Advanced search
Publication Cover
Infection and Drug Resistance Volume 13, 2020 - Issue
Submit an article Journal homepage
129
Views
18
CrossRef citations to date
0
Altmetric
Case Report

Human Umbilical Cord Mesenchymal Stem Cells for Adjuvant Treatment of a Critically Ill COVID-19 Patient: A Case Report

Yue Zhu1 Stem Cell Lab, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei430081, People’s Republic of China
,
Rongjia Zhu2 Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing100005, People’s Republic of China
,
Kun Liu3 Otorhinolaryngology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei430081, People’s Republic of China
,
Xin Li1 Stem Cell Lab, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei430081, People’s Republic of China
,
Dezhong Chen4 Department of Respiratory and Critical Care Medicine, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei430081, People’s Republic of China
,
Dunyao Bai5 Molecular Laboratory, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei430081, People’s Republic of China
,
Jieli Luo5 Molecular Laboratory, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei430081, People’s Republic of China
,
Yixun Liu6 Gonadal Biology Research Group, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, People’s Republic of China
,
Yan Zhang7 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing100101, People’s Republic of China
,
Li Li8 The Ministry of Science and Education, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei430081, People’s Republic of China
,
Junfang Hu9 Department of Pharmacy, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei430081, People’s Republic of China
,
Dayong Xu10 Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei430081, People’s Republic of China
,
Yan Liu10 Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei430081, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9123-4974
ORCID Icon &
Robert Chunhua Zhao2 Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing100005, People’s Republic of China;11 School of Life Sciences, Shanghai University, Shanghai200444, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 3295-3300 | Published online: 28 Sep 2020

References

  • Munster VJ, Koopmans M, van Doremalen N, et al. A novel coronavirus emerging in China – key questions for impact assessment. N Engl J Med. 2020;382:692–694. doi:10.1056/NEJMp200092931978293
  • Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. doi:10.1016/S0140-6736(20)30183-531986264
  • Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395:565–574. doi:10.1016/S0140-6736(20)30251-832007145
  • Xu X, Chen P, Wang J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci. 2020;63:457–460. doi:10.1007/s11427-020-1637-532009228
  • Zhang Q, Lu S, Li T, et al. ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway. CR. 2019;38:173. doi:10.1186/s13046-019-1156-531023337
  • Wilson JG, K D L, Zhuo H, et al. Mesenchymal stem (stromal) cells for treatment of ARDS: a Phase 1 clinical trial. Lancet Respiratory Med. 2015;3:24–32. doi:10.1016/S2213-2600(14)70291-7
  • Connick P, Kolappan M, Crawley C, et al. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol. 2012;11:150–156. doi:10.1016/S1474-4422(11)70305-222236384
  • Hashmi S, Ahmed M, Murad MH, et al. Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: systematic review and meta-analysis. Lancet Haematol. 2016;3:e4552. doi:10.1016/S2352-3026(15)00224-0
  • Bernardo ME, Fibbe WE. Mesenchymal stromal cells: sensors and switchers of inflammation. Cell Stem Cell. 2013;13:392–402. doi:10.1016/j.stem.2013.09.00624094322
  • Darwish I, Mubareka S, Liles WC. Immunomodulatory therapy for severe influenza. Expert Rev Anti Infect Ther. 2011;9:807–822. doi:10.1586/eri.11.5621810053
  • Muraca M, Pessina A, Pozzobon M, et al. Mesenchymal stromal cells and their secreted extracellular vesicles as therapeutic tools for COVID-19 pneumonia? Published online ahead of print, 2020 Jul 3. J Control Release. 2020;325:135–140. doi:10.1016/j.jconrel.2020.06.03632622963
  • Bari E, Ferrarotti I, Saracino L, Perteghella S, Torre ML, Corsico AG. Mesenchymal stromal cell secretome for severe COVID-19 infections: premises for the therapeutic use. Cells. 2020;9(4):924. doi:10.3390/cells9040924
  • Bari E, Ferrarotti I, Torre ML, Corsico AG, Perteghella S. Mesenchymal stem/stromal cell secretome for lung regeneration: the long way through “pharmaceuticalization” for the best formulation. J Control Release. 2019;309:11–24. doi:10.1016/j.jconrel.2019.07.02231326462
  • Esposito M, Lucariello A, Costanzo C, et al. Differentiation of human umbilical cord-derived mesenchymal stem cells, WJ-MSCs, into chondrogenic cells in the presence of pulsed electromagnetic fields. In Vivo (Brooklyn). 2013;27:495–500.
  • Shu Y, Yang C, Ji X, et al. Reversibly immortalized human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are responsive to BMP9-induced osteogenic and adipogenic differentiation. J Cell Biochem. 2018;119:8872–8886. doi:10.1002/jcb.2714030076626

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.