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Case Series

Two Cases of Intrafamilial Transmission of Community-Acquired Methicillin-Resistant Staphylococcus aureus Producing Both PVL and TSST-1 Causing Fatal Necrotizing Pneumonia and Sepsis

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Pages 2921-2927 | Published online: 20 Aug 2020

References

  • Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998;339(8):520–532. doi:10.1056/NEJM1998082033908069709046
  • Moellering RC Jr. MRSA: the first half century. J Antimicrob Chemother. 2012;67(1):4–11. doi:10.1093/jac/dkr43722010206
  • David MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev. 2010;23(3):616–687.20610826
  • Lee AS, de Lencastre H, Garau J, et al. Methicillin-resistant Staphylococcus aureus. Nat Rev Dis Primers. 2018;4:18033. doi:10.1038/nrdp.2018.3329849094
  • DeLeo FR, Otto M, Kreiswirth BN, et al. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 2010;375(9725):1557–1568. doi:10.1016/S0140-6736(09)61999-120206987
  • Lina G, Piémont Y, Godail-Gamot F, et al. Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis. 1999;29(5):1128–1132. doi:10.1086/31346110524952
  • Bubeck Wardenburg J, Bae T, Otto M, et al. Poring over pores: α-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med. 2007;13(12):1405–1406. doi:10.1038/nm1207-140518064027
  • Labandeira-Rey M, Couzon F, Boisset S, et al. Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science. 2007;315(5815):1130–1133. doi:10.1126/science.113716517234914
  • Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med. 2006;355(7):666–674. doi:10.1056/NEJMoa05535616914702
  • Chuang YY, Huang YC. Molecular epidemiology of community-associated meticillin-resistant Staphylococcus aureus in Asia. Lancet Infect Dis. 2013;13(8):698–708. doi:10.1016/S1473-3099(13)70136-123827369
  • Yamaguchi T, Okamura S, Miura Y, et al. Molecular characterization of community-associated methicillin-resistant Staphylococcus aureus isolated from skin and pus samples of outpatients in Japan. Microb Drug Resist. 2015;21(4):441–447. doi:10.1089/mdr.2014.015325789579
  • Spaulding AR, Salgado-Pabón W, Kohler PL, et al. Staphylococcal and streptococcal superantigen exotoxins. Clin Microbiol Rev. 2013;26(3):422–447.23824366
  • Takadama S, Nakaminami H, Takii T, et al. Identification and detection of USA300 methicillin-resistant Staphylococcus aureus clones with a partial deletion in the ccrB2 gene on the type IV SCCmec element. Diagn Microbiol Infect Dis. 2019;94(1):86–87. doi:10.1016/j.diagmicrobio.2018.11.01630579658
  • Mushtaq F, Hildrew S, Okugbeni G, et al. Necrotizing haemorrhagic pneumonia proves fatal in an immunocompetent child due to Panton-Valentine Leucocidin, toxic shock syndrome toxins 1 and 2 and enterotoxin C-producing Staphylococcus aureus. Acta Paediatr. 2008;97(7):985–987. doi:10.1111/j.1651-2227.2008.00797.x18532937
  • CLSI. Performance. Standards for Antimicrobial Susceptibility Testing. 26th ed CLSI supplement M100S Wayne, PA: Clinical and Laboratory Standards Institute; 2016
  • Yamaguchi T, Ono D, Sato A. Staphylococcal Cassette Chromosome mec (SCCmec) analysis of MRSA. Methods Mol Biol. 2020;2069:59–78.31523765
  • Center for Genomic Epidemiology; 2019 Available from: http://www.genomicepidemiology.org. Accessed 1121, 2019.
  • Richardson JF, Reith S. Characterization of a strain of methicillin-resistant Staphylococcus aureus (EMRSA-15) by conventional and molecular methods. J Hosp Infect. 1993;25(1):45–52. doi:10.1016/0195-6701(93)90007-M7901274
  • Yamamoto T, Takano T, Yabe S, et al. Super-sticky familial infections caused by Panton-Valentine leukocidin-positive ST22 community-acquired methicillin-resistant Staphylococcus aureus in Japan. J Infect Chemother. 2012;18(2):187–198. doi:10.1007/s10156-011-0316-022160592
  • Pokhrel RH, Aung MS, Thapa B, et al. Detection of ST772 Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus (Bengal Bay clone) and ST22 S. aureus isolates with a genetic variant of elastin binding protein in Nepal. New Microbes New Infect. 2016;11:20–27. doi:10.1016/j.nmni.2016.02.00127014464
  • Roberts MC, Joshi PR, Greninger AL, et al. The human clone ST22 SCCmec IV methicillin-resistant Staphylococcus aureus isolated from swine herds and wild primates in Nepal: is man the common source? FEMS Microbiol Ecol. 2018;94(5):fiy052. doi:10.1093/femsec/fiy052
  • Murray RJ, Lim TT, Pearson JC, et al. Community-onset methicillin-resistant Staphylococcus aureus bacteremia in Northern Australia. Int J Infect Dis. 2004;8(5):275–283. doi:10.1016/j.ijid.2003.11.00815325596
  • Iyer S, Jones DH. Community-acquired methicillin-resistant Staphylococcus aureus skin infection: a retrospective analysis of clinical presentation and treatment of a local outbreak. J Am Acad Dermatol. 2004;50(6):854–858. doi:10.1016/j.jaad.2003.12.04315153884
  • Löffler B, Niemann S, Ehrhardt C, et al. Pathogenesis of Staphylococcus aureus necrotizing pneumonia: the role of PVL and an influenza coinfection. Expert Rev Anti Infect Ther. 2013;11(10):1041–1051. doi:10.1586/14787210.2013.82789124073746
  • Vandenesch F, Naimi T, Enright MC, et al. Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis. 2003;9(8):978–984. doi:10.3201/eid0908.03008912967497
  • Al Laham N, Mediavilla JR, Chen L, et al. MRSA clonal complex 22 strains harboring toxic shock syndrome toxin (TSST-1) are endemic in the primary hospital in Gaza, Palestine. PLoS One. 2015;10(3):e0120008. doi:10.1371/journal.pone.012000825781188
  • Holmes A, Ganner M, McGuane S, Pitt TL, Cookson BD, Kearns AM. Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease. J Clin Microbiol. 2005;43(5):2384–2390. doi:10.1128/JCM.43.5.2384-2390.200515872271
  • Lobo LJ, Reed KD, Wunderink RG. Expanded clinical presentation of community-acquired methicillin-resistant Staphylococcus aureus pneumonia. Chest. 2010;138(1):130–136. doi:10.1378/chest.09-156220173050