428
Views
14
CrossRef citations to date
0
Altmetric
Original Research

Plasmid-Mediated AmpC β-Lactamase CITM and DHAM Genes Among Gram-Negative Clinical Isolates

ORCID Icon, , ORCID Icon, ORCID Icon, , ORCID Icon, ORCID Icon, & ORCID Icon show all
Pages 4249-4261 | Published online: 24 Nov 2020

References

  • Bush K, Bradford PA. β-lactams and β-lactamase inhibitors: an overview. Cold Spring Harb Perspect Med. 2016;6(8):a025247. doi:10.1101/cshperspect.a02524727329032
  • Perez F, El Chakhtoura NG, Papp-Wallace KM, Wilson BM, Bonomo RA. Treatment options for infections caused by carbapenem-resistant Enterobacteriaceae: can we apply “precision medicine” to antimicrobial chemotherapy? Expert Opin Pharmacother. 2016;17:761–781.26799840
  • Falagas ME, Karageorgopoulos DE. Extended-spectrum β-lactamase-producing organisms. J Hosp Infect. 2009;73:345–354. doi:10.1016/j.jhin.2009.02.02119596491
  • Philippon A, Arlet G, Jacoby GA. Plasmid-determined AmpC-type beta-lactamases. Antimicrob Agents Chemother. 2002;46:1–11. doi:10.1128/AAC.46.1.1-11.200211751104
  • Bauernfeind A, Stemplinger I, Jungwirth R, Wilhelm R, Chong Y. Comparative characterization of the cephamycinase blaCMY-1 gene and its relationship with other beta-lactamase genes. Antimicrob Agents Chemother. 1996;40:1926–1930. doi:10.1128/AAC.40.8.19268843306
  • Jacoby GA. AmpC beta-lactamases. Clin Microbiol Rev. 2009;22:161–182. doi:10.1128/CMR.00036-0819136439
  • Alvarez M, Tran JH, Chow N, Jacoby GA. Epidemiology of conjugative plasmid-mediated AmpC beta-lactamases in the United States. Antimicrob Agents Chemother. 2004;48:533–537. doi:10.1128/AAC.48.2.533-537.200414742206
  • Choi SH, Lee JE, Park SJ, et al. Emergence of antibiotic resistance during therapy for infections caused by Enterobacteriaceae producing AmpC beta-lactamase: implications for antibiotic use. Antimicrob Agents Chemother. 2008;52:995–1000. doi:10.1128/AAC.01083-0718086837
  • Yu WL, Cheng KC, Chi CJ, Chen HE, Chuang YC, Wu LT. Characterisation and molecular epidemiology of extended-spectrum beta-lactamase-producing Enterobacter cloacae isolated from a district teaching hospital in Taiwan. Clin Microbiol Infect. 2006;12:579–582.16700709
  • Jacoby GA, Walsh KE, Walker VJ. Identification of extended-spectrum, AmpC, and carbapenem- hydrolyzing beta-lactamases in Escherichia coli and Klebsiella pneumoniae by disk tests. J Clin Microbiol. 2006;44:1971–1976. doi:10.1128/JCM.00062-0616757586
  • Perez-Perez FJ, Hanson ND. Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol. 2002;40:2153–2162. doi:10.1128/JCM.40.6.2153-2162.200212037080
  • Kayastha K, Dhungel B, Karki S, et al. Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species in pediatric patients visiting International Friendship Children’s Hospital, Kathmandu, Nepal. Infect Dis (Auckl). 2020;13:1178633720909798. doi:10.1177/117863372090979832158219
  • Thapa Shrestha U, Shrestha S, Adhikari N, et al. Plasmid profiling and occurrence of beta-lactamase enzymes in multidrug-resistant uropathogenic Escherichia coli in Kathmandu, Nepal. Infect Drug Resist. 2020;13:1905–1917. doi:10.2147/IDR.S25059132606839
  • Guragin N, Pradhan A, Dhungel B, Banjara MR, Rijal KR, Ghimire P. Extended spectrum B-lactamase producing Gram negative bacterial isolates from urine of patients visiting Everest Hospital, Kathmandu, Nepal. TUJM. 2019;6(1):26–31.
  • Raut S, Adhikari B. ESBL and their identification in peripheral laboratories of Nepal. Nepal Med Coll J. 2015;17(3–4):176–181.
  • Koirala A, Agrahari G, Dahal N, Ghimire P, Rijal KR. ESBL and MBL mediated resistance in clinical isolates of nonfermentating Gram negative bacilli (NFGNB) in Nepal. J Microb Antimicrob Agents. 2017;3(1):18–24.
  • Baral P, Neupane S, Shrestha B, Ghimire KR, Marasini BP, Lekhak B. Clinical and microbiological observational study on AmpC-beta -lactamase producing Enterobacteriaceae in a hospital of Nepal. Braz J Infect Dis. 2013;17(2):256–259. doi:10.1016/j.bjid.2012.09.01223453408
  • Isenberg HD. Clinical Microbiology Procedures Handbook. 2nd edition ed. ASM Press WD; 2004.
  • Forbes BA, Sahm DF, Weissfelt AS. Study Guide for Bailey and Scott’s Diagnostic Microbiology. USA, Mosby: Mosby Publication; 2007.
  • Cheesbrough M. District Laboratory Practice in Tropical Countries. United Kingdom: CUPC; 2006.
  • Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing. 28th ed. Informational supplement M100-S28. Wayne: PA: Clinical and Laboratory Standards Institutei; 2018.
  • Magiorakos AP, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18:268–281. doi:10.1111/j.1469-0691.2011.03570.x21793988
  • CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 25th ed. Approved Standard M100 S25 Wayne, PA: Clinical and Laboratory Standards Institute; 2018
  • Tan TY, Ng SY, Teo L, Koh Y, Teok CH. Detection of plasmid-mediated AmpC in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. J Clin Pathol. 2008;61:642–644. doi:10.1136/jcp.2007.05347018057079
  • Tille P. Bailey and Scott’s Diagnostic Microbiology. 13th ed. Mosby Inc; 2014:323–324.
  • Sambrook J, Russell D. Molecular Cloning: A Laboratory Manual. 3rd ed. New York: Cold Spring Harbor Lab Press; 2001.
  • Maleki A, Khosravi A, Ghafourian S, et al. High prevalence of AmpC beta-lactamases in clinical isolates of Escherichia coli in Ilam, Iran. Osong Public Health Res Perspect. 2015;6:201–204. doi:10.1016/j.phrp.2015.02.00126430617
  • Gurung S, Kafle S, Dhungel B, et al. Detection of OXA-48 gene in carbapenem -resistant Escherichia coli and Klebsiella pneumoniae from urine samples. Infect Drug Resist. 2020;13:2311–2321. doi:10.2147/IDR.S25996732765007
  • Pokharel S, Adhikari B. Antimicrobial resistance and over the counter use of drugs in Nepal. J Glob Health. 2020;10:010360. doi:10.7189/jogh.10.01036032566152
  • Pokharel S, Raut S, Adhikari B. Tackling antimicrobial resistance in low-income and middle-income countries. BMJ Glob Health. 2019;4:e002104. doi:10.1136/bmjgh-2019-002104
  • Shakya P, Shrestha D, Maharjan E, Sharma VK, Paudyal R. ESBL production among E. coli and Klebsiella spp. causing urinary tract infection: a hospital based study. Open Microbiol J. 2017;11:23–30. doi:10.2174/187428580171101002328553414
  • Upadhyaya G, Bhattarai A, Rijal KR, Ghimire P, Upadhyaya B. Urinary tract infections in kidney transplant patients of Kathmandu Valley. Int J Microbiol Res Rev. 2013;3(1):1–6.
  • Raut S, Rijal KR, Khatiwada S, et al. Trend and characteristics of Acinetobacter baumannii infections in patients attending Universal College of Medical Sciences, Bhairahawa, Western Nepal: a longitudinal study of 2018. Infect Drug Resist. 2020;13:1631–1641. doi:10.2147/IDR.S25785132606814
  • Shrestha LB, Baral R, Poudel P, Khanal B. Clinical, etiological and antimicrobial susceptibility profile of pediatric urinary tract infections in a tertiary care hospital of Nepal. BMC Pediatr. 2019;19:36. doi:10.1186/s12887-019-1410-130696410
  • Thakur P, Ghimire P, Rijal KR, Singh GK. Antimicrobial resistance pattern of Escherichia coli isolated from urine samples in patients visiting tertiary health care centre in eastern Nepal. Sunsari Tech Coll J. 2012;1(1):22–26. doi:10.3126/stcj.v1i1.8657
  • Kaur N, Sharma S, Malhotra S, Madan P, Hans C. Urinary tract infection: aetiology and antimicrobial resistance pattern in infants from a tertiary care hospital in northern India. J Clin Diagn Res. 2014;8:1–3.
  • Majeed HT, Aljanaby AAJ. Antibiotic susceptibility patterns and prevalence of some extended spectrum beta-lactamases genes in Gram-Negative bacteria isolated from patients infected with urinary tract infections in Al-Najaf City, Iraq. Avicenna J Med Biotechnol. 2019;11:192–201.31057723
  • Seifu WD, Gebissa AD. Prevalence and antibiotic susceptibility of Uropathogens from cases of urinary tract infections (UTI) in Shashemene referral hospital, Ethiopia. BMC Infect Dis. 2018;18:30. doi:10.1186/s12879-017-2911-x29320984
  • Ponce-de-Leon A, Rodriguez-Noriega E, Morfin-Otero R, et al. Antimicrobial susceptibility of Gram-negative bacilli isolated from intra-abdominal and urinary-tract infections in Mexico from 2009 to 2015: results from the study for monitoring antimicrobial resistance trends (SMART). PLoS One. 2018;13:e0198621. doi:10.1371/journal.pone.019862129927958
  • John MS, Meenakshi K, Lakshmi PM, Reddy PS. Prevalence and distribution of bacterial pathogens causing urinary tract infections in humans: a study from tertiary care hospital in AP, India. Int J of Curr Microbio and App Sci. 2015;4:251–257.
  • Bisht HS, Bisht T, Kumar D. The prevalence of post-operative infection among the male and female patients in a Tertiary Care Hospital of Western UP India. ISJR. 2014;3(5):381–383.
  • Gautam R, Chapagain M, Acharya A, et al. Antimicrobial susceptibility patterns of Escherichia coli from various clinical sources. JCMC. 2013;3(1):14–17. doi:10.3126/jcmc.v3i1.8459
  • Tamang K, Shrestha P, Koirala A, Khadka J, Gautam N, Rijal KR. Prevalence of bacterial uropathogens among diabetic patients attending padma Nursing Hospital of Western Nepal. HiJOST. 2017;1:15–19.
  • Oteo J, Delgado-Iribarren A, Vega D, et al. Emergence of imipenem resistance in clinical Escherichia coli during therapy. Int J Antimicrob Agents. 2008;32(6):534–537. doi:10.1016/j.ijantimicag.2008.06.01218775649
  • Kehl SC, Dowzicky MJ. Global assessment of antimicrobial susceptibility among Gram-negative organisms collected from pediatric patients between 2004 and 2012: results from the tigecycline evaluation and surveillance trial. J Clin Microbiol. 2015;53:1286–1293. doi:10.1128/JCM.03184-1425653413
  • Mishra SK, Awal BK, Kattel HP, et al. Drug resistant bacteria are growing menace in a University Hospital in Nepal. Amer J Epidem Infec Dis. 2014;2:19–23.
  • Neupane S, Pant ND, Khatiwada S, Chaudhary R, Banjara MR. Correlation between biofilm formation and resistance toward different commonly used antibiotics along with extended spectrum beta lactamase production in uropathogenic Escherichia coli isolated from the patients suspected of urinary tract infections visiting Shree Birendra Hospital, Chhauni, Kathmandu, Nepal. Antimicrob Resist Infect Control. 2016;5:5.26885364
  • Nepal K, Pant ND, Neupane B, et al. Extended spectrum beta-lactamase and metallo beta-lactamase production among Escherichia coli and Klebsiella pneumoniae isolated from different clinical samples in a tertiary care hospital in Kathmandu, Nepal. Ann Clin Microbiol Antimicrob. 2017;16:62. doi:10.1186/s12941-017-0236-728927454
  • Parajuli NP, Maharjan P, Parajuli H, et al. High rates of multidrug resistance among uropathogenic Escherichia coli in children and analyses of ESBL producers from Nepal. Antimicrob Resist Infect Control. 2017;6:9. doi:10.1186/s13756-016-0168-628096977
  • Upadhyay A, Parajuli P. Extended spectrum β-lactamases (ESBL)-producing Klebsiella species isolated at National Medical College and Teaching Hospital Nepal. Asian J Pharma and Clin Res. 2013;1:161–164.
  • Shrestha S, Amatya R, Dutta R. Prevalence of extended spectrum beta lactamase (ESBL) production in gram negative isolates from pyogenic infection in tertiary care hospital of eastern Nepal. Nepal Med Coll J. 2011;13:186–189.22808812
  • Kaur DC, Puri JS, Kulkarni SS, Jayawant AN. Prevalenc of Ampc beta-lactamases in clinical isolates of E. coli from a tertiary care rural hospital. Int J Pharm and Pharmaceut Sci. 2015;7:165–168.
  • Nikaido H. Multidrug resistance in bacteria. Annu Rev Biochem. 2009;78:119–146. doi:10.1146/annurev.biochem.78.082907.14592319231985
  • Yusuf I, Haruna M, Yahaya H. Prevalence and antibiotic susceptibility of AmpC and ESBLs producing clinical isolates at a tertiary health care center in Kano, north-west Nigeria. Afr J Clin and Experi Microbiol. 2013;14:109–119.
  • Ogefere HO, Osikobia JG, Omoregie R. Prevalence of AmpC β-lactamase among Gram-negative bacteria recovered from clinical specimens in Benin City, Nigeria. Tropic J Pharmaceut Res. 2016;15:1947–1953. doi:10.4314/tjpr.v15i9.20
  • Tondi D, Calo S, Shoichet BK, Costi MP. Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors. Bioorg Med Chem Lett. 2010;20:3416–3419. doi:10.1016/j.bmcl.2010.04.00720452208
  • Khan GM, Thappa RK, Adhikari DS, et al. Cancer prevalence trend in central region of Nepal. J Chitwan Med Colleg. 2013;3:22–25. doi:10.3126/jcmc.v3i1.8461
  • Ansari S, Nepal HP, Gautam R, et al. Community acquired multi-drug resistant clinical isolates of Escherichia coli in a tertiary care center of Nepal. Antimicrob Resist Infect Control. 2015;4:15. doi:10.1186/s13756-015-0059-225937923
  • Hemalatha V, Padma M, Sekar U, Vinodh TM, Arunkumar AS. Detection of Amp C beta lactamases production in Escherichia coli & Klebsiella by an inhibitor based method. Indian J Med Res. 2007;126:220–223.18037717
  • Chakraborty AP, Shenoy S, Saralaya V. Characterization of plasmid mediated AmpC producing Escherichia coli clinical isolates from a tertiary care hospital in South India. Indian J Pathol Microbiol. 2014;57:255–258. doi:10.4103/0377-4929.13470024943759
  • Chaudhary U, Agarwal S, Raghuraman K. Identification of extended spectrum beta lactamases, AmpC and carbapenemase production among isolates of Escherichia coli in North Indian tertiary care centre. Avicenna J Med. 2018;8:46–50. doi:10.4103/ajm.AJM_156_1729682477
  • Dhungana K, Awal BK, Dhungel B, Sharma S, Banjara MR, Rijal KR. Detection of Klebsiella pneumoniae carbapenemase (KPC) and metallo betalactamae (MBL) producing Gram negative bacteria isolated from different clinical samples in a Transplant Center, Kathmandu, Nepal. Acta Scientific Microbiol. 2019;2(12):60–69. doi:10.31080/ASMI.2019.02.0432