BMC Microbiol. 2018;18(1):6. doi:10.1186/s12866-017-1148-629433440
   PubMed Web of Science ®Google Scholar
• Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence. 2013;4(2):107–118. doi:10.4161/viru.2271823302790
   PubMed Web of Science ®Google Scholar
• Cryz S, Mortimer P, Mansfield V, et al. Seroepidemiology of Klebsiella bacteremic isolates and implications for vaccine development. J Clin Microbiol. 1986;23(4):687–690. doi:10.1128/JCM.23.4.687-690.19863517058
   PubMed Web of Science ®Google Scholar
• Yeh K-M, Kurup A, Siu L, et al. Capsular serotype K1 or K2, rather than magA and rmpA, is a major virulence determinant for Klebsiella pneumoniae liver abscess in Singapore and Taiwan. J Clin Microbiol. 2007;45(2):466–471. doi:10.1128/JCM.01150-0617151209
   PubMed Web of Science ®Google Scholar
• Chen Y-T, Lai Y-C, Tan M-C, et al. Prevalence and characteristics of pks genotoxin gene cluster-positive clinical Klebsiella pneumoniae isolates in Taiwan. Sci Rep. 2017;7(1):43120. doi:10.1038/srep4312028233784
   PubMed Web of Science ®Google Scholar
• Ma Y, Bao C, Liu J, et al. Microbiological characterisation of Klebsiella pneumoniae isolates causing bloodstream infections from five tertiary hospitals in Beijing, China. J Glob Antimicrob Resist. 2018;12:162–166. doi:10.1016/j.jgar.2017.10.00229032055
   PubMed Web of Science ®Google Scholar
• Yeh KM, Lin JC, Yin FY, et al. Revisiting the importance of virulence determinant magA and its surrounding genes in Klebsiella pneumoniae causing pyogenic liver abscesses: exact role in serotype K1 capsule formation. J Infect Dis. 2010;201(8):1259–1267. doi:10.1086/60601019785524
   PubMed Web of Science ®Google Scholar
• TAVAKOL M, MOMTAZ H. Molecular characterization of serotypes and capsular virulence genes in cps gen group of Klebsiella pneumonia isolated from Tehran hospitals. JMW. 2017;10:18–25.
   Google Scholar
• Fang C-T, Lai S-Y, Yi W-C, et al. Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Clin Infect Dis. 2007;45(3):284–293. doi:10.1086/51926217599305
   PubMed Web of Science ®Google Scholar
• Aljanaby AAJ, Alhasani AHA. Virulence factors and antibiotic susceptibility patterns of multidrug resistance Klebsiella pneumoniae isolated from different clinical infections. Afr J Microbiol Res. 2016;10(22):829–843. doi:10.5897/AJMR2016.8051
   Google Scholar
• Regué M, Hita B, Piqué N, et al. A gene, uge, is essential for Klebsiella pneumoniae virulence. Infect Immun. 2004;72(1):54–61. doi:10.1128/IAI.72.1.54-61.200414688080
   PubMed Web of Science ®Google Scholar
• Cheng H, Chen Y, Wu C, et al. RmpA regulation of capsular polysaccharide biosynthesis in Klebsiella pneumoniae CG43. J Bacteriol. 2010;192(12):3144–3158. doi:10.1128/JB.00031-1020382770
   PubMed Web of Science ®Google Scholar
• Hsu C-R, Lin T-L, Chen Y-C, et al. The role of Klebsiella pneumoniae rmpA in capsular polysaccharide synthesis and virulence revisited. Microbiol. 2011;157(12):3446–3457. doi:10.1099/mic.0.050336-0
   PubMed Web of Science ®Google Scholar
• Lin H-A, Huang Y-L, Yeh K-M, et al. Regulator of the mucoid phenotype A gene increases the virulent ability of extended-spectrum beta-lactamase-producing serotype non-K1/K2 Klebsiella pneumonia. J Microbiol Immunol Infect. 2016;49(4):494–501. doi:10.1016/j.jmii.2014.08.02325442871
   PubMedGoogle Scholar
• Yu W-L, Ko W-C, Cheng K-C, et al. Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. Clin Infect Dis. 2006;42(10):1351–1358. doi:10.1086/50342016619144
   PubMed Web of Science ®Google Scholar
• Shu H-Y, Fung C-P, Liu Y-M, et al. Genetic diversity of capsular polysaccharide biosynthesis in Klebsiella pneumoniae clinical isolates. Microbiol. 2009;155(12):4170–4183. doi:10.1099/mic.0.029017-0
   Web of Science ®Google Scholar
• Yeh K-M, Lin J-C, Yin F-Y, et al. Revisiting the importance of virulence determinant magA and its surrounding genes in Klebsiella pneumoniae causing pyogenic liver abscesses: exact role in serotype K1 capsule formation. J Infect Dis. 2010;201(8):1259–1267. doi:10.1086/60601019785524
   PubMed Web of Science ®Google Scholar
• Liu C, Guo J. Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor. Ann Clin Microbiol Antimicrob. 2019;18(1):4. doi:10.1186/s12941-018-0302-930665418
   PubMed Web of Science ®Google Scholar
• Lee C-H, Liu J-W, Su L-H, et al. Hypermucoviscosity associated with Klebsiella pneumoniae-mediated invasive syndrome: a prospective cross-sectional study in Taiwan. Int J Infect Dis. 2010;14(8):e688–e92. doi:10.1016/j.ijid.2010.01.00720547084
   PubMed Web of Science ®Google Scholar