1,168
Views
8
CrossRef citations to date
0
Altmetric
Original Research

Prescribing Pattern of Antibiotics Using WHO Prescribing Indicators Among Inpatients in Ethiopia: A Need for Antibiotic Stewardship Program

ORCID Icon, ORCID Icon, , , , ORCID Icon & ORCID Icon show all
Pages 2783-2794 | Published online: 11 Aug 2020

References

  • WHO. How to Investigate Antimicrobial Use in Hospitals: Selected Indicators. World Health Organization; 2012.
  • Cantas L, Shah SQA, Cavaco LM, et al. A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota. Front Microbiol. 2013;4:96. doi:10.3389/fmicb.2013.0009623675371
  • Davies J, Davies D. Origins and evolution of antibiotic resistance. Microbiol Mol Biol Rev. 2010;74(3):417–433. doi:10.1128/MMBR.00016-1020805405
  • Organization WH. Global antimicrobial resistance surveillance system (GLASS) report: early implementation 2016–2017. Global antimicrobial resistance surveillance system (GLASS) report: early implementation 2016–2017. 2017.
  • WHO. Worldwide Country Situation Analysis: Response to Antimicrobial Resistance. World Health Organization (WHO); 2015.
  • Atif M, Azeem M, Saqib A, Scahill S. Investigation of antimicrobial use at a tertiary care hospital in Southern Punjab, Pakistan using WHO methodology. Antimicrob Resist Infect Control. 2017;6(1):41. doi:10.1186/s13756-017-0199-728465825
  • CDC. Antibiotic prescribing and use in doctor’s office. CDC, 2017 Available from: https://www.cdc.gov/antibiotic-use/community/index.html. Accessed 723, 2020.
  • CDC. Core elements of hospital antibiotic stewardship programs? Antibiotic use/CDC. 2019 Available from: https://www.cdc.gov/antibiotic-use/core-elements/hospital.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fantibiotic-use%2Fhealthcare%2Fimplementation%2Fcore-elements.html. Accessed 723, 2020.
  • Dyar OJ, Huttner B, Schouten J, Pulcini C. What is antimicrobial stewardship? Clin Microbiol Infect. 2017;23(11):793–798. doi:10.1016/j.cmi.2017.08.02628882725
  • Manning ML. The urgent need for nurse practitioners to lead antimicrobial stewardship in ambulatory health care. J Am Assoc Nurse Pract. 2014;26(8):411–413. doi:10.1002/2327-6924.1215025048218
  • Maraolo AE, Ong DSY, Cimen C, et al. Organization and training at national level of antimicrobial stewardship and infection control activities in Europe: an ESCMID cross-sectional survey. Eur J Clin Microbiol Infect Dis. 2019;38(11):2061–2068. doi:10.1007/s10096-019-03648-231396830
  • Barlam TF, Cosgrove SE, Abbo LM, et al. Executive summary: implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016;62(10):1197–1202. doi:10.1093/cid/ciw21727118828
  • Gottlieb T, Nimmo GR. Antibiotic resistance is an emerging threat to public health: an urgent call to action at the antimicrobial resistance summit 2011. Med J Aust. 2011;194(6):281–283. doi:10.5694/j.1326-5377.2011.tb02973.x21426279
  • Li Q, Zhao G, Wu L, et al. Prevalence and patterns of drug resistance among pulmonary tuberculosis patients in Hangzhou, China. Antimicrob Resist Infect Control. 2018;7(1):61. doi:10.1186/s13756-018-0348-729744042
  • Kimang’a AN. A situational analysis of antimicrobial drug resistance in Africa: are we losing the battle? Ethiop J Health Sci. 2012;22(2).
  • Aidara-Kane A, Angulo FJ, Conly JM, et al. World Health Organization (WHO) guidelines on use of medically important antimicrobials in food-producing animals. Antimicrob Resist Infect Control. 2018;7(1):7. doi:10.1186/s13756-017-0294-929375825
  • Ayukekbong JA, Ntemgwa M, Atabe AN. The threat of antimicrobial resistance in developing countries: causes and control strategies. Antimicrob Resist Infect Control. 2017;6(1):47. doi:10.1186/s13756-017-0208-x28515903
  • Williams A, Mathai AS, Phillips AS. Antibiotic prescription patterns at admission into a tertiary level intensive care unit in Northern India. J Pharm Bioallied Sci. 2011;3(4):531. doi:10.4103/0975-7406.9010822219587
  • Storr J, Twyman A, Zingg W, et al. Core components for effective infection prevention and control programmes: new WHO evidence-based recommendations. Antimicrob Resist Infect Control. 2017;6(1):6. doi:10.1186/s13756-016-0149-928078082
  • Yallew WW, Kumie A, Yehuala FM. Point prevalence of hospital-acquired infections in two teaching hospitals of Amhara region in Ethiopia. Drug Healthc Patient Saf. 2016;8:71. doi:10.2147/DHPS.S10734427601932
  • Woldu MA, Suleman S, Workneh N, Berhane H. Retrospective study of the pattern of antibiotic use in Hawassa University referral hospital pediatric ward, Southern Ethiopia. J Appl Pharm Sci. 2013;3(2):93.
  • Summoro TS, Gidebo KD, Kanche ZZ, Woticha EW. Evaluation of trends of drug-prescribing patterns based on WHO prescribing indicators at outpatient departments of four hospitals in southern Ethiopia. Drug Des Devel Ther. 2015;9:4551. doi:10.2147/DDDT.S83588
  • Desalegn AA. Assessment of drug use pattern using WHO prescribing indicators at Hawassa University teaching and referral hospital, south Ethiopia: a cross-sectional study. BMC Health Serv Res. 2013;13(1):170. doi:10.1186/1472-6963-13-17023647871
  • Worku F, Tewahido D. Retrospective assessment of antibiotics prescribing at public primary healthcare facilities in Addis Ababa, Ethiopia. Interdiscip Perspect Infect Dis. 2018;2018:1–9. doi:10.1155/2018/4323769
  • Bilal AI, Osman ED, Mulugeta A. Assessment of medicines use pattern using World Health Organization’s prescribing, patient care and health facility indicators in selected health facilities in eastern Ethiopia. BMC Health Serv Res. 2016;16(1):144. doi:10.1186/s12913-016-1414-627106610
  • Demeke B, Molla F, Assen A, Melkam W, Abrha S, Masresha B. Evaluation of drugs utilization pattern using WHO prescribing indicators in Ayder referral hospital, Northern Ethiopia. IJPSR. 2015;6(2):343–347.
  • Amaha ND, Berhe YH, Kaushik A. Assessment of inpatient antibiotic use in Halibet National Referral Hospital using WHO indicators: a retrospective study. BMC Res Notes. 2018;11:904. doi:10.1186/s13104-018-4000-730563558
  • EpiData Association, att. Jens M.Lauritsen. Enghavevej 34, DK5230 Odense M. Denmark, Europe; 2006.
  • WHO. What-is-the-difference-between-antibiotic-and-antimicrobial-resistance 2020 updated January 20 Available from: http://www.emro.who.int/health-topics/drug-resistance/what-is-the-difference-between-antibiotic-and-antimicrobial-resistance.html. Accessed 723, 2020.
  • Asgin N, Otlu B. Antibiotic resistance and molecular epidemiology of vancomycin-resistant enterococci in a Tertiary Care Hospital in Turkey. Infect Drug Resist. 2020;13:191–198. doi:10.2147/IDR.S19188132021333
  • Pulcini C, Binda F, Lamkang AS, et al. Developing core elements and checklist items for global hospital antimicrobial stewardship programmes: a consensus approach. Clin Microbiol Infect. 2019;25(1):20–25. doi:10.1016/j.cmi.2018.03.03329625170
  • Harmon S, Richardson T, Simons H, Monforte S, Fanning S, Harrington K. The clinical and financial impact of a pharmacist-driven penicillin skin testing program on antimicrobial stewardship practices. Hosp Pharm. 2020;55(1):58–63. doi:10.1177/001857871881791731983768
  • Garcia Reeves AB, Lewis JW, Trogdon JG, Stearns SC, Weber DJ, Weinberger M. Association between statewide adoption of the CDC’s core elements of hospital antimicrobial stewardship programs and rates of methicillin-resistant Staphylococcus aureus bacteremia and Clostridioides difficile infection in the United States. Infect Control Hosp Epidemiol. 2019;1–8.
  • Kim B, Lee MJ, Moon SM, et al. Current status of antimicrobial stewardship programmes in Korean hospitals: results of a 2018 nationwide survey. J Hosp Infect. 2020;104(2):172–180.31513880
  • FMHACA. List of Medicines for Ethiopia: Food, Medicine and Healthcare Administration and Control Authority of Ethiopia. Vol. 6 FMHACA; 2010.
  • Erku DA, Aberra SY. Non-prescribed sale of antibiotics for acute childhood diarrhea and upper respiratory tract infection in community pharmacies: a 2 phase mixed-methods study. Antimicrob Resist Infect Control. 2018;7(1):92. doi:10.1186/s13756-018-0389-y30079248
  • Prah J, Kizzie-Hayford J, Walker E, Ampofo-Asiama A. Antibiotic prescription pattern in a Ghanaian primary health care facility. Pan Afr Med J. 2017;28(1). doi:10.11604/pamj.2017.28.214.13940
  • Enato EF, Chima IE. Evaluation of drug utilization patterns and patient care practices. West Afr J Pharm. 2011;22(1).
  • Atif M, Sarwar MR, Azeem M, et al. Assessment of WHO/INRUD core drug use indicators in two tertiary care hospitals of Bahawalpur, Punjab, Pakistan. J Pharm Policy Pract. 2016;9:27. doi:10.1186/s40545-016-0076-427688887
  • Yan K, Xue M, Ye D, et al. Antibiotic prescribing practices in secondary and tertiary hospitals in Shaanxi province, western China, 2013–2015. PLoS One. 2018;13(12):e0207229. doi:10.1371/journal.pone.020722930540753
  • Gube A, Gonfa R, Tadesse T. Evaluation of antibiotic use in medical ward of Fitche District hospital, north Showa zone, Oromia region, Ethiopia. Adv Pharmacoepidemiol Drug Saf. 2017;6(217):2167.
  • Gashaw T, Sisay M, Mengistu G, Amare F. Investigation of prescribing behavior at outpatient settings of governmental hospitals in eastern Ethiopia: an overall evaluation beyond World Health Organization core prescribing indicators. J Pharm Policy Pract. 2018;11:26. doi:10.1186/s40545-018-0152-z30364357
  • Yohannes Y, Mengesha Y, Tewelde Y. Timing, choice and duration of perioperative prophylactic antibiotic use in surgery: a teaching hospital based experience from Eritrea, in 2009. J Eritrean Med Assoc. 2009;4(1):65–67.
  • Wambale J, Iyamba J, Mathe D, Kavuo S. Takaisi-kikuni point prevalence study of antibiotic use in hospitals in Butembo. Int J Med Sci. 2016.
  • Landstedt K, Sharma A, Johansson F, Lundborg CS, Sharma M. Antibiotic prescriptions for inpatients having non-bacterial diagnosis at medicine departments of two private sector hospitals in Madhya Pradesh, India: a cross-sectional study. BMJ Open. 2017;7(4):e012974. doi:10.1136/bmjopen-2016-012974
  • Getachew E, Aragaw S, Adissie W, Agalu A. Antibiotic prescribing pattern in a referral hospital in Ethiopia. Afr J Pharm Pharmacol. 2013;7(38):2657–2661. doi:10.5897/AJPP12.505
  • Admassie E, Begashaw B, Hailu W. Assessment of drug use practices and completeness of prescriptions in Gondar University Teaching Referral Hospital. Int J Pharm Sci Res. 2013;4(1):265.
  • Chem ED, Anong DN, Akoachere J-FKT, Godman B. Prescribing patterns and associated factors of antibiotic prescription in primary health care facilities of Kumbo East and Kumbo West Health Districts, North West Cameroon. PLoS One. 2018;13(3):e0193353. doi:10.1371/journal.pone.019335329505584
  • El Mahalli AA, Akl OA, Al-Dawood SF, et al. WHO/INRUD patient care and facility-specific drug use indicators at primary health care centres in Eastern province, Saudi Arabia. East Mediterr Health J. 2012;18(11):1086–1090. doi:10.26719/2012.18.11.108623301368
  • Gutema G, Håkonsen H, Engidawork E, Toverud E-L. Multiple challenges of antibiotic use in a large hospital in Ethiopia–a ward-specific study showing high rates of hospital-acquired infections and ineffective prophylaxis. BMC Health Serv Res. 2018;18(1):326. doi:10.1186/s12913-018-3107-929724214
  • Ntšekhe M, Hoohlo-Khotle N, Tlali M, Tjipura D. Antibiotic prescribing patterns at six hospitals in Lesotho Published for the U.S. Agency for International Development by the Strengthening Pharmaceutical Systems Program. Arlington: Management Sciences for Health; 2011 In: Accessed on April 2, 2020, from https://www.msh.org/sites/msh.org/files/siapstechbrief-services-antimicrobial-stewardship-17july2014_0.pdf.
  • Aravamuthan A, Arputhavanan M, Subramaniam K, Udaya Chander J SJ. Assessment of current prescribing practices using World Health Organization core drug use and complementary indicators in selected rural community pharmacies in Southern India. J Pharm Policy Pract. 2017;10(1):1. doi:10.1186/s40545-016-0074-627446591
  • Shankar RP, Partha P, Shenoy NK, Easow JM, Brahmadathan KN. Prescribing patterns of antibiotics and sensitivity patterns of common microorganisms in the internal medicine ward of a teaching hospital in Western Nepal: a prospective study. Ann Clin Microbiol Antimicrob. 2003;2(1):7. doi:10.1186/1476-0711-2-712904265
  • WHO. How to Investigate drug use in health facilities: selected drug use indicators - EDM research series no. 007 1993 Available from: https://www.who.int/medicines/publications/how-to-investigate_drug-use/en/. Accessed 723, 2020.
  • Kallen MC, Prins JM. A systematic review of quality indicators for appropriate antibiotic use in hospitalized adult patients. Infect Dis Rep. 2017;9(1). doi:10.4081/idr.2017.6821
  • Tanaka A, Yano A, Watanabe S, Tanaka M, Araki H. Impact of switching from intravenous to oral linezolid therapy in Japanese patients: a retrospective cohort study. J Pharm Policy Pract. 2016;9(1):35. doi:10.1186/s40545-016-0087-127795831
  • Gidebo KD, Summoro TS, Kanche ZZ, Woticha EW. Assessment of drug use patterns in terms of the WHO patient-care and facility indicators at four hospitals in Southern Ethiopia: a cross-sectional study. BMC Health Serv Res. 2016;16(1):643. doi:10.1186/s12913-016-1882-827832773
  • Ahmed AM, Awad AI. Drug use practices at pediatric hospitals of Khartoum State, Sudan. Ann Pharmacother. 2010;44(12):1986–1993. doi:10.1345/aph.1P42321119094
  • Mudenda W, Chikatula E, Chambula E, et al. Prescribing patterns and medicine use at the university teaching hospital, Lusaka, Zambia. Med J Zambia. 2016;43(2):94–102.
  • Sisay M, Mengistu G, Molla B, Amare F, Gabriel T. Evaluation of rational drug use based on World Health Organization core drug use indicators in selected public hospitals of eastern Ethiopia: a cross sectional study. BMC Health Serv Res. 2017;17(1):161. doi:10.1186/s12913-017-2097-328231833
  • Veronin MA. Should we have concerns with generic versus brand antimicrobial drugs? A review of issues. J Pharm Health Serv Res. 2011;2(3):135–150. doi:10.1111/j.1759-8893.2011.00059.x
  • Fadare JO, Adeoti AO, Desalu OO, et al. The prescribing of generic medicines in Nigeria: knowledge, perceptions and attitudes of physicians. Expert Rev Pharmacoecon Outcomes Res. 2016;16(5):639–650. doi:10.1586/14737167.2016.112067326567041
  • Al Shimemeri A, Al Ghadeer H, Memish Z. Antibiotic utilization pattern in a general medical ward of a tertiary medical center in Saudi Arabia. Avicenna J Med. 2011;1(1):8. doi:10.4103/2231-0770.8371723210003