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Original Research

The Osteogenic Effect of Local Delivery of Vancomycin and Tobramycin on Bone Marrow Stromal Cells

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Pages 2083-2091 | Published online: 01 Jul 2020

References

  • Sweet FA, Forsthoefel CW, Sweet AR, Dahlberg RK. Local versus systemic antibiotics for surgical infection prophylaxis in a rat model. J Bone Joint Surg Am. 2018;100(18):e120. doi:10.2106/JBJS.18.0010530234625
  • Pais GM, Liu J, Avedissian SN, et al. Scheetz. Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model. J Antimicrob Chemother. 2020;75(5):1228–1236. doi:10.1093/jac/dkz56332011685
  • Ishida W, Perdomo-Pantoja A, Elder BD, et al. Effects of intraoperative intrawound antibiotic administration on spinal fusion: a comparison of vancomycin and tobramycin in a rat model. J Bone Joint Surg Am. 2019;101(19):1741–1749. doi:10.2106/JBJS.18.0098831577679
  • Edelstein AI, Weiner JA, Cook RW, et al. Intra-articular vancomycin powder eliminates methicillin-resistant S. aureus in a rat model of a contaminated intra-articular implant. J Bone Joint Surg Am. 2017;99(3):232–238. doi:10.2106/JBJS.16.0012728145954
  • Haimoto S, Schar RT, Nishimura Y, Hara M, Wakabayashi T, Ginsberg HJ. Reduction in surgical site infection with suprafascial intrawound application of vancomycin powder in instrumented posterior spinal fusion: a retrospective case-control study. J Neurosurg Spine. 2018;29(2):193–198. doi:10.3171/2017.12.SPINE1799729726801
  • Slane J, Gietman B, Squire M. Antibiotic elution from acrylic bone cement loaded with high doses of tobramycin and vancomycin. J Orthop Res. 2018;36:1078–1085.28876459
  • Aljutayli A, Marsot A, Nekka F. An Update on Population Pharmacokinetic Analyses of Vancomycin, Part I: in Adults. Clin Pharmacokinet. 2020;59(6):671–698. doi:10.1007/s40262-020-00866-232020531
  • Palser S, Smith S, Nash EF, Agarwal A, Smyth AR, Buchbinder R. Treatments for preventing recurrence of infection with Pseudomonas aeruginosa in people with cystic fibrosis. Cochrane Database Syst Rev. 2019;12:CD012300. doi:10.1002/14651858.CD01350231845758
  • Eder C, Schenk S, Trifinopoulos J, et al. Does intrawound application of vancomycin influence bone healing in spinal surgery? Eur Spine J. 2016;25(4):1021–1028. doi:10.1007/s00586-015-3943-925904413
  • Seavey JG, Wheatley BM, Pavey GJ, et al. Early local delivery of vancomycin suppresses ectopic bone formation in a rat model of trauma-induced heterotopic ossification. J Orthop Res. 2017;35(11):2397–2406. doi:10.1002/jor.2354428390182
  • Adogwa O, Elsamadicy AA, Sergesketter A, et al. Prophylactic use of intraoperative vancomycin powder and postoperative infection: an analysis of microbiological patterns in 1200 consecutive surgical cases. J Neurosurg Spine. 2017;27(3):328–334. doi:10.3171/2017.2.SPINE16131028665245
  • Mendoza MC, Sonn KA, Kannan AS, et al. The effect of vancomycin powder on bone healing in a rat spinal rhBMP-2 model. J Neurosurg Spine. 2016;25(2):147–153. doi:10.3171/2015.11.SPINE1553627035510
  • González Della A, Valle M, Bostrom B, Brause C, Salvati EA. Salvati. Effective bactericidal activity of tobramycin and vancomycin eluted from acrylic bone cement. Acta Orthop Scand. 2001;72(3):237–240. doi:10.1080/0001647015284654711480597
  • Shekhar C. An innovative technique in local antibiotic delivery method in open infected wounds of the musculoskeletal system. Int J Low Extrem Wounds. 2019;18(2):153–160. doi:10.1177/153473461984176431066316
  • Owen MT, Keener EM, Hyde ZB, et al. Intraoperative topical antibiotics for infection prophylaxis in pelvic and acetabular surgery. J Orthop Trauma. 2017;31(11):589–594. doi:10.1097/BOT.000000000000094128708777
  • Tennent DJ, Shiels SM, Jennings JA, Haggard WO, Wenke JC. Local control of polymicrobial infections via a dual antibiotic delivery system. J Orthop Surg Res. 2018;13(1):53. doi:10.1186/s13018-018-0760-y29544509
  • Rathbone CR, Cross JD, Brown KV, Murray CK, Wenke JC. Effect of various concentrations of antibiotics on osteogenic cell viability and activity. J Orthop Res. 2011;29(7):1070–1074. doi:10.1002/jor.2134321567453
  • de Guzman RC, Saul JM, Ellenburg MD, et al. Bone regeneration with BMP-2 delivered from keratose scaffolds. Biomaterials. 2013;34(6):1644–1656. doi:10.1016/j.biomaterials.2012.11.00223211447
  • Rao M, Pang X, Yang J. Tobramycin promotes fracture healing by accelerating osteogenesis differentiation of MSCs through activating Wnt/beta-catenin pathway. Minerva Med. 2019;111:189.31124631
  • Nart J, de Tapia B, Pujol A, Pascual A, Valles C. Vancomycin and tobramycin impregnated mineralized allograft for the surgical regenerative treatment of peri-implantitis: a 1-year follow-up case series. Clin Oral Investig. 2018;22(6):2199–2207. doi:10.1007/s00784-017-2310-0
  • Sanicola SM, Albert SF. The in vitro elution characteristics of vancomycin and tobramycin from calcium sulfate beads. J Foot Ankle Surg. 2005;44(2):121–124. doi:10.1053/j.jfas.2005.01.00615768360
  • Anagnostakos K, Meyer C. Antibiotic elution from hip and knee acrylic bone cement spacers: a systematic review. Biomed Res Int. 2017;2017:4657874.28656144
  • Takeuchi M, Wakao N, Kamiya M, Hirasawa A, Murotani K, Takayasu M. A double-blind randomized controlled trial of the local application of vancomycin versus ampicillin powder into the operative field for thoracic and/or lumbar fusions. J Neurosurg Spine. 2018;29(5):553–559. doi:10.3171/2018.3.SPINE17111130095381
  • Boles LR, Awais R, Beenken KE, Smeltzer MS, Haggard WO, Jessica AJ. Local delivery of amikacin and vancomycin from chitosan sponges prevent polymicrobial implant-associated biofilm. Mil Med. 2018;183(suppl_1):459–465. doi:10.1093/milmed/usx16129635622