116
Views
2
CrossRef citations to date
0
Altmetric
Original Research

HBVsvp-Pulsed Dendritic Cell Immunotherapy Induces Th1 Polarization and Hepatitis B Virus-Specific Cytotoxic T Lymphocytes Production

ORCID Icon, , , , ORCID Icon, , , ORCID Icon & show all
Pages 2699-2709 | Published online: 05 Aug 2020

References

  • Michel ML, Deng Q, Mancini-Bourgine M. Therapeutic vaccines and immune based therapies for the treatment of chronic hepatitis B: perspectives and challenges. J Hepatol. 2011;45(6):1286–1296. doi:10.1016/j.jhep.2010.12.031
  • Akbar SM, Horiike N, Onji M. Immune therapy including dendritic cell based- therapy in chronic hepatitis B virus infection. World J Gastroenterol. 2006;12(18):2876–2883. doi:10.3748/wjg.v12.i18.287616718812
  • van der Molen RG, Sprengers D, Binda RS, et al. Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B. Hepatology. 2004;40(3):738–746. doi:10.1002/hep.2036615349914
  • Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol. 1995;13(1):29–60. doi:10.1146/annurev.iy.13.040195.0003337612225
  • Marinos G, Torre F, Chokshi S, et al. Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: a major factor in activation of the host immune response to the hepatitis B virus. Hepatology. 1995;22(4):1040–1049. doi:10.1016/0270-9139(95)90607-x7557849
  • Maini MK, Boni C, Lee CK, et al. The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med. 2000;191(8):1269–1280. doi:10.1084/jem.191.8.126910770795
  • Op den Brouw ML, Binda RS, van Roosmalen MH, et al. Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virus. Immunology. 2009;126(2):280–289. doi:10.1111/j.1365-2567.2008.02896.x18624732
  • Cesar Aguilar J, Lobaina Y. Immunotherapy for chronic hepatitis B using HBsAg-based vaccine formulations: from preventive commercial vaccines to therapeutic approach julio cesar aguilar. Euroasian J Hepatogastroenterol. 2014;4(2):92–97. doi:10.5005/jp-journals-10018-110929699355
  • Maini MK, Boni C, Ogg GS, et al. Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection. Gastroenterology. 1999;117(6):1386–1396. doi:10.1016/s0016-5085(99)70289-110579980
  • Webster GJ, Reignat S, Maini MK, et al. Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology. 2000;32(5):1117–1124. doi:10.1053/jhep.2000.1932411050064
  • Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol. 1991;9(1):271–296. doi:10.1146/annurev.iy.09.040191.0014151910679
  • Beckebaum S, Cicinnati VR, Zhang X, et al. Hepatitis B virus-induced defect of monocyte derived dendritic cells leads to impaired T helper type 1 response in vitro: mechanisms for viral immune escape. Immunology. 2003;109(4):487–495. doi:10.1046/j.1365-2567.2003.01699.x12871214
  • Knight SC, Macatonia SE, Patterson S. Infection of dendritic cells with HIV1: virus load regulates stimulation and suppression of T‐cell activity. Res Virol. 1993;144:75–80. doi:10.1016/s0923-2516(06)80015-48446782
  • Auffermann‐Gretzinger S, Keeffe EB, Levy S. Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection. Blood. 2001;97(10):3171–3176. doi:10.1182/blood.v97.10.317111342445
  • Kruse M, Rosorius O, Kratzer F, et al. Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T‐cell stimulatory capacity. J Virol. 2000;74(15):7127–7136. doi:10.1128/jvi.74.15.7127-7136.200010888653
  • Grosjean I, Caux C, Bella C, et al. Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4+ T cells. J Exp Med. 1997;186(6):801–812. doi:10.1084/jem.186.6.8019294135
  • Engelmayer J, Larsson M, Subklewe M, et al. Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion. J Immunol. 1999;163(12):6762–6768.10586075
  • Inaba K, Inaba M, Romani N, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte macrophage colony stimulating factor. J Exp Med. 1992;176(6):1693–1702. doi:10.1084/jem.176.6.16931460426
  • Romani N, Gruner S, Brang D, et al. Proliferating dendritic cell progenitors in human blood. J Exp Med. 1994;180(1):83–93. doi:10.1084/jem.180.1.838006603
  • Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor a. J Exp Med. 1994;179(4):1109–1118. doi:10.1084/jem.179.4.11098145033
  • Farag MM, Hoyler B, Encke J, et al. Dendritic cells can effectively be pulsed by HBVsvp and induce specific immune reactions in mice. Vaccine. 2010;29(2):200–206. doi:10.1016/j.vaccine.2010.10.05621050902
  • Farag MMS, Tedjokusumo R, Flechtenmacher C, et al. Immune tolerance against HBV can be overcome in HBV transgenic mice by immunization with dendritic cells pulsed by HBVsvp. Vaccine. 2012;30(42):6034–6039. doi:10.1016/j.vaccine.2012.07.05722867720
  • Beckebaum S, Cicinnati VR, Dworacki G, et al. Reduction in the circulating pDC1/pDC2 ratio and impaired function of ex vivo generated DC1 in chronic hepatitis B infection. Clin Immunol. 2002;104(2):138–150. doi:10.1006/clim.2002.524512165275
  • Chen W, Shi M, Shi F, et al. HBcAg-pulsed dendritic cell vaccine induces Th1 polarization and production of hepatitis B virus-specific cytotoxic T lymphocytes. Hepatol Res. 2009;39(4):355–365. doi:10.1111/j.1872-034X.2008.00468.x19889049
  • Mizukoshi E, Sidney J, Livingston B, et al. Cellular immune responses to the hepatitis B virus polymerase. J Immunol. 2004;173(9):5863–5871. doi:10.4049/jimmunol.173.9.586315494540
  • Szkaradkiewicz A, Jopek A, Wysocki J. Effects of IL-12 and IL-18 on HBcAg-specific cytokine production by CD4 T lymphocytes of children with chronic hepatitis B infection. Antiviral Res. 2005;66(1):23–27. doi:10.1016/j.antiviral.2004.12.00515781128
  • Akbar SM, Furukawa S, Horiike N, et al. Vaccine therapy for hepatitis B virus carrier. Curr Drug Targets Infect Disord. 2004;4(2):93–101. doi:10.2174/156800504334088515180457
  • Farag MM, Peschel G, Müller M, et al. Characterization of the interaction between subviral particles of hepatitis B virus and dendritc cells in vitro study. Infect Drug Resist. 2019;12:3125–3135. doi:10.2147/IDR.S22129431632101
  • Limmer A, Ohl J, Kurts C, et al. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen‐specific T‐cell tolerance. Nat Med. 2000;6(12):1348–1354. doi:10.1038/8216111100119
  • Bertoletti A, Sette A, Chisari FV, et al. Natural variants of cytotoxic epitopes are T‐cell receptor antagonists for anti‐viral cytotoxic T cells. Nature. 1994;369(6479):407–410. doi:10.1038/369407a08196768
  • Tsai SL, Sheen IS, Chien RN, et al. Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: tetramer assay and therapeutic implications. J Biomed Sci. 2003;10(1):120–135. doi:10.1007/bf225600412566993
  • Boni C, Bertoletti A, Penna A, et al. Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. J Clin Invest. 1998;102(5):968–975. doi:10.1172/JCI37319727065
  • de Jong EC, Vieira PL, Kalinski P, et al. Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J Immunol. 2002;168(4):1704–1709. doi:10.4049/jimmunol.168.4.170411823500
  • d’Ostiani CF, Del Sero G, Bacci A, et al. Dendritic cells discriminate between yeasts and hyphae of the fungus candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J Exp Med. 2000;191(10):1661–1674. doi:10.1084/jem.191.10.166110811860
  • Vieira PL, de Jong EC, Wierenga EA, et al. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J Immunol. 2000;164(9):4507–4512. doi:10.4049/jimmunol.164.9.450710779751
  • Shi M, Qian S, Chen WW, et al. Hepatitis B virus (HBV) antigen-pulsed monocyte-derived dendritic cells from HBV-associated hepatocellular carcinoma patients significantly enhance specific T cell responses in vitro. Clin Exp Immunol. 2007;147(2):277–286. doi:10.1111/j.1365-2249.2006.03281.x17223969
  • Kapsenberg ML. Dendritic-cell control of pathogen driven T-cell polarization. Nat Rev Immunol. 2003;3(12):984–993. doi:10.1038/nri124614647480
  • Reise Sousa C. Dendritic cells in a mature age. Nat Rev Immunol. 2006;6(6):476–483. doi:10.1038/nri184516691244
  • Shimizu Y, Guidotti LG, Fowler P, et al. Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice. J Immunol. 1998;161(9):4520–4529.9794377
  • Oka Y, Akbar SM, Horiike N, et al. Mechanism and therapeutic potential of DNA-based immunization against the envelope proteins of hepatitis B virus in normal and transgenic mice. Immunology. 2001;103(1):90–97. doi:10.1046/j.1365-2567.2001.01202.x11380696
  • Huang Y, Chen Z, Jia H, et al. Induction of Tc1 response and enhanced cytotoxic T lymphocyte activity in mice by dendritic cells transduced with adenovirus expressing HBsAg. Clin Immunol. 2006;119(3):280–290. doi:10.1016/j.clim.2006.01.01516531121
  • Fazle Akbar SM, Furukawa S, Onji M, et al. Safety and efficacy of hepatitis B surface antigen-pulsed dendritic cells in human volunteers. Hepatol Res. 2004;29(3):136–141. doi:10.1016/j.hepres.2004.03.00315203076
  • Akbar SM, Furukawa S, Hasebe A, et al. Production and efficacy of a dendritic cell-based therapeutic vaccine for murine chronic hepatitis B virus carrier. Int J Mol Med. 2004;14(2):295–299.15254781
  • Milich DR, Schödel F, Hughes JL, et al. The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype. J Virol. 1997;71(3):2192–2201. doi:10.1128/JVI.71.3.2192-2201.19979032353
  • Ma XJ, Tian DY, Xu D, et al. Uric acid enhances T cell immune responses to hepatitis B surface antigen-pulsed-dendritic cells in mice. World J Gastroenterol. 2007;13(7):1060–1066. doi:10.3748/wjg.v13.i7.106017373740
  • Phillipps KS, Wykes MN, Liu XQ, et al. A novel synthetic adjuvant enhances dendritic cell function. Immunology. 2009;128(1):582–588. doi:10.1111/j.1365-2567.2008.03038.x
  • Gamvrellis A, Leong D, Hanley JC, et al. Vaccines that facilitate antigen entry into dendritic cells. Immunol Cell Biol. 2004;82(5):506–516. doi:10.1111/j.0818-9641.2004.01271.x15479436
  • Qiu SJ, Lu L, Qiao C, et al. Induction of tumor immunity and cytotoxic t lymphocyte responses using dendritic cells transduced by adenoviral vectors encoding HBsAg: comparison to protein immunization. J Cancer Res Clin Oncol. 2005;131(7):429–438. doi:10.1007/s00432-004-0616-115818505