Clinical and Microbiological Prognostic Factors of in-Hospital Mortality Caused by Hypervirulent Klebsiella pneumoniae Infections: A Retrospective Study in a Tertiary Hospital in Southwestern China

References

• Paczosa M, Mecsas J. Klebsiella pneumoniae: going on the offense with a strong defense. Microbiol Mol Biol Rev. 2016;80(3):629–661. doi:10.1128/mmbr.00078-1527307579
   PubMed Web of Science ®Google Scholar
• Martin R, Bachman M. Colonization, infection, and the accessory genome of Klebsiella pneumoniae. Front Cell Infect Microbiol. 2018;8:4. doi:10.3389/fcimb.2018.0000429404282
   PubMed Web of Science ®Google Scholar
• Liu Y, Li B, Zhang Y, et al. Clinical and molecular characteristics of emerging hypervirulent Klebsiella pneumoniae bloodstream infections in mainland China. Antimicrob Agents Chemother. 2014;58(9):5379–5385. doi:10.1128/AAC.02523-1424982067
   PubMed Web of Science ®Google Scholar
• Fang C, Lai S, Yi W, Hsueh P, Liu K, Chang S. Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Clin Infect Dis. 2007;45(3):284–293. doi:10.1086/51926217599305
   PubMed Web of Science ®Google Scholar
• Cubero M, Grau I, Tubau F, et al. Hypervirulent Klebsiella pneumoniae clones causing bacteraemia in adults in a teaching hospital in Barcelona, Spain (2007–2013). Clin Microbiol Infect. 2016;22(2):154–160. doi:10.1016/j.cmi.2015.09.02526454059
   PubMed Web of Science ®Google Scholar
• Liu C, Guo J. Characteristics of ventilator-associated pneumonia due to hypervirulent Klebsiella pneumoniae genotype in genetic background for the elderly in two tertiary hospitals in China. Antimicrob Resist Infect Control. 2018;7:95. doi:10.1186/s13756-018-0371-830128143
   PubMed Web of Science ®Google Scholar
• Alvarez D, Merino S, Tomas J, Benedi V, Alberti S, Moore RN. Capsular polysaccharide is a major complement resistance factor in lipopolysaccharide O side chain-deficient Klebsiella pneumoniae clinical isolates. Infect Immun. 2000;68(2):953–955. doi:10.1128/iai.68.2.953-955.200010639470
   PubMed Web of Science ®Google Scholar
• Llobet E, Campos M, Gimenez P, Moranta D, Bengoechea J, Fang FC. Analysis of the networks controlling the antimicrobial-peptide-dependent induction of Klebsiella pneumoniae virulence factors. Infect Immun. 2011;79(9):3718–3732. doi:10.1128/iai.05226-1121708987
   PubMed Web of Science ®Google Scholar
• Yeh K, Kurup A, Siu L, et al. Capsular serotype K1 or K2, rather than magA and rmpA, is a major virulence determinant for Klebsiella pneumoniae liver abscess in Singapore and Taiwan. J Clin Microbiol. 2007;45(2):466–471. doi:10.1128/jcm.01150-0617151209
   PubMed Web of Science ®Google Scholar
• Liu C, Guo J. Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor. Ann Clin Microbiol Antimicrob. 2019;18(1):4. doi:10.1186/s12941-018-0302-930665418
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhao C, Wang Q, et al. High prevalence of hypervirulent Klebsiella pneumoniae infection in China: geographic distribution, clinical characteristics, and antimicrobial resistance. Antimicrob Agents Chemother. 2016;60(10):6115–6120. doi:10.1128/aac.01127-1627480857
   PubMed Web of Science ®Google Scholar
• Russo T, Olson R, MacDonald U, Beanan J, Davidson B, Camilli A. Aerobactin, but not yersiniabactin, salmochelin, or enterobactin, enables the growth/survival of hypervirulent (hypermucoviscous) Klebsiella pneumoniae ex vivo and in vivo. Infect Immun. 2015;83(8):3325–3333. doi:10.1128/IAI.00430-1526056379
   PubMed Web of Science ®Google Scholar
• Lai Y, Lu M, Hsueh P. Hypervirulence and carbapenem resistance: two distinct evolutionary directions that led high-risk clones to epidemic success. Expert Rev Mol Diagn. 2019;19(9):825–837. doi:10.1080/14737159.2019.164914531343934
   PubMed Web of Science ®Google Scholar
• Gu D, Dong N, Zheng Z, et al. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018;18(1):37–46. doi:10.1016/s1473-3099(17)30489-928864030
   PubMed Web of Science ®Google Scholar
• Alba-Loureiro T, Munhoz C, Martins J, et al. Neutrophil function and metabolism in individuals with diabetes mellitus. Braz J Med Biol Res. 2007;40(8):1037–1044. doi:10.1590/s0100-879x200600500014317665039
   PubMed Web of Science ®Google Scholar
• Bruni E, Cazzetta V, Donadon M, et al. Chemotherapy accelerates immune-senescence and functional impairments of Vδ2(pos) T cells in elderly patients affected by liver metastatic colorectal cancer. J Immunother Cancer. 2019;7(1):347. doi:10.1186/s40425-019-0825-431829255
   PubMed Web of Science ®Google Scholar
• Li W, Sun G, Yu Y, et al. Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China. Clin Infect Dis. 2014;58(2):225–232. doi:10.1093/cid/cit67524099919
   PubMed Web of Science ®Google Scholar
• Turton J, Perry C, Elgohari S, Hampton C. PCR characterization and typing of Klebsiella pneumoniae using capsular type-specific, variable number tandem repeat and virulence gene targets. J Med Microbiol. 2010;59(5):541–547. doi:10.1099/jmm.0.015198-020110386
   PubMed Web of Science ®Google Scholar
• Kim D, Park B, Choi M, et al. Antimicrobial resistance and virulence factors of Klebsiella pneumoniae affecting 30 day mortality in patients with bloodstream infection. J Antimicrob Chemother. 2019;74(1):190–199. doi:10.1093/jac/dky39730295771
   PubMed Web of Science ®Google Scholar
• Fu L, Huang M, Zhang X, et al. Frequency of virulence factors in high biofilm formation bla(KPC-2) producing Klebsiella pneumoniae strains from hospitals. Microb Pathog. 2018;116:168–172. doi:10.1016/j.micpath.2018.01.03029360567
   PubMed Web of Science ®Google Scholar
• Russo T, Olson R, Fang C, et al. Identification of biomarkers for differentiation of hypervirulent Klebsiella pneumoniae from classical K. pneumoniae. J Clin Microbiol. 2018;56(9). doi:10.1128/jcm.00776-18
   PubMed Web of Science ®Google Scholar
• Cheng H, Chen Y, Wu C, Chang H, Lai Y, Peng H. RmpA regulation of capsular polysaccharide biosynthesis in Klebsiella pneumoniae CG43. J Bacteriol. 2010;192(12):3144–3158. doi:10.1128/jb.00031-1020382770
   PubMed Web of Science ®Google Scholar
• CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 28th ed. Wayne, PA: CLSI; 2018.
   Google Scholar
• Tian X, Sun S, Jia X, Zou H, Li S, Zhang L. Epidemiology of and risk factors for infection with extended-spectrum β-lactamase-producing carbapenem-resistant Enterobacteriaceae: results of a double case-control study. Infect Drug Resist. 2018;11:1339–1346. doi:10.2147/idr.S17345630214254
   PubMed Web of Science ®Google Scholar
• Li J, Ren J, Wang W, et al. Risk factors and clinical outcomes of hypervirulent Klebsiella pneumoniae induced bloodstream infections. Eur J Clin Microbiol Infect Dis. 2018;37(4):679–689. doi:10.1007/s10096-017-3160-z29238932
   PubMed Web of Science ®Google Scholar
• Liu C, Shi J, Guo J. High prevalence of hypervirulent Klebsiella pneumoniae infection in the genetic background of elderly patients in two teaching hospitals in China. Infect Drug Resist. 2018;11:1031–1041. doi:10.2147/idr.S16107530104891
   PubMed Web of Science ®Google Scholar
• Namikawa H, Yamada K, Sakiyama A, et al. Clinical characteristics of bacteremia caused by hypermucoviscous Klebsiella pneumoniae at a tertiary hospital. Diagn Microbiol Infect Dis. 2019;95(1):84–88. doi:10.1016/j.diagmicrobio.2019.04.00831256940
   PubMed Web of Science ®Google Scholar
• Kim D. Bacterial siderophores promote animal host iron acquisition and growth. Cell. 2018;175(2):311–312. doi:10.1016/j.cell.2018.09.02030290138
   PubMed Web of Science ®Google Scholar
• Holden V, Breen P, Houle S, Dozois C, Bachman M. Klebsiella pneumoniae siderophores induce inflammation, bacterial dissemination, and HIF-1α stabilization during pneumonia. mBio. 2016;7(5). doi:10.1128/mBio.01397-16
   Web of Science ®Google Scholar
• Lamont I, Beare P, Ochsner U, Vasil A, Vasil M. Siderophore-mediated signaling regulates virulence factor production in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2002;99(10):7072–7077. doi:10.1073/pnas.09201699911997446
   PubMed Web of Science ®Google Scholar
• Saha P, Yeoh B, Olvera R, et al. Bacterial siderophores hijack neutrophil functions. J Immunol. 2017;198(11):4293–4303. doi:10.4049/jimmunol.170026128432145
   PubMed Web of Science ®Google Scholar
• Hantke K, Nicholson G, Rabsch W, Winkelmann G. Salmochelins, siderophores of Salmonella enterica and uropathogenic Escherichia coli strains, are recognized by the outer membrane receptor IroN. Proc Natl Acad Sci U S A. 2003;100(7):3677–3682. doi:10.1073/pnas.073768210012655053
   PubMed Web of Science ®Google Scholar
• Skaar E. A precious metal heist. Cell Host Microbe. 2009;5(5):422–424. doi:10.1016/j.chom.2009.05.00519454345
   PubMed Web of Science ®Google Scholar
• Lam M, Wyres K, Judd L, et al. Tracking key virulence loci encoding aerobactin and salmochelin siderophore synthesis in Klebsiella pneumoniae. Genome Med. 2018;10(1):77. doi:10.1186/s13073-018-0587-530371343
   PubMed Web of Science ®Google Scholar
• Magistro G, Hoffmann C, Schubert S. The salmochelin receptor IroN itself, but not salmochelin-mediated iron uptake promotes biofilm formation in extraintestinal pathogenic Escherichia coli (ExPEC). Int J Med Microbiol. 2015;305:435–445. doi:10.1016/j.ijmm.2015.03.00825921426
   PubMed Web of Science ®Google Scholar
• Chen Y, Chang H, Lai Y, Pan C, Tsai S, Peng H. Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43. Gene. 2004;337:189–198. doi:10.1016/j.gene.2004.05.00815276215
   PubMed Web of Science ®Google Scholar
• Struve C, Roe C, Stegger M, et al. Mapping the evolution of hypervirulent Klebsiella pneumoniae. mBio. 2015;6(4):e00630. doi:10.1128/mBio.00630-1526199326
   PubMed Web of Science ®Google Scholar
• Long D, Zhu LL, Du FL, et al. Phenotypical profile and global transcriptomic profile of Hypervirulent Klebsiella pneumoniae due to carbapenemase-encoding plasmid acquisition. BMC Genomics. 2019;20(1):480. doi:10.1186/s12864-019-5705-231185888
   PubMed Web of Science ®Google Scholar
• Siu L, Huang D, Chiang T. Plasmid transferability of KPC into a virulent K2 serotype Klebsiella pneumoniae. BMC Infect Dis. 2014;14:176. doi:10.1186/1471-2334-14-17624678611
   PubMed Web of Science ®Google Scholar
• Li J, Huang Z, Yu T, et al. Isolation and characterization of a sequence type 25 carbapenem-resistant hypervirulent Klebsiella pneumoniae from the mid-south region of China. BMC Microbiol. 2019;19(1):219. doi:10.1186/s12866-019-1593-531533609
   PubMed Web of Science ®Google Scholar